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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063330
Ensembl Protein ID ENSMUSP00000101215.1
UniProt Accession P19785; Q9JJT5; Q9QY51; Q9QY52; ESR1_MOUSE
Genbank Protein ID AAA37580.1; BAC29510.1; BAC30973.1; CAB85618.1; AAF22562.1; AAF22561.1
Protein Name Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Genbank Nucleotide ID M38651; AK036627; AK041525; AJ276597; AF128221; AF128220
Gene Name Esr1; Esr; Estr; Estra; Nr3a1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000019768.16 ENSMUST00000105590.7 ENSMUSP00000101215.1
ENSMUSG00000019768.16 ENSMUST00000105588.7 ENSMUSP00000101213.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
O-GlycBase
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UMI 88.98 0.00e+00 939.00 IUUC-Hsa-046944
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
 Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
Protein Sequence
(Fasta)
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPT VFNYPEGAAY 60
EFNAAAAAAA AASAPVYGQS GIAYGPGSEA AAFSANSLGA FPQLNSVSPS PLMLLHPPPQ 120
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Protein Fasta Sequence


>IUUC-Mmu-063330|UBD,UMI|Mus musculus
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Nucleotide Sequence
(Fasta)
ACGGACTTAG CTGGTTGAGT CAATGAGTGA AAGAGAAACT CTGAGAAGCG CTCACATTAG 60
AAACACCCTT ATGCCCCTTC TTAGCTAGTT TTCAGCGAGG AAAATCTGTG TGCAGAAAGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063330|UBD,UMI|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA
PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2
Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4
PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER
SMART

SM00430--HOLI
SM00399--ZnF_C4
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0051117--F:ATPase binding
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0019899--F:enzyme binding
GO:0034056--F:estrogen response element binding
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0008134--F:transcription factor binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0016049--P:cell growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0030518--P:intracellular steroid hormone receptor signaling pathway
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045839--P:negative regulation of mitotic nuclear division
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0032355--P:response to estradiol
GO:0043627--P:response to estrogen
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0060065--P:uterus development
GO:0060068--P:vagina development
KEGG mmu:13982
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001925 Ailuropoda melanoleuca 91.31 0.00e+00 781.00
IUUC-Apl-003688 Anas platyrhynchos 78.97 0.00e+00 800.00
IUUC-Aca-005222 Anolis carolinensis 76.94 0.00e+00 862.00
IUUC-Ame-010731 Astyanax mexicanus 56.69 1.00e-136 480.00
IUUC-Bta-013112 Bos taurus 86.00 0.00e+00 904.00
IUUC-Cja-019408 Callithrix jacchus 89.82 0.00e+00 979.00
IUUC-Cfa-020694 Canis familiaris 87.00 0.00e+00 931.00
IUUC-Cpo-021426 Cavia porcellus 86.33 0.00e+00 931.00
IUUC-Cre-022648 Chlamydomonas reinhardtii 30.23 2.30e+00 26.60
IUUC-Csa-023736 Chlorocebus sabaeus 91.58 0.00e+00 866.00
IUUC-Dre-027698 Danio rerio 56.47 2.00e-133 469.00
IUUC-Dno-029477 Dasypus novemcinctus 89.81 0.00e+00 754.00
IUUC-Dor-030572 Dipodomys ordii 92.33 0.00e+00 771.00
IUUC-Ete-032849 Echinops telfairi 69.08 0.00e+00 634.00
IUUC-Eca-033605 Equus caballus 84.47 0.00e+00 926.00
IUUC-Eeu-034683 Erinaceus europaeus 90.14 6.00e-106 377.00
IUUC-Fca-035928 Felis catus 91.50 0.00e+00 779.00
IUUC-Fal-036754 Ficedula albicollis 76.83 0.00e+00 879.00
IUUC-Gmo-038872 Gadus morhua 56.05 5.00e-112 397.00
IUUC-Gga-040988 Gallus gallus 77.67 0.00e+00 872.00
IUUC-Gac-042015 Gasterosteus aculeatus 64.88 1.00e-125 443.00
IUUC-Ggo-044749 Gorilla gorilla 89.98 0.00e+00 979.00
IUUC-Hsa-046944 Homo sapiens 88.98 0.00e+00 967.00
IUUC-Itr-048863 Ictidomys tridecemlineatus 91.51 0.00e+00 992.00
IUUC-Loc-052414 Lepisosteus oculatus 58.20 0.00e+00 639.00
IUUC-Mcc-054781 Macaca mulatta 89.65 0.00e+00 976.00
IUUC-Meu-056232 Macropus eugenii 83.47 0.00e+00 901.00
IUUC-Mga-059319 Meleagris gallopavo 78.00 0.00e+00 875.00
IUUC-Mmr-061636 Microcebus murinus 87.84 3.00e-166 578.00
IUUC-Mdo-062661 Monodelphis domestica 84.14 0.00e+00 909.00
IUUC-Mpu-065757 Mustela putorius furo 88.85 0.00e+00 951.00
IUUC-Mlu-067712 Myotis lucifugus 89.15 0.00e+00 847.00
IUUC-Nle-069283 Nomascus leucogenys 89.65 0.00e+00 942.00
IUUC-Opr-070391 Ochotona princeps 87.98 0.00e+00 983.00
IUUC-Ont-071369 Oreochromis niloticus 55.53 4.00e-120 425.00
IUUC-Oan-073734 Ornithorhynchus anatinus 73.47 4.00e-131 461.00
IUUC-Ocu-074292 Oryctolagus cuniculus 91.32 0.00e+00 981.00
IUUC-Oba-075103 Oryza barthii 29.11 1.00e-03 38.10
IUUC-Ogu-079042 Oryza glumaepatula 29.11 2.00e-04 40.80
IUUC-Olo-080944 Oryza longistaminata 29.11 4.00e-04 37.70
IUUC-Oni-082560 Oryza nivara 29.11 1.00e-03 38.50
IUUC-Ola-087052 Oryzias latipes 51.45 7.00e-129 454.00
IUUC-Oga-088586 Otolemur garnettii 89.37 0.00e+00 968.00
IUUC-Oar-090156 Ovis aries 89.49 0.00e+00 802.00
IUUC-Ptr-091321 Pan troglodytes 89.82 0.00e+00 978.00
IUUC-Pan-092851 Papio anubis 89.48 0.00e+00 974.00
IUUC-Psi-093434 Pelodiscus sinensis 76.96 0.00e+00 905.00
IUUC-Pfo-097379 Poecilia formosa 55.91 2.00e-134 472.00
IUUC-Pab-097735 Pongo abelii 89.65 0.00e+00 976.00
IUUC-Pva-102125 Pteropus vampyrus 86.31 0.00e+00 927.00
IUUC-Rno-106121 Rattus norvegicus 97.67 0.00e+00 1029.00
IUUC-Sha-107547 Sarcophilus harrisii 84.47 0.00e+00 910.00
IUUC-Sar-113650 Sorex araneus 77.75 3.00e-174 604.00
IUUC-Tgu-117175 Taeniopygia guttata 77.33 0.00e+00 887.00
IUUC-Tru-117545 Takifugu rubripes 53.86 4.00e-134 472.00
IUUC-Tsy-119586 Tarsius syrichta 75.17 0.00e+00 805.00
IUUC-Tni-120121 Tetraodon nigroviridis 54.24 5.00e-136 478.00
IUUC-Tbe-127548 Tupaia belangeri 81.04 2.00e-180 625.00
IUUC-Ttr-128374 Tursiops truncatus 83.81 0.00e+00 848.00
IUUC-Vpa-130464 Vicugna pacos 81.10 8.00e-152 530.00
IUUC-Xtr-132171 Xenopus tropicalis 68.28 0.00e+00 723.00
Created Date 25-Jun-2017

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