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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046461
Ensembl Protein ID ENSP00000365720.4
UniProt Accession Q04727; F8W6T6; Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9; TLE4_HUMAN
Genbank Protein ID BAA86575.1; BAG59027.1; CAC22598.1; CAC22599.1; CAI13644.1; CAI13644.1; CAI13644.1; CAI41315.1; CAI41315.1; CAI41315.1; CAI13734.1; CAI13734.1; CAI13734.1; AAH45650.1; AAH59405.2; CAB82397.1; AAA61195.1
Protein Name Transducin-like enhancer protein 4; Grg-4; Groucho-related protein 4
Genbank Nucleotide ID AB033087; AK296342; AL358975; AL358975; AL445252; AL353813; AL358975; AL353813; AL445252; AL358975; AL358975; AL445252; AL353813; BC045650; BC059405; AL162059; M99439
Gene Name TLE4; GRG4; KIAA1261
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106829.18 ENST00000376552.6 ENSP00000365735.2
ENSG00000106829.18 ENST00000461758.6 ENSP00000417906.1
ENSG00000106829.18 ENST00000470872.5 ENSP00000417245.1
ENSG00000106829.18 ENST00000435650.5 ENSP00000415423.2
ENSG00000106829.18 ENST00000414465.5 ENSP00000397822.1
ENSG00000106829.18 ENST00000376537.8 ENSP00000365720.4
ENSG00000106829.18 ENST00000462803.5 ENSP00000417715.1
ENSG00000106829.18 ENST00000265284.10 ENSP00000265284.6
ENSG00000106829.18 ENST00000425506.5 ENSP00000412567.1
ENSG00000106829.18 ENST00000428713.5 ENSP00000409313.1
ENSG00000106829.18 ENST00000490347.5 ENSP00000417844.1
ENSG00000106829.18 ENST00000496114.5 ENSP00000417102.1
ENSG00000106829.18 ENST00000417836.1 ENSP00000400334.1
ENSG00000106829.18 ENST00000376544.7 ENSP00000365727.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.40e-22 77.8 649 687
UBD/Beta-Prp 1.00e-39 138.2 517 686
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 649  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 687
           8***********999*********************998 PP
   

   UBD/Beta-Prp
   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.tlsg 135
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  l+ 
   Q: 517  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaELTS 607
           5566678889998884.555555579*******999888999988889*******************************9988766658888 PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
              +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 608  SAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 686
           88888999*********************************9.********************************99754 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Protein Sequence
(Fasta)
MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046461|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGAGCTCG CCAGAGCGCT CGCATGGCGG GCCGGTGATT GTAGTCAATC TGGCCGTATT 60
CTCAGGCAGG GTCGCCCGGG GCGGACTACA TCTCCCGGGA TGCTGCGCGG CCGCCCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046461|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:7091
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001359 Ailuropoda melanoleuca 98.43 0.00e+00 1273.00
IUUC-Apl-003434 Anas platyrhynchos 81.34 0.00e+00 1105.00
IUUC-Bta-012646 Bos taurus 91.94 0.00e+00 1341.00
IUUC-Cel-018361 Caenorhabditis elegans 58.99 4.00e-122 431.00
IUUC-Cja-019079 Callithrix jacchus 92.55 0.00e+00 1387.00
IUUC-Cfa-020987 Canis familiaris 92.07 0.00e+00 1332.00
IUUC-Cpo-021606 Cavia porcellus 90.23 0.00e+00 1297.00
IUUC-Csa-023445 Chlorocebus sabaeus 92.92 0.00e+00 1358.00
IUUC-Cho-024590 Choloepus hoffmanni 86.99 0.00e+00 1254.00
IUUC-Cin-025282 Ciona intestinalis 75.69 5.00e-154 538.00
IUUC-Dno-028979 Dasypus novemcinctus 92.22 0.00e+00 1310.00
IUUC-Dor-030533 Dipodomys ordii 94.70 0.00e+00 1168.00
IUUC-Dme-031576 Drosophila melanogaster 86.03 0.00e+00 665.00
IUUC-Ete-032887 Echinops telfairi 90.76 0.00e+00 1266.00
IUUC-Eca-034397 Equus caballus 91.82 0.00e+00 1250.00
IUUC-Eeu-035237 Erinaceus europaeus 89.56 0.00e+00 1201.00
IUUC-Fca-036030 Felis catus 92.29 0.00e+00 1347.00
IUUC-Fal-037460 Ficedula albicollis 92.15 0.00e+00 1325.00
IUUC-Gga-040416 Gallus gallus 92.55 0.00e+00 1353.00
IUUC-Ggo-045633 Gorilla gorilla 99.75 0.00e+00 1435.00
IUUC-Itr-048974 Ictidomys tridecemlineatus 92.80 0.00e+00 1355.00
IUUC-Lch-049943 Latimeria chalumnae 88.93 0.00e+00 1218.00
IUUC-Loc-052835 Lepisosteus oculatus 91.71 0.00e+00 1256.00
IUUC-Laf-053425 Loxodonta africana 92.66 0.00e+00 1355.00
IUUC-Mcc-055766 Macaca mulatta 99.75 0.00e+00 1467.00
IUUC-Meu-056209 Macropus eugenii 95.90 0.00e+00 1400.00
IUUC-Mmr-061317 Microcebus murinus 98.01 0.00e+00 1426.00
IUUC-Mdo-062956 Monodelphis domestica 91.94 0.00e+00 1342.00
IUUC-Mmu-063576 Mus musculus 92.80 0.00e+00 1349.00
IUUC-Mpu-066410 Mustela putorius furo 92.06 0.00e+00 1256.00
IUUC-Mlu-067456 Myotis lucifugus 90.61 0.00e+00 1271.00
IUUC-Nle-069495 Nomascus leucogenys 92.78 0.00e+00 1328.00
IUUC-Opr-070645 Ochotona princeps 89.19 0.00e+00 1256.00
IUUC-Ont-071419 Oreochromis niloticus 82.57 0.00e+00 1169.00
IUUC-Oan-072842 Ornithorhynchus anatinus 89.35 0.00e+00 1331.00
IUUC-Ocu-074453 Oryctolagus cuniculus 91.55 0.00e+00 1336.00
IUUC-Ola-087090 Oryzias latipes 82.18 0.00e+00 1177.00
IUUC-Oga-087939 Otolemur garnettii 92.68 0.00e+00 1353.00
IUUC-Oar-090347 Ovis aries 91.40 0.00e+00 1228.00
IUUC-Ptr-091048 Pan troglodytes 92.92 0.00e+00 1358.00
IUUC-Pan-091973 Papio anubis 88.45 0.00e+00 1304.00
IUUC-Pfo-097518 Poecilia formosa 81.50 0.00e+00 1120.00
IUUC-Pab-097539 Pongo abelii 99.73 0.00e+00 1338.00
IUUC-Pca-101137 Procavia capensis 93.76 0.00e+00 1244.00
IUUC-Pva-103037 Pteropus vampyrus 96.02 0.00e+00 1425.00
IUUC-Rno-105314 Rattus norvegicus 92.47 0.00e+00 1280.00
IUUC-Sar-113267 Sorex araneus 93.25 0.00e+00 769.00
IUUC-Ssc-116408 Sus scrofa 92.21 0.00e+00 1372.00
IUUC-Tgu-117068 Taeniopygia guttata 91.32 0.00e+00 1317.00
IUUC-Tru-118782 Takifugu rubripes 81.23 0.00e+00 1138.00
IUUC-Tsy-118884 Tarsius syrichta 88.72 0.00e+00 1145.00
IUUC-Tni-120404 Tetraodon nigroviridis 80.76 0.00e+00 1167.00
IUUC-Tbe-128013 Tupaia belangeri 93.80 0.00e+00 1323.00
IUUC-Ttr-129285 Tursiops truncatus 97.22 0.00e+00 1436.00
IUUC-Vpa-130577 Vicugna pacos 90.61 0.00e+00 719.00
IUUC-Xtr-132974 Xenopus tropicalis 89.75 0.00e+00 1267.00
Created Date 25-Jun-2017

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