iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-14	52.8	65	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            + + +lydy+a +d++L+++kG+ ++++  +++ ++W+ + ++ +  +G +P+n+v+kl+
   Q: 65   AKIFVALYDYDARTDEDLSFRKGEHLEIL--NDTQGDWWLARSKKTRSEGYIPSNYVAKLK 123
           57889************************..78889**********************997 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834).

Protein Sequence
(Fasta)

MGNCLTTQKG EPDKPADRIK LDDPPTIGVG VGVPQIPMPS HAGQPPEQIR PVPQIPESET 60
AGANAKIFVA LYDYDARTDE DLSFRKGEHL EILNDTQGDW WLARSKKTRS EGYIPSNYVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCTTTTGG TATTTCTCGA GTCCGCGTAC TGGTCACACA GCTTTTTGCA ACGCGATGGG 60
AAAAAGAGGA CGATATTTGA GTTAAAATGT GAATACGGAT GCCAGCCCAA CTAAATAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005912--C:adherens junction
GO:0005737--C:cytoplasm
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0051017--P:actin filament bundle assembly
GO:0034332--P:adherens junction organization
GO:0043277--P:apoptotic cell clearance
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0048749--P:compound eye development
GO:0042742--P:defense response to bacterium
GO:0007391--P:dorsal closure
GO:0007395--P:dorsal closure, spreading of leading edge cells
GO:0090136--P:epithelial cell-cell adhesion
GO:0046529--P:imaginal disc fusion, thorax closure
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0045087--P:innate immune response
GO:0036335--P:intestinal stem cell homeostasis
GO:0007254--P:JNK cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0007424--P:open tracheal system development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0006468--P:protein phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0048167--P:regulation of synaptic plasticity
GO:0007435--P:salivary gland morphogenesis
GO:0019233--P:sensory perception of pain
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0006099--P:tricarboxylic acid cycle

KEGG

dme:Dmel_CG44128

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	61.37	1.00e-163	568.00
IUUC-Apl-003394	Anas platyrhynchos	59.96	3.00e-164	570.00
IUUC-Aca-004553	Anolis carolinensis	56.84	2.00e-171	594.00
IUUC-Ame-011533	Astyanax mexicanus	61.86	2.00e-164	571.00
IUUC-Bta-012645	Bos taurus	61.37	1.00e-163	568.00
IUUC-Bdi-014122	Brachypodium distachyon	29.17	1.00e-20	94.40
IUUC-Cel-018682	Caenorhabditis elegans	66.52	0.00e+00	630.00
IUUC-Cja-019885	Callithrix jacchus	63.04	1.00e-175	608.00
IUUC-Cfa-021163	Canis familiaris	61.37	1.00e-163	568.00
IUUC-Cpo-022315	Cavia porcellus	61.37	1.00e-163	568.00
IUUC-Csa-023721	Chlorocebus sabaeus	61.37	1.00e-163	568.00
IUUC-Cho-025014	Choloepus hoffmanni	61.37	1.00e-163	568.00
IUUC-Cin-025605	Ciona intestinalis	61.62	9.00e-174	602.00
IUUC-Csv-026029	Ciona savignyi	59.78	4.00e-147	513.00
IUUC-Dre-028274	Danio rerio	62.09	1.00e-170	592.00
IUUC-Dno-029689	Dasypus novemcinctus	61.02	6.00e-173	599.00
IUUC-Dor-031035	Dipodomys ordii	60.49	2.00e-160	558.00
IUUC-Ete-033170	Echinops telfairi	58.77	6.00e-152	529.00
IUUC-Eca-033581	Equus caballus	60.83	8.00e-163	566.00
IUUC-Eeu-035004	Erinaceus europaeus	49.87	1.00e-103	369.00
IUUC-Fca-035582	Felis catus	61.37	1.00e-163	568.00
IUUC-Fal-036892	Ficedula albicollis	61.11	2.00e-168	584.00
IUUC-Gmo-038992	Gadus morhua	61.49	1.00e-165	575.00
IUUC-Gga-041072	Gallus gallus	60.98	1.00e-162	565.00
IUUC-Gac-042461	Gasterosteus aculeatus	61.49	1.00e-166	578.00
IUUC-Ggo-044469	Gorilla gorilla	61.37	1.00e-163	568.00
IUUC-Hsa-045723	Homo sapiens	61.37	1.00e-163	568.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	61.37	1.00e-163	568.00
IUUC-Lch-049825	Latimeria chalumnae	60.67	3.00e-160	557.00
IUUC-Loc-052913	Lepisosteus oculatus	61.23	9.00e-171	592.00
IUUC-Laf-053659	Loxodonta africana	61.37	3.00e-163	567.00
IUUC-Mcc-055039	Macaca mulatta	60.35	4.00e-159	553.00
IUUC-Meu-056155	Macropus eugenii	59.34	4.00e-152	530.00
IUUC-Mtr-058733	Medicago truncatula	31.11	2.00e-23	103.00
IUUC-Mga-059456	Meleagris gallopavo	60.25	7.00e-162	562.00
IUUC-Mmr-061480	Microcebus murinus	59.88	1.00e-171	595.00
IUUC-Mdo-062628	Monodelphis domestica	61.37	1.00e-163	568.00
IUUC-Mmu-063896	Mus musculus	61.37	1.00e-163	568.00
IUUC-Mpu-066333	Mustela putorius furo	61.37	1.00e-163	568.00
IUUC-Mlu-067315	Myotis lucifugus	61.37	1.00e-163	568.00
IUUC-Nle-069786	Nomascus leucogenys	61.65	1.00e-174	605.00
IUUC-Opr-070705	Ochotona princeps	57.92	5.00e-154	536.00
IUUC-Ont-072417	Oreochromis niloticus	60.55	3.00e-171	594.00
IUUC-Oan-073714	Ornithorhynchus anatinus	61.23	1.00e-163	568.00
IUUC-Ocu-074284	Oryctolagus cuniculus	61.37	1.00e-163	568.00
IUUC-Ola-086419	Oryzias latipes	59.92	4.00e-172	596.00
IUUC-Oga-088789	Otolemur garnettii	60.93	6.00e-160	556.00
IUUC-Oar-089408	Ovis aries	61.37	1.00e-163	568.00
IUUC-Ptr-091068	Pan troglodytes	61.37	1.00e-163	568.00
IUUC-Pan-092732	Papio anubis	61.65	5.00e-174	603.00
IUUC-Psi-093899	Pelodiscus sinensis	57.04	7.00e-171	592.00
IUUC-Pma-094230	Petromyzon marinus	64.64	3.00e-179	620.00
IUUC-Pfo-097084	Poecilia formosa	61.71	4.00e-167	580.00
IUUC-Pab-097673	Pongo abelii	61.15	6.00e-163	566.00
IUUC-Pca-100245	Procavia capensis	61.23	1.00e-163	568.00
IUUC-Pva-102645	Pteropus vampyrus	60.93	2.00e-162	565.00
IUUC-Rno-105269	Rattus norvegicus	62.04	5.00e-172	596.00
IUUC-Sha-107637	Sarcophilus harrisii	61.37	2.00e-163	568.00
IUUC-Stu-112331	Solanum tuberosum	28.79	7.00e-23	101.00
IUUC-Sar-113364	Sorex araneus	56.77	1.00e-147	515.00
IUUC-Ssc-116389	Sus scrofa	61.23	8.00e-164	569.00
IUUC-Tgu-116491	Taeniopygia guttata	60.34	2.00e-168	584.00
IUUC-Tru-118241	Takifugu rubripes	62.08	1.00e-165	575.00
IUUC-Tsy-119440	Tarsius syrichta	54.85	1.00e-144	505.00
IUUC-Tni-120512	Tetraodon nigroviridis	61.57	2.00e-174	604.00
IUUC-Tbe-127707	Tupaia belangeri	60.79	9.00e-161	559.00
IUUC-Ttr-128817	Tursiops truncatus	63.02	2.00e-175	607.00
IUUC-Vpa-130815	Vicugna pacos	61.15	1.00e-161	561.00
IUUC-Xtr-132360	Xenopus tropicalis	58.10	4.00e-165	573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence