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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063520
UUCD1 version UUC-MuM-00033
Ensembl Protein ID ENSMUSP00000054428.4
UniProt Accession Q80SY4; Q5XK51; Q6IS57; Q6YI52; Q6ZPT8; Q8BNR1; Q8C6W2; Q921Q1; MIB1_MOUSE
Genbank Protein ID AAO91933.1; AAN75492.1; AAN18022.1; AAX84653.1; BAC35245.1; BAC38042.1; AAH11287.1; AAH69870.1; AAH83072.1; BAC98141.1
Protein Name E3 ubiquitin-protein ligase MIB1; DAPK-interacting protein 1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1
Genbank Nucleotide ID AY245539; AY149907; AY147848; AY974091; AK053035; AK080847; BC011287; BC069870; BC083072; AK129331
Gene Name Mib1; Dip1; Kiaa1323; Mib
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024294.13 ENSMUST00000052838.10 ENSMUSP00000054428.4
ENSMUSG00000024294.13 ENSMUST00000124288.7 ENSMUSP00000114289.1
ENSMUSG00000024294.13 ENSMUST00000150000.1 ENSMUSP00000122879.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18043734; 12351649
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 91.76 0.00e+00 1972.00 IUUC-Dre-028261
E3 activity/RING/RING 66.36 0.00e+00 1326.00 IUUC-Dme-031616
E3 activity/RING/RING 99.30 0.00e+00 2068.00 IUUC-Hsa-046439
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Protein Sequence
(Fasta)
MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY 60
RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT VCYHGDKHHL 120
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Protein Fasta Sequence


>IUUC-Mmu-063520|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
ACTCCCTCGG CGTCCCGGGG ACGCTTAGCG ATCCGTTTCC TTCCCCCTTT TCCTGGATCG 60
CGCGACTCCC CCAAACCCTT CCCATCCCGT TGTCGCTGAG GAGCACCTCG CAGTTCCTCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063520|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001370--BIR_rpt
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0005813--C:centrosome
GO:0031410--C:cytoplasmic vesicle
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001568--P:blood vessel development
GO:0007507--P:heart development
GO:0001947--P:heart looping
GO:0001701--P:in utero embryonic development
GO:0045665--P:negative regulation of neuron differentiation
GO:0001841--P:neural tube formation
GO:0007219--P:Notch signaling pathway
GO:0045807--P:positive regulation of endocytosis
GO:0001756--P:somitogenesis
KEGG mmu:225164
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001993 Ailuropoda melanoleuca 99.39 0.00e+00 1979.00
IUUC-Atr-002913 Amborella trichopoda 27.54 1.00e-21 99.40
IUUC-Apl-003867 Anas platyrhynchos 98.89 0.00e+00 1995.00
IUUC-Aca-004471 Anolis carolinensis 98.81 0.00e+00 2022.00
IUUC-Aly-006101 Arabidopsis lyrata 28.67 3.00e-18 86.70
IUUC-Ath-007301 Arabidopsis thaliana 29.46 7.00e-20 92.00
IUUC-Ang-009817 Aspergillus niger 36.24 7.00e-31 128.00
IUUC-Ame-011923 Astyanax mexicanus 87.42 0.00e+00 1830.00
IUUC-Bta-012972 Bos taurus 99.30 0.00e+00 2031.00
IUUC-Bol-015345 Brassica oleracea 27.81 1.00e-21 99.40
IUUC-Bra-017946 Brassica rapa 27.10 6.00e-21 97.40
IUUC-Cel-018156 Caenorhabditis elegans 23.25 9.00e-24 105.00
IUUC-Cja-019044 Callithrix jacchus 94.79 0.00e+00 1806.00
IUUC-Cfa-020049 Canis familiaris 97.22 0.00e+00 1974.00
IUUC-Cpo-022228 Cavia porcellus 98.93 0.00e+00 1865.00
IUUC-Csa-023228 Chlorocebus sabaeus 99.20 0.00e+00 2028.00
IUUC-Cho-024456 Choloepus hoffmanni 86.82 0.00e+00 823.00
IUUC-Cin-025506 Ciona intestinalis 71.85 0.00e+00 878.00
IUUC-Csv-026037 Ciona savignyi 64.77 0.00e+00 1202.00
IUUC-Dre-028261 Danio rerio 91.76 0.00e+00 1943.00
IUUC-Dno-029816 Dasypus novemcinctus 99.20 0.00e+00 2029.00
IUUC-Dor-030678 Dipodomys ordii 79.31 0.00e+00 1420.00
IUUC-Dme-031616 Drosophila melanogaster 65.05 0.00e+00 1284.00
IUUC-Ete-032436 Echinops telfairi 93.59 1.00e-131 464.00
IUUC-Eca-033837 Equus caballus 99.35 0.00e+00 1873.00
IUUC-Eeu-034896 Erinaceus europaeus 84.79 0.00e+00 683.00
IUUC-Fca-036568 Felis catus 99.46 0.00e+00 1860.00
IUUC-Fal-037586 Ficedula albicollis 98.81 0.00e+00 2021.00
IUUC-Gmo-038802 Gadus morhua 90.17 0.00e+00 1899.00
IUUC-Gga-040131 Gallus gallus 98.81 0.00e+00 2024.00
IUUC-Gac-042052 Gasterosteus aculeatus 90.79 0.00e+00 1942.00
IUUC-Ggo-044970 Gorilla gorilla 99.30 0.00e+00 2031.00
IUUC-Hsa-046439 Homo sapiens 99.30 0.00e+00 2031.00
IUUC-Itr-048363 Ictidomys tridecemlineatus 98.99 0.00e+00 807.00
IUUC-Lch-049434 Latimeria chalumnae 90.88 0.00e+00 1838.00
IUUC-Lpe-051464 Leersia perrieri 26.46 1.00e-15 79.70
IUUC-Loc-052278 Lepisosteus oculatus 90.58 0.00e+00 1888.00
IUUC-Laf-054292 Loxodonta africana 98.39 0.00e+00 1853.00
IUUC-Meu-056752 Macropus eugenii 80.86 8.00e-148 518.00
IUUC-Mpo-057569 Magnaporthe poae 36.90 6.00e-33 136.00
IUUC-Mtr-058673 Medicago truncatula 27.51 5.00e-20 94.40
IUUC-Mga-059408 Meleagris gallopavo 98.40 0.00e+00 1874.00
IUUC-Mmr-061628 Microcebus murinus 99.40 0.00e+00 2032.00
IUUC-Mdo-062055 Monodelphis domestica 99.01 0.00e+00 2026.00
IUUC-Mac-065553 Musa acuminata 26.59 9.00e-17 82.80
IUUC-Mpu-065864 Mustela putorius furo 99.60 0.00e+00 2035.00
IUUC-Mlu-067802 Myotis lucifugus 99.35 0.00e+00 1872.00
IUUC-Nle-069568 Nomascus leucogenys 97.89 0.00e+00 1967.00
IUUC-Opr-071018 Ochotona princeps 78.11 7.00e-172 598.00
IUUC-Ont-072079 Oreochromis niloticus 91.92 0.00e+00 1957.00
IUUC-Oan-073346 Ornithorhynchus anatinus 99.24 0.00e+00 1308.00
IUUC-Ocu-073932 Oryctolagus cuniculus 99.50 0.00e+00 2034.00
IUUC-Oba-075968 Oryza barthii 27.08 1.00e-15 79.70
IUUC-Obr-076548 Oryza brachyantha 26.77 3.00e-20 94.70
IUUC-Ogl-077477 Oryza glaberrima 27.08 1.00e-15 79.70
IUUC-Ogu-079004 Oryza glumaepatula 27.08 2.00e-15 79.30
IUUC-Oin-079705 Oryza indica 27.08 1.00e-15 79.70
IUUC-Olo-080410 Oryza longistaminata 27.08 1.00e-15 79.30
IUUC-Ome-081845 Oryza meridionalis 27.08 4.00e-16 81.30
IUUC-Oni-082055 Oryza nivara 26.63 5.00e-15 77.80
IUUC-Opu-083740 Oryza punctata 26.40 2.00e-16 82.80
IUUC-Oru-085255 Oryza rufipogon 27.08 1.00e-15 79.70
IUUC-Osa-085560 Oryza sativa 29.62 2.00e-18 87.00
IUUC-Ola-087184 Oryzias latipes 91.36 0.00e+00 1929.00
IUUC-Oga-089002 Otolemur garnettii 96.52 0.00e+00 2009.00
IUUC-Oar-089440 Ovis aries 99.25 0.00e+00 1877.00
IUUC-Ptr-090690 Pan troglodytes 98.71 0.00e+00 2011.00
IUUC-Pan-092295 Papio anubis 99.20 0.00e+00 2028.00
IUUC-Psi-093118 Pelodiscus sinensis 98.71 0.00e+00 2013.00
IUUC-Pma-094438 Petromyzon marinus 89.13 0.00e+00 693.00
IUUC-Pfo-096302 Poecilia formosa 87.23 0.00e+00 1831.00
IUUC-Pab-097804 Pongo abelii 98.89 0.00e+00 1096.00
IUUC-Pca-101028 Procavia capensis 90.83 0.00e+00 827.00
IUUC-Pva-102890 Pteropus vampyrus 92.70 0.00e+00 904.00
IUUC-Rno-105470 Rattus norvegicus 99.20 0.00e+00 2037.00
IUUC-Sha-106650 Sarcophilus harrisii 98.87 0.00e+00 1953.00
IUUC-Sly-111367 Solanum lycopersicum 25.84 1.00e-20 96.70
IUUC-Sar-113247 Sorex araneus 85.92 0.00e+00 804.00
IUUC-Ssc-115706 Sus scrofa 99.50 0.00e+00 2034.00
IUUC-Tgu-116863 Taeniopygia guttata 98.81 0.00e+00 2017.00
IUUC-Tru-117733 Takifugu rubripes 90.80 0.00e+00 1930.00
IUUC-Tsy-119313 Tarsius syrichta 99.29 0.00e+00 1385.00
IUUC-Tni-120601 Tetraodon nigroviridis 92.38 0.00e+00 1915.00
IUUC-Tbe-127979 Tupaia belangeri 94.57 0.00e+00 1542.00
IUUC-Ttr-128673 Tursiops truncatus 99.30 0.00e+00 2029.00
IUUC-Vda-129784 Verticillium dahliae 35.21 8.00e-32 132.00
IUUC-Vpa-130332 Vicugna pacos 95.50 0.00e+00 1926.00
IUUC-Vvi-131705 Vitis vinifera 27.07 3.00e-19 91.70
IUUC-Xtr-132423 Xenopus tropicalis 96.02 0.00e+00 1979.00
Created Date 25-Jun-2017

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