iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	PHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19734906

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.11	14.2	282	337

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++ ++ +             k++++ l+CgHv   +  ++w ++     k   CP Cr
   Q: 282  CPVGFNTLafpsmkrkdvvdeKQPWVYLNCGHV---HGYHNWGNKEERDGKDRECPMCR 337
           555555555555555555554556888****98...445689777777788888****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

Protein Sequence
(Fasta)

MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA 60
CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAGTCCCG GTCCCTCCTT CCCAGTGTGT GTCAGTGACC CAAAGGCGGT TCGAGGCGGA 60
GGGACCGTCG GGGGCGCCGC CGCCGCCTTC TCCAGCGCCA GCAACAGCAG CAGCAGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006800--Pellino_fam
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF04710--Pellino

Gene Ontology

GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0050868--P:negative regulation of T cell activation
GO:0042130--P:negative regulation of T cell proliferation
GO:0050871--P:positive regulation of B cell activation
GO:0030890--P:positive regulation of B cell proliferation
GO:0001819--P:positive regulation of cytokine production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0043331--P:response to dsRNA
GO:0032496--P:response to lipopolysaccharide
GO:0008063--P:Toll signaling pathway

KEGG

mmu:67245

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001486	Ailuropoda melanoleuca	99.76	0.00e+00	879.00
IUUC-Apl-003642	Anas platyrhynchos	99.04	0.00e+00	875.00
IUUC-Aca-004878	Anolis carolinensis	97.61	0.00e+00	862.00
IUUC-Ame-011117	Astyanax mexicanus	85.38	0.00e+00	771.00
IUUC-Bta-012657	Bos taurus	99.28	0.00e+00	875.00
IUUC-Bci-013893	Botrytis cinerea	30.00	5.50e-02	32.30
IUUC-Cel-018562	Caenorhabditis elegans	44.36	8.00e-101	360.00
IUUC-Cja-019539	Callithrix jacchus	99.52	0.00e+00	879.00
IUUC-Cfa-020479	Canis familiaris	99.52	0.00e+00	878.00
IUUC-Cpo-021657	Cavia porcellus	99.28	0.00e+00	872.00
IUUC-Csa-023842	Chlorocebus sabaeus	99.76	0.00e+00	879.00
IUUC-Cho-025068	Choloepus hoffmanni	99.15	0.00e+00	738.00
IUUC-Cin-025429	Ciona intestinalis	56.24	3.00e-137	481.00
IUUC-Dre-028217	Danio rerio	89.18	0.00e+00	792.00
IUUC-Dno-029357	Dasypus novemcinctus	80.84	0.00e+00	742.00
IUUC-Dor-030597	Dipodomys ordii	99.28	0.00e+00	877.00
IUUC-Dse-031384	Dothistroma septosporum	26.37	1.30e-02	34.70
IUUC-Ete-032925	Echinops telfairi	99.28	0.00e+00	875.00
IUUC-Eca-034037	Equus caballus	99.52	0.00e+00	877.00
IUUC-Fca-036415	Felis catus	99.76	0.00e+00	879.00
IUUC-Fal-037444	Ficedula albicollis	99.04	0.00e+00	873.00
IUUC-Fox-037816	Fusarium oxysporum	34.04	2.90e-02	33.10
IUUC-Gmo-039248	Gadus morhua	78.79	0.00e+00	693.00
IUUC-Gga-040551	Gallus gallus	99.04	0.00e+00	873.00
IUUC-Gac-041981	Gasterosteus aculeatus	72.37	0.00e+00	655.00
IUUC-Ggo-045270	Gorilla gorilla	99.76	0.00e+00	879.00
IUUC-Hsa-046261	Homo sapiens	99.76	0.00e+00	879.00
IUUC-Itr-047919	Ictidomys tridecemlineatus	99.76	0.00e+00	879.00
IUUC-Kpa-049153	Komagataella pastoris	32.79	5.60e-01	31.20
IUUC-Loc-052528	Lepisosteus oculatus	91.90	0.00e+00	823.00
IUUC-Laf-054201	Loxodonta africana	99.04	0.00e+00	874.00
IUUC-Mga-059547	Meleagris gallopavo	98.80	0.00e+00	873.00
IUUC-Mdo-062133	Monodelphis domestica	99.04	0.00e+00	876.00
IUUC-Mac-065171	Musa acuminata	27.69	2.00e-01	29.60
IUUC-Mpu-066566	Mustela putorius furo	99.76	0.00e+00	879.00
IUUC-Mlu-067015	Myotis lucifugus	99.52	0.00e+00	877.00
IUUC-Nle-069510	Nomascus leucogenys	99.76	0.00e+00	879.00
IUUC-Ont-072324	Oreochromis niloticus	87.09	0.00e+00	777.00
IUUC-Oan-073059	Ornithorhynchus anatinus	99.04	0.00e+00	876.00
IUUC-Ocu-073888	Oryctolagus cuniculus	99.41	0.00e+00	704.00
IUUC-Ola-086600	Oryzias latipes	86.15	0.00e+00	770.00
IUUC-Oga-088926	Otolemur garnettii	99.52	0.00e+00	878.00
IUUC-Oar-089559	Ovis aries	99.76	0.00e+00	879.00
IUUC-Ptr-090954	Pan troglodytes	99.28	0.00e+00	874.00
IUUC-Pan-092719	Papio anubis	99.76	0.00e+00	879.00
IUUC-Psi-093982	Pelodiscus sinensis	98.80	0.00e+00	872.00
IUUC-Pno-095123	Phaeosphaeria nodorum	32.69	3.30e-02	32.30
IUUC-Pfo-097047	Poecilia formosa	88.26	0.00e+00	785.00
IUUC-Pab-097906	Pongo abelii	99.76	0.00e+00	879.00
IUUC-Pca-101126	Procavia capensis	98.22	0.00e+00	811.00
IUUC-Rno-105984	Rattus norvegicus	99.52	0.00e+00	877.00
IUUC-Sar-112939	Sorex araneus	99.26	0.00e+00	841.00
IUUC-Ssc-115320	Sus scrofa	99.76	0.00e+00	879.00
IUUC-Tgu-116492	Taeniopygia guttata	98.56	0.00e+00	872.00
IUUC-Tru-118750	Takifugu rubripes	86.62	0.00e+00	767.00
IUUC-Tsy-119254	Tarsius syrichta	99.75	0.00e+00	843.00
IUUC-Tni-119865	Tetraodon nigroviridis	87.44	0.00e+00	729.00
IUUC-Tae-124278	Triticum aestivum	31.73	2.20e-02	34.30
IUUC-Tbe-127454	Tupaia belangeri	91.63	0.00e+00	798.00
IUUC-Ttr-129040	Tursiops truncatus	99.28	0.00e+00	874.00
IUUC-Vpa-130078	Vicugna pacos	99.52	0.00e+00	873.00
IUUC-Xtr-131992	Xenopus tropicalis	96.89	0.00e+00	858.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence