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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046873
Ensembl Protein ID ENSP00000460885.1
UniProt Accession P57737; B4DFD6; B4DL18; I3L416; Q17RK4; CORO7_HUMAN
Genbank Protein ID BAB15211.1; BAG57397.1; BAG59380.1; EAW85307.1; AAI17290.1; AAI17292.1
Protein Name Coronin-7; 70 kDa WD repeat tumor rejection antigen homolog
Genbank Nucleotide ID AK025674; AK294045; AK296807; AC012676; BC032732; BC117291
Gene Name CORO7-PAM16; CORO7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103426.12 ENST00000572467.5 ENSP00000460885.1
ENSG00000103426.12 ENST00000575334.5 ENSP00000458607.1
Annotation
Cancer Mutation
ICGCIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
CircNetTRANSFACTargetScanSomamiR
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
PhosphositePlusdbPTMHPRDPhospho.ELM
BioGRID
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.60e-36 122.6 635 672
UBD/Beta-Prp 3.00e-40 139.9 542 669
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d +++la+ +d   l++ + Dg ++v+++r+g+ +
   Q: 635  GHQDQIFSLAWsPDgQQLATVCKDGRVRVYRPRSGPEP 672
           8***********9999*****************99865 PP
   

   UBD/Beta-Prp
   S: 91   kghedsvlslsfsp.sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrt 174
           + + + v++l+++p + ++l+++++d  ir+w ++ +   e       +l+gh++ ++++++hp + n+l+s+s+D tvr+Wdl+ g    +
   Q: 542  Q-NGAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEGLEEVlttpetVLTGHTEKICSLRFHPLAaNVLASSSYDLTVRIWDLQAGADRLK 632
           5.66889*******666*****************99877666789*********************************************** PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
           l+g h+d++ sl+++++g++l+++ +dg+v+++  ++g
   Q: 633  LQG-HQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSG 669
           **9.*****************************98765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
 F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Protein Sequence
(Fasta)
MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD RPGVLGIVPL 60
QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR TVKLWRLPGP GQALPSAPGV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046873|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTAAGGAGT GGAGTGGATG ATGGTAATTA CCAAAAGAGA GGACAAAGTC CTTGGGATCT 60
GCCACACAGA AGAAAGAAAA ACATGGGAAA GACTCCCAGC TGAGAGCAGC CTGGGCCTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046873|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027331--CORO7
IPR015505--Coronin
IPR003143--Cyt_cd1_C
IPR015048--DUF1899
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08953--DUF1899
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01166--DUF1899
SM00320--WD40
Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005802--C:trans-Golgi network
GO:0003779--F:actin binding
GO:0030041--P:actin filament polymerization
GO:0006895--P:Golgi to endosome transport
GO:0015031--P:protein transport
KEGG hsa:79585
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002235 Ailuropoda melanoleuca 86.35 0.00e+00 1367.00
IUUC-Apl-004126 Anas platyrhynchos 59.27 3.00e-116 412.00
IUUC-Ame-011310 Astyanax mexicanus 66.48 2.00e-73 269.00
IUUC-Bta-012843 Bos taurus 85.39 0.00e+00 1403.00
IUUC-Cel-018204 Caenorhabditis elegans 35.46 2.00e-70 261.00
IUUC-Cja-019024 Callithrix jacchus 91.67 0.00e+00 1449.00
IUUC-Cfa-020626 Canis familiaris 86.90 0.00e+00 1393.00
IUUC-Cpo-022429 Cavia porcellus 86.36 0.00e+00 1479.00
IUUC-Csa-023919 Chlorocebus sabaeus 96.85 0.00e+00 1756.00
IUUC-Dno-029234 Dasypus novemcinctus 74.22 0.00e+00 1174.00
IUUC-Dor-030242 Dipodomys ordii 87.77 0.00e+00 1422.00
IUUC-Dme-032156 Drosophila melanogaster 43.97 1.00e-120 428.00
IUUC-Ete-032862 Echinops telfairi 82.49 0.00e+00 1240.00
IUUC-Eca-033902 Equus caballus 85.53 0.00e+00 1361.00
IUUC-Eeu-034540 Erinaceus europaeus 65.01 0.00e+00 657.00
IUUC-Fca-036335 Felis catus 87.73 0.00e+00 1432.00
IUUC-Fal-037278 Ficedula albicollis 72.19 0.00e+00 681.00
IUUC-Gmo-038846 Gadus morhua 66.67 5.00e-179 621.00
IUUC-Gga-041144 Gallus gallus 60.74 0.00e+00 1030.00
IUUC-Ggo-045469 Gorilla gorilla 90.30 0.00e+00 702.00
IUUC-Itr-048351 Ictidomys tridecemlineatus 88.31 0.00e+00 1449.00
IUUC-Laf-053869 Loxodonta africana 71.76 0.00e+00 968.00
IUUC-Mcc-054896 Macaca mulatta 97.04 0.00e+00 1781.00
IUUC-Meu-056428 Macropus eugenii 74.05 0.00e+00 1282.00
IUUC-Mga-059389 Meleagris gallopavo 64.61 0.00e+00 1104.00
IUUC-Mvi-060231 Microbotryum violaceum 34.90 3.00e-60 227.00
IUUC-Mmr-060935 Microcebus murinus 87.97 0.00e+00 1468.00
IUUC-Mdo-062707 Monodelphis domestica 74.78 0.00e+00 1322.00
IUUC-Mmu-063976 Mus musculus 83.77 0.00e+00 1462.00
IUUC-Mpu-066441 Mustela putorius furo 87.27 0.00e+00 1349.00
IUUC-Mlu-067524 Myotis lucifugus 87.23 0.00e+00 1446.00
IUUC-Opr-071099 Ochotona princeps 84.34 0.00e+00 1266.00
IUUC-Oan-072860 Ornithorhynchus anatinus 69.16 0.00e+00 808.00
IUUC-Ocu-074794 Oryctolagus cuniculus 86.80 0.00e+00 1378.00
IUUC-Oga-088030 Otolemur garnettii 85.28 0.00e+00 1320.00
IUUC-Oar-090379 Ovis aries 72.36 0.00e+00 1159.00
IUUC-Ptr-091006 Pan troglodytes 94.70 0.00e+00 1488.00
IUUC-Pan-092428 Papio anubis 96.65 0.00e+00 1597.00
IUUC-Pfo-096558 Poecilia formosa 55.58 0.00e+00 1011.00
IUUC-Pab-098298 Pongo abelii 86.50 0.00e+00 1318.00
IUUC-Pca-100305 Procavia capensis 77.92 0.00e+00 930.00
IUUC-Pva-102702 Pteropus vampyrus 85.41 0.00e+00 1150.00
IUUC-Rno-105934 Rattus norvegicus 77.62 0.00e+00 1406.00
IUUC-Sar-112987 Sorex araneus 83.77 4.00e-110 392.00
IUUC-Ssc-116071 Sus scrofa 86.80 0.00e+00 1433.00
IUUC-Tgu-116813 Taeniopygia guttata 66.03 9.00e-175 606.00
IUUC-Tru-118359 Takifugu rubripes 54.81 0.00e+00 1006.00
IUUC-Ttr-129020 Tursiops truncatus 84.63 0.00e+00 1439.00
Created Date 25-Jun-2017

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