iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.80e-07	30.6	27	68

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle  ++  +v  CgH+++  Cl++w         ++ CP+C+
   Q: 27   CNICLETARE-AVVSVCGHLYCWPCLHQW---LETRPDRQECPVCK 68
           99******88.888***************...556889999****7 PP

Organism

Mus musculus

Functional Description
(View)

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150 'leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Protein Sequence
(Fasta)

MAAAEEEDGG PEGPNRERGG ASATFECNIC LETAREAVVS VCGHLYCWPC LHQWLETRPD 60
RQECPVCKAG ISREKVVPLY GRGSQKPQDP RLKTPPRPQG QRPAPESRGG FQPFGDAGGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATCAATCG TGTCCTTTGA ATTCTATATG ATTGGCAGGT ACCTCGACCA ATAATGATGA 60
GAAAAACTTG AAGTTTGCCC AACGATCCTG GGCCGAAGGC GGACCTGCTT TGTTGGGGCG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0031966--C:mitochondrial membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0044257--P:cellular protein catabolic process
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0036503--P:ERAD pathway
GO:0010507--P:negative regulation of autophagy
GO:0031648--P:protein destabilization
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000785--P:regulation of autophagosome assembly
GO:0009617--P:response to bacterium

KEGG

mmu:54197

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001155	Aegilops tauschii	54.65	8.00e-24	103.00
IUUC-Aml-001417	Ailuropoda melanoleuca	94.57	4.00e-70	256.00
IUUC-Aca-004254	Anolis carolinensis	77.01	1.00e-36	145.00
IUUC-Ame-011316	Astyanax mexicanus	69.48	1.00e-56	212.00
IUUC-Bta-013109	Bos taurus	96.45	1.00e-78	285.00
IUUC-Bdi-014313	Brachypodium distachyon	54.65	1.00e-23	102.00
IUUC-Cja-019902	Callithrix jacchus	95.74	7.00e-78	282.00
IUUC-Cfa-020079	Canis familiaris	95.74	6.00e-78	282.00
IUUC-Cpo-021320	Cavia porcellus	92.81	8.00e-87	312.00
IUUC-Csa-023595	Chlorocebus sabaeus	97.16	4.00e-79	286.00
IUUC-Cme-027164	Cyanidioschyzon merolae	32.89	5.00e-17	81.30
IUUC-Dre-027716	Danio rerio	73.33	6.00e-42	163.00
IUUC-Dno-029843	Dasypus novemcinctus	83.69	7.00e-56	209.00
IUUC-Dor-030170	Dipodomys ordii	97.58	3.00e-69	253.00
IUUC-Eca-033642	Equus caballus	96.34	1.00e-90	325.00
IUUC-Eeu-034778	Erinaceus europaeus	96.58	2.00e-63	234.00
IUUC-Fca-036326	Felis catus	94.33	3.00e-77	280.00
IUUC-Fso-038195	Fusarium solani	40.91	5.00e-10	59.30
IUUC-Gac-042258	Gasterosteus aculeatus	80.00	5.00e-56	210.00
IUUC-Ggo-045474	Gorilla gorilla	97.87	2.00e-79	288.00
IUUC-Hsa-046046	Homo sapiens	97.87	2.00e-79	288.00
IUUC-Hvu-047124	Hordeum vulgare	54.65	1.00e-23	103.00
IUUC-Itr-048037	Ictidomys tridecemlineatus	97.33	5.00e-84	303.00
IUUC-Lch-050367	Latimeria chalumnae	72.73	5.00e-46	176.00
IUUC-Lpe-051034	Leersia perrieri	45.26	1.00e-25	109.00
IUUC-Laf-053395	Loxodonta africana	97.87	4.00e-79	286.00
IUUC-Mcc-054833	Macaca mulatta	97.16	4.00e-79	286.00
IUUC-Meu-055984	Macropus eugenii	83.54	3.00e-35	140.00
IUUC-Mdo-062437	Monodelphis domestica	89.02	1.00e-83	301.00
IUUC-Mac-065053	Musa acuminata	57.65	1.00e-23	103.00
IUUC-Mlu-067689	Myotis lucifugus	91.36	5.00e-83	300.00
IUUC-Nle-069705	Nomascus leucogenys	97.87	2.00e-79	288.00
IUUC-Opr-070392	Ochotona princeps	45.39	9.00e-22	95.50
IUUC-Ont-072482	Oreochromis niloticus	74.13	2.00e-58	218.00
IUUC-Ocu-074208	Oryctolagus cuniculus	96.45	4.00e-78	283.00
IUUC-Obr-076382	Oryza brachyantha	56.98	9.00e-25	106.00
IUUC-Ogl-077553	Oryza glaberrima	57.30	2.00e-26	112.00
IUUC-Oin-080177	Oryza indica	57.30	2.00e-26	112.00
IUUC-Olo-080378	Oryza longistaminata	54.65	2.00e-23	102.00
IUUC-Oni-082458	Oryza nivara	57.30	5.00e-26	112.00
IUUC-Opu-083362	Oryza punctata	58.14	2.00e-25	109.00
IUUC-Oru-084757	Oryza rufipogon	55.91	7.00e-27	113.00
IUUC-Osa-086198	Oryza sativa	56.12	1.00e-26	114.00
IUUC-Ola-086507	Oryzias latipes	69.09	2.00e-61	228.00
IUUC-Olu-087623	Ostreococcus lucimarinus	49.28	3.00e-17	81.30
IUUC-Oga-088912	Otolemur garnettii	97.16	3.00e-79	286.00
IUUC-Oar-090284	Ovis aries	92.62	2.00e-70	258.00
IUUC-Ptr-090919	Pan troglodytes	97.62	2.00e-70	257.00
IUUC-Pan-092843	Papio anubis	97.16	4.00e-79	286.00
IUUC-Pfo-096818	Poecilia formosa	78.40	1.00e-56	212.00
IUUC-Pab-098244	Pongo abelii	97.16	3.00e-79	286.00
IUUC-Pop-099595	Populus trichocarpa	44.83	9.00e-28	116.00
IUUC-Pca-100319	Procavia capensis	95.12	1.00e-81	295.00
IUUC-Pva-102249	Pteropus vampyrus	92.20	4.00e-72	263.00
IUUC-Rno-106042	Rattus norvegicus	100.00	1.00e-81	295.00
IUUC-Smo-109079	Selaginella moellendorffii	46.99	5.00e-22	99.00
IUUC-Sit-110690	Setaria italica	53.57	4.00e-22	98.20
IUUC-Sly-110917	Solanum lycopersicum	49.46	3.00e-25	108.00
IUUC-Sbi-114275	Sorghum bicolor	54.65	3.00e-23	101.00
IUUC-Ssc-115934	Sus scrofa	97.16	3.00e-79	286.00
IUUC-Tru-118679	Takifugu rubripes	61.73	2.00e-23	100.00
IUUC-Tsy-119615	Tarsius syrichta	92.96	7.00e-74	268.00
IUUC-Tca-121830	Theobroma cacao	44.12	9.00e-26	110.00
IUUC-Tae-124655	Triticum aestivum	47.27	6.00e-24	103.00
IUUC-Tur-126198	Triticum urartu	54.65	1.00e-23	103.00
IUUC-Tbe-127773	Tupaia belangeri	94.33	2.00e-75	274.00
IUUC-Ttr-128690	Tursiops truncatus	94.87	2.00e-62	231.00
IUUC-Vvi-131225	Vitis vinifera	60.00	8.00e-26	109.00
IUUC-Xtr-132608	Xenopus tropicalis	80.00	2.00e-45	174.00
IUUC-Xma-134225	Xiphophorus maculatus	78.40	7.00e-57	213.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence