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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046324
Ensembl Protein ID ENSP00000401112.1
UniProt Accession Q9UPW6; A8K5Z8; Q3ZB87; Q4V763; SATB2_HUMAN
Genbank Protein ID BAA82986.1; BAF84152.1; EAW70180.1; AAH98136.1; AAH99723.1; AAI03493.1; AAI03501.1
Protein Name DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2
Genbank Nucleotide ID AB028957; AK291463; AC016746; BC098136; BC099723; BC103492; BC103500
Gene Name SATB2; KIAA1034
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119042.16 ENST00000417098.5 ENSP00000401112.1
ENSG00000119042.16 ENST00000443023.5 ENSP00000388764.1
ENSG00000119042.16 ENST00000428695.5 ENSP00000388581.1
ENSG00000119042.16 ENST00000440919.1 ENSP00000415610.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Protein 3D Structure
PDBMMDBSCOP
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 6.60e-06 27.6 62 148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlkvnpsd.tVaeLKeki.....ekk.lgip.peqqrLiykGki.L..eddktLady.glkdgstihllekksg 75
           v+++v++ldgs e++ + ++++ +V+++K+ +     e++ l ++ +++++ + +G+i L  +++ +L+++ +++d++++++l+++++
   Q: 62   VFCVVEQLDGSlEYDNR-EEHAeFVLVRKDVLfsqlvETAlLALGySHSSAAQAQGIIkLgrWNPLPLSYVtDAPDATVADMLQDVYH 148
           689************99.77777*******55555578888****************96599************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
 Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Protein Sequence
(Fasta)
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA VAKAVGGLMI 60
PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA LLALGYSHSS AAQAQGIIKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046324|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGAGGCGCTT AAGTTACCAA GGGATTAGGG CTGATCTCAG GAGAGGTAAA CGACCATCCT 60
TGGAACACGG AGCCCTTCTT CCCTGCCCGG TATCTGCGCG TGCCTTGGGT AGTCCGCACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046324|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR003350--CUT_dom
IPR032355--CUTL
IPR009057--Homeobox-like
IPR001356--Homeobox_dom
IPR010982--Lambda_DNA-bd_dom
IPR032392--ULD
PROSITE

PS51042--CUT
PS50071--HOMEOBOX_2
Pfam

PF02376--CUT
PF16557--CUTL
PF00046--Homeobox
PF16534--ULD
SMART

SM01109--CUT
SM00389--HOX
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0051216--P:cartilage development
GO:0071310--P:cellular response to organic substance
GO:0006338--P:chromatin remodeling
GO:0021902--P:commitment of neuronal cell to specific neuron type in forebrain
GO:0016569--P:covalent chromatin modification
GO:0009880--P:embryonic pattern specification
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764--P:neuron migration
GO:0002076--P:osteoblast development
GO:0060021--P:palate development
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG hsa:23314
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001646 Ailuropoda melanoleuca 99.70 0.00e+00 1189.00
IUUC-Apl-004052 Anas platyrhynchos 94.83 0.00e+00 1146.00
IUUC-Aca-004787 Anolis carolinensis 91.50 0.00e+00 1233.00
IUUC-Bta-013408 Bos taurus 99.56 0.00e+00 1204.00
IUUC-Cja-019389 Callithrix jacchus 99.73 0.00e+00 1266.00
IUUC-Cfa-020265 Canis familiaris 99.59 0.00e+00 1211.00
IUUC-Cpo-022536 Cavia porcellus 93.89 0.00e+00 1043.00
IUUC-Csa-023562 Chlorocebus sabaeus 99.73 0.00e+00 1266.00
IUUC-Cho-024887 Choloepus hoffmanni 99.59 0.00e+00 1265.00
IUUC-Dno-029724 Dasypus novemcinctus 99.45 0.00e+00 1227.00
IUUC-Dor-030304 Dipodomys ordii 97.19 0.00e+00 726.00
IUUC-Ete-032494 Echinops telfairi 98.31 3.00e-126 446.00
IUUC-Eca-034263 Equus caballus 99.03 0.00e+00 1235.00
IUUC-Eeu-035070 Erinaceus europaeus 86.22 0.00e+00 1080.00
IUUC-Fca-035798 Felis catus 99.27 0.00e+00 1219.00
IUUC-Fal-037543 Ficedula albicollis 94.96 0.00e+00 1145.00
IUUC-Ggo-045271 Gorilla gorilla 100.00 0.00e+00 1268.00
IUUC-Laf-053934 Loxodonta africana 99.45 0.00e+00 1264.00
IUUC-Mcc-054634 Macaca mulatta 99.86 0.00e+00 1268.00
IUUC-Meu-056505 Macropus eugenii 98.22 9.00e-134 470.00
IUUC-Mga-060057 Meleagris gallopavo 94.24 0.00e+00 1137.00
IUUC-Mmr-061381 Microcebus murinus 99.70 0.00e+00 1110.00
IUUC-Mdo-061840 Monodelphis domestica 97.82 0.00e+00 1287.00
IUUC-Mmu-064308 Mus musculus 99.59 0.00e+00 1266.00
IUUC-Mpu-066080 Mustela putorius furo 99.85 0.00e+00 1226.00
IUUC-Mlu-066936 Myotis lucifugus 96.73 0.00e+00 1213.00
IUUC-Nle-069956 Nomascus leucogenys 99.86 0.00e+00 1268.00
IUUC-Ocu-073904 Oryctolagus cuniculus 99.18 0.00e+00 1228.00
IUUC-Oga-088311 Otolemur garnettii 99.03 0.00e+00 1234.00
IUUC-Oar-089530 Ovis aries 99.71 0.00e+00 1206.00
IUUC-Ptr-090832 Pan troglodytes 100.00 0.00e+00 1268.00
IUUC-Pan-091847 Papio anubis 99.73 0.00e+00 1266.00
IUUC-Psi-093659 Pelodiscus sinensis 95.50 0.00e+00 1282.00
IUUC-Pab-098649 Pongo abelii 100.00 0.00e+00 1268.00
IUUC-Pca-100908 Procavia capensis 98.25 0.00e+00 1203.00
IUUC-Pva-102867 Pteropus vampyrus 99.71 0.00e+00 1226.00
IUUC-Rno-105849 Rattus norvegicus 98.91 0.00e+00 1267.00
IUUC-Sha-106557 Sarcophilus harrisii 97.41 0.00e+00 1301.00
Created Date 25-Jun-2017

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