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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105539
Ensembl Protein ID ENSRNOP00000056021.3
UniProt Accession O08623; Q8CH59; SQSTM_RAT
Genbank Protein ID CAA69642.1; AAO15463.1; AAH61575.1
Protein Name Sequestosome-1; Protein kinase C-zeta-interacting protein; Ubiquitin-binding protein p62
Genbank Nucleotide ID Y08355; AF439403; BC061575
Gene Name Sqstm1; Zip
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000003147.8 ENSRNOT00000059255.5 ENSRNOP00000056021.3
ENSRNOG00000003147.8 ENSRNOT00000004308.6 ENSRNOP00000004308.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 25496309; 25761618; 25825496; 27236019
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.00064 20.2 395 429
ULD/UDP/UFD/PB1 3.50e-17 62.8 22 100
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAvey 37
           + l q+ +MGF d+  +l+ L+++ n+++ aA++ 
   Q: 395  ESLSQMLSMGFsDEGGWLTRLLQTkNYDIGAALDT 429
           6799*******6666*****************985 PP
   

   ULD/UDP/UFD/PB1
   S: 3    rvkvsykgeirsfaldlekpgkfedLlkavrt.ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           r+ +++++e++  a+++++pg +e+Ll++v+  +++l+   ++ +Y+DedGDlv+++sDe+l++a+s+   k++++r++i++k
   Q: 22   RFSFCFSPEPE--AEAAAGPGPCERLLSRVAVlFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSY--VKDDIFRIYIKEK 100
           899*******6..69*****************999********************************7..9*********975 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.
 Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.
Protein Sequence
(Fasta)
MASLTVKAYL LGKEEAAREI RRFSFCFSPE PEAEAAAGPG PCERLLSRVA VLFPALRPGG 60
FQAHYRDEDG DLVAFSSDEE LTMAMSYVKD DIFRIYIKEK KECRREHRPP CAQEARSMVH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105539|UBD,UBA;ULD,PB1|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCCAGCTGT TTCCTCCGTA CCTAGTCTGC GGTTATGGCT TCGCTCACGG TGAAGGCCTA 60
TCTACTGGGC AAGGAGGAGG CGGCCCGCGA GATCCGCCGC TTCAGCTTCT GCTTCAGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105539|UBD,UBA;ULD,PB1|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000270--PB1_dom
IPR033741--SQSTM_UBA
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ
PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF00564--PB1
PF16577--UBA_5
PF00569--ZZ
SMART

SM00666--PB1
SM00165--UBA
SM00291--ZnF_ZZ
Gene Ontology

GO:0016235--C:aggresome
GO:0044753--C:amphisome
GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0000932--C:P-body
GO:0016605--C:PML body
GO:0000407--C:pre-autophagosomal structure
GO:0097225--C:sperm midpiece
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0005080--F:protein kinase C binding
GO:0042169--F:SH2 domain binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0002376--P:immune system process
GO:0016236--P:macroautophagy
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016239--P:positive regulation of macroautophagy
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051291--P:protein heterooligomerization
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061635--P:regulation of protein complex stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:113894
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001367 Ailuropoda melanoleuca 88.24 2.00e-168 584.00
IUUC-Apl-003897 Anas platyrhynchos 57.49 8.00e-119 420.00
IUUC-Aca-004699 Anolis carolinensis 49.24 5.00e-97 348.00
IUUC-Ame-010982 Astyanax mexicanus 71.30 5.00e-41 162.00
IUUC-Bta-012634 Bos taurus 88.69 0.00e+00 743.00
IUUC-Cel-018540 Caenorhabditis elegans 50.00 9.00e-10 58.90
IUUC-Cja-019684 Callithrix jacchus 88.01 0.00e+00 734.00
IUUC-Cfa-020573 Canis familiaris 81.82 5.00e-134 471.00
IUUC-Cpo-021425 Cavia porcellus 79.15 3.00e-180 624.00
IUUC-Csa-023968 Chlorocebus sabaeus 88.69 0.00e+00 708.00
IUUC-Cho-024596 Choloepus hoffmanni 81.53 2.00e-52 199.00
IUUC-Cin-025557 Ciona intestinalis 27.50 7.00e-14 71.20
IUUC-Csv-025974 Ciona savignyi 26.98 3.00e-16 79.30
IUUC-Dre-028621 Danio rerio 44.12 3.00e-96 345.00
IUUC-Dno-029060 Dasypus novemcinctus 85.36 0.00e+00 715.00
IUUC-Dor-030547 Dipodomys ordii 86.45 1.00e-136 479.00
IUUC-Ete-033201 Echinops telfairi 77.81 8.00e-165 572.00
IUUC-Eca-033456 Equus caballus 88.05 0.00e+00 667.00
IUUC-Eeu-035157 Erinaceus europaeus 81.65 1.00e-172 598.00
IUUC-Fca-035403 Felis catus 87.22 0.00e+00 699.00
IUUC-Fal-036798 Ficedula albicollis 57.42 2.00e-137 482.00
IUUC-Gmo-039619 Gadus morhua 42.01 6.00e-49 187.00
IUUC-Gga-040137 Gallus gallus 56.03 2.00e-132 465.00
IUUC-Gac-042410 Gasterosteus aculeatus 47.11 2.00e-97 348.00
IUUC-Ggo-044690 Gorilla gorilla 88.91 0.00e+00 714.00
IUUC-Hsa-046390 Homo sapiens 88.69 0.00e+00 710.00
IUUC-Itr-048536 Ictidomys tridecemlineatus 91.63 0.00e+00 777.00
IUUC-Lch-049658 Latimeria chalumnae 47.67 1.00e-110 393.00
IUUC-Loc-052589 Lepisosteus oculatus 47.23 2.00e-110 392.00
IUUC-Laf-053746 Loxodonta africana 79.24 0.00e+00 637.00
IUUC-Mcc-055635 Macaca mulatta 88.01 0.00e+00 718.00
IUUC-Meu-056528 Macropus eugenii 52.61 7.00e-108 383.00
IUUC-Mga-059458 Meleagris gallopavo 57.78 2.00e-118 419.00
IUUC-Mvi-060347 Microbotryum violaceum 51.16 1.00e-07 52.40
IUUC-Mmr-061539 Microcebus murinus 83.70 7.00e-133 466.00
IUUC-Mdo-063083 Monodelphis domestica 64.10 5.00e-155 540.00
IUUC-Mmu-063589 Mus musculus 95.93 0.00e+00 812.00
IUUC-Mpu-065727 Mustela putorius furo 87.13 3.00e-178 617.00
IUUC-Mlu-067026 Myotis lucifugus 85.15 4.00e-179 620.00
IUUC-Nle-069356 Nomascus leucogenys 62.88 1.00e-119 423.00
IUUC-Opr-071091 Ochotona princeps 66.55 2.00e-92 332.00
IUUC-Ont-071864 Oreochromis niloticus 48.53 4.00e-102 364.00
IUUC-Oan-073308 Ornithorhynchus anatinus 63.25 2.00e-142 498.00
IUUC-Ocu-074110 Oryctolagus cuniculus 86.65 0.00e+00 720.00
IUUC-Ola-086944 Oryzias latipes 46.19 8.00e-40 156.00
IUUC-Oga-088869 Otolemur garnettii 85.94 0.00e+00 723.00
IUUC-Oar-089857 Ovis aries 88.59 0.00e+00 645.00
IUUC-Ptr-091640 Pan troglodytes 88.91 0.00e+00 714.00
IUUC-Pan-092831 Papio anubis 88.39 0.00e+00 708.00
IUUC-Psi-093925 Pelodiscus sinensis 56.54 7.00e-130 457.00
IUUC-Pma-094576 Petromyzon marinus 31.30 6.00e-45 174.00
IUUC-Pfo-097297 Poecilia formosa 45.41 9.00e-93 333.00
IUUC-Pab-098725 Pongo abelii 81.22 0.00e+00 635.00
IUUC-Pca-101106 Procavia capensis 87.27 0.00e+00 702.00
IUUC-Pva-102710 Pteropus vampyrus 84.44 0.00e+00 652.00
IUUC-Sha-107469 Sarcophilus harrisii 59.64 1.00e-124 439.00
IUUC-Ssc-115526 Sus scrofa 89.82 0.00e+00 720.00
IUUC-Tgu-117194 Taeniopygia guttata 58.78 9.00e-120 423.00
IUUC-Tru-117896 Takifugu rubripes 48.09 7.00e-103 367.00
IUUC-Tni-119943 Tetraodon nigroviridis 48.54 8.00e-93 333.00
IUUC-Ttr-128676 Tursiops truncatus 88.91 0.00e+00 744.00
IUUC-Vda-129812 Verticillium dahliae 48.94 1.00e-06 48.50
IUUC-Vpa-130319 Vicugna pacos 94.00 3.00e-54 205.00
IUUC-Xtr-132907 Xenopus tropicalis 53.73 8.00e-129 453.00
Created Date 25-Jun-2017

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