iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141198.13	ENST00000570371.5	ENSP00000458553.1
ENSG00000141198.13	ENST00000575882.5	ENSP00000460823.1
ENSG00000141198.13	ENST00000570965.5	ENSP00000459079.1
ENSG00000141198.13	ENST00000445275.6	ENSP00000408958.2
ENSG00000141198.13	ENST00000572405.5	ENSP00000460721.1
ENSG00000141198.13	ENST00000576932.5	ENSP00000461876.1
ENSG00000141198.13	ENST00000572158.5	ENSP00000461284.1
ENSG00000141198.13	ENST00000571319.5	ENSP00000458219.1
ENSG00000141198.13	ENST00000572360.5	ENSP00000460565.1
ENSG00000141198.13	ENST00000570499.5	ENSP00000461215.1
ENSG00000141198.13	ENST00000572576.5	ENSP00000458809.1
ENSG00000141198.13	ENST00000575909.1	ENSP00000460213.1
ENSG00000141198.13	ENST00000574318.1	ENSP00000467227.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/GAT	GAT	15611048

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/GAT	1.00e-25	91.9	200	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/GAT

   S: 39   ekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykqlk 127
           e+i+kl+sel++vk+nv++++++l+e++p++e++ed ellq+ly+t +++++++++l+   ++n++++ el+++n++ln++++ y++++
   Q: 200  EQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVV-VENEDVTVELIQVNEDLNNAILGYERFT 287
           89**********************************************************.*************************997 PP

Organism

Homo sapiens

Functional Description
(View)

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).

Protein Sequence
(Fasta)

MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK DAVKALKKRI 60
SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN LVKLLNPRYN LPLDIQNRIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGTAAGGA AGTTGATAAA CGGCAACATC TGAAATAGCT ACTCGCCCTG AATAGGCAGG 60
TGGAGAATAT TAGTTACACG TGGGACAAAT CCCATTATGA GACATATCAT CACAACAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0729--SH3-binding
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR027428--TOM1L1
IPR002014--VHS_dom

PROSITE

PS50909--GAT
PS50179--VHS

Pfam

PF03127--GAT
PF00790--VHS

SMART

SM00288--VHS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005795--C:Golgi stack
GO:0005764--C:lysosome
GO:0030276--F:clathrin binding
GO:0030295--F:protein kinase activator activity
GO:0019901--F:protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0032147--P:activation of protein kinase activity
GO:0006886--P:intracellular protein transport
GO:0045839--P:negative regulation of mitotic nuclear division
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0007165--P:signal transduction
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

hsa:10040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001565	Ailuropoda melanoleuca	86.76	0.00e+00	819.00
IUUC-Apl-004174	Anas platyrhynchos	54.12	1.00e-99	356.00
IUUC-Bta-012349	Bos taurus	82.66	0.00e+00	748.00
IUUC-Cja-019078	Callithrix jacchus	95.80	0.00e+00	935.00
IUUC-Cfa-020228	Canis familiaris	85.84	0.00e+00	775.00
IUUC-Cpo-021541	Cavia porcellus	78.24	0.00e+00	681.00
IUUC-Csa-024260	Chlorocebus sabaeus	96.15	0.00e+00	769.00
IUUC-Cho-025095	Choloepus hoffmanni	67.54	1.00e-173	602.00
IUUC-Dno-029738	Dasypus novemcinctus	83.51	0.00e+00	761.00
IUUC-Dor-030805	Dipodomys ordii	73.11	0.00e+00	654.00
IUUC-Ete-032525	Echinops telfairi	76.97	0.00e+00	681.00
IUUC-Eeu-034961	Erinaceus europaeus	66.79	9.00e-97	347.00
IUUC-Fca-036355	Felis catus	83.40	0.00e+00	793.00
IUUC-Fal-036691	Ficedula albicollis	54.22	1.00e-126	446.00
IUUC-Gga-040722	Gallus gallus	52.55	1.00e-121	430.00
IUUC-Ggo-044686	Gorilla gorilla	98.95	0.00e+00	907.00
IUUC-Itr-048619	Ictidomys tridecemlineatus	89.22	1.00e-177	615.00
IUUC-Lch-050448	Latimeria chalumnae	47.38	5.00e-113	401.00
IUUC-Laf-054440	Loxodonta africana	79.71	0.00e+00	726.00
IUUC-Mcc-055179	Macaca mulatta	95.74	0.00e+00	678.00
IUUC-Meu-056149	Macropus eugenii	61.10	4.00e-149	521.00
IUUC-Mga-059815	Meleagris gallopavo	56.68	1.00e-111	396.00
IUUC-Mmr-061673	Microcebus murinus	90.13	0.00e+00	817.00
IUUC-Mdo-062647	Monodelphis domestica	66.53	1.00e-169	589.00
IUUC-Mmu-063838	Mus musculus	80.54	0.00e+00	751.00
IUUC-Mpu-065968	Mustela putorius furo	85.71	0.00e+00	812.00
IUUC-Mlu-067663	Myotis lucifugus	82.14	0.00e+00	774.00
IUUC-Nle-069514	Nomascus leucogenys	98.11	0.00e+00	898.00
IUUC-Opr-070400	Ochotona princeps	75.22	7.00e-177	613.00
IUUC-Ocu-074210	Oryctolagus cuniculus	83.89	0.00e+00	756.00
IUUC-Oga-088524	Otolemur garnettii	84.66	0.00e+00	686.00
IUUC-Oar-090252	Ovis aries	81.84	0.00e+00	716.00
IUUC-Ptr-090624	Pan troglodytes	99.58	0.00e+00	908.00
IUUC-Pan-092547	Papio anubis	96.43	0.00e+00	845.00
IUUC-Psi-093440	Pelodiscus sinensis	57.17	3.00e-146	511.00
IUUC-Pab-097710	Pongo abelii	99.30	2.00e-160	557.00
IUUC-Pca-100911	Procavia capensis	70.39	3.00e-172	598.00
IUUC-Pva-102626	Pteropus vampyrus	85.50	0.00e+00	804.00
IUUC-Rno-105217	Rattus norvegicus	80.71	0.00e+00	776.00
IUUC-Sha-107467	Sarcophilus harrisii	63.70	2.00e-135	475.00
IUUC-Sar-113062	Sorex araneus	70.20	4.00e-151	527.00
IUUC-Ssc-116377	Sus scrofa	78.53	0.00e+00	676.00
IUUC-Tgu-116578	Taeniopygia guttata	65.55	1.00e-82	299.00
IUUC-Tsy-119264	Tarsius syrichta	81.72	0.00e+00	703.00
IUUC-Tbe-127731	Tupaia belangeri	68.75	6.00e-84	304.00
IUUC-Ttr-128951	Tursiops truncatus	82.35	0.00e+00	753.00
IUUC-Vpa-130520	Vicugna pacos	77.19	0.00e+00	654.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence