iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-11	44.5	538	594

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           k++ ++l+d+e  +ddeL +++ d++++i   ++de  ++g  el+g rG fP+ Fve l+
   Q: 538  KRRAKALHDFERHDDDELGFRRNDIITII--SQKDEHCWVG--ELNGLRGWFPAKFVELLD 594
           67899************************..777888888*..9*************9886 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MDMARSIFGR DHEGYVGREE HTRKLQNLGS EDDLGELPPM MEELSVADGL RPNPGGPFSA 60
LTASMWPQEI LAKLGGGAEL ASGPNDQPEY RFDEFGFRVE EEDGPEQSSN KLLSIPFVED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGAACAGCT GATAGTGAAA TCAGATTCGG TAGCTAATTG AAAACGAAAC AATGAAGAAA 60
TAATATTTGT TTTTCACACG CCACAAAGAG ACACTTAAGA GAAACTTTCA CTGAATGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000195--Rab-GTPase-TBC_dom
IPR004012--Run_dom
IPR001452--SH3_domain

PROSITE

PS50826--RUN
PS50002--SH3
PS50086--TBC_RABGAP

Pfam

PF00566--RabGAP-TBC
PF02759--RUN
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00593--RUN
SM00326--SH3
SM00164--TBC

Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005622--C:intracellular
GO:0005096--F:GTPase activator activity
GO:0017137--F:Rab GTPase binding
GO:0090630--P:activation of GTPase activity
GO:0006886--P:intracellular protein transport
GO:0043547--P:positive regulation of GTPase activity
GO:0031338--P:regulation of vesicle fusion

KEGG

dme:Dmel_CG12241

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004863	Anolis carolinensis	65.12	0.00e+00	1031.00
IUUC-Cja-019526	Callithrix jacchus	62.01	0.00e+00	630.00
IUUC-Cfa-021075	Canis familiaris	64.94	0.00e+00	1018.00
IUUC-Dno-029715	Dasypus novemcinctus	64.67	0.00e+00	1016.00
IUUC-Eca-033476	Equus caballus	65.34	0.00e+00	1024.00
IUUC-Fca-035397	Felis catus	66.97	7.00e-179	619.00
IUUC-Laf-054163	Loxodonta africana	50.85	0.00e+00	716.00
IUUC-Mcc-055074	Macaca mulatta	76.45	6.00e-123	432.00
IUUC-Mmu-063863	Mus musculus	64.94	0.00e+00	1000.00
IUUC-Mpu-065920	Mustela putorius furo	65.21	0.00e+00	1018.00
IUUC-Pan-092392	Papio anubis	35.84	3.00e-38	153.00
IUUC-Psi-093779	Pelodiscus sinensis	66.05	0.00e+00	1051.00
IUUC-Pop-098848	Populus trichocarpa	42.31	4.90e-01	28.10
IUUC-Rno-105265	Rattus norvegicus	64.54	0.00e+00	989.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence