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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064192
Ensembl Protein ID ENSMUSP00000099810.4
UniProt Accession P53762; Q60661; Q921F3; ARNT_MOUSE
Genbank Protein ID AAA56717.1; AAA61732.1; BAE31928.1; EDL38816.1; AAH12870.1
Protein Name Aryl hydrocarbon receptor nuclear translocator; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta
Genbank Nucleotide ID U10325; U14333; AK153355; CH466620; BC012870
Gene Name Arnt
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000015522.18 ENSMUST00000102749.10 ENSMUSP00000099810.4
ENSMUSG00000015522.18 ENSMUST00000107161.7 ENSMUSP00000102779.1
ENSMUSG00000015522.18 ENSMUST00000136413.1 ENSMUSP00000116688.1
ENSMUSG00000015522.18 ENSMUST00000090804.11 ENSMUSP00000088313.5
ENSMUSG00000015522.18 ENSMUST00000015666.16 ENSMUSP00000015666.10
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsiteJASPARmiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 91.66 0.00e+00 1375.00 IUUC-Hsa-046946
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
 Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
Protein Sequence
(Fasta)
MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD DEVEVNTKFL 60
RCDDDQMCND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS 120
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Protein Fasta Sequence


>IUUC-Mmu-064192|E3,Cullin RING/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGTGGGCG TCCGCCATCT TGGATTCCGC GGTAGCGGTG GCGGCGGTAA GGTGCCTAAT 60
CTGCGGAGTG GCTCTTCCCT CCCCTCCCCC AGCTCGGTGG CGGCTGCCCC TCCCACCGAG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064192|E3,Cullin RING/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011598--bHLH_dom
IPR001067--Nuc_translocat
IPR001610--PAC
IPR000014--PAS
IPR013767--PAS_fold
PROSITE

PS50888--BHLH
PS50112--PAS
Pfam

PF00010--HLH
PF00989--PAS
PRINTS

PR00785--NCTRNSLOCATR
SMART

SM00353--HLH
SM00086--PAC
SM00091--PAS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0005667--C:transcription factor complex
GO:0004874--F:aryl hydrocarbon receptor activity
GO:0017162--F:aryl hydrocarbon receptor binding
GO:0003677--F:DNA binding
GO:0035326--F:enhancer binding
GO:0046982--F:protein heterodimerization activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000989--F:transcription factor activity, transcription factor binding
GO:0008134--F:transcription factor binding
GO:0030154--P:cell differentiation
GO:0001892--P:embryonic placenta development
GO:0046886--P:positive regulation of hormone biosynthetic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0043619--P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0001666--P:response to hypoxia
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated
KEGG mmu:11863
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001940 Ailuropoda melanoleuca 90.14 0.00e+00 1299.00
IUUC-Apl-003615 Anas platyrhynchos 78.88 0.00e+00 1220.00
IUUC-Aca-005047 Anolis carolinensis 76.56 0.00e+00 1171.00
IUUC-Bta-012420 Bos taurus 90.93 0.00e+00 1353.00
IUUC-Cja-019740 Callithrix jacchus 90.64 0.00e+00 1287.00
IUUC-Cfa-020981 Canis familiaris 90.41 0.00e+00 1285.00
IUUC-Cpo-021428 Cavia porcellus 90.98 0.00e+00 1284.00
IUUC-Csa-023451 Chlorocebus sabaeus 91.66 0.00e+00 1348.00
IUUC-Cho-024979 Choloepus hoffmanni 73.63 9.00e-150 524.00
IUUC-Cne-027059 Cryptococcus neoformans 30.59 9.00e-08 53.10
IUUC-Dno-029839 Dasypus novemcinctus 85.66 0.00e+00 1320.00
IUUC-Eca-034359 Equus caballus 86.59 0.00e+00 1270.00
IUUC-Fca-035413 Felis catus 87.00 0.00e+00 1319.00
IUUC-Gga-041165 Gallus gallus 77.20 0.00e+00 1184.00
IUUC-Ggo-045192 Gorilla gorilla 91.69 0.00e+00 1281.00
IUUC-Hsa-046946 Homo sapiens 91.53 0.00e+00 1278.00
IUUC-Itr-048123 Ictidomys tridecemlineatus 91.09 0.00e+00 1368.00
IUUC-Lch-050137 Latimeria chalumnae 65.06 0.00e+00 908.00
IUUC-Laf-053433 Loxodonta africana 90.04 0.00e+00 1328.00
IUUC-Mcc-055174 Macaca mulatta 91.15 0.00e+00 1337.00
IUUC-Mga-059606 Meleagris gallopavo 76.08 0.00e+00 1128.00
IUUC-Mmr-060626 Microcebus murinus 87.75 0.00e+00 1285.00
IUUC-Mdo-062779 Monodelphis domestica 85.10 0.00e+00 1273.00
IUUC-Mpu-066471 Mustela putorius furo 90.34 0.00e+00 1223.00
IUUC-Mlu-066968 Myotis lucifugus 89.78 0.00e+00 1387.00
IUUC-Nle-069762 Nomascus leucogenys 90.96 0.00e+00 1301.00
IUUC-Oan-073371 Ornithorhynchus anatinus 72.40 0.00e+00 1030.00
IUUC-Ocu-074390 Oryctolagus cuniculus 81.68 0.00e+00 1192.00
IUUC-Oga-088408 Otolemur garnettii 90.45 0.00e+00 1348.00
IUUC-Oar-089959 Ovis aries 90.52 0.00e+00 1363.00
IUUC-Ptr-091057 Pan troglodytes 91.66 0.00e+00 1295.00
IUUC-Pan-092602 Papio anubis 90.66 0.00e+00 1329.00
IUUC-Psi-093661 Pelodiscus sinensis 77.52 0.00e+00 1233.00
IUUC-Pab-098708 Pongo abelii 91.53 0.00e+00 1307.00
IUUC-Rno-105732 Rattus norvegicus 94.88 0.00e+00 1399.00
IUUC-Sha-107369 Sarcophilus harrisii 84.95 0.00e+00 1263.00
IUUC-Smo-108833 Selaginella moellendorffii 33.33 2.00e-04 41.20
IUUC-Sar-113492 Sorex araneus 83.33 0.00e+00 667.00
IUUC-Ssc-115814 Sus scrofa 91.40 0.00e+00 1350.00
IUUC-Tgu-116662 Taeniopygia guttata 75.03 0.00e+00 1149.00
IUUC-Tni-120034 Tetraodon nigroviridis 55.36 0.00e+00 707.00
Created Date 25-Jun-2017

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