• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046212
UUCD1 version UUC-HoS-00087
Ensembl Protein ID ENSP00000315212.8
UniProt Accession P78317; B2R6D6; D6RF58; Q49AR8; RNF4_HUMAN
Genbank Protein ID BAA19122.1; AAC52022.1; BAG54620.1; BAG35433.1; AAH31935.1
Protein Name E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein
Genbank Nucleotide ID AB000468; U95140; AK128038; AK309509; AL110117
Gene Name RNF4; SNURF; RES4-26
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000063978.15 ENST00000314289.12 ENSP00000315212.8
ENSG00000063978.15 ENST00000509258.5 ENSP00000422500.1
ENSG00000063978.15 ENST00000513284.5 ENSP00000425724.1
ENSG00000063978.15 ENST00000513578.5 ENSP00000422938.1
ENSG00000063978.15 ENST00000511859.5 ENSP00000426615.1
ENSG00000063978.15 ENST00000508235.1 ENSP00000427212.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18408734; 19380586; 20212317; 20026589; 22661230; 22635276
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.70e-08 35.8 132 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf......kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++ +       +  +++ CgHvf+ +Cl       +s +++ +CP+Cr
   Q: 132  CPICMDGYseivqnGRLIVSTECGHVFCSQCL------RDSLKNANTCPTCR 177
           ********55553322255788*********9......4559*********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
 E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Protein Sequence
(Fasta)
MSTRKRRGGA INSRQAQKRT REATSTPEIS LEAEPIELVE TAGDEIVDLT CESLEPVVVD 60
LTHNDSVVIV DERRRPRRNA RRLPQDHADS CVVSSDDEEL SRDRDVYVTT HTPRNARDEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046212|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAGAAGTGCT GGAGACTCCC CCAACCCCTC CAGCCCCTGA GCGGTGGTAC TGTCTAGGAG 60
CGCGCCGCGG CCCCTGGGCC TCGCTGTCTG TCCTAAATCA TTCCGGTGAA CCTCTCCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046212|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0031491--F:nucleosome binding
GO:0032184--F:SUMO polymer binding
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030521--P:androgen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0090234--P:regulation of kinetochore assembly
GO:0090169--P:regulation of spindle assembly
GO:0046685--P:response to arsenic-containing substance
GO:0006351--P:transcription, DNA-templated
KEGG hsa:6047
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000620 Aegilops tauschii 39.34 2.00e-10 59.70
IUUC-Aml-002206 Ailuropoda melanoleuca 93.58 6.00e-85 306.00
IUUC-Atr-002771 Amborella trichopoda 35.38 5.00e-09 54.70
IUUC-Apl-004120 Anas platyrhynchos 70.92 1.00e-70 258.00
IUUC-Aca-004236 Anolis carolinensis 63.16 1.00e-60 225.00
IUUC-Ame-011555 Astyanax mexicanus 50.93 1.00e-36 145.00
IUUC-Bta-012913 Bos taurus 86.84 2.00e-86 311.00
IUUC-Bdi-014655 Brachypodium distachyon 42.62 1.00e-10 60.10
IUUC-Bol-016418 Brassica oleracea 37.70 5.00e-09 55.10
IUUC-Bra-016890 Brassica rapa 36.84 1.00e-07 50.10
IUUC-Cel-018585 Caenorhabditis elegans 33.33 2.00e-08 52.40
IUUC-Cja-019151 Callithrix jacchus 95.81 3.00e-87 314.00
IUUC-Cfa-020868 Canis familiaris 90.53 2.00e-81 295.00
IUUC-Cpo-022249 Cavia porcellus 87.17 9.00e-74 269.00
IUUC-Csa-024125 Chlorocebus sabaeus 98.42 1.00e-91 328.00
IUUC-Cin-025749 Ciona intestinalis 40.98 2.00e-13 69.30
IUUC-Csv-026318 Ciona savignyi 40.98 7.00e-13 67.00
IUUC-Dre-028145 Danio rerio 43.75 1.00e-32 132.00
IUUC-Dno-029605 Dasypus novemcinctus 92.11 9.00e-94 335.00
IUUC-Dor-030898 Dipodomys ordii 87.37 2.00e-89 321.00
IUUC-Dme-032177 Drosophila melanogaster 42.37 1.00e-10 60.50
IUUC-Ete-032694 Echinops telfairi 83.96 2.00e-71 261.00
IUUC-Eca-033443 Equus caballus 94.74 2.00e-87 314.00
IUUC-Eeu-034603 Erinaceus europaeus 95.15 6.00e-56 208.00
IUUC-Fca-035507 Felis catus 91.44 6.00e-81 293.00
IUUC-Fal-037382 Ficedula albicollis 67.86 6.00e-64 236.00
IUUC-Gmo-038960 Gadus morhua 71.43 8.00e-19 85.90
IUUC-Gga-040493 Gallus gallus 68.21 4.00e-67 246.00
IUUC-Gac-042194 Gasterosteus aculeatus 49.01 1.00e-35 142.00
IUUC-Ggo-044726 Gorilla gorilla 100.00 1.00e-92 331.00
IUUC-Hvu-047337 Hordeum vulgare 37.70 2.00e-10 59.70
IUUC-Itr-047892 Ictidomys tridecemlineatus 96.26 9.00e-86 308.00
IUUC-Lpe-050920 Leersia perrieri 34.57 5.00e-11 61.20
IUUC-Loc-051907 Lepisosteus oculatus 47.59 2.00e-35 142.00
IUUC-Laf-054145 Loxodonta africana 89.84 4.00e-80 290.00
IUUC-Mcc-055689 Macaca mulatta 98.95 2.00e-91 328.00
IUUC-Meu-056654 Macropus eugenii 46.52 1.00e-39 155.00
IUUC-Mtr-058314 Medicago truncatula 45.45 1.00e-10 58.90
IUUC-Mga-059303 Meleagris gallopavo 69.90 8.00e-70 256.00
IUUC-Mmr-061355 Microcebus murinus 96.84 5.00e-89 319.00
IUUC-Mdo-062968 Monodelphis domestica 65.61 1.00e-65 242.00
IUUC-Mmu-064421 Mus musculus 91.44 2.00e-92 331.00
IUUC-Mac-064573 Musa acuminata 31.68 7.00e-12 64.70
IUUC-Mpu-066522 Mustela putorius furo 93.58 6.00e-85 306.00
IUUC-Mlu-067065 Myotis lucifugus 89.30 9.00e-81 292.00
IUUC-Nle-069198 Nomascus leucogenys 98.42 3.00e-91 327.00
IUUC-Opr-071141 Ochotona princeps 88.24 1.00e-86 311.00
IUUC-Oan-073341 Ornithorhynchus anatinus 66.67 3.00e-36 144.00
IUUC-Ocu-073787 Oryctolagus cuniculus 95.19 1.00e-94 338.00
IUUC-Oba-075460 Oryza barthii 40.32 5.00e-11 61.60
IUUC-Obr-076349 Oryza brachyantha 37.70 9.00e-10 57.40
IUUC-Ogl-077094 Oryza glaberrima 37.97 2.00e-12 66.20
IUUC-Ogu-078677 Oryza glumaepatula 40.32 4.00e-11 61.60
IUUC-Oin-079992 Oryza indica 37.97 2.00e-12 66.20
IUUC-Olo-080257 Oryza longistaminata 41.94 3.00e-11 62.00
IUUC-Ome-081943 Oryza meridionalis 37.97 2.00e-12 66.60
IUUC-Oni-082671 Oryza nivara 40.32 5.00e-11 61.60
IUUC-Opu-083644 Oryza punctata 40.32 7.00e-11 60.80
IUUC-Oru-084650 Oryza rufipogon 40.32 5.00e-11 61.60
IUUC-Osa-086110 Oryza sativa 37.97 2.00e-12 66.20
IUUC-Ola-086970 Oryzias latipes 43.37 1.00e-33 135.00
IUUC-Olu-087634 Ostreococcus lucimarinus 37.29 3.00e-10 58.20
IUUC-Oga-088242 Otolemur garnettii 95.72 2.00e-95 341.00
IUUC-Oar-089469 Ovis aries 87.70 6.00e-90 323.00
IUUC-Ptr-091254 Pan troglodytes 94.21 2.00e-85 308.00
IUUC-Pan-092776 Papio anubis 98.95 2.00e-91 328.00
IUUC-Psi-093929 Pelodiscus sinensis 70.05 1.00e-67 248.00
IUUC-Pma-094118 Petromyzon marinus 50.62 4.00e-21 92.00
IUUC-Ppa-095567 Physcomitrella patens 44.26 3.00e-11 62.40
IUUC-Pfo-097412 Poecilia formosa 47.83 6.00e-34 136.00
IUUC-Pab-098424 Pongo abelii 99.47 4.00e-92 330.00
IUUC-Pop-099483 Populus trichocarpa 37.10 7.00e-09 53.90
IUUC-Pca-100463 Procavia capensis 83.69 9.00e-50 189.00
IUUC-Pva-102594 Pteropus vampyrus 89.36 3.00e-61 227.00
IUUC-Rno-105460 Rattus norvegicus 91.01 2.00e-82 298.00
IUUC-Sha-107487 Sarcophilus harrisii 70.37 5.00e-67 246.00
IUUC-Sit-109959 Setaria italica 36.07 4.00e-05 42.40
IUUC-Stu-112694 Solanum tuberosum 39.06 4.00e-09 54.70
IUUC-Sar-113601 Sorex araneus 88.77 8.00e-79 285.00
IUUC-Sbi-114398 Sorghum bicolor 36.07 1.00e-04 40.40
IUUC-Ssc-115911 Sus scrofa 94.21 1.00e-86 311.00
IUUC-Tgu-117264 Taeniopygia guttata 68.25 2.00e-61 228.00
IUUC-Tru-117663 Takifugu rubripes 47.90 3.00e-36 144.00
IUUC-Tsy-118883 Tarsius syrichta 89.19 5.00e-68 249.00
IUUC-Tae-124035 Triticum aestivum 39.34 1.00e-10 60.10
IUUC-Tur-126408 Triticum urartu 39.34 2.00e-10 59.70
IUUC-Ttr-128950 Tursiops truncatus 65.26 2.00e-65 242.00
IUUC-Vvi-130833 Vitis vinifera 40.32 4.00e-10 58.50
IUUC-Xtr-132879 Xenopus tropicalis 60.39 2.00e-39 154.00
IUUC-Xma-133319 Xiphophorus maculatus 46.94 2.00e-32 130.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved