iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046583

UUCD1 version

UUC-HoS-00058

Ensembl Protein ID

ENSP00000254436.7

UniProt Accession

P19474; Q5XPV5; Q96RF8; RO52_HUMAN

Genbank Protein ID

AAA36581.1; AAB87094.1; AAA36651.1; AAA79867.1; AAA79867.1; AAK76432.1; AAU89982.1; AAH10861.1

Protein Name

E3 ubiquitin-protein ligase TRIM21; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; Tripartite motif-containing protein 21

Genbank Nucleotide ID

M34551; U01882; M62800; U13658; U13657; AF391283; AY742713; AC009758

Gene Name

TRIM21; RNF81; RO52; SSA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132109.9	ENST00000533692.1	ENSP00000434053.1
ENSG00000132109.9	ENST00000254436.7	ENSP00000254436.7

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19571111; 18641315; 18687060; 19489724; 16472766; 19201866; 19675099; 18022694

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.40e-09	38.3	12	74
E3 activity/RING/RING	1.30e-08	36.9	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  CpI l+++ +Pv +++G+++ +++I +  + gg+ cPv+rq++  ++l Pn  l ++++
   Q: 12   EEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVN 74
           6889***************************9999999******************9988875 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f + p++  CgH f+++C+ ++      + +   CP+Cr
   Q: 16   CPICLDPFVE-PVSIECGHSFCQECISQV-----GKGGGSVCPVCR 55
           **********.***************999.....6788888****8 PP

Organism

Homo sapiens

Functional Description
(View)

Functional Description

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 60
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120

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Nucleotide Sequence
(Fasta)

GCTTCTGAGC GGAAACTGAA AGTGAAATAG GGAGCTGGCT ACCAGCGTTG AGTCCCCTGT 60
AAAGGTGAGT GAACCCCACT AGATCAAGGG ACCCCTGCCC TCCTAGGGGA CCTCTCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0016567--P:protein ubiquitination
GO:0032479--P:regulation of type I interferon production
GO:0034341--P:response to interferon-gamma

KEGG

hsa:6737

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	78.85	0.00e+00	772.00
IUUC-Ang-009772	Aspergillus niger	32.94	3.00e-08	51.60
IUUC-Bta-013083	Bos taurus	72.60	0.00e+00	677.00
IUUC-Bol-016562	Brassica oleracea	47.92	4.00e-09	54.30
IUUC-Bra-016652	Brassica rapa	45.10	5.00e-09	55.50
IUUC-Cel-018124	Caenorhabditis elegans	20.87	3.00e-12	65.90
IUUC-Cja-019002	Callithrix jacchus	92.42	0.00e+00	892.00
IUUC-Cfa-020415	Canis familiaris	75.69	0.00e+00	739.00
IUUC-Cpo-021948	Cavia porcellus	72.22	0.00e+00	687.00
IUUC-Csa-023135	Chlorocebus sabaeus	96.21	0.00e+00	848.00
IUUC-Cho-024493	Choloepus hoffmanni	66.08	1.00e-97	349.00
IUUC-Dre-028064	Danio rerio	30.85	5.00e-61	228.00
IUUC-Dno-030061	Dasypus novemcinctus	72.00	0.00e+00	709.00
IUUC-Ete-033168	Echinops telfairi	70.12	2.00e-169	588.00
IUUC-Eca-033578	Equus caballus	81.37	0.00e+00	773.00
IUUC-Eeu-034749	Erinaceus europaeus	57.63	7.00e-132	464.00
IUUC-Fca-035468	Felis catus	74.69	0.00e+00	719.00
IUUC-Gac-041721	Gasterosteus aculeatus	35.56	2.00e-75	276.00
IUUC-Ggo-045190	Gorilla gorilla	98.95	0.00e+00	910.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	78.20	0.00e+00	730.00
IUUC-Laf-053455	Loxodonta africana	75.56	0.00e+00	679.00
IUUC-Mcc-054609	Macaca mulatta	95.79	0.00e+00	842.00
IUUC-Mmr-061369	Microcebus murinus	77.68	0.00e+00	671.00
IUUC-Mmu-063166	Mus musculus	70.50	0.00e+00	661.00
IUUC-Mpu-066889	Mustela putorius furo	76.50	0.00e+00	754.00
IUUC-Mlu-067647	Myotis lucifugus	79.44	0.00e+00	708.00
IUUC-Nle-069567	Nomascus leucogenys	97.47	0.00e+00	899.00
IUUC-Opr-071178	Ochotona princeps	64.42	2.00e-172	598.00
IUUC-Ont-072250	Oreochromis niloticus	34.23	5.00e-71	261.00
IUUC-Olu-087666	Ostreococcus lucimarinus	32.95	2.00e-11	63.90
IUUC-Oar-090413	Ovis aries	77.63	0.00e+00	702.00
IUUC-Ptr-091187	Pan troglodytes	100.00	0.00e+00	919.00
IUUC-Pan-092231	Papio anubis	96.15	0.00e+00	832.00
IUUC-Pab-098079	Pongo abelii	95.18	0.00e+00	640.00
IUUC-Pca-100639	Procavia capensis	74.65	3.00e-151	528.00
IUUC-Pva-102476	Pteropus vampyrus	78.53	0.00e+00	746.00
IUUC-Rno-105054	Rattus norvegicus	70.82	4.00e-175	607.00
IUUC-Sar-113204	Sorex araneus	74.00	0.00e+00	660.00
IUUC-Ssc-116291	Sus scrofa	77.14	0.00e+00	722.00
IUUC-Tsy-118803	Tarsius syrichta	78.40	6.00e-144	504.00
IUUC-Tbe-127337	Tupaia belangeri	62.94	1.00e-112	399.00
IUUC-Ttr-128914	Tursiops truncatus	77.14	0.00e+00	664.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence