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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046745
UUCD1 version UUC-HoS-00252
Ensembl Protein ID ENSP00000255499.2
UniProt Accession Q8TEB7; A0PJI4; Q6PH80; Q6ZTJ8; Q96RF3; Q9H5E4; RN128_HUMAN
Genbank Protein ID AAK77554.1; BAB15682.1; BAB85033.1; BAC86589.1; CAI39545.1; CAI39546.1; CAI39546.1; CAI41228.1; CAI41228.1; AAH30951.1; AAH56677.1; AAH63404.1
Protein Name E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128
Genbank Nucleotide ID AF394689; AK027169; AK074264; AK126553; AL391315; AL391315; AL606833; AL606833; AL391315; BC030951; BC056677; BC063404
Gene Name RNF128
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000133135.13 ENST00000324342.7 ENSP00000316127.3
ENSG00000133135.13 ENST00000255499.2 ENSP00000255499.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
PhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19542455; 20493730
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.40e-05 26.4 277 318
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e +   d +++l C+H+fh++C+  w         + +CP C+
   Q: 277  CAVCIELYkpNDLVRILTCNHIFHKTCVDPW------LLEHRTCPMCK 318
           *****9985545499****************......9999******6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
 E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Protein Sequence
(Fasta)
MGPPPGAGVS CRGGCGFSRL LAWCFLLALS PQAPGSRGAE AVWTAYLNVS WRVPHTGVNR 60
TVWELSEEGV YGQDSPLEPV AGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046745|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
TGGAGGAGGG GCAAGCAAAG GGGAATGTAG ATAACTAAAG TGAAATAGAG CTGATGTATC 60
CAGAGGTTAT GTTGCTAGAG GTGAGATCAG TTACCTACGT GCAACTGAAA TTTCAAACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046745|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042036--P:negative regulation of cytokine biosynthetic process
GO:1904352--P:positive regulation of protein catabolic process in the vacuole
GO:0016579--P:protein deubiquitination
GO:0061462--P:protein localization to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031647--P:regulation of protein stability
KEGG hsa:79589
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000408 Aegilops tauschii 48.21 1.00e-12 66.20
IUUC-Aml-001674 Ailuropoda melanoleuca 96.29 0.00e+00 830.00
IUUC-Apl-003776 Anas platyrhynchos 66.56 3.00e-106 377.00
IUUC-Aca-004318 Anolis carolinensis 68.17 8.00e-117 413.00
IUUC-Ame-011286 Astyanax mexicanus 45.89 1.00e-84 306.00
IUUC-Bta-013454 Bos taurus 94.20 0.00e+00 813.00
IUUC-Cja-019864 Callithrix jacchus 98.13 0.00e+00 842.00
IUUC-Cfa-020185 Canis familiaris 96.06 0.00e+00 825.00
IUUC-Csa-023224 Chlorocebus sabaeus 97.20 0.00e+00 806.00
IUUC-Cho-024710 Choloepus hoffmanni 79.83 9.00e-146 509.00
IUUC-Cne-026951 Cryptococcus neoformans 34.69 8.00e-11 61.60
IUUC-Dre-028249 Danio rerio 52.73 2.00e-89 323.00
IUUC-Dno-029216 Dasypus novemcinctus 95.94 4.00e-136 477.00
IUUC-Dor-030487 Dipodomys ordii 82.73 0.00e+00 660.00
IUUC-Dse-031357 Dothistroma septosporum 45.21 2.00e-12 67.40
IUUC-Ete-032376 Echinops telfairi 94.58 6.00e-135 473.00
IUUC-Eca-034264 Equus caballus 96.06 0.00e+00 827.00
IUUC-Eeu-034606 Erinaceus europaeus 92.55 4.00e-129 454.00
IUUC-Fca-036503 Felis catus 96.52 0.00e+00 830.00
IUUC-Fal-036671 Ficedula albicollis 60.32 3.00e-112 398.00
IUUC-Gmo-039483 Gadus morhua 47.35 3.00e-80 291.00
IUUC-Gga-040248 Gallus gallus 66.57 1.00e-130 459.00
IUUC-Itr-048362 Ictidomys tridecemlineatus 96.96 0.00e+00 833.00
IUUC-Lch-050549 Latimeria chalumnae 56.97 9.00e-121 426.00
IUUC-Loc-051929 Lepisosteus oculatus 56.25 3.00e-96 345.00
IUUC-Laf-054197 Loxodonta africana 93.97 0.00e+00 781.00
IUUC-Mcc-055146 Macaca mulatta 97.66 0.00e+00 812.00
IUUC-Meu-056649 Macropus eugenii 75.98 2.00e-162 565.00
IUUC-Mga-059520 Meleagris gallopavo 65.68 1.00e-130 459.00
IUUC-Mmr-061502 Microcebus murinus 96.50 0.00e+00 800.00
IUUC-Mdo-062875 Monodelphis domestica 64.95 3.00e-122 431.00
IUUC-Mmu-064235 Mus musculus 95.33 0.00e+00 822.00
IUUC-Mpu-066452 Mustela putorius furo 91.52 7.00e-170 589.00
IUUC-Mlu-067189 Myotis lucifugus 94.66 0.00e+00 799.00
IUUC-Ncr-068771 Neurospora crassa 41.18 2.00e-13 70.90
IUUC-Nle-070026 Nomascus leucogenys 98.60 0.00e+00 818.00
IUUC-Opr-070435 Ochotona princeps 71.05 2.00e-94 338.00
IUUC-Oan-073238 Ornithorhynchus anatinus 74.83 6.00e-117 413.00
IUUC-Ocu-074960 Oryctolagus cuniculus 95.79 0.00e+00 786.00
IUUC-Ola-086348 Oryzias latipes 47.04 3.00e-77 281.00
IUUC-Oga-088543 Otolemur garnettii 94.86 0.00e+00 816.00
IUUC-Oar-089599 Ovis aries 94.20 0.00e+00 813.00
IUUC-Ptr-091576 Pan troglodytes 95.61 6.00e-174 603.00
IUUC-Pan-091690 Papio anubis 97.44 0.00e+00 807.00
IUUC-Psi-093642 Pelodiscus sinensis 77.82 8.00e-106 376.00
IUUC-Pfo-096270 Poecilia formosa 41.64 7.00e-76 277.00
IUUC-Pab-097965 Pongo abelii 98.36 0.00e+00 814.00
IUUC-Pva-102991 Pteropus vampyrus 84.97 4.00e-175 607.00
IUUC-Rno-105667 Rattus norvegicus 95.33 0.00e+00 823.00
IUUC-Sha-107293 Sarcophilus harrisii 77.48 1.00e-154 539.00
IUUC-Ssl-108451 Sclerotinia sclerotiorum 54.00 1.00e-12 67.80
IUUC-Sar-113682 Sorex araneus 95.49 6.00e-143 499.00
IUUC-Ssc-115583 Sus scrofa 96.29 0.00e+00 826.00
IUUC-Tgu-117406 Taeniopygia guttata 58.33 2.00e-81 295.00
IUUC-Tru-118147 Takifugu rubripes 44.05 9.00e-74 270.00
IUUC-Tsy-118918 Tarsius syrichta 95.33 0.00e+00 769.00
IUUC-Tni-120865 Tetraodon nigroviridis 45.91 6.00e-70 257.00
IUUC-Ttr-128640 Tursiops truncatus 96.29 0.00e+00 803.00
IUUC-Vpa-130536 Vicugna pacos 88.19 0.00e+00 736.00
IUUC-Xma-133114 Xiphophorus maculatus 48.14 8.00e-78 283.00
Created Date 25-Jun-2017

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