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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045851
UUCD1 version UUC-HoS-01167
Ensembl Protein ID ENSP00000294383.5
UniProt Accession Q9UPU5; Q6ZSY2; Q8N2Y4; Q9NXD1; UBP24_HUMAN
Genbank Protein ID BAA91084.1; BAC86814.1; BAA83009.1; AAH29660.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 24; Deubiquitinating enzyme 24; Ubiquitin thioesterase 24; Ubiquitin-specific-processing protease 24
Genbank Nucleotide ID AC091609; AK127075; AB028980; BC029660
Gene Name USP24; KIAA1057
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162402.13 ENST00000294383.6 ENSP00000294383.5
ENSG00000162402.13 ENST00000484447.5 ENSP00000489026.1
ENSG00000162402.13 ENST00000634589.1 ENSP00000489531.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12401499
UBD/Alpha-Helix/UBA UBA 23159851
Classification
Family E-value Score Start End
DUB/USP 1.50e-78 266.0 1689 2041
UBD/Alpha-Helix/UBA 4.00e-05 25.2 4 41
Active Site
Position(s) Description Evidence
1698 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
1970 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           +Gl+N g+tCYmN+v Q+L++ p l e ll+     ++++  ++p+ ++  ++q+lf +l++sk +++ p++++k++k++++e+   eqq
   Q: 1689 VGLRNGGATCYMNAVFQQLYMQPGLPESLLS-----VDDD-TDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQ 1772
           6******************************.....5444.468999******************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
           Da Ef++ l+dq++e+l                          kk+  +++ +++Fqg +++q +c++c ++++ree f+ l+l v + +
   Q: 1773 DAYEFFTSLIDQMDEYL--------------------------KKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQ 1836
           *****************..........................78999****************************************** PP
   S: 181  etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
                sl+ +L++f++ e leg+n+yycekck+k+ ++k++ +k+lP vL++hL+Rf f+ e ++++k ++++ fp +L+++p+++s   
   Q: 1837 -----SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSgma 1921
           .....9*********************************************************************************666 PP
   S: 268  ..peekqke.........................kkkYeLiavvvHsGslssGHYvayvkn....ekgkWllfdDskVtevk.eeevlee 325
             +     +                         +++YeL++v+vHsG+++ GHY++++k+     kgkW++f+D+ ++e +  +e le 
   Q: 1922 rqD-----SssevgengrsvdqggggsprkkvalTENYELVGVIVHSGQAHAGHYYSFIKDrrgcGKGKWYKFNDTVIEEFDlNDETLEY 2006
           550.....34445555566666666666666666***************************55555666************844666664 PP
   S: 326  tg.......................staYvlfYkr 337
           +                        ++aY+lfY+r
   Q: 2007 ECfggeyrpkvydqtnpytdvrrryWNAYMLFYQR 2041
           449******************************98 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGF.dreealqaLraannnleaAveyL 38
           e+e+ +  l  MGF d+ ++++aLr a n++++Av++L
   Q: 4    EEEQHMTTLLCMGFsDPATIRKALRLAKNDINEAVALL 41
           6788889999**************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.
 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.
Protein Sequence
(Fasta)
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG 60
GPSPGPGGGP RGDGGGDGGG GGPSRGGSTG GGGGFDPPPA YHEVVDAEKN DENGNCSGEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045851|DUB,USP;UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAATCGG AGGAGGAGCA GCACATGACC ACGCTGCTGT GCATGGGCTT CTCAGACCCC 60
GCCACCATCC GCAAGGCCCT GCGCCTGGCC AAGAACGACA TTAACGAGGC CGTGGCACTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045851|DUB,USP;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR033382--USP24
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:23358
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002266 Ailuropoda melanoleuca 99.05 0.00e+00 4841.00
IUUC-Apl-003203 Anas platyrhynchos 74.72 0.00e+00 3504.00
IUUC-Aca-004396 Anolis carolinensis 90.02 0.00e+00 4512.00
IUUC-Ame-011886 Astyanax mexicanus 84.62 0.00e+00 1770.00
IUUC-Bta-013381 Bos taurus 98.09 0.00e+00 4912.00
IUUC-Cel-018352 Caenorhabditis elegans 29.80 2.00e-61 233.00
IUUC-Cja-018955 Callithrix jacchus 99.24 0.00e+00 4455.00
IUUC-Cfa-020720 Canis familiaris 98.85 0.00e+00 4826.00
IUUC-Cpo-022430 Cavia porcellus 96.06 0.00e+00 3447.00
IUUC-Csa-024180 Chlorocebus sabaeus 99.67 0.00e+00 4675.00
IUUC-Cho-025074 Choloepus hoffmanni 92.64 0.00e+00 1842.00
IUUC-Dre-027696 Danio rerio 80.68 0.00e+00 4088.00
IUUC-Dno-029307 Dasypus novemcinctus 95.78 0.00e+00 4776.00
IUUC-Dor-030889 Dipodomys ordii 95.26 0.00e+00 4621.00
IUUC-Ete-032294 Echinops telfairi 92.94 0.00e+00 2324.00
IUUC-Eca-033823 Equus caballus 93.07 0.00e+00 4524.00
IUUC-Eeu-035178 Erinaceus europaeus 89.22 0.00e+00 2129.00
IUUC-Fca-035444 Felis catus 98.85 0.00e+00 4774.00
IUUC-Fal-037555 Ficedula albicollis 92.79 0.00e+00 4528.00
IUUC-Gmo-038587 Gadus morhua 80.19 0.00e+00 2494.00
IUUC-Gga-041231 Gallus gallus 92.29 0.00e+00 4638.00
IUUC-Gac-041584 Gasterosteus aculeatus 80.19 0.00e+00 2463.00
IUUC-Ggo-044502 Gorilla gorilla 99.27 0.00e+00 4920.00
IUUC-Itr-048746 Ictidomys tridecemlineatus 98.32 0.00e+00 1582.00
IUUC-Lch-049999 Latimeria chalumnae 79.69 0.00e+00 3927.00
IUUC-Loc-051767 Lepisosteus oculatus 82.40 0.00e+00 4118.00
IUUC-Laf-054139 Loxodonta africana 98.02 0.00e+00 4885.00
IUUC-Mcc-055217 Macaca mulatta 99.20 0.00e+00 4926.00
IUUC-Meu-056659 Macropus eugenii 81.68 0.00e+00 2258.00
IUUC-Mga-059267 Meleagris gallopavo 93.04 0.00e+00 4565.00
IUUC-Mmr-060971 Microcebus murinus 96.89 0.00e+00 4845.00
IUUC-Mdo-061925 Monodelphis domestica 94.24 0.00e+00 4648.00
IUUC-Mmu-064019 Mus musculus 96.76 0.00e+00 4952.00
IUUC-Mpu-066652 Mustela putorius furo 98.44 0.00e+00 4945.00
IUUC-Mlu-067518 Myotis lucifugus 98.53 0.00e+00 4768.00
IUUC-Nle-069763 Nomascus leucogenys 99.52 0.00e+00 4800.00
IUUC-Opr-071031 Ochotona princeps 91.76 0.00e+00 4418.00
IUUC-Ont-072136 Oreochromis niloticus 78.41 0.00e+00 3997.00
IUUC-Oan-072908 Ornithorhynchus anatinus 84.97 0.00e+00 966.00
IUUC-Ocu-073880 Oryctolagus cuniculus 97.18 0.00e+00 4897.00
IUUC-Ola-086544 Oryzias latipes 77.33 0.00e+00 3848.00
IUUC-Oga-088695 Otolemur garnettii 98.28 0.00e+00 4947.00
IUUC-Oar-089401 Ovis aries 98.33 0.00e+00 4759.00
IUUC-Ptr-091657 Pan troglodytes 99.92 0.00e+00 4832.00
IUUC-Pan-092394 Papio anubis 99.24 0.00e+00 4928.00
IUUC-Psi-093813 Pelodiscus sinensis 93.16 0.00e+00 4543.00
IUUC-Pma-094698 Petromyzon marinus 53.63 4.00e-137 481.00
IUUC-Pfo-096811 Poecilia formosa 78.99 0.00e+00 3984.00
IUUC-Pab-097814 Pongo abelii 99.24 0.00e+00 4927.00
IUUC-Pca-101135 Procavia capensis 93.26 0.00e+00 2228.00
IUUC-Pva-102334 Pteropus vampyrus 93.54 0.00e+00 4646.00
IUUC-Rno-105040 Rattus norvegicus 96.56 0.00e+00 4900.00
IUUC-Sha-106658 Sarcophilus harrisii 94.72 0.00e+00 4663.00
IUUC-Sar-113153 Sorex araneus 87.04 0.00e+00 2755.00
IUUC-Ssc-115641 Sus scrofa 97.21 0.00e+00 4620.00
IUUC-Tgu-117467 Taeniopygia guttata 93.49 0.00e+00 3317.00
IUUC-Tru-118074 Takifugu rubripes 72.44 0.00e+00 3456.00
IUUC-Tsy-119165 Tarsius syrichta 94.43 0.00e+00 4531.00
IUUC-Tni-119923 Tetraodon nigroviridis 68.86 0.00e+00 3222.00
IUUC-Tbe-127910 Tupaia belangeri 91.24 0.00e+00 1821.00
IUUC-Ttr-128218 Tursiops truncatus 97.33 0.00e+00 4759.00
IUUC-Vpa-130090 Vicugna pacos 99.08 0.00e+00 1741.00
IUUC-Xtr-131911 Xenopus tropicalis 86.30 0.00e+00 1713.00
Created Date 25-Jun-2017

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