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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045863
UUCD1 version UUC-HoS-00128
Ensembl Protein ID ENSP00000477792.1
UniProt Accession Q15345; A8K5G8; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0; LRC41_HUMAN
Genbank Protein ID BAC86308.1; BAF83972.1; BAG59981.1; CAI21964.1; CAI21964.1; CAI22118.1; CAI22118.1; EAX06927.1; AAH04953.2; AAI01523.1; AAI01525.1; CAD97609.1; AAQ15266.1; CAA60013.1
Protein Name Leucine-rich repeat-containing protein 41; Protein Muf1
Genbank Nucleotide ID AK125827; AK291283; AK297596; AL122001; AL121602; AL121602; AL122001; CH471059; BC004953; BC101522; BC101524; BX537366; AF370430; X86018
Gene Name LRRC41; MUF1; PP7759
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132128.16 ENST00000496156.5 ENSP00000477909.1
ENSG00000132128.16 ENST00000617190.4 ENSP00000477792.1
ENSG00000132128.16 ENST00000472710.2 ENSP00000478135.1
ENSG00000132128.16 ENST00000498402.2 ENSP00000483633.1
ENSG00000132128.16 ENST00000617760.4 ENSP00000484558.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 11384984
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 93.84 0.00e+00 1297.00 IUUC-Mmu-063358
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV 60
LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045863|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTACTACC AGCCGCAGGC AGAGGTTAGG GGTAGCTGAT GTTTGCACCC GAGGAGGCTT 60
TGCTAAGAAA CATCCCCTTA GTCATACCAC ACCCAAGTAT AATTGATCTA GGAGTTTATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045863|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR032675--L_dom-like
IPR026137--Leu_rpt_41
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination
KEGG hsa:10489
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003769 Anas platyrhynchos 53.71 6.00e-167 581.00
IUUC-Aca-005345 Anolis carolinensis 48.48 2.00e-158 552.00
IUUC-Ame-011074 Astyanax mexicanus 32.69 4.00e-17 82.80
IUUC-Bta-012962 Bos taurus 94.49 0.00e+00 680.00
IUUC-Cja-019020 Callithrix jacchus 98.77 0.00e+00 1363.00
IUUC-Cfa-020137 Canis familiaris 96.19 0.00e+00 1320.00
IUUC-Cpo-021856 Cavia porcellus 95.95 0.00e+00 1320.00
IUUC-Csa-024137 Chlorocebus sabaeus 99.37 0.00e+00 1305.00
IUUC-Dre-027630 Danio rerio 28.94 2.00e-23 103.00
IUUC-Dno-028994 Dasypus novemcinctus 95.33 0.00e+00 1318.00
IUUC-Dse-031281 Dothistroma septosporum 26.80 2.30e+00 27.30
IUUC-Ete-032443 Echinops telfairi 87.82 1.00e-153 536.00
IUUC-Eca-033730 Equus caballus 91.34 0.00e+00 1219.00
IUUC-Eeu-034789 Erinaceus europaeus 93.20 0.00e+00 1181.00
IUUC-Fca-035714 Felis catus 95.58 0.00e+00 1258.00
IUUC-Fal-036765 Ficedula albicollis 52.93 0.00e+00 630.00
IUUC-Fso-038317 Fusarium solani 34.09 3.20e-01 29.30
IUUC-Gmo-038656 Gadus morhua 21.76 3.00e-04 38.10
IUUC-Gga-040164 Gallus gallus 50.30 2.00e-179 622.00
IUUC-Gac-041941 Gasterosteus aculeatus 34.07 5.00e-25 107.00
IUUC-Ggo-045159 Gorilla gorilla 100.00 0.00e+00 1357.00
IUUC-Itr-048804 Ictidomys tridecemlineatus 98.15 0.00e+00 1273.00
IUUC-Lpe-051218 Leersia perrieri 31.25 4.00e-03 33.90
IUUC-Loc-052391 Lepisosteus oculatus 34.62 9.00e-36 145.00
IUUC-Lma-053146 Leptosphaeria maculans 32.39 4.00e-02 33.90
IUUC-Laf-054362 Loxodonta africana 95.95 0.00e+00 1311.00
IUUC-Mcc-055382 Macaca mulatta 99.60 0.00e+00 1241.00
IUUC-Meu-056890 Macropus eugenii 52.76 0.00e+00 685.00
IUUC-Mla-058850 Melampsora laricipopulina 25.93 8.30e-02 31.60
IUUC-Mga-059832 Meleagris gallopavo 52.05 4.00e-163 568.00
IUUC-Mmr-061383 Microcebus murinus 96.19 0.00e+00 1386.00
IUUC-Mdo-062507 Monodelphis domestica 59.98 0.00e+00 827.00
IUUC-Mmu-063358 Mus musculus 93.72 0.00e+00 1306.00
IUUC-Mpu-066845 Mustela putorius furo 97.18 0.00e+00 1328.00
IUUC-Mlu-067006 Myotis lucifugus 93.52 0.00e+00 1303.00
IUUC-Nfi-068505 Neosartorya fischeri 37.74 7.20e-02 31.20
IUUC-Nle-069386 Nomascus leucogenys 99.75 0.00e+00 1352.00
IUUC-Opr-070396 Ochotona princeps 97.61 3.00e-119 422.00
IUUC-Oan-073068 Ornithorhynchus anatinus 54.26 0.00e+00 686.00
IUUC-Ocu-074054 Oryctolagus cuniculus 96.56 0.00e+00 1310.00
IUUC-Ogl-077410 Oryza glaberrima 27.66 3.80e-02 33.10
IUUC-Oin-079496 Oryza indica 27.66 3.40e-02 33.50
IUUC-Olo-080740 Oryza longistaminata 27.66 3.30e-02 33.10
IUUC-Oni-082831 Oryza nivara 27.66 3.90e-02 33.10
IUUC-Oru-084740 Oryza rufipogon 27.66 3.60e-02 33.90
IUUC-Osa-085903 Oryza sativa 27.66 3.50e-02 33.50
IUUC-Oga-088549 Otolemur garnettii 96.68 0.00e+00 1348.00
IUUC-Oar-089776 Ovis aries 96.13 0.00e+00 1230.00
IUUC-Ptr-090774 Pan troglodytes 100.00 0.00e+00 1357.00
IUUC-Pan-092510 Papio anubis 99.63 0.00e+00 1358.00
IUUC-Psi-094058 Pelodiscus sinensis 54.99 0.00e+00 634.00
IUUC-Pma-094518 Petromyzon marinus 30.81 3.00e-15 75.90
IUUC-Ppa-095577 Physcomitrella patens 26.00 4.30e-01 28.50
IUUC-Pfo-097181 Poecilia formosa 34.02 1.00e-25 111.00
IUUC-Pab-098616 Pongo abelii 86.58 0.00e+00 1071.00
IUUC-Pop-100048 Populus trichocarpa 30.00 3.00e-03 34.70
IUUC-Pca-101105 Procavia capensis 94.04 0.00e+00 987.00
IUUC-Pva-102749 Pteropus vampyrus 90.40 1.00e-166 580.00
IUUC-Rno-105070 Rattus norvegicus 95.20 0.00e+00 1358.00
IUUC-Sha-106634 Sarcophilus harrisii 54.75 2.00e-143 503.00
IUUC-Sar-113288 Sorex araneus 92.38 0.00e+00 696.00
IUUC-Ssc-115559 Sus scrofa 95.45 0.00e+00 1271.00
IUUC-Tgu-116561 Taeniopygia guttata 51.17 1.00e-179 623.00
IUUC-Tni-120099 Tetraodon nigroviridis 31.60 1.00e-17 84.70
IUUC-Tme-127168 Tuber melanosporum 22.86 3.90e-02 32.70
IUUC-Tbe-127527 Tupaia belangeri 95.78 2.00e-142 500.00
IUUC-Ttr-128532 Tursiops truncatus 96.28 0.00e+00 1227.00
IUUC-Xtr-131881 Xenopus tropicalis 41.19 4.00e-91 328.00
Created Date 25-Jun-2017

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