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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046925
UUCD1 version UUC-HoS-00079
Ensembl Protein ID ENSP00000264606.3
UniProt Accession P56524; E9PGB9; F5GX36; Q86YH7; Q9UND6; HDAC4_HUMAN
Genbank Protein ID AAD29046.1; BAA22957.2; EAW71165.1; AAH39904.1
Protein Name Histone deacetylase 4
Genbank Nucleotide ID AF132607; AB006626; AC017028; BC039904
Gene Name HDAC4; KIAA0288
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000068024.16 ENST00000345617.7 ENSP00000264606.3
ENSG00000068024.16 ENST00000430200.1 ENSP00000410551.1
ENSG00000068024.16 ENST00000445704.1 ENSP00000391226.1
ENSG00000068024.16 ENST00000454542.5 ENSP00000405226.1
ENSG00000068024.16 ENST00000543185.5 ENSP00000440481.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 18820298; 17218271; 15743823; 17218271; 19782030; 16166628; 19923268
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Protein Sequence
(Fasta)
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120
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Protein Fasta Sequence



>IUUC-Hsa-046925|E3,E3 activity/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCACTGCCAG TATCCAAGAT GGACGCCGCG GCGAGGCCTG GCCGGCTCCC CGCGTTAGCC 60
TGCACCCCAT TGTGTGCCCT CTAAGCGCGA ATTAGGCTCG CAGACATGCG GTGCTGACCG 120
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Nucleotide Fasta Sequence



>IUUC-Hsa-046925|E3,E3 activity/Other|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1268--Autism spectrum disorder
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0017053--C:transcriptional repressor complex
GO:0030018--C:Z disc
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0033558--F:protein deacetylase activity
GO:0070491--F:repressing transcription factor binding
GO:0001025--F:RNA polymerase III transcription factor binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0042113--P:B cell activation
GO:0030183--P:B cell differentiation
GO:0014898--P:cardiac muscle hypertrophy in response to stress
GO:0071260--P:cellular response to mechanical stimulus
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006338--P:chromatin remodeling
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0006954--P:inflammatory response
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:1903428--P:positive regulation of reactive oxygen species biosynthetic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006476--P:protein deacetylation
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0042493--P:response to drug
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

KEGG hsa:9759
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002279 Ailuropoda melanoleuca 92.64 0.00e+00 1756.00
IUUC-Apl-003250 Anas platyrhynchos 87.84 0.00e+00 1607.00
IUUC-Aca-004668 Anolis carolinensis 83.21 0.00e+00 1658.00
IUUC-Bta-013215 Bos taurus 92.69 0.00e+00 1772.00
IUUC-Cja-019816 Callithrix jacchus 98.22 0.00e+00 1897.00
IUUC-Cfa-020861 Canis familiaris 93.45 0.00e+00 1767.00
IUUC-Cpo-021562 Cavia porcellus 93.06 0.00e+00 1805.00
IUUC-Csa-023612 Chlorocebus sabaeus 98.60 0.00e+00 1870.00
IUUC-Csv-026359 Ciona savignyi 55.41 3.00e-95 341.00
IUUC-Dre-028284 Danio rerio 77.14 0.00e+00 1367.00
IUUC-Dno-029951 Dasypus novemcinctus 90.31 0.00e+00 1612.00
IUUC-Dor-030362 Dipodomys ordii 83.26 0.00e+00 1503.00
IUUC-Dme-031766 Drosophila melanogaster 58.22 3.00e-159 556.00
IUUC-Fca-036187 Felis catus 94.38 0.00e+00 1746.00
IUUC-Gmo-038473 Gadus morhua 76.69 0.00e+00 741.00
IUUC-Gga-040501 Gallus gallus 90.51 0.00e+00 1690.00
IUUC-Gac-042335 Gasterosteus aculeatus 69.45 0.00e+00 1253.00
IUUC-Ggo-045380 Gorilla gorilla 99.06 0.00e+00 1882.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 93.94 0.00e+00 1726.00
IUUC-Lch-050325 Latimeria chalumnae 83.75 0.00e+00 1552.00
IUUC-Loc-052231 Lepisosteus oculatus 80.25 0.00e+00 1456.00
IUUC-Laf-054490 Loxodonta africana 86.15 0.00e+00 1654.00
IUUC-Mcc-055265 Macaca mulatta 98.79 0.00e+00 1885.00
IUUC-Meu-056676 Macropus eugenii 85.84 0.00e+00 759.00
IUUC-Mmr-061633 Microcebus murinus 86.44 0.00e+00 1572.00
IUUC-Mmu-063089 Mus musculus 93.56 0.00e+00 1727.00
IUUC-Mpu-065887 Mustela putorius furo 92.80 0.00e+00 1763.00
IUUC-Mlu-067470 Myotis lucifugus 93.83 0.00e+00 1763.00
IUUC-Nle-069099 Nomascus leucogenys 95.68 0.00e+00 1259.00
IUUC-Ont-071613 Oreochromis niloticus 71.78 0.00e+00 1274.00
IUUC-Oan-073275 Ornithorhynchus anatinus 89.06 0.00e+00 1675.00
IUUC-Ola-087031 Oryzias latipes 66.67 0.00e+00 1192.00
IUUC-Oga-088201 Otolemur garnettii 88.99 0.00e+00 1543.00
IUUC-Oar-089997 Ovis aries 84.83 0.00e+00 1434.00
IUUC-Ptr-091116 Pan troglodytes 99.53 0.00e+00 1926.00
IUUC-Pan-092132 Papio anubis 98.93 0.00e+00 1233.00
IUUC-Psi-093734 Pelodiscus sinensis 89.31 0.00e+00 1587.00
IUUC-Pma-094347 Petromyzon marinus 70.33 0.00e+00 704.00
IUUC-Pfo-096293 Poecilia formosa 69.21 0.00e+00 1202.00
IUUC-Pab-098491 Pongo abelii 95.98 0.00e+00 1815.00
IUUC-Pca-101004 Procavia capensis 83.72 0.00e+00 936.00
IUUC-Pva-102961 Pteropus vampyrus 71.86 0.00e+00 897.00
IUUC-Rno-105005 Rattus norvegicus 93.38 0.00e+00 1699.00
IUUC-Sha-107646 Sarcophilus harrisii 66.70 0.00e+00 983.00
IUUC-Ssc-115428 Sus scrofa 92.44 0.00e+00 1659.00
IUUC-Tgu-116776 Taeniopygia guttata 90.18 0.00e+00 1675.00
IUUC-Tru-118180 Takifugu rubripes 70.14 0.00e+00 1285.00
IUUC-Tsy-119468 Tarsius syrichta 90.45 0.00e+00 778.00
IUUC-Tni-120196 Tetraodon nigroviridis 69.74 0.00e+00 1273.00
IUUC-Ttr-128360 Tursiops truncatus 83.88 0.00e+00 1000.00
IUUC-Xtr-132956 Xenopus tropicalis 80.04 0.00e+00 1466.00
Created Date 25-Jun-2017

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