iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Drug and target
Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	11463878; 19656949; 12388757
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	11463878; 19656949; 12388757
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-46	151.3	550	587
E3 adaptor/Cullin RING/SCF/F-box	1.10e-06	27.2	183	227
UBD/Beta-Prp	1.10e-98	328.5	295	637

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvllks 38
           gH ++v+++a  d  +++sGs+Dg+ikvWDl +g++ ++
   Q: 550  GHVEGVWDIAA-DnFRIISGSHDGSIKVWDLQSGKCMHT 587
           79999999977.4367********************875 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            ++ lp+e+ ++il++ld ++l++a+rvcr+wq+la+++++w ++
   Q: 183  FISILPQELSLKILSYLDCQSLCNATRVCRKWQKLADDDRVWYHM 227
           56789*******************************999999765 PP

UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           i+++kgh+++v+t ++f  +++ll+tgs+d+ti +wd++tgkl+r+lsgh+++v++++f+++   l+tgs D+ti+vw++ tg+c++t++gh+dsvls+++
   Q: 295  IQEFKGHMDGVLT-LQF--NYRLLFTGSYDSTIGIWDLFTGKLIRRLSGHSDGVKTLYFDDR--KLITGSLDKTIRVWNYITGECISTYRGHSDSVLSVDS 390
           7899*********.***..*******************************************..6************************************ PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..............fd 189
           ++  +++vsGs+d+t++vw++e+++c+  tl+gh+++vncv++hp+++ ++s+s+D+t+r+Wd++t+++l+ ++g h ++v++++                
   Q: 391  YQ--KVIVSGSADKTVKVWHVESRTCY--TLRGHTEWVNCVKLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRG-HVGQVQKIIpltikdvenlatdnT- 485
           **..***********************..7********************************************9.************999999876651. PP
   S: 190  sng....................................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsg 254
             +                                    ++l+s++ld+t+klwd++tg+c+rt+ gh + v++++++  + r++sgs+Dgsi++Wdl+sg
   Q: 486  --SdgsspqddptmtdgadesdtpsneqetvldenipypTHLLSCGLDNTIKLWDVKTGKCIRTQFGHVEGVWDIAAD--NFRIISGSHDGSIKVWDLQSG 582
           ..14456777888888899999999999**************************************************..********************* PP
   S: 255  dllktlqlhn..............ssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++++t+++++              ++v ++a++++gd+++++g+e+++v+++k++
   Q: 583  KCMHTFNGRRlqretqhtqtqslgDKVAPIACVCIGDSECFSGDEFGCVKMYKFD 637
           *****************************************************96 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Negatively regulates sulfur amino acids biosynthesis genes expression. Controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). Required for the efficient binding of CDC45 and MCM proteins to origins of replication. Involved in the S-adenosylmethionine (AdoMet)-mediated inhibition of the transcription function of MET4. In the context of the E3 ubiquitin ligase complex SCF(Met30), involved in the degradation of MET4 and the cellular response to cadmium. Required for efficient expression of G1 cyclins.

Protein Sequence
(Fasta)

MRRERQRMMS FEDKDKDDLD NSNSNNSSEM TDTAMMPPLK RLLITGSSDD LAQGSSGKKK 60
MTMATRSPSS SPDLATNDSG TRVQPLPEYN FTKFCYRHNP DIQFSPTHTA CYKQDLKRTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGAGAG AGAGGCAAAG GATGATGAGT TTCGAGGACA AGGACAAGGA CGACCTTGAC 60
AATAGTAATA GTAATAACAG CAGTGAAATG ACAGATACGG CGATGATGCC ACCATTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0028--Amino-acid biosynthesis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0198--Cysteine biosynthesis
KW-0963--Cytoplasm
KW-0486--Methionine biosynthesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0043130--F:ubiquitin binding
GO:0019344--P:cysteine biosynthetic process
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0009086--P:methionine biosynthetic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0046686--P:response to cadmium ion
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YIL046W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	30.54	7.00e-61	226.00
IUUC-Aca-005318	Anolis carolinensis	30.54	9.00e-61	226.00
IUUC-Ago-007794	Ashbya gossypii	63.90	0.00e+00	728.00
IUUC-Acl-008078	Aspergillus clavatus	41.63	2.00e-138	484.00
IUUC-Afl-008744	Aspergillus flavus	40.85	4.00e-125	439.00
IUUC-Afu-008939	Aspergillus fumigatus	42.13	3.00e-133	467.00
IUUC-Ani-009383	Aspergillus nidulans	41.27	9.00e-133	465.00
IUUC-Ang-009570	Aspergillus niger	41.13	4.00e-127	446.00
IUUC-Aor-010217	Aspergillus oryzae	40.72	5.00e-125	439.00
IUUC-Ate-010336	Aspergillus terreus	43.62	6.00e-92	329.00
IUUC-Bgr-012225	Blumeria graminis	38.84	4.00e-123	432.00
IUUC-Bci-013916	Botrytis cinerea	41.32	7.00e-129	452.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	33.57	5.00e-34	136.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	33.75	7.00e-92	329.00
IUUC-Cne-026800	Cryptococcus neoformans	37.79	9.00e-51	193.00
IUUC-Dno-029576	Dasypus novemcinctus	29.86	2.00e-55	208.00
IUUC-Dse-031413	Dothistroma septosporum	35.13	1.00e-69	256.00
IUUC-Eeu-034996	Erinaceus europaeus	31.67	1.00e-60	225.00
IUUC-Fal-037267	Ficedula albicollis	30.75	1.00e-60	225.00
IUUC-Fox-037683	Fusarium oxysporum	40.75	9.00e-118	415.00
IUUC-Fso-038092	Fusarium solani	40.69	2.00e-134	471.00
IUUC-Gmo-039119	Gadus morhua	28.22	1.00e-45	175.00
IUUC-Ggr-039842	Gaeumannomyces graminis	39.39	3.00e-83	301.00
IUUC-Kpa-049101	Komagataella pastoris	54.34	1.00e-180	624.00
IUUC-Lma-053200	Leptosphaeria maculans	38.63	1.00e-85	308.00
IUUC-Meu-056778	Macropus eugenii	35.66	2.00e-36	145.00
IUUC-Mor-057039	Magnaporthe oryzae	36.72	2.00e-119	421.00
IUUC-Mpo-057381	Magnaporthe poae	34.10	2.00e-90	325.00
IUUC-Mla-059099	Melampsora laricipopulina	37.65	5.00e-69	253.00
IUUC-Mvi-060426	Microbotryum violaceum	28.94	4.00e-53	201.00
IUUC-Nfi-068464	Neosartorya fischeri	42.20	5.00e-133	466.00
IUUC-Ncr-068962	Neurospora crassa	37.20	2.00e-119	421.00
IUUC-Opr-071229	Ochotona princeps	30.09	6.00e-47	179.00
IUUC-Oga-088604	Otolemur garnettii	30.09	1.00e-46	179.00
IUUC-Pno-095133	Phaeosphaeria nodorum	38.67	3.00e-76	277.00
IUUC-Pca-100571	Procavia capensis	35.85	5.00e-51	193.00
IUUC-Pgr-103527	Puccinia graminis	33.70	6.00e-55	206.00
IUUC-Ptt-103819	Puccinia triticina	29.95	4.00e-46	177.00
IUUC-Pte-104035	Pyrenophora teres	36.17	7.00e-114	402.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	36.10	4.00e-115	406.00
IUUC-Rno-105706	Rattus norvegicus	32.13	3.00e-61	228.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	38.95	8.00e-110	388.00
IUUC-Spo-108115	Schizosaccharomyces pombe	37.97	1.00e-103	368.00
IUUC-Sre-115173	Sporisorium reilianum	37.27	6.00e-54	204.00
IUUC-Ssc-115787	Sus scrofa	31.07	1.00e-58	219.00
IUUC-Tre-122126	Trichoderma reesei	40.58	8.00e-132	462.00
IUUC-Tvi-122482	Trichoderma virens	41.29	1.00e-134	471.00
IUUC-Tme-127212	Tuber melanosporum	42.01	5.00e-139	486.00
IUUC-Uma-129406	Ustilago maydis	37.24	1.00e-52	199.00
IUUC-Vda-129799	Verticillium dahliae	39.20	3.00e-130	457.00
IUUC-Vpa-130082	Vicugna pacos	31.59	4.00e-60	223.00
IUUC-Xtr-132213	Xenopus tropicalis	31.29	3.00e-61	227.00
IUUC-Yli-134408	Yarrowia lipolytica	43.03	7.00e-147	512.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence