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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064406
Ensembl Protein ID ENSMUSP00000006444.7
UniProt Accession P97499; TEP1_MOUSE
Genbank Protein ID AAC53043.1
Protein Name Telomerase protein component 1; Telomerase-associated protein 1; p240; p80 telomerase homolog
Genbank Nucleotide ID U86137
Gene Name Tep1; Tp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006281.7 ENSMUST00000006444.7 ENSMUSP00000006444.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.10e-46 154.9 2114 2148
UBD/Beta-Prp 1.60e-77 261.8 1939 2185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvl 35
           H d++t++a+  d++lvs+s Dg++ +W++  g +
   Q: 2114 HRDWITGCAWtKDNILVSCSSDGSVGLWNPEAGQQ 2148
           9*********877****************988766 PP
   

   UBD/Beta-Prp
   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls..tgkcvhtlkghedsvls 99
           +v+  pd++++a+g+r + i ++++++g+   + ++ + +v+a+ + + + +lv+g+eD+ ++ w ++  +   +  l++ ++ vl 
   Q: 1939 SVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWLSPS-VLVSGAEDGSLHGWMFKgdSLHSLWLLSRYQKPVLG 2024
           57778999999999999999999999999977777777778887776665.899999999999995542255566666788888888 PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkl 171
           l+ s+  + ++++s+d t+r+w  +  +   +             l+gh+g v+c +++pdg +l++++ Dr +  Wd+   +   l
   Q: 2025 LAASR--ELMAAASEDFTVRLWPRQLLT---QphvhavelpccaELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMkiaQAPLL 2106
           88888..999999999999999544333...23336688888888999999999999999999999999999999999977777788 PP
   S: 172  lrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
           ++t+++ h d ++  +++++ + lvs+s dg+v lw+ ++g+ + ++ gh++ v+ v +   +e++vs+s Dg++++Wd + 
   Q: 2107 IHTFSSCHRDWITGCAWTKD-NILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVVAV--EEHIVSVSRDGTLKVWDHQG 2185
           99999999999999999997.699999999999999999999999999999999988888..89999999999999998544 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
 Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
Protein Sequence
(Fasta)
MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ CLTMLSDLQP 60
TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS HPDVLSLENQ CLATLPTVKS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064406|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCACCCCTTG GCCTCACTAG GGTGTTGGTT TTCTTTCAGT TCTCTGCTTC CAACCAGTCC 60
ACTGGCTGAC CCAGGCCGGT TTCTGCTCCC CGTTGCGGAG AACCAACGCG CCTCTCATTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064406|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0779--Telomere
KW-0853--WD repeat
Interpro

IPR025139--DUF4062
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase
IPR008850--TEP1_N
IPR008858--TROVE_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50837--NACHT
PS51226--TEP1_N
PS50988--TROVE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF13271--DUF4062
PF05386--TEP1_N
PF05731--TROVE
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0016363--C:nuclear matrix
GO:0071011--C:precatalytic spliceosome
GO:0005697--C:telomerase holoenzyme complex
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0003720--F:telomerase activity
GO:0070034--F:telomerase RNA binding
GO:0008380--P:RNA splicing
GO:0000722--P:telomere maintenance via recombination
KEGG mmu:21745
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001482 Ailuropoda melanoleuca 71.17 0.00e+00 3452.00
IUUC-Aca-005102 Anolis carolinensis 41.88 0.00e+00 1603.00
IUUC-Ame-011822 Astyanax mexicanus 32.05 2.00e-176 614.00
IUUC-Bta-012323 Bos taurus 71.90 0.00e+00 3507.00
IUUC-Cja-019005 Callithrix jacchus 74.41 0.00e+00 3794.00
IUUC-Cfa-020803 Canis familiaris 66.97 0.00e+00 3124.00
IUUC-Cpo-022312 Cavia porcellus 70.14 0.00e+00 3279.00
IUUC-Csa-023287 Chlorocebus sabaeus 75.09 0.00e+00 3778.00
IUUC-Dre-028825 Danio rerio 34.48 0.00e+00 1076.00
IUUC-Dno-029455 Dasypus novemcinctus 71.34 0.00e+00 3438.00
IUUC-Dor-030328 Dipodomys ordii 70.19 0.00e+00 2415.00
IUUC-Ete-032385 Echinops telfairi 69.14 0.00e+00 1821.00
IUUC-Eca-033726 Equus caballus 74.87 0.00e+00 3751.00
IUUC-Eeu-034665 Erinaceus europaeus 59.63 0.00e+00 921.00
IUUC-Fca-035365 Felis catus 73.06 0.00e+00 3602.00
IUUC-Gmo-039584 Gadus morhua 32.00 5.00e-115 410.00
IUUC-Gac-042307 Gasterosteus aculeatus 36.10 0.00e+00 978.00
IUUC-Ggo-045432 Gorilla gorilla 73.41 0.00e+00 3546.00
IUUC-Hsa-046182 Homo sapiens 75.06 0.00e+00 3774.00
IUUC-Itr-049021 Ictidomys tridecemlineatus 74.96 0.00e+00 3757.00
IUUC-Lch-050186 Latimeria chalumnae 36.11 3.00e-76 279.00
IUUC-Laf-054524 Loxodonta africana 71.48 0.00e+00 3554.00
IUUC-Mcc-055628 Macaca mulatta 75.33 0.00e+00 3791.00
IUUC-Meu-056338 Macropus eugenii 60.65 0.00e+00 1228.00
IUUC-Mmr-060854 Microcebus murinus 74.44 0.00e+00 3702.00
IUUC-Mdo-062247 Monodelphis domestica 57.27 0.00e+00 2647.00
IUUC-Mpu-065806 Mustela putorius furo 71.16 0.00e+00 3528.00
IUUC-Mlu-068116 Myotis lucifugus 73.34 0.00e+00 3503.00
IUUC-Nle-069628 Nomascus leucogenys 76.04 0.00e+00 3368.00
IUUC-Opr-070242 Ochotona princeps 72.25 0.00e+00 2559.00
IUUC-Oan-073598 Ornithorhynchus anatinus 50.77 0.00e+00 1881.00
IUUC-Ocu-073933 Oryctolagus cuniculus 72.38 0.00e+00 3532.00
IUUC-Ola-086886 Oryzias latipes 34.42 0.00e+00 1110.00
IUUC-Oga-088609 Otolemur garnettii 72.77 0.00e+00 3575.00
IUUC-Oar-089957 Ovis aries 71.16 0.00e+00 3421.00
IUUC-Ptr-090577 Pan troglodytes 73.73 0.00e+00 3707.00
IUUC-Pan-092397 Papio anubis 75.03 0.00e+00 3772.00
IUUC-Pma-094373 Petromyzon marinus 32.81 4.00e-67 249.00
IUUC-Pfo-096497 Poecilia formosa 35.50 0.00e+00 1030.00
IUUC-Pab-098028 Pongo abelii 74.75 0.00e+00 3718.00
IUUC-Pca-101002 Procavia capensis 74.89 0.00e+00 1690.00
IUUC-Pva-102144 Pteropus vampyrus 69.21 0.00e+00 1616.00
IUUC-Rno-105828 Rattus norvegicus 88.80 0.00e+00 4492.00
IUUC-Sha-106469 Sarcophilus harrisii 57.08 0.00e+00 2689.00
IUUC-Sar-113035 Sorex araneus 64.27 0.00e+00 1804.00
IUUC-Ssc-116122 Sus scrofa 74.61 0.00e+00 2667.00
IUUC-Tru-118412 Takifugu rubripes 33.19 0.00e+00 1170.00
IUUC-Tsy-119257 Tarsius syrichta 66.72 0.00e+00 1387.00
IUUC-Tni-120032 Tetraodon nigroviridis 32.79 3.00e-32 132.00
IUUC-Tbe-127312 Tupaia belangeri 63.08 0.00e+00 952.00
IUUC-Ttr-128335 Tursiops truncatus 69.56 0.00e+00 3442.00
IUUC-Xtr-132524 Xenopus tropicalis 39.27 0.00e+00 1355.00
Created Date 25-Jun-2017

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