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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045658
Ensembl Protein ID ENSP00000336923.3
UniProt Accession A1A4S6; A1L0S5; Q2VPC4; Q2VPC5; Q96EV3; Q96S75; RHG10_HUMAN
Genbank Protein ID BAB61771.1; AAH11920.2; AAI09030.1; AAI09031.1; AAI26900.1; AAI28056.1
Protein Name Rho GTPase-activating protein 10; GTPase regulator associated with focal adhesion kinase 2; Graf-related protein 2; Rho-type GTPase-activating protein 10
Genbank Nucleotide ID AB050785; BC011920; BC109029; BC109030; BC126899; BC128055
Gene Name ARHGAP10; GRAF2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000071205.11 ENST00000336498.7 ENSP00000336923.3
ENSG00000071205.11 ENST00000507661.1 ENSP00000422358.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTInWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-10 43.0 731 785
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +k ++ y+ ea+++ eL+++ G + + + +++ + gWl+g  +l+gkrGl+P+n+v+ 
   Q: 731  RKARAVYPCEAEHSSELSFEIGAIFEDV-QTSREPGWLEG--TLNGKRGLIPQNYVKL 785
           57899***********************.***********..8*************85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
 GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
Protein Sequence
(Fasta)
MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLIAAT KSLSVAQRKF 60
AHSLRDFKFE FIGDAVTDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045658|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCTCGGCG GGGGCTGCCG GGATTGGGGC GCCGCAGCTA GCGCTGGTCT CGGTGGCAGC 60
TCCTCCGCGC CGCAGGACTC GGCTCTACGG GACATGTCCG TGCCGCGCTC GCCGCGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045658|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain
PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3
Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9
SMART

SM00233--PH
SM00324--RhoGAP
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0007010--P:cytoskeleton organization
GO:0043066--P:negative regulation of apoptotic process
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction
KEGG hsa:79658
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001253 Ailuropoda melanoleuca 93.51 0.00e+00 1455.00
IUUC-Apl-003297 Anas platyrhynchos 78.43 0.00e+00 1208.00
IUUC-Aca-005285 Anolis carolinensis 78.24 0.00e+00 1227.00
IUUC-Bta-012379 Bos taurus 92.37 0.00e+00 1388.00
IUUC-Cja-019182 Callithrix jacchus 95.93 0.00e+00 1496.00
IUUC-Cfa-021141 Canis familiaris 93.77 0.00e+00 1440.00
IUUC-Csa-023847 Chlorocebus sabaeus 98.23 0.00e+00 1405.00
IUUC-Cin-025725 Ciona intestinalis 40.27 2.00e-148 519.00
IUUC-Dre-027525 Danio rerio 60.43 0.00e+00 884.00
IUUC-Dno-029215 Dasypus novemcinctus 86.92 0.00e+00 932.00
IUUC-Dor-030308 Dipodomys ordii 82.97 0.00e+00 1168.00
IUUC-Ete-032666 Echinops telfairi 79.53 0.00e+00 773.00
IUUC-Eca-033545 Equus caballus 94.14 0.00e+00 1344.00
IUUC-Fca-036457 Felis catus 93.64 0.00e+00 1454.00
IUUC-Fal-036703 Ficedula albicollis 80.23 0.00e+00 1251.00
IUUC-Gga-040830 Gallus gallus 79.29 0.00e+00 1255.00
IUUC-Gac-041728 Gasterosteus aculeatus 56.53 0.00e+00 836.00
IUUC-Ggo-044569 Gorilla gorilla 96.73 0.00e+00 1350.00
IUUC-Loc-051740 Lepisosteus oculatus 64.54 0.00e+00 991.00
IUUC-Laf-053641 Loxodonta africana 92.62 0.00e+00 1392.00
IUUC-Mcc-055152 Macaca mulatta 98.09 0.00e+00 1521.00
IUUC-Mmr-061434 Microcebus murinus 94.82 0.00e+00 1376.00
IUUC-Mdo-062864 Monodelphis domestica 87.40 0.00e+00 1364.00
IUUC-Mmu-064061 Mus musculus 91.48 0.00e+00 1436.00
IUUC-Mlu-067375 Myotis lucifugus 92.23 0.00e+00 1325.00
IUUC-Nle-069319 Nomascus leucogenys 97.74 0.00e+00 801.00
IUUC-Ont-071443 Oreochromis niloticus 61.49 0.00e+00 917.00
IUUC-Oan-072978 Ornithorhynchus anatinus 82.97 0.00e+00 1105.00
IUUC-Ocu-074591 Oryctolagus cuniculus 87.94 0.00e+00 1271.00
IUUC-Ola-087508 Oryzias latipes 54.69 0.00e+00 844.00
IUUC-Oga-088922 Otolemur garnettii 89.92 0.00e+00 656.00
IUUC-Oar-089531 Ovis aries 92.62 0.00e+00 1405.00
IUUC-Ptr-091149 Pan troglodytes 98.09 0.00e+00 1469.00
IUUC-Pan-092591 Papio anubis 98.35 0.00e+00 1541.00
IUUC-Pma-094731 Petromyzon marinus 32.54 9.00e-20 93.60
IUUC-Pfo-097265 Poecilia formosa 66.94 0.00e+00 816.00
IUUC-Pab-097780 Pongo abelii 99.36 0.00e+00 1473.00
IUUC-Rno-104991 Rattus norvegicus 90.97 0.00e+00 1429.00
IUUC-Sha-107629 Sarcophilus harrisii 84.26 0.00e+00 1110.00
IUUC-Ssc-115511 Sus scrofa 77.76 0.00e+00 727.00
IUUC-Tgu-117458 Taeniopygia guttata 79.16 0.00e+00 1239.00
IUUC-Tru-117724 Takifugu rubripes 63.04 0.00e+00 766.00
IUUC-Tbe-128126 Tupaia belangeri 26.67 1.00e-06 48.50
IUUC-Ttr-129045 Tursiops truncatus 90.19 0.00e+00 1266.00
IUUC-Xtr-132112 Xenopus tropicalis 70.04 0.00e+00 1094.00
Created Date 25-Jun-2017

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