iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17463329; 15684388; 16277698

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.40e-08	34.1	411	472

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..............kdgpl......vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                  +      +++CgH++h+ Cl ++ +++ ++ ++ +CP+C+
   Q: 411  CTICMERLvtasgyegvlrhkgV---RpelvgrLGRCGHMYHLLCLVAM-YSNGNKDGSLQCPTCK 472
           9*******888876666654331...2333333799**********666.79999**********6 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Protein Sequence
(Fasta)

MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV 60
VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA 120

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Nucleotide Sequence
(Fasta)

GCACGGCCGA GGCCTCCTCC CACCCGCGAG ATCCCGGCGG CCGCCAGCCG GCTCCTGCGT 60
CCGTCCGTCG GCCGGGCAGT CTGTCCACGC GCGGAAAGCT CGGCGCGGCG GCCGAGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005112--F:Notch binding
GO:0003713--F:transcription coactivator activity
GO:0016740--F:transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0010001--P:glial cell differentiation
GO:0045665--P:negative regulation of neuron differentiation
GO:0045581--P:negative regulation of T cell differentiation
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0008593--P:regulation of Notch signaling pathway
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:1840

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000830	Aegilops tauschii	31.25	7.00e-05	42.00
IUUC-Aml-001735	Ailuropoda melanoleuca	99.34	9.00e-159	553.00
IUUC-Aca-005007	Anolis carolinensis	81.42	0.00e+00	993.00
IUUC-Ame-011497	Astyanax mexicanus	74.35	0.00e+00	893.00
IUUC-Bta-012612	Bos taurus	96.61	0.00e+00	1036.00
IUUC-Bdi-014427	Brachypodium distachyon	28.12	3.00e-04	40.00
IUUC-Csa-023525	Chlorocebus sabaeus	97.44	0.00e+00	1045.00
IUUC-Dre-028108	Danio rerio	82.30	8.00e-146	509.00
IUUC-Eca-033826	Equus caballus	90.77	2.00e-155	542.00
IUUC-Fca-036290	Felis catus	79.49	0.00e+00	747.00
IUUC-Gmo-039078	Gadus morhua	82.21	1.00e-156	546.00
IUUC-Gga-040162	Gallus gallus	80.50	0.00e+00	908.00
IUUC-Gac-042521	Gasterosteus aculeatus	75.89	0.00e+00	877.00
IUUC-Ggo-044598	Gorilla gorilla	87.04	0.00e+00	995.00
IUUC-Hvu-047201	Hordeum vulgare	31.25	8.00e-05	42.00
IUUC-Loc-052134	Lepisosteus oculatus	76.58	0.00e+00	941.00
IUUC-Laf-054360	Loxodonta africana	95.32	0.00e+00	1017.00
IUUC-Meu-056430	Macropus eugenii	93.11	6.00e-165	574.00
IUUC-Mmr-061378	Microcebus murinus	88.15	4.00e-149	521.00
IUUC-Mmu-064234	Mus musculus	94.58	0.00e+00	1028.00
IUUC-Mpu-066343	Mustela putorius furo	98.71	4.00e-162	563.00
IUUC-Mlu-067905	Myotis lucifugus	92.81	3.00e-162	565.00
IUUC-Nle-069498	Nomascus leucogenys	97.90	0.00e+00	1015.00
IUUC-Opr-070885	Ochotona princeps	88.82	0.00e+00	926.00
IUUC-Oan-073617	Ornithorhynchus anatinus	79.72	0.00e+00	674.00
IUUC-Oba-075224	Oryza barthii	27.27	3.00e-05	43.10
IUUC-Ogl-077568	Oryza glaberrima	27.27	3.00e-05	43.10
IUUC-Ogu-077958	Oryza glumaepatula	27.27	3.00e-05	43.10
IUUC-Oin-079699	Oryza indica	27.27	3.00e-05	43.10
IUUC-Ome-081380	Oryza meridionalis	27.27	3.00e-05	43.10
IUUC-Oni-082776	Oryza nivara	27.27	3.00e-05	43.10
IUUC-Opu-083671	Oryza punctata	26.36	2.00e-05	43.50
IUUC-Oru-085146	Oryza rufipogon	27.27	3.00e-05	43.10
IUUC-Osa-085571	Oryza sativa	27.27	3.00e-05	43.10
IUUC-Oga-088768	Otolemur garnettii	95.98	0.00e+00	1024.00
IUUC-Ptr-090522	Pan troglodytes	96.29	0.00e+00	994.00
IUUC-Pan-092352	Papio anubis	97.43	0.00e+00	1046.00
IUUC-Psi-093534	Pelodiscus sinensis	88.03	3.00e-146	510.00
IUUC-Pab-098315	Pongo abelii	95.48	0.00e+00	982.00
IUUC-Pca-100459	Procavia capensis	95.54	2.00e-105	376.00
IUUC-Pva-102574	Pteropus vampyrus	89.81	5.00e-176	611.00
IUUC-Pyt-104708	Pyrenophora triticirepentis	27.48	3.00e-03	36.60
IUUC-Rno-105607	Rattus norvegicus	95.06	0.00e+00	1030.00
IUUC-Sha-107129	Sarcophilus harrisii	83.36	0.00e+00	1016.00
IUUC-Sit-110693	Setaria italica	23.64	3.00e-05	43.10
IUUC-Ssc-116198	Sus scrofa	93.67	8.00e-163	567.00
IUUC-Tru-118569	Takifugu rubripes	74.24	0.00e+00	923.00
IUUC-Tae-125197	Triticum aestivum	31.25	8.00e-05	42.00
IUUC-Ttr-128583	Tursiops truncatus	94.52	0.00e+00	1007.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence