iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020687.13	ENSMUST00000093923.8	ENSMUSP00000091452.2
ENSMUSG00000020687.13	ENSMUST00000106962.8	ENSMUSP00000102575.2
ENSMUSG00000020687.13	ENSMUST00000106961.1	ENSMUSP00000102574.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	40.80	5.00e-63	237.00	IUUC-Sce-106187

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).

Protein Sequence
(Fasta)

MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL 60
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDLVTEF GDSACFTLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTCACCTC GGCTCTTTCC GACCTCTTTC GGGCTTTTCC GTCTTGTTCT CGTTTCTCTC 60
TCTCCACTTC GGCTATTTCC GTGTCTCGCT CGGAAGAGCT CGGCAGCCAC TCGGCCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat

PROSITE

PS50005--TPR
PS50293--TPR_REGION

Pfam

PF00515--TPR_1
PF13181--TPR_8

SMART

SM00028--TPR

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0019903--F:protein phosphatase binding
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0070979--P:protein K11-linked ubiquitination

KEGG

mmu:217232

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000478	Aegilops tauschii	48.40	3.00e-89	323.00
IUUC-Aml-002123	Ailuropoda melanoleuca	96.61	0.00e+00	1634.00
IUUC-Atr-002921	Amborella trichopoda	47.80	2.00e-96	347.00
IUUC-Apl-003652	Anas platyrhynchos	93.86	0.00e+00	1592.00
IUUC-Aca-004797	Anolis carolinensis	92.01	0.00e+00	1471.00
IUUC-Aly-006146	Arabidopsis lyrata	42.22	1.00e-84	307.00
IUUC-Ath-007523	Arabidopsis thaliana	46.08	5.00e-94	338.00
IUUC-Ago-007939	Ashbya gossypii	38.10	3.00e-64	239.00
IUUC-Acl-008169	Aspergillus clavatus	37.39	5.00e-85	309.00
IUUC-Afl-008631	Aspergillus flavus	45.14	1.00e-77	284.00
IUUC-Afu-008990	Aspergillus fumigatus	31.35	6.00e-102	365.00
IUUC-Ani-009208	Aspergillus nidulans	50.30	2.00e-48	187.00
IUUC-Ang-009561	Aspergillus niger	46.39	4.00e-85	309.00
IUUC-Aor-009958	Aspergillus oryzae	45.14	5.00e-77	282.00
IUUC-Ate-010597	Aspergillus terreus	40.93	1.00e-86	314.00
IUUC-Ame-010734	Astyanax mexicanus	78.51	0.00e+00	684.00
IUUC-Bgr-012282	Blumeria graminis	31.30	3.00e-93	336.00
IUUC-Bta-013499	Bos taurus	97.70	0.00e+00	1655.00
IUUC-Bci-013946	Botrytis cinerea	30.52	1.00e-93	337.00
IUUC-Bdi-014213	Brachypodium distachyon	33.12	6.00e-106	378.00
IUUC-Bol-016307	Brassica oleracea	45.87	1.00e-93	337.00
IUUC-Bra-017042	Brassica rapa	45.78	7.00e-94	338.00
IUUC-Cel-018481	Caenorhabditis elegans	40.19	6.00e-76	278.00
IUUC-Cja-019393	Callithrix jacchus	96.50	0.00e+00	1458.00
IUUC-Cfa-020221	Canis familiaris	97.33	0.00e+00	1648.00
IUUC-Cpo-021792	Cavia porcellus	96.97	0.00e+00	1622.00
IUUC-Csa-023091	Chlorocebus sabaeus	96.97	0.00e+00	1639.00
IUUC-Cin-025231	Ciona intestinalis	46.96	0.00e+00	670.00
IUUC-Csv-025983	Ciona savignyi	44.21	0.00e+00	679.00
IUUC-Cgl-026436	Colletotrichum gloeosporioides	43.17	5.00e-72	265.00
IUUC-Cne-026779	Cryptococcus neoformans	40.44	5.00e-65	242.00
IUUC-Cme-027126	Cyanidioschyzon merolae	36.15	2.00e-62	233.00
IUUC-Dre-028038	Danio rerio	78.75	0.00e+00	1261.00
IUUC-Dno-029681	Dasypus novemcinctus	97.08	0.00e+00	1635.00
IUUC-Dor-030742	Dipodomys ordii	76.10	5.00e-151	528.00
IUUC-Dse-031468	Dothistroma septosporum	34.79	8.00e-66	245.00
IUUC-Dme-031900	Drosophila melanogaster	44.56	3.00e-118	419.00
IUUC-Ete-032396	Echinops telfairi	87.39	0.00e+00	1450.00
IUUC-Eca-034414	Equus caballus	97.33	0.00e+00	1649.00
IUUC-Eeu-034864	Erinaceus europaeus	84.97	0.00e+00	765.00
IUUC-Fca-036459	Felis catus	96.94	0.00e+00	1627.00
IUUC-Fox-037700	Fusarium oxysporum	43.05	8.00e-68	250.00
IUUC-Fso-038112	Fusarium solani	42.32	2.00e-76	280.00
IUUC-Gmo-038876	Gadus morhua	72.21	0.00e+00	1170.00
IUUC-Ggr-039822	Gaeumannomyces graminis	44.05	6.00e-74	272.00
IUUC-Gga-040585	Gallus gallus	93.56	0.00e+00	1569.00
IUUC-Gac-042126	Gasterosteus aculeatus	74.34	0.00e+00	1222.00
IUUC-Gma-044263	Glycine max	32.05	5.00e-112	398.00
IUUC-Ggo-045272	Gorilla gorilla	84.17	0.00e+00	983.00
IUUC-Hsa-045682	Homo sapiens	96.85	0.00e+00	1632.00
IUUC-Hvu-047421	Hordeum vulgare	49.80	2.00e-70	258.00
IUUC-Itr-048133	Ictidomys tridecemlineatus	98.41	0.00e+00	1007.00
IUUC-Kpa-049367	Komagataella pastoris	29.52	3.00e-86	313.00
IUUC-Lch-049755	Latimeria chalumnae	84.51	0.00e+00	1429.00
IUUC-Lpe-051689	Leersia perrieri	32.29	2.00e-104	373.00
IUUC-Loc-052907	Lepisosteus oculatus	84.48	0.00e+00	1340.00
IUUC-Lma-053272	Leptosphaeria maculans	43.12	1.00e-73	271.00
IUUC-Laf-054312	Loxodonta africana	96.39	0.00e+00	1639.00
IUUC-Mcc-055312	Macaca mulatta	96.97	0.00e+00	1639.00
IUUC-Meu-056290	Macropus eugenii	84.24	0.00e+00	1422.00
IUUC-Mor-057118	Magnaporthe oryzae	43.57	1.00e-74	274.00
IUUC-Mpo-057620	Magnaporthe poae	44.05	1.00e-74	275.00
IUUC-Mtr-058302	Medicago truncatula	32.93	1.00e-116	414.00
IUUC-Mla-058835	Melampsora laricipopulina	36.54	2.00e-60	226.00
IUUC-Mga-060010	Meleagris gallopavo	93.29	0.00e+00	1589.00
IUUC-Mvi-060340	Microbotryum violaceum	39.75	2.00e-60	227.00
IUUC-Mmr-060610	Microcebus murinus	96.15	0.00e+00	1609.00
IUUC-Mdo-062216	Monodelphis domestica	94.72	0.00e+00	1615.00
IUUC-Mac-065409	Musa acuminata	45.43	4.00e-94	339.00
IUUC-Mpu-066213	Mustela putorius furo	97.33	0.00e+00	1648.00
IUUC-Mlu-067540	Myotis lucifugus	97.31	0.00e+00	1635.00
IUUC-Nfi-068437	Neosartorya fischeri	38.34	2.00e-85	310.00
IUUC-Ncr-068882	Neurospora crassa	31.36	2.00e-90	327.00
IUUC-Nle-068976	Nomascus leucogenys	96.27	0.00e+00	1631.00
IUUC-Opr-071171	Ochotona princeps	91.40	0.00e+00	774.00
IUUC-Ont-071295	Oreochromis niloticus	73.71	0.00e+00	1212.00
IUUC-Oan-072896	Ornithorhynchus anatinus	94.17	0.00e+00	714.00
IUUC-Ocu-074828	Oryctolagus cuniculus	97.70	0.00e+00	1686.00
IUUC-Oba-075176	Oryza barthii	30.68	9.00e-96	344.00
IUUC-Obr-076622	Oryza brachyantha	33.08	5.00e-114	405.00
IUUC-Ogu-078158	Oryza glumaepatula	33.71	1.00e-109	390.00
IUUC-Oin-079840	Oryza indica	34.27	3.00e-118	419.00
IUUC-Olo-080632	Oryza longistaminata	48.86	3.00e-92	332.00
IUUC-Ome-081193	Oryza meridionalis	34.27	6.00e-118	418.00
IUUC-Oni-082335	Oryza nivara	31.19	2.00e-96	346.00
IUUC-Opu-083857	Oryza punctata	48.43	7.00e-84	304.00
IUUC-Oru-085165	Oryza rufipogon	31.19	4.00e-96	345.00
IUUC-Osa-085529	Oryza sativa	48.32	5.00e-97	347.00
IUUC-Olu-087803	Ostreococcus lucimarinus	46.85	5.00e-87	314.00
IUUC-Oga-088851	Otolemur garnettii	96.58	0.00e+00	1622.00
IUUC-Oar-089794	Ovis aries	97.58	0.00e+00	1648.00
IUUC-Ptr-091588	Pan troglodytes	97.09	0.00e+00	1641.00
IUUC-Pan-092083	Papio anubis	91.64	0.00e+00	1530.00
IUUC-Psi-093368	Pelodiscus sinensis	94.43	0.00e+00	1587.00
IUUC-Pma-094306	Petromyzon marinus	64.68	0.00e+00	1055.00
IUUC-Pno-094898	Phaeosphaeria nodorum	41.77	1.00e-74	274.00
IUUC-Ppa-095288	Physcomitrella patens	49.73	5.00e-104	372.00
IUUC-Pfo-097263	Poecilia formosa	72.17	0.00e+00	1150.00
IUUC-Pab-097782	Pongo abelii	96.73	0.00e+00	1634.00
IUUC-Pca-100771	Procavia capensis	82.57	0.00e+00	1286.00
IUUC-Ppe-102042	Prunus persica	41.04	8.00e-98	351.00
IUUC-Pva-103207	Pteropus vampyrus	97.33	0.00e+00	1650.00
IUUC-Pgr-103352	Puccinia graminis	37.88	3.00e-52	200.00
IUUC-Ptt-103992	Puccinia triticina	39.62	2.00e-28	121.00
IUUC-Pte-104138	Pyrenophora teres	42.41	2.00e-75	276.00
IUUC-Pyt-104652	Pyrenophora triticirepentis	42.72	8.00e-76	278.00
IUUC-Rno-105451	Rattus norvegicus	98.18	0.00e+00	1652.00
IUUC-Sce-106187	Saccharomyces cerevisiae	40.80	2.00e-63	237.00
IUUC-Sha-107398	Sarcophilus harrisii	71.33	0.00e+00	1147.00
IUUC-Sja-107984	Schizosaccharomyces japonicus	43.60	7.00e-75	275.00
IUUC-Spo-108274	Schizosaccharomyces pombe	46.18	5.00e-83	302.00
IUUC-Smo-109678	Selaginella moellendorffii	54.97	4.00e-112	398.00
IUUC-Sit-110813	Setaria italica	32.01	6.00e-110	391.00
IUUC-Sly-111637	Solanum lycopersicum	47.31	3.00e-100	359.00
IUUC-Stu-112086	Solanum tuberosum	47.47	1.00e-97	351.00
IUUC-Sar-113214	Sorex araneus	96.85	0.00e+00	1600.00
IUUC-Sre-114904	Sporisorium reilianum	35.34	1.00e-33	138.00
IUUC-Ssc-115692	Sus scrofa	96.01	0.00e+00	1333.00
IUUC-Tgu-116466	Taeniopygia guttata	93.24	0.00e+00	1557.00
IUUC-Tru-118417	Takifugu rubripes	73.32	0.00e+00	1180.00
IUUC-Tsy-118796	Tarsius syrichta	92.41	0.00e+00	1514.00
IUUC-Tni-120331	Tetraodon nigroviridis	85.71	0.00e+00	660.00
IUUC-Tca-121321	Theobroma cacao	47.85	2.00e-94	340.00
IUUC-Tre-122083	Trichoderma reesei	41.23	6.00e-73	269.00
IUUC-Tvi-122558	Trichoderma virens	41.38	3.00e-73	270.00
IUUC-Tae-125209	Triticum aestivum	33.38	5.00e-109	389.00
IUUC-Tur-126187	Triticum urartu	42.63	7.00e-70	258.00
IUUC-Tme-127012	Tuber melanosporum	40.65	9.00e-87	315.00
IUUC-Tbe-127774	Tupaia belangeri	84.61	0.00e+00	1362.00
IUUC-Ttr-128605	Tursiops truncatus	94.06	0.00e+00	1581.00
IUUC-Uma-129576	Ustilago maydis	33.89	5.00e-33	136.00
IUUC-Vda-129996	Verticillium dahliae	43.08	2.00e-57	215.00
IUUC-Vpa-130122	Vicugna pacos	97.20	0.00e+00	1641.00
IUUC-Vvi-131580	Vitis vinifera	46.09	8.00e-100	358.00
IUUC-Xtr-131756	Xenopus tropicalis	89.33	0.00e+00	1452.00
IUUC-Xma-133214	Xiphophorus maculatus	72.20	0.00e+00	1184.00
IUUC-Yli-134473	Yarrowia lipolytica	42.77	4.00e-74	272.00
IUUC-Zma-135179	Zea mays	32.78	2.00e-114	406.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence