iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064250

Ensembl Protein ID

ENSMUSP00000032924.5

UniProt Accession

Q8BGV7; Q6AXE9; BACD1_MOUSE

Genbank Protein ID

AAO16177.1; BAC35910.1; AAH79607.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; Polymerase delta-interacting protein 1

Genbank Nucleotide ID

AF534881; AK075722; BC079607

Gene Name

Kctd13; Poldip1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030685.5	ENSMUST00000032924.5	ENSMUSP00000032924.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.90e-06	29.2	43	109

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 3    vilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           v l+vgg+   ++  +L+ +  +++a+f++  e  ++ ++ v i+ ++  +f ++l++l+ g+++++e
   Q: 43   VKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEvLTDAGGWVLID-RSGRHFGTILNYLRDGSVPLPE 109
           99********************************9999******9.******************9986 PP

Organism

Mus musculus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration (By similarity).

Protein Sequence
(Fasta)

MSAEASGPAP AAAECLESPS PSSVEPGSPS YSLKPLTPNS KYVKLNVGGS LHYTTLRTLT 60
GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL RDGSVPLPES ARELGELLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTCCGGG TGGAGAGAGC GCGCGATGGG GCGGCTGGTG GACGTCGCGG AGTAGCTGTG 60
GAGAGTGGGC GTGTGCGCCG AGCGGCCGGG CGCCGGCGCT GGAGTCGCGG GATCTCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0017049--F:GTP-Rho binding
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016477--P:cell migration
GO:0006260--P:DNA replication
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045740--P:positive regulation of DNA replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0043149--P:stress fiber assembly

KEGG

mmu:233877

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001238	Ailuropoda melanoleuca	93.58	4.00e-158	550.00
IUUC-Aca-004311	Anolis carolinensis	74.18	3.00e-133	468.00
IUUC-Bta-012415	Bos taurus	93.31	2.00e-156	544.00
IUUC-Cja-019451	Callithrix jacchus	94.90	2.00e-155	541.00
IUUC-Cfa-020804	Canis familiaris	95.42	1.00e-155	542.00
IUUC-Cpo-022466	Cavia porcellus	96.21	7.00e-140	489.00
IUUC-Csa-023225	Chlorocebus sabaeus	96.08	6.00e-153	533.00
IUUC-Cho-024629	Choloepus hoffmanni	74.90	5.00e-99	353.00
IUUC-Dno-028944	Dasypus novemcinctus	94.83	2.00e-153	534.00
IUUC-Ete-032820	Echinops telfairi	79.29	2.00e-112	398.00
IUUC-Eca-034400	Equus caballus	95.90	1.00e-142	498.00
IUUC-Eeu-034457	Erinaceus europaeus	94.16	1.00e-137	482.00
IUUC-Fca-035698	Felis catus	96.41	2.00e-151	528.00
IUUC-Ggo-044675	Gorilla gorilla	95.78	1.00e-153	535.00
IUUC-Hsa-045986	Homo sapiens	95.75	2.00e-152	531.00
IUUC-Itr-048073	Ictidomys tridecemlineatus	94.90	2.00e-151	528.00
IUUC-Lch-049441	Latimeria chalumnae	76.70	5.00e-132	463.00
IUUC-Laf-053592	Loxodonta africana	94.59	1.00e-152	532.00
IUUC-Mcc-054864	Macaca mulatta	97.36	8.00e-131	459.00
IUUC-Mdo-062807	Monodelphis domestica	92.98	6.00e-134	469.00
IUUC-Mpu-066138	Mustela putorius furo	96.77	9.00e-124	436.00
IUUC-Mlu-067108	Myotis lucifugus	94.68	1.00e-134	472.00
IUUC-Nle-069621	Nomascus leucogenys	95.75	2.00e-152	531.00
IUUC-Opr-070867	Ochotona princeps	94.09	4.00e-129	454.00
IUUC-Ocu-074347	Oryctolagus cuniculus	96.41	2.00e-154	537.00
IUUC-Oga-087959	Otolemur garnettii	95.54	8.00e-153	532.00
IUUC-Oar-089835	Ovis aries	93.63	6.00e-150	523.00
IUUC-Ptr-090744	Pan troglodytes	95.75	2.00e-152	531.00
IUUC-Pan-092607	Papio anubis	96.08	6.00e-153	533.00
IUUC-Psi-093501	Pelodiscus sinensis	78.14	1.00e-135	476.00
IUUC-Pab-098026	Pongo abelii	95.42	3.00e-152	531.00
IUUC-Pca-100340	Procavia capensis	94.17	2.00e-151	528.00
IUUC-Pva-102916	Pteropus vampyrus	94.21	2.00e-154	538.00
IUUC-Rno-105757	Rattus norvegicus	99.04	8.00e-156	542.00
IUUC-Sha-107042	Sarcophilus harrisii	92.67	4.00e-134	470.00
IUUC-Sar-113695	Sorex araneus	93.64	6.00e-131	459.00
IUUC-Tsy-119307	Tarsius syrichta	77.73	2.00e-86	311.00
IUUC-Ttr-128588	Tursiops truncatus	97.17	6.00e-118	416.00
IUUC-Vda-129852	Verticillium dahliae	31.90	1.00e-04	41.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence