iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046795

Ensembl Protein ID

ENSP00000397219.2

UniProt Accession

Q9BUR4; B3KPR9; D3DTQ4; Q08ET9; Q9NW09; WAP53_HUMAN

Genbank Protein ID

AAW92115.1; ABD92817.1; ABD92818.1; BAA91579.1; BAG51781.1; EAW90136.1; EAW90138.1; EAW90139.1; AAH02336.1

Protein Name

Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene

Genbank Nucleotide ID

AY766322; DQ431240; DQ431241; AK001247; AK056669; CH471108; CH471108; CH471108; BC002336

Gene Name

WRAP53; TCAB1; WDR79

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141499.16	ENST00000431639.6	ENSP00000397219.2
ENSG00000141499.16	ENST00000498311.5	ENSP00000432991.1
ENSG00000141499.16	ENST00000534050.5	ENSP00000434999.1
ENSG00000141499.16	ENST00000463804.6	ENSP00000465025.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-17	64.8	365	399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs.dDgtikvWDlrt 32
           gH++++t l+f +d +++ sG+  D  + +WDlr+
   Q: 365  GHQGGITHLCFhPDgNRFFSGArKDAELLCWDLRQ 399
           8***********999*******88899*****987 PP

Organism

Homo sapiens

Functional Description
(View)

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Protein Sequence
(Fasta)

MKTLETQPLA PDCCPSDQDP APAHPSPHAS PMNKNADSEL MPPPPERGDP PRLSPDPVAG 60
SAVSQELREG DPVSLSTPLE TEFGSPSELS PRIEEQELSE NTSLPAEEAN GSLSEEEANG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATTCGAG TTCCGCCTCC TACCAGGAAG AACCGGCTCG GGCCGGAGGG CTGCACGGAG 60
GACCACACGG ACGCCTGCGG GCCCGCCCCT TCCGCTTCAC GACGTTCAGC CTGCGTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1011--Dyskeratosis congenita
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015030--C:Cajal body
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005697--C:telomerase holoenzyme complex
GO:0051087--F:chaperone binding
GO:0032403--F:protein complex binding
GO:0003723--F:RNA binding
GO:0070034--F:telomerase RNA binding
GO:0070200--P:establishment of protein localization to telomere
GO:1904851--P:positive regulation of establishment of protein localization to telomere
GO:0051973--P:positive regulation of telomerase activity
GO:0032212--P:positive regulation of telomere maintenance via telomerase
GO:1904867--P:protein localization to Cajal body
GO:0090666--P:scaRNA localization to Cajal body
GO:0090671--P:telomerase RNA localization to Cajal body
GO:0032203--P:telomere formation via telomerase
GO:0007004--P:telomere maintenance via telomerase

KEGG

hsa:55135

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000305	Aegilops tauschii	42.51	8.00e-65	240.00
IUUC-Aml-001893	Ailuropoda melanoleuca	81.20	0.00e+00	840.00
IUUC-Atr-002472	Amborella trichopoda	39.45	9.00e-70	257.00
IUUC-Aca-004937	Anolis carolinensis	66.57	8.00e-134	469.00
IUUC-Aly-006492	Arabidopsis lyrata	43.67	2.00e-77	283.00
IUUC-Ath-006592	Arabidopsis thaliana	43.40	2.00e-78	286.00
IUUC-Acl-008296	Aspergillus clavatus	28.63	2.00e-16	79.70
IUUC-Ani-009149	Aspergillus nidulans	27.57	2.00e-28	120.00
IUUC-Aor-009938	Aspergillus oryzae	27.56	2.00e-25	110.00
IUUC-Ate-010481	Aspergillus terreus	27.54	5.00e-30	125.00
IUUC-Ame-011296	Astyanax mexicanus	58.82	4.00e-129	454.00
IUUC-Bgr-012232	Blumeria graminis	24.71	4.00e-16	79.30
IUUC-Bta-012362	Bos taurus	83.11	0.00e+00	877.00
IUUC-Bdi-014971	Brachypodium distachyon	42.65	6.00e-76	278.00
IUUC-Bol-016557	Brassica oleracea	43.11	6.00e-77	281.00
IUUC-Bra-016734	Brassica rapa	41.62	6.00e-77	281.00
IUUC-Cja-019681	Callithrix jacchus	92.31	0.00e+00	925.00
IUUC-Cfa-020148	Canis familiaris	84.93	0.00e+00	796.00
IUUC-Cpo-022128	Cavia porcellus	90.33	0.00e+00	736.00
IUUC-Cre-022680	Chlamydomonas reinhardtii	44.65	6.00e-69	254.00
IUUC-Csa-023779	Chlorocebus sabaeus	94.17	0.00e+00	917.00
IUUC-Cin-025318	Ciona intestinalis	36.67	1.00e-66	246.00
IUUC-Cne-026778	Cryptococcus neoformans	32.35	5.00e-38	152.00
IUUC-Dre-027809	Danio rerio	51.88	5.00e-133	468.00
IUUC-Dno-028896	Dasypus novemcinctus	90.71	4.00e-174	603.00
IUUC-Dor-030656	Dipodomys ordii	71.90	0.00e+00	669.00
IUUC-Dme-031828	Drosophila melanogaster	39.58	6.00e-66	245.00
IUUC-Eca-033305	Equus caballus	91.87	0.00e+00	753.00
IUUC-Eeu-034936	Erinaceus europaeus	80.93	2.00e-98	353.00
IUUC-Fca-036371	Felis catus	81.30	0.00e+00	789.00
IUUC-Gmo-039283	Gadus morhua	63.48	4.00e-88	317.00
IUUC-Gac-042297	Gasterosteus aculeatus	68.26	8.00e-94	336.00
IUUC-Gma-044331	Glycine max	41.33	8.00e-74	271.00
IUUC-Ggo-044938	Gorilla gorilla	99.06	0.00e+00	971.00
IUUC-Itr-048964	Ictidomys tridecemlineatus	83.97	0.00e+00	877.00
IUUC-Lch-050551	Latimeria chalumnae	51.90	2.00e-86	313.00
IUUC-Lpe-051458	Leersia perrieri	41.98	1.00e-68	253.00
IUUC-Loc-052833	Lepisosteus oculatus	64.26	8.00e-124	436.00
IUUC-Laf-054404	Loxodonta africana	82.55	0.00e+00	805.00
IUUC-Mcc-055500	Macaca mulatta	96.80	0.00e+00	942.00
IUUC-Meu-056062	Macropus eugenii	80.56	3.00e-39	156.00
IUUC-Mtr-058157	Medicago truncatula	42.73	2.00e-77	282.00
IUUC-Mla-058898	Melampsora laricipopulina	28.57	7.00e-31	127.00
IUUC-Mvi-060351	Microbotryum violaceum	28.35	7.00e-37	148.00
IUUC-Mmr-061204	Microcebus murinus	87.13	0.00e+00	887.00
IUUC-Mdo-062997	Monodelphis domestica	78.96	9.00e-154	536.00
IUUC-Mmu-063379	Mus musculus	78.43	0.00e+00	776.00
IUUC-Mac-065509	Musa acuminata	41.14	6.00e-74	273.00
IUUC-Mpu-066898	Mustela putorius furo	84.14	0.00e+00	762.00
IUUC-Mlu-067405	Myotis lucifugus	91.78	0.00e+00	697.00
IUUC-Nle-069679	Nomascus leucogenys	87.97	0.00e+00	825.00
IUUC-Opr-070544	Ochotona princeps	82.13	8.00e-98	350.00
IUUC-Oan-073233	Ornithorhynchus anatinus	61.45	2.00e-87	315.00
IUUC-Ocu-074700	Oryctolagus cuniculus	79.50	0.00e+00	711.00
IUUC-Oba-075164	Oryza barthii	38.92	2.00e-70	263.00
IUUC-Ogl-077700	Oryza glaberrima	42.39	1.00e-75	280.00
IUUC-Ogu-078612	Oryza glumaepatula	34.97	6.00e-47	185.00
IUUC-Oin-079494	Oryza indica	42.94	8.00e-76	277.00
IUUC-Olo-081051	Oryza longistaminata	43.49	2.00e-66	245.00
IUUC-Ome-081868	Oryza meridionalis	35.69	8.00e-53	204.00
IUUC-Oni-082904	Oryza nivara	42.39	5.00e-76	281.00
IUUC-Opu-084082	Oryza punctata	43.21	1.00e-75	280.00
IUUC-Oru-084683	Oryza rufipogon	43.52	4.00e-76	278.00
IUUC-Osa-085518	Oryza sativa	42.94	1.00e-75	276.00
IUUC-Ola-086492	Oryzias latipes	61.29	6.00e-40	156.00
IUUC-Oga-088207	Otolemur garnettii	83.68	0.00e+00	876.00
IUUC-Oar-089463	Ovis aries	80.86	0.00e+00	843.00
IUUC-Ptr-090994	Pan troglodytes	99.06	0.00e+00	988.00
IUUC-Pan-091793	Papio anubis	94.18	0.00e+00	919.00
IUUC-Psi-093816	Pelodiscus sinensis	61.14	5.00e-127	447.00
IUUC-Ppa-095348	Physcomitrella patens	41.32	2.00e-77	283.00
IUUC-Pfo-096740	Poecilia formosa	65.31	2.00e-133	469.00
IUUC-Pab-098447	Pongo abelii	98.43	0.00e+00	653.00
IUUC-Pop-099065	Populus trichocarpa	38.83	1.00e-75	276.00
IUUC-Pca-101130	Procavia capensis	79.03	0.00e+00	762.00
IUUC-Ppe-101669	Prunus persica	43.23	5.00e-78	284.00
IUUC-Pva-102685	Pteropus vampyrus	75.55	8.00e-107	380.00
IUUC-Pgr-103262	Puccinia graminis	30.00	2.00e-39	156.00
IUUC-Ptt-103932	Puccinia triticina	29.41	3.00e-36	146.00
IUUC-Pte-104073	Pyrenophora teres	23.51	4.00e-11	62.80
IUUC-Rno-105017	Rattus norvegicus	77.65	0.00e+00	784.00
IUUC-Sha-107405	Sarcophilus harrisii	75.92	0.00e+00	635.00
IUUC-Sja-107997	Schizosaccharomyces japonicus	27.36	8.00e-21	94.70
IUUC-Spo-108316	Schizosaccharomyces pombe	29.93	8.00e-28	117.00
IUUC-Smo-108985	Selaginella moellendorffii	43.58	4.00e-76	278.00
IUUC-Sit-109820	Setaria italica	43.95	3.00e-78	285.00
IUUC-Sly-110899	Solanum lycopersicum	44.41	3.00e-79	289.00
IUUC-Stu-112753	Solanum tuberosum	43.28	2.00e-77	283.00
IUUC-Sar-113155	Sorex araneus	78.09	0.00e+00	764.00
IUUC-Sbi-114408	Sorghum bicolor	43.79	1.00e-80	293.00
IUUC-Sre-115186	Sporisorium reilianum	27.19	7.00e-29	122.00
IUUC-Ssc-116125	Sus scrofa	85.05	0.00e+00	864.00
IUUC-Tru-117888	Takifugu rubripes	61.07	1.00e-133	469.00
IUUC-Tsy-119064	Tarsius syrichta	78.22	0.00e+00	677.00
IUUC-Tni-120323	Tetraodon nigroviridis	64.81	9.00e-131	459.00
IUUC-Tca-121784	Theobroma cacao	42.20	1.00e-74	273.00
IUUC-Tae-123366	Triticum aestivum	42.57	4.00e-75	275.00
IUUC-Tur-126046	Triticum urartu	43.88	1.00e-65	243.00
IUUC-Tbe-127406	Tupaia belangeri	87.79	8.00e-108	384.00
IUUC-Ttr-128268	Tursiops truncatus	83.49	0.00e+00	857.00
IUUC-Vpa-130534	Vicugna pacos	84.83	2.00e-140	491.00
IUUC-Vvi-131612	Vitis vinifera	40.31	8.00e-78	285.00
IUUC-Xtr-132969	Xenopus tropicalis	59.42	2.00e-125	442.00
IUUC-Xma-134075	Xiphophorus maculatus	64.16	7.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence