iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032309.15	ENSMUST00000034859.14	ENSMUSP00000034859.8
ENSMUSG00000032309.15	ENSMUST00000153970.7	ENSMUSP00000122828.1
ENSMUSG00000032309.15	ENSMUST00000140375.7	ENSMUSP00000117341.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	92.31	0.00e+00	763.00	IUUC-Hsa-046995

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Protein Sequence
(Fasta)

MEPAGGGGGV SSSTDPRSTY VLSNLAEVVE RVFTFLPAKA LLRVAGVCRL WRECVRRVLR 60
THRSVTWISA GVAEAGHLEG HCLVRVVAEA LENVRILPQT VLYMADSETF ISLEECRGHK 120

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Nucleotide Sequence
(Fasta)

GTCCAGTACC GGAAGCGGCC CACCGGAAGT GGCGCGCGCC TGCTCAGGGA GCTCGGGTTG 60
TAGGTGGTGC GCCGGCCGCT CCGGTACCCC TGAGACTCTG TAGGGCCTTC GGGCCGGTAG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR019494--FIST_C

Pfam

PF00646--F-box
PF10442--FIST_C

SMART

SM01204--FIST_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0009267--P:cellular response to starvation
GO:0006913--P:nucleocytoplasmic transport
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0010830--P:regulation of myotube differentiation
GO:0048742--P:regulation of skeletal muscle fiber development

KEGG

mmu:71999

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001386	Ailuropoda melanoleuca	91.82	0.00e+00	751.00
IUUC-Atr-002780	Amborella trichopoda	50.00	6.00e-07	49.30
IUUC-Apl-004192	Anas platyrhynchos	66.77	6.00e-126	443.00
IUUC-Aca-004748	Anolis carolinensis	86.11	1.00e-16	77.40
IUUC-Aor-010231	Aspergillus oryzae	19.84	1.00e-01	32.00
IUUC-Ame-010876	Astyanax mexicanus	51.50	7.00e-64	236.00
IUUC-Bta-013288	Bos taurus	89.18	0.00e+00	718.00
IUUC-Bra-017851	Brassica rapa	38.46	3.80e-02	32.70
IUUC-Cja-019337	Callithrix jacchus	92.76	0.00e+00	748.00
IUUC-Cfa-020236	Canis familiaris	87.92	0.00e+00	719.00
IUUC-Cpo-021841	Cavia porcellus	82.67	5.00e-178	617.00
IUUC-Cre-022684	Chlamydomonas reinhardtii	41.86	1.00e-01	31.20
IUUC-Csa-023548	Chlorocebus sabaeus	86.49	0.00e+00	741.00
IUUC-Cho-024526	Choloepus hoffmanni	81.38	9.00e-169	586.00
IUUC-Dre-028434	Danio rerio	50.39	2.00e-100	358.00
IUUC-Dno-030026	Dasypus novemcinctus	91.79	0.00e+00	742.00
IUUC-Ete-032223	Echinops telfairi	88.41	1.00e-72	266.00
IUUC-Eca-033274	Equus caballus	90.45	0.00e+00	675.00
IUUC-Eeu-035160	Erinaceus europaeus	64.92	3.00e-89	322.00
IUUC-Fca-036405	Felis catus	92.01	0.00e+00	746.00
IUUC-Fal-037025	Ficedula albicollis	65.63	3.00e-152	531.00
IUUC-Gmo-038877	Gadus morhua	49.74	5.00e-105	374.00
IUUC-Gga-041274	Gallus gallus	65.37	5.00e-150	523.00
IUUC-Gac-042032	Gasterosteus aculeatus	49.74	4.00e-106	378.00
IUUC-Gma-044381	Glycine max	41.86	3.00e-04	40.40
IUUC-Ggo-045390	Gorilla gorilla	93.61	0.00e+00	757.00
IUUC-Hsa-046995	Homo sapiens	93.86	0.00e+00	759.00
IUUC-Hvu-047063	Hordeum vulgare	28.57	5.00e-03	35.40
IUUC-Itr-048696	Ictidomys tridecemlineatus	93.37	0.00e+00	763.00
IUUC-Lch-049717	Latimeria chalumnae	57.61	4.00e-128	451.00
IUUC-Lpe-051707	Leersia perrieri	57.69	2.00e-03	36.60
IUUC-Loc-052463	Lepisosteus oculatus	55.41	7.00e-123	433.00
IUUC-Laf-054467	Loxodonta africana	91.84	0.00e+00	748.00
IUUC-Mcc-055596	Macaca mulatta	93.08	2.00e-177	615.00
IUUC-Mpo-057515	Magnaporthe poae	40.00	9.90e-02	28.90
IUUC-Mtr-058238	Medicago truncatula	30.77	4.00e-04	40.00
IUUC-Mga-059974	Meleagris gallopavo	66.35	2.00e-124	438.00
IUUC-Mmr-061349	Microcebus murinus	91.84	0.00e+00	748.00
IUUC-Mdo-062898	Monodelphis domestica	66.67	7.00e-157	546.00
IUUC-Mpu-066283	Mustela putorius furo	90.79	0.00e+00	743.00
IUUC-Mlu-067324	Myotis lucifugus	78.93	2.00e-136	478.00
IUUC-Nle-069629	Nomascus leucogenys	93.86	0.00e+00	759.00
IUUC-Opr-071177	Ochotona princeps	85.71	0.00e+00	668.00
IUUC-Ont-072531	Oreochromis niloticus	49.87	4.00e-107	381.00
IUUC-Oan-072774	Ornithorhynchus anatinus	64.31	9.00e-112	396.00
IUUC-Ocu-074384	Oryctolagus cuniculus	84.06	0.00e+00	635.00
IUUC-Oba-075218	Oryza barthii	38.10	3.90e-01	31.60
IUUC-Olo-080717	Oryza longistaminata	40.48	9.40e-02	32.70
IUUC-Oni-082080	Oryza nivara	40.48	1.40e-01	33.10
IUUC-Ola-086930	Oryzias latipes	50.00	2.00e-105	375.00
IUUC-Oga-087924	Otolemur garnettii	91.33	0.00e+00	752.00
IUUC-Oar-089765	Ovis aries	87.89	0.00e+00	710.00
IUUC-Ptr-090695	Pan troglodytes	93.86	0.00e+00	757.00
IUUC-Pan-092209	Papio anubis	93.62	0.00e+00	760.00
IUUC-Psi-093751	Pelodiscus sinensis	65.98	1.00e-152	532.00
IUUC-Ppa-095563	Physcomitrella patens	51.85	3.00e-03	36.60
IUUC-Pfo-097170	Poecilia formosa	49.74	7.00e-107	380.00
IUUC-Pab-098587	Pongo abelii	93.61	0.00e+00	757.00
IUUC-Pop-099427	Populus trichocarpa	37.11	1.00e-06	48.50
IUUC-Pca-100536	Procavia capensis	78.39	2.00e-145	508.00
IUUC-Ppe-101327	Prunus persica	52.27	1.00e-06	48.10
IUUC-Pva-102535	Pteropus vampyrus	87.00	0.00e+00	647.00
IUUC-Rno-105972	Rattus norvegicus	97.01	0.00e+00	793.00
IUUC-Sha-106865	Sarcophilus harrisii	62.44	2.00e-143	502.00
IUUC-Sly-111465	Solanum lycopersicum	36.36	2.00e-04	40.40
IUUC-Stu-112413	Solanum tuberosum	47.73	1.00e-04	41.60
IUUC-Sar-113081	Sorex araneus	89.35	7.00e-167	579.00
IUUC-Ssc-115861	Sus scrofa	85.71	9.00e-110	389.00
IUUC-Tgu-117324	Taeniopygia guttata	66.15	1.00e-151	529.00
IUUC-Tru-118740	Takifugu rubripes	48.46	2.00e-96	346.00
IUUC-Tsy-118948	Tarsius syrichta	92.71	0.00e+00	735.00
IUUC-Tni-120182	Tetraodon nigroviridis	46.95	6.00e-96	343.00
IUUC-Tca-121806	Theobroma cacao	43.14	2.00e-05	44.70
IUUC-Tbe-127382	Tupaia belangeri	82.82	0.00e+00	632.00
IUUC-Ttr-128894	Tursiops truncatus	91.19	4.00e-104	371.00
IUUC-Vpa-130065	Vicugna pacos	89.13	2.00e-72	266.00
IUUC-Vvi-130950	Vitis vinifera	28.57	2.00e-04	40.40
IUUC-Xtr-131922	Xenopus tropicalis	52.21	9.00e-111	393.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence