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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018240
Ensembl Protein ID Y48G8AL.6
UniProt Accession O76512; Q9BL16; RENT1_CAEEL
Genbank Protein ID AAC26789.1; CCD73461.1
Protein Name Regulator of nonsense transcripts 1; ATP-dependent helicase smg-2; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog
Genbank Nucleotide ID AF074017; FO081800
Gene Name smg-2; Y48G8AL.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004880 Y48G8AL.6 Y48G8AL.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 49.62 0.00e+00 801.00 IUUC-Sce-106206
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity).
 RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity).
Protein Sequence
(Fasta)
MDDSDDEYSR SHGETLTFVD PEDDGVSIGN TQDSQFAYEQ FSVPTQSSQA TDLLPGGTDG 60
TTNDLPFHDV EDDESDSEKS LTEEQQQQKL PEHACRYCGI SDPLCVAKCT VCRKWFCNSN 120
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Protein Fasta Sequence


>IUUC-Cel-018240|E3,E3 activity/Other|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAATGGACGA TTCGGACGAC GAATATTCGA GAAGCCACGG GGAAACCCTC ACATTTGTGG 60
ATCCCGAGGA CGATGGAGTC TCTATTGGGA ACACGCAGGA CTCTCAGTTC GCCTATGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018240|E3,E3 activity/Other|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027417--P-loop_NTPase
IPR018999--RNA-helicase_UPF1_UPF2-interct
Pfam

PF09416--UPF1_Zn_bind
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003677--F:DNA binding
GO:0051721--F:protein phosphatase 2A binding
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0030538--P:embryonic genitalia morphogenesis
GO:0034660--P:ncRNA metabolic process
GO:0000956--P:nuclear-transcribed mRNA catabolic process
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0016246--P:RNA interference
KEGG cel:CELE_Y48G8AL.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000680 Aegilops tauschii 55.35 0.00e+00 862.00
IUUC-Aml-002008 Ailuropoda melanoleuca 53.24 0.00e+00 1010.00
IUUC-Atr-002632 Amborella trichopoda 56.98 0.00e+00 936.00
IUUC-Apl-003997 Anas platyrhynchos 57.42 0.00e+00 998.00
IUUC-Aca-004322 Anolis carolinensis 31.53 1.00e-52 200.00
IUUC-Aly-006521 Arabidopsis lyrata 57.48 0.00e+00 935.00
IUUC-Ath-007059 Arabidopsis thaliana 57.48 0.00e+00 936.00
IUUC-Ago-007801 Ashbya gossypii 46.53 0.00e+00 811.00
IUUC-Acl-008312 Aspergillus clavatus 53.52 0.00e+00 907.00
IUUC-Afl-008429 Aspergillus flavus 53.03 0.00e+00 905.00
IUUC-Afu-009092 Aspergillus fumigatus 53.52 0.00e+00 908.00
IUUC-Ani-009317 Aspergillus nidulans 53.52 0.00e+00 912.00
IUUC-Ang-009783 Aspergillus niger 53.17 0.00e+00 906.00
IUUC-Aor-010178 Aspergillus oryzae 53.03 0.00e+00 905.00
IUUC-Ate-010294 Aspergillus terreus 52.69 0.00e+00 905.00
IUUC-Ame-010774 Astyanax mexicanus 64.58 7.00e-110 390.00
IUUC-Bgr-012293 Blumeria graminis 53.78 0.00e+00 911.00
IUUC-Bta-012382 Bos taurus 53.02 0.00e+00 1011.00
IUUC-Bci-013937 Botrytis cinerea 54.60 0.00e+00 913.00
IUUC-Bdi-014612 Brachypodium distachyon 56.98 0.00e+00 938.00
IUUC-Bol-015145 Brassica oleracea 56.98 0.00e+00 926.00
IUUC-Bra-017370 Brassica rapa 55.97 0.00e+00 897.00
IUUC-Cja-019892 Callithrix jacchus 58.15 0.00e+00 1002.00
IUUC-Cfa-020700 Canis familiaris 52.85 0.00e+00 1009.00
IUUC-Cpo-021510 Cavia porcellus 53.02 0.00e+00 1004.00
IUUC-Cre-022731 Chlamydomonas reinhardtii 49.87 0.00e+00 776.00
IUUC-Csa-023665 Chlorocebus sabaeus 53.54 0.00e+00 1010.00
IUUC-Cin-025798 Ciona intestinalis 55.37 0.00e+00 937.00
IUUC-Csv-025901 Ciona savignyi 54.20 0.00e+00 946.00
IUUC-Cgl-026653 Colletotrichum gloeosporioides 51.31 0.00e+00 895.00
IUUC-Cne-027014 Cryptococcus neoformans 52.13 0.00e+00 917.00
IUUC-Dre-028705 Danio rerio 54.43 0.00e+00 1016.00
IUUC-Dor-030369 Dipodomys ordii 55.56 0.00e+00 947.00
IUUC-Dme-031767 Drosophila melanogaster 52.41 0.00e+00 972.00
IUUC-Ete-032800 Echinops telfairi 32.71 5.00e-52 198.00
IUUC-Eca-033840 Equus caballus 58.15 0.00e+00 1002.00
IUUC-Fca-035466 Felis catus 57.37 0.00e+00 996.00
IUUC-Fal-037548 Ficedula albicollis 57.99 0.00e+00 993.00
IUUC-Fox-038023 Fusarium oxysporum 51.31 0.00e+00 898.00
IUUC-Gmo-039285 Gadus morhua 54.09 0.00e+00 996.00
IUUC-Ggr-039810 Gaeumannomyces graminis 52.44 0.00e+00 896.00
IUUC-Gga-040972 Gallus gallus 53.49 0.00e+00 1011.00
IUUC-Gac-042075 Gasterosteus aculeatus 54.25 0.00e+00 998.00
IUUC-Gma-042713 Glycine max 55.01 0.00e+00 956.00
IUUC-Ggo-045398 Gorilla gorilla 58.15 0.00e+00 1002.00
IUUC-Hsa-046152 Homo sapiens 53.54 0.00e+00 1010.00
IUUC-Hvu-047555 Hordeum vulgare 52.59 4.00e-140 489.00
IUUC-Itr-048247 Ictidomys tridecemlineatus 57.32 0.00e+00 984.00
IUUC-Kpa-049205 Komagataella pastoris 43.33 0.00e+00 709.00
IUUC-Lch-049587 Latimeria chalumnae 62.93 0.00e+00 668.00
IUUC-Lpe-051059 Leersia perrieri 56.86 0.00e+00 938.00
IUUC-Loc-051911 Lepisosteus oculatus 54.68 0.00e+00 1016.00
IUUC-Lma-053007 Leptosphaeria maculans 53.58 0.00e+00 903.00
IUUC-Laf-054234 Loxodonta africana 52.96 0.00e+00 1009.00
IUUC-Mcc-054762 Macaca mulatta 53.25 0.00e+00 1006.00
IUUC-Meu-056677 Macropus eugenii 61.71 4.00e-115 408.00
IUUC-Mor-057147 Magnaporthe oryzae 53.15 0.00e+00 897.00
IUUC-Mpo-057314 Magnaporthe poae 52.44 0.00e+00 895.00
IUUC-Mtr-058329 Medicago truncatula 55.13 0.00e+00 957.00
IUUC-Mla-059094 Melampsora laricipopulina 47.82 3.00e-140 490.00
IUUC-Mga-060126 Meleagris gallopavo 57.00 0.00e+00 982.00
IUUC-Mvi-060373 Microbotryum violaceum 54.35 0.00e+00 957.00
IUUC-Mmr-060628 Microcebus murinus 53.25 0.00e+00 1006.00
IUUC-Mdo-061858 Monodelphis domestica 55.84 0.00e+00 1005.00
IUUC-Mmu-064116 Mus musculus 51.48 0.00e+00 1010.00
IUUC-Mac-065136 Musa acuminata 55.97 0.00e+00 920.00
IUUC-Mpu-066463 Mustela putorius furo 53.42 0.00e+00 1014.00
IUUC-Mlu-068098 Myotis lucifugus 53.42 0.00e+00 1015.00
IUUC-Nfi-068370 Neosartorya fischeri 53.52 0.00e+00 908.00
IUUC-Ncr-068792 Neurospora crassa 52.13 0.00e+00 905.00
IUUC-Nle-070102 Nomascus leucogenys 58.15 0.00e+00 999.00
IUUC-Opr-070620 Ochotona princeps 55.43 0.00e+00 929.00
IUUC-Ont-072685 Oreochromis niloticus 54.68 0.00e+00 1014.00
IUUC-Oan-073665 Ornithorhynchus anatinus 52.95 0.00e+00 1008.00
IUUC-Ocu-074154 Oryctolagus cuniculus 31.95 1.00e-53 204.00
IUUC-Oba-075075 Oryza barthii 53.33 0.00e+00 733.00
IUUC-Obr-076183 Oryza brachyantha 56.23 0.00e+00 794.00
IUUC-Ogl-077691 Oryza glaberrima 56.98 0.00e+00 939.00
IUUC-Ogu-078423 Oryza glumaepatula 56.98 0.00e+00 938.00
IUUC-Oin-080107 Oryza indica 56.98 0.00e+00 939.00
IUUC-Olo-080269 Oryza longistaminata 56.31 0.00e+00 870.00
IUUC-Ome-081779 Oryza meridionalis 56.98 0.00e+00 937.00
IUUC-Oni-082366 Oryza nivara 56.98 0.00e+00 939.00
IUUC-Opu-083958 Oryza punctata 56.98 0.00e+00 939.00
IUUC-Oru-084182 Oryza rufipogon 56.98 0.00e+00 938.00
IUUC-Osa-085285 Oryza sativa 56.98 0.00e+00 937.00
IUUC-Ola-086954 Oryzias latipes 53.25 0.00e+00 973.00
IUUC-Olu-087685 Ostreococcus lucimarinus 50.75 0.00e+00 808.00
IUUC-Oga-088591 Otolemur garnettii 53.54 0.00e+00 1010.00
IUUC-Oar-089417 Ovis aries 53.33 0.00e+00 997.00
IUUC-Ptr-091510 Pan troglodytes 53.00 0.00e+00 994.00
IUUC-Pan-091886 Papio anubis 53.54 0.00e+00 1010.00
IUUC-Psi-093755 Pelodiscus sinensis 59.51 0.00e+00 705.00
IUUC-Pma-094470 Petromyzon marinus 53.31 0.00e+00 988.00
IUUC-Pno-094963 Phaeosphaeria nodorum 53.96 0.00e+00 905.00
IUUC-Ppa-095479 Physcomitrella patens 54.82 0.00e+00 942.00
IUUC-Pfo-097456 Poecilia formosa 54.68 0.00e+00 1005.00
IUUC-Pab-098075 Pongo abelii 49.84 0.00e+00 901.00
IUUC-Pop-099557 Populus trichocarpa 54.58 0.00e+00 945.00
IUUC-Pca-100717 Procavia capensis 69.49 3.00e-125 442.00
IUUC-Ppe-101675 Prunus persica 54.72 0.00e+00 961.00
IUUC-Pva-103029 Pteropus vampyrus 52.54 0.00e+00 748.00
IUUC-Pgr-103318 Puccinia graminis 52.17 0.00e+00 935.00
IUUC-Ptt-103956 Puccinia triticina 52.76 0.00e+00 936.00
IUUC-Pte-104399 Pyrenophora teres 53.64 0.00e+00 904.00
IUUC-Pyt-104749 Pyrenophora triticirepentis 53.64 0.00e+00 905.00
IUUC-Rno-105784 Rattus norvegicus 51.48 0.00e+00 1011.00
IUUC-Sce-106206 Saccharomyces cerevisiae 48.33 0.00e+00 784.00
IUUC-Sha-106566 Sarcophilus harrisii 57.30 0.00e+00 991.00
IUUC-Sja-107721 Schizosaccharomyces japonicus 51.43 0.00e+00 875.00
IUUC-Spo-108258 Schizosaccharomyces pombe 51.04 0.00e+00 863.00
IUUC-Ssl-108640 Sclerotinia sclerotiorum 51.24 0.00e+00 791.00
IUUC-Sit-109760 Setaria italica 57.36 0.00e+00 943.00
IUUC-Sly-111807 Solanum lycopersicum 54.85 0.00e+00 950.00
IUUC-Stu-112869 Solanum tuberosum 54.87 0.00e+00 937.00
IUUC-Sar-112950 Sorex araneus 31.15 2.00e-39 156.00
IUUC-Sbi-114863 Sorghum bicolor 57.23 0.00e+00 942.00
IUUC-Sre-115092 Sporisorium reilianum 52.99 0.00e+00 944.00
IUUC-Tgu-117214 Taeniopygia guttata 48.23 0.00e+00 871.00
IUUC-Tru-118386 Takifugu rubripes 53.80 0.00e+00 984.00
IUUC-Tsy-119550 Tarsius syrichta 54.09 1.00e-80 293.00
IUUC-Tni-120212 Tetraodon nigroviridis 54.09 0.00e+00 974.00
IUUC-Tca-121353 Theobroma cacao 56.48 0.00e+00 950.00
IUUC-Tre-122245 Trichoderma reesei 33.95 2.00e-49 190.00
IUUC-Tvi-122452 Trichoderma virens 51.60 0.00e+00 879.00
IUUC-Tae-123692 Triticum aestivum 57.11 0.00e+00 939.00
IUUC-Tur-126770 Triticum urartu 51.43 1.00e-160 559.00
IUUC-Tme-126956 Tuber melanosporum 52.21 0.00e+00 922.00
IUUC-Tbe-127873 Tupaia belangeri 34.11 5.00e-46 178.00
IUUC-Ttr-128212 Tursiops truncatus 50.87 0.00e+00 924.00
IUUC-Uma-129327 Ustilago maydis 55.23 0.00e+00 943.00
IUUC-Vda-129858 Verticillium dahliae 52.04 0.00e+00 878.00
IUUC-Vpa-130743 Vicugna pacos 31.89 3.00e-47 182.00
IUUC-Vvi-131222 Vitis vinifera 55.11 0.00e+00 930.00
IUUC-Xtr-131800 Xenopus tropicalis 48.00 0.00e+00 795.00
IUUC-Xma-133216 Xiphophorus maculatus 54.68 0.00e+00 1004.00
IUUC-Yli-134482 Yarrowia lipolytica 48.12 0.00e+00 791.00
IUUC-Zma-134802 Zea mays 57.23 0.00e+00 941.00
Created Date 25-Jun-2017

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