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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046078
Ensembl Protein ID ENSP00000357048.3
UniProt Accession P53621; Q5T201; Q8IXZ9; COPA_HUMAN
Genbank Protein ID AAB70879.1; CAI12454.1; CAI12454.1; CAI12455.1; CAI12455.1; CAI15004.1; CAI15004.1; CAI15005.1; CAI15005.1; EAW52723.1; EAW52725.1; AAH38447.1
Protein Name Coatomer subunit alpha; Alpha-coat protein; HEP-COP; Xenin; Xenopsin-related peptide; Proxenin
Genbank Nucleotide ID U24105; AL513282; AL445230; AL513282; AL445230; AL445230; AL513282; AL445230; AL513282; CH471121; CH471121; BC038447
Gene Name COPA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000122218.14 ENST00000368069.7 ENSP00000357048.3
ENSG00000122218.14 ENST00000241704.7 ENSP00000241704.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.80e-36 122.2 50 80
UBD/Beta-Prp 7.10e-76 256.9 3 324
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           t +++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl gh d
   Q: 3    TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLD 94
           67889999************************************************************************************ PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..................... 166
           +++++ f+ +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                     
   Q: 95   YIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDIsglrkknlspgavesdvrgit 185
           ***********************************.******************************************************** PP
   S: 167  ......ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
                  t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s+D+sir+Wd
   Q: 186  gvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
           ******888888888777********************************888888************************************ PP
   S: 251  lrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           + +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 278  MSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 324
           **********************.5554444444.589999999988765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity). Interacts with JAGN1.
 Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity). Interacts with JAGN1.
Protein Sequence
(Fasta)
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046078|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCATCTTGCC TCTCTGCTGA GCGGAAGCCC CCGTTCGGCT CCTGTCTGTT AGCGGCCTCT 60
CTAGGCTACC ACTGACACCG TCTCTGTGGC CCGGAGCCTA AGAGACCGGA AGTTCGTGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046078|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0372--Hormone
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0691--RNA editing
KW-0964--Secreted
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0016020--C:membrane
GO:0030133--C:transport vesicle
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
KEGG hsa:1314
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000064 Aegilops tauschii 53.46 0.00e+00 1313.00
IUUC-Aml-001758 Ailuropoda melanoleuca 99.11 0.00e+00 2521.00
IUUC-Atr-002493 Amborella trichopoda 53.83 0.00e+00 1311.00
IUUC-Apl-003385 Anas platyrhynchos 95.05 0.00e+00 2053.00
IUUC-Aca-005154 Anolis carolinensis 96.62 4.00e-121 426.00
IUUC-Aly-006020 Arabidopsis lyrata 61.18 0.00e+00 1090.00
IUUC-Ath-007058 Arabidopsis thaliana 61.45 0.00e+00 1085.00
IUUC-Ago-007992 Ashbya gossypii 44.44 0.00e+00 1028.00
IUUC-Acl-008027 Aspergillus clavatus 56.60 0.00e+00 1000.00
IUUC-Afl-008644 Aspergillus flavus 48.99 0.00e+00 1186.00
IUUC-Afu-008964 Aspergillus fumigatus 49.07 0.00e+00 1192.00
IUUC-Ani-009379 Aspergillus nidulans 56.00 0.00e+00 1006.00
IUUC-Ang-009756 Aspergillus niger 49.64 0.00e+00 1210.00
IUUC-Aor-010174 Aspergillus oryzae 48.99 0.00e+00 1184.00
IUUC-Ate-010302 Aspergillus terreus 49.36 0.00e+00 1225.00
IUUC-Ame-011229 Astyanax mexicanus 86.05 0.00e+00 2194.00
IUUC-Bgr-012300 Blumeria graminis 48.24 0.00e+00 1139.00
IUUC-Bta-012524 Bos taurus 98.30 0.00e+00 2472.00
IUUC-Bci-013781 Botrytis cinerea 48.27 0.00e+00 1191.00
IUUC-Bdi-014549 Brachypodium distachyon 54.14 0.00e+00 1338.00
IUUC-Bol-015925 Brassica oleracea 61.09 0.00e+00 1076.00
IUUC-Bra-016978 Brassica rapa 60.40 0.00e+00 1072.00
IUUC-Cel-018115 Caenorhabditis elegans 63.70 0.00e+00 1120.00
IUUC-Cja-019107 Callithrix jacchus 97.16 0.00e+00 2466.00
IUUC-Cfa-020675 Canis familiaris 97.55 0.00e+00 2447.00
IUUC-Cpo-021813 Cavia porcellus 98.30 0.00e+00 2491.00
IUUC-Cre-022969 Chlamydomonas reinhardtii 64.00 0.00e+00 1107.00
IUUC-Csa-023523 Chlorocebus sabaeus 98.95 0.00e+00 2515.00
IUUC-Cho-024704 Choloepus hoffmanni 84.87 0.00e+00 1916.00
IUUC-Cin-025572 Ciona intestinalis 72.57 0.00e+00 1879.00
IUUC-Csv-025864 Ciona savignyi 75.39 0.00e+00 1294.00
IUUC-Cgl-026510 Colletotrichum gloeosporioides 56.62 0.00e+00 1016.00
IUUC-Cne-027053 Cryptococcus neoformans 51.43 0.00e+00 1244.00
IUUC-Cme-027222 Cyanidioschyzon merolae 32.01 3.00e-161 563.00
IUUC-Dre-027421 Danio rerio 85.98 0.00e+00 2228.00
IUUC-Dno-029303 Dasypus novemcinctus 97.90 0.00e+00 2483.00
IUUC-Dor-030290 Dipodomys ordii 98.23 0.00e+00 1123.00
IUUC-Dse-031543 Dothistroma septosporum 45.96 0.00e+00 1115.00
IUUC-Dme-031945 Drosophila melanogaster 75.47 0.00e+00 1291.00
IUUC-Ete-032873 Echinops telfairi 93.21 0.00e+00 2177.00
IUUC-Eca-033773 Equus caballus 96.03 0.00e+00 2413.00
IUUC-Eeu-034874 Erinaceus europaeus 86.04 0.00e+00 1527.00
IUUC-Fca-035739 Felis catus 98.21 0.00e+00 2428.00
IUUC-Fal-037263 Ficedula albicollis 87.05 0.00e+00 2122.00
IUUC-Fox-037738 Fusarium oxysporum 48.37 0.00e+00 1211.00
IUUC-Fso-038153 Fusarium solani 48.72 0.00e+00 1199.00
IUUC-Gmo-039602 Gadus morhua 81.07 0.00e+00 2052.00
IUUC-Ggr-039931 Gaeumannomyces graminis 55.71 0.00e+00 1009.00
IUUC-Gga-040590 Gallus gallus 95.94 0.00e+00 2414.00
IUUC-Gac-041318 Gasterosteus aculeatus 85.90 0.00e+00 2211.00
IUUC-Gma-043567 Glycine max 54.42 0.00e+00 1327.00
IUUC-Ggo-045029 Gorilla gorilla 99.76 0.00e+00 2544.00
IUUC-Hvu-047556 Hordeum vulgare 54.86 0.00e+00 1353.00
IUUC-Itr-048881 Ictidomys tridecemlineatus 98.98 0.00e+00 1773.00
IUUC-Kpa-049256 Komagataella pastoris 44.77 0.00e+00 1080.00
IUUC-Lch-049706 Latimeria chalumnae 92.62 0.00e+00 2316.00
IUUC-Lpe-051316 Leersia perrieri 62.32 0.00e+00 1103.00
IUUC-Loc-051867 Lepisosteus oculatus 72.16 0.00e+00 1221.00
IUUC-Lma-053138 Leptosphaeria maculans 55.85 0.00e+00 1016.00
IUUC-Laf-053510 Loxodonta africana 97.32 0.00e+00 2472.00
IUUC-Mcc-055836 Macaca mulatta 99.11 0.00e+00 2519.00
IUUC-Meu-056238 Macropus eugenii 88.02 0.00e+00 1196.00
IUUC-Mor-057172 Magnaporthe oryzae 48.44 0.00e+00 1193.00
IUUC-Mpo-057300 Magnaporthe poae 47.97 0.00e+00 1178.00
IUUC-Mtr-058248 Medicago truncatula 54.95 0.00e+00 1359.00
IUUC-Mla-059019 Melampsora laricipopulina 52.08 0.00e+00 1284.00
IUUC-Mga-059499 Meleagris gallopavo 95.79 0.00e+00 2407.00
IUUC-Mvi-060336 Microbotryum violaceum 52.29 0.00e+00 1266.00
IUUC-Mmr-061102 Microcebus murinus 99.19 0.00e+00 2490.00
IUUC-Mdo-062594 Monodelphis domestica 97.16 0.00e+00 2510.00
IUUC-Mmu-063736 Mus musculus 98.46 0.00e+00 2508.00
IUUC-Mac-065398 Musa acuminata 51.89 0.00e+00 1236.00
IUUC-Mpu-066701 Mustela putorius furo 97.74 0.00e+00 2437.00
IUUC-Mlu-067392 Myotis lucifugus 96.52 0.00e+00 2442.00
IUUC-Nfi-068270 Neosartorya fischeri 56.96 0.00e+00 1004.00
IUUC-Ncr-068892 Neurospora crassa 48.84 0.00e+00 1182.00
IUUC-Nle-069634 Nomascus leucogenys 98.21 0.00e+00 1372.00
IUUC-Opr-070952 Ochotona princeps 87.07 0.00e+00 1831.00
IUUC-Ont-072488 Oreochromis niloticus 87.67 0.00e+00 2224.00
IUUC-Ocu-074211 Oryctolagus cuniculus 98.70 0.00e+00 2502.00
IUUC-Oba-075761 Oryza barthii 62.20 0.00e+00 1103.00
IUUC-Obr-076429 Oryza brachyantha 62.20 0.00e+00 1102.00
IUUC-Ogl-077364 Oryza glaberrima 62.20 0.00e+00 1103.00
IUUC-Ogu-078257 Oryza glumaepatula 62.46 0.00e+00 1102.00
IUUC-Oin-079274 Oryza indica 62.09 0.00e+00 1102.00
IUUC-Olo-080466 Oryza longistaminata 62.11 0.00e+00 1088.00
IUUC-Ome-081668 Oryza meridionalis 61.76 0.00e+00 927.00
IUUC-Oni-082874 Oryza nivara 62.46 0.00e+00 1102.00
IUUC-Opu-083697 Oryza punctata 53.57 0.00e+00 1323.00
IUUC-Oru-084274 Oryza rufipogon 62.20 0.00e+00 1103.00
IUUC-Osa-085565 Oryza sativa 62.20 0.00e+00 1103.00
IUUC-Ola-086921 Oryzias latipes 87.13 0.00e+00 2215.00
IUUC-Olu-087639 Ostreococcus lucimarinus 55.81 0.00e+00 1362.00
IUUC-Oga-087991 Otolemur garnettii 93.21 0.00e+00 2353.00
IUUC-Oar-089590 Ovis aries 98.22 0.00e+00 2492.00
IUUC-Ptr-090808 Pan troglodytes 99.84 0.00e+00 2546.00
IUUC-Pan-092475 Papio anubis 98.46 0.00e+00 2501.00
IUUC-Psi-093044 Pelodiscus sinensis 79.30 0.00e+00 1686.00
IUUC-Pno-094839 Phaeosphaeria nodorum 47.65 0.00e+00 1112.00
IUUC-Ppa-095254 Physcomitrella patens 56.19 0.00e+00 1400.00
IUUC-Pfo-097493 Poecilia formosa 87.19 0.00e+00 2192.00
IUUC-Pab-098497 Pongo abelii 98.95 0.00e+00 2517.00
IUUC-Pop-099992 Populus trichocarpa 56.10 0.00e+00 1338.00
IUUC-Pca-100413 Procavia capensis 90.93 0.00e+00 1039.00
IUUC-Ppe-101899 Prunus persica 54.23 0.00e+00 1321.00
IUUC-Pva-102126 Pteropus vampyrus 95.13 0.00e+00 2402.00
IUUC-Pgr-103376 Puccinia graminis 52.70 0.00e+00 1301.00
IUUC-Ptt-103978 Puccinia triticina 47.13 0.00e+00 1086.00
IUUC-Pte-104126 Pyrenophora teres 56.21 0.00e+00 976.00
IUUC-Pyt-104778 Pyrenophora triticirepentis 46.35 2.00e-177 616.00
IUUC-Rno-105428 Rattus norvegicus 97.73 0.00e+00 2479.00
IUUC-Sce-106464 Saccharomyces cerevisiae 43.39 0.00e+00 1011.00
IUUC-Sha-107301 Sarcophilus harrisii 97.21 0.00e+00 2450.00
IUUC-Sja-107961 Schizosaccharomyces japonicus 45.53 0.00e+00 1090.00
IUUC-Spo-108217 Schizosaccharomyces pombe 46.54 0.00e+00 1132.00
IUUC-Ssl-108643 Sclerotinia sclerotiorum 48.36 0.00e+00 1197.00
IUUC-Smo-109582 Selaginella moellendorffii 65.28 0.00e+00 1152.00
IUUC-Sit-109697 Setaria italica 61.73 0.00e+00 1095.00
IUUC-Sly-111447 Solanum lycopersicum 54.68 0.00e+00 1356.00
IUUC-Stu-112564 Solanum tuberosum 54.55 0.00e+00 1355.00
IUUC-Sar-113313 Sorex araneus 88.97 0.00e+00 1508.00
IUUC-Sbi-114388 Sorghum bicolor 62.32 0.00e+00 1102.00
IUUC-Sre-115209 Sporisorium reilianum 57.11 0.00e+00 1041.00
IUUC-Ssc-115933 Sus scrofa 98.30 0.00e+00 2491.00
IUUC-Tgu-117109 Taeniopygia guttata 79.73 0.00e+00 739.00
IUUC-Tru-117772 Takifugu rubripes 86.68 0.00e+00 2194.00
IUUC-Tsy-119105 Tarsius syrichta 85.00 0.00e+00 2126.00
IUUC-Tni-120556 Tetraodon nigroviridis 70.10 0.00e+00 1518.00
IUUC-Tca-121046 Theobroma cacao 54.21 0.00e+00 1365.00
IUUC-Tre-121951 Trichoderma reesei 56.46 0.00e+00 1013.00
IUUC-Tvi-122359 Trichoderma virens 56.73 0.00e+00 1019.00
IUUC-Tae-125527 Triticum aestivum 53.18 0.00e+00 1309.00
IUUC-Tur-126754 Triticum urartu 61.49 0.00e+00 1096.00
IUUC-Tme-127170 Tuber melanosporum 50.16 0.00e+00 1230.00
IUUC-Tbe-127882 Tupaia belangeri 97.25 0.00e+00 845.00
IUUC-Ttr-128217 Tursiops truncatus 96.84 0.00e+00 2449.00
IUUC-Uma-129337 Ustilago maydis 56.42 0.00e+00 1037.00
IUUC-Vda-129828 Verticillium dahliae 48.33 0.00e+00 1183.00
IUUC-Vpa-130537 Vicugna pacos 98.46 0.00e+00 2479.00
IUUC-Vvi-130958 Vitis vinifera 62.56 0.00e+00 1108.00
IUUC-Xtr-132857 Xenopus tropicalis 89.19 0.00e+00 2266.00
IUUC-Xma-133138 Xiphophorus maculatus 86.94 0.00e+00 2189.00
IUUC-Yli-134399 Yarrowia lipolytica 50.23 0.00e+00 862.00
IUUC-Zma-135612 Zea mays 54.06 0.00e+00 1334.00
Created Date 25-Jun-2017

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