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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046847
Ensembl Protein ID ENSP00000329967.5
UniProt Accession Q9UHD2; A8K4S4; Q8IYV3; Q9NUJ5; TBK1_HUMAN
Genbank Protein ID AAF05989.1; AAF69106.1; BAA92129.1; BAF83728.1; EAW97133.1; AAH34950.1
Protein Name Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1
Genbank Nucleotide ID AF191838; AF174536; AK002192; AK291039; CH471054; BC034950
Gene Name TBK1; NAK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183735.9 ENST00000331710.9 ENSP00000329967.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
TTDKPIDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 94.10 0.00e+00 1459.00 IUUC-Mmu-064107
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.
 Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.
Protein Sequence
(Fasta)
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046847|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
AATCCCAATT ACTGTGTTCG CTGCTCAGGG CTCCTCATTC CCCTTTAGAG TAAAGGGCGA 60
GGGCAACAGT GGACGGGGTG TCTCCAGACA TCCCCCTCAT TACCGTGGCC GCGGAAGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046847|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0036--Amyotrophic lateral sclerosis
KW-0051--Antiviral defense
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0955--Glaucoma
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0523--Neurodegeneration
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005524--F:ATP binding
GO:0003676--F:nucleic acid binding
GO:0051219--F:phosphoprotein binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0050830--P:defense response to Gram-positive bacterium
GO:0051607--P:defense response to virus
GO:0044565--P:dendritic cell proliferation
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0010629--P:negative regulation of gene expression
GO:0032480--P:negative regulation of type I interferon production
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0032728--P:positive regulation of interferon-beta production
GO:0016239--P:positive regulation of macroautophagy
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032481--P:positive regulation of type I interferon production
GO:1904417--P:positive regulation of xenophagy
GO:1901214--P:regulation of neuron death
GO:0032479--P:regulation of type I interferon production
GO:0009615--P:response to virus
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0032606--P:type I interferon production
KEGG hsa:29110
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001638 Ailuropoda melanoleuca 97.39 0.00e+00 1491.00
IUUC-Apl-004028 Anas platyrhynchos 87.24 0.00e+00 1360.00
IUUC-Aca-004998 Anolis carolinensis 82.44 0.00e+00 1288.00
IUUC-Ame-011617 Astyanax mexicanus 71.03 0.00e+00 1068.00
IUUC-Bta-012799 Bos taurus 97.12 0.00e+00 1488.00
IUUC-Cja-019357 Callithrix jacchus 98.49 0.00e+00 1501.00
IUUC-Cfa-020309 Canis familiaris 96.71 0.00e+00 1481.00
IUUC-Cpo-022062 Cavia porcellus 96.57 0.00e+00 1476.00
IUUC-Csa-023517 Chlorocebus sabaeus 99.04 0.00e+00 1513.00
IUUC-Cho-025037 Choloepus hoffmanni 93.94 0.00e+00 977.00
IUUC-Cin-025580 Ciona intestinalis 41.03 1.00e-150 526.00
IUUC-Csv-025818 Ciona savignyi 40.84 2.00e-145 509.00
IUUC-Dre-027527 Danio rerio 71.39 0.00e+00 1088.00
IUUC-Dno-029475 Dasypus novemcinctus 84.60 0.00e+00 1130.00
IUUC-Dme-031698 Drosophila melanogaster 39.63 2.00e-133 470.00
IUUC-Ete-033090 Echinops telfairi 82.85 0.00e+00 1230.00
IUUC-Eca-033996 Equus caballus 94.92 0.00e+00 1467.00
IUUC-Eeu-035082 Erinaceus europaeus 88.49 0.00e+00 867.00
IUUC-Fca-035921 Felis catus 93.85 0.00e+00 1427.00
IUUC-Fal-037406 Ficedula albicollis 87.11 0.00e+00 1362.00
IUUC-Gmo-038721 Gadus morhua 71.33 0.00e+00 1055.00
IUUC-Gga-041234 Gallus gallus 86.56 0.00e+00 1357.00
IUUC-Gac-042315 Gasterosteus aculeatus 72.00 0.00e+00 1074.00
IUUC-Ggo-044885 Gorilla gorilla 93.55 0.00e+00 1404.00
IUUC-Itr-047906 Ictidomys tridecemlineatus 96.33 0.00e+00 1474.00
IUUC-Lch-049731 Latimeria chalumnae 54.62 0.00e+00 779.00
IUUC-Loc-051879 Lepisosteus oculatus 73.21 0.00e+00 1111.00
IUUC-Laf-054232 Loxodonta africana 95.34 0.00e+00 1464.00
IUUC-Mcc-055447 Macaca mulatta 99.04 0.00e+00 1513.00
IUUC-Meu-056138 Macropus eugenii 96.98 0.00e+00 684.00
IUUC-Mga-059460 Meleagris gallopavo 85.36 0.00e+00 1328.00
IUUC-Mmr-061445 Microcebus murinus 97.81 0.00e+00 1495.00
IUUC-Mmu-064107 Mus musculus 94.10 0.00e+00 1434.00
IUUC-Mpu-066834 Mustela putorius furo 97.39 0.00e+00 1493.00
IUUC-Mlu-068006 Myotis lucifugus 92.74 0.00e+00 1400.00
IUUC-Nle-069280 Nomascus leucogenys 99.59 0.00e+00 1519.00
IUUC-Opr-070728 Ochotona princeps 89.13 0.00e+00 1201.00
IUUC-Ont-071621 Oreochromis niloticus 72.88 0.00e+00 1087.00
IUUC-Oan-073162 Ornithorhynchus anatinus 91.14 0.00e+00 1367.00
IUUC-Ocu-074787 Oryctolagus cuniculus 97.53 0.00e+00 1492.00
IUUC-Ola-086737 Oryzias latipes 33.48 4.00e-28 120.00
IUUC-Oga-088764 Otolemur garnettii 94.92 0.00e+00 1462.00
IUUC-Oar-090333 Ovis aries 96.58 0.00e+00 1479.00
IUUC-Ptr-090568 Pan troglodytes 99.59 0.00e+00 1516.00
IUUC-Pan-091979 Papio anubis 98.77 0.00e+00 1504.00
IUUC-Psi-093336 Pelodiscus sinensis 86.83 0.00e+00 1342.00
IUUC-Pma-094200 Petromyzon marinus 44.61 2.00e-177 615.00
IUUC-Pfo-096354 Poecilia formosa 71.69 0.00e+00 1080.00
IUUC-Pab-098499 Pongo abelii 99.59 0.00e+00 1520.00
IUUC-Pva-102454 Pteropus vampyrus 95.61 0.00e+00 1446.00
IUUC-Rno-105595 Rattus norvegicus 94.51 0.00e+00 1432.00
IUUC-Sha-106864 Sarcophilus harrisii 93.17 0.00e+00 1446.00
IUUC-Sar-113728 Sorex araneus 88.00 0.00e+00 1266.00
IUUC-Tgu-117200 Taeniopygia guttata 86.07 0.00e+00 1345.00
IUUC-Tsy-119017 Tarsius syrichta 96.88 0.00e+00 1105.00
IUUC-Tni-120724 Tetraodon nigroviridis 71.35 0.00e+00 1075.00
IUUC-Tbe-127887 Tupaia belangeri 87.54 0.00e+00 1048.00
IUUC-Ttr-129111 Tursiops truncatus 89.30 0.00e+00 1345.00
IUUC-Vpa-130724 Vicugna pacos 97.53 0.00e+00 1491.00
IUUC-Xtr-132091 Xenopus tropicalis 74.97 0.00e+00 1168.00
Created Date 25-Jun-2017

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