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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018195
UUCD1 version UUC-CaE-00043
Ensembl Protein ID ZK287.5.1
UniProt Accession Q23457; Q8WSQ1; RBX1_CAEEL
Genbank Protein ID CAA94801.1; BAB83695.1
Protein Name RING-box protein 1; Ce-rbx-1
Genbank Nucleotide ID Z70757; AB077287
Gene Name rbx-1; ZK287.5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004320 ZK287.5.1 ZK287.5.1
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17609115
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.40e-09 37.4 44 99
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+++++d +++                  ++C+H+fh++C+ +w       ++++ CPl+
   Q: 44   CAICRNHIMD-LCIecqanqaaglkdectvawGNCNHAFHFHCISRW------LKTRQVCPLD 99
           ********66.44333333333333333334499*************......********97 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
 Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
Protein Sequence
(Fasta)
MAQASDSTAM EVEEATNQTV KKRFEVKKWS AVALWAWDIQ VDNCAICRNH IMDLCIECQA 60
NQAAGLKDEC TVAWGNCNHA FHFHCISRWL KTRQVCPLDN REWEFQKYGH
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018195|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTCAATATT AAGTATTTCA TTATATCATC AATGCTACTT TTGCGCTCTT ATTTTGAAAT 60
GATTACTGTT ATTCTCATTT GTATTTTTTC CAGAAATGGC CCAAGCAAGC GACAGCACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018195|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902104--P:positive regulation of metaphase/anaphase transition of meiotic cell cycle
GO:0016567--P:protein ubiquitination
GO:0051759--P:sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation
KEGG cel:CELE_ZK287.5
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001798 Ailuropoda melanoleuca 79.28 8.00e-48 180.00
IUUC-Atr-002900 Amborella trichopoda 87.78 2.00e-46 175.00
IUUC-Apl-003762 Anas platyrhynchos 89.74 3.00e-39 151.00
IUUC-Aca-005328 Anolis carolinensis 79.28 8.00e-48 180.00
IUUC-Aly-005923 Arabidopsis lyrata 89.77 1.00e-45 173.00
IUUC-Ath-007535 Arabidopsis thaliana 87.64 4.00e-44 167.00
IUUC-Ago-007991 Ashbya gossypii 56.48 1.00e-35 139.00
IUUC-Acl-008332 Aspergillus clavatus 87.64 7.00e-45 170.00
IUUC-Afl-008537 Aspergillus flavus 88.37 2.00e-43 166.00
IUUC-Afu-008985 Aspergillus fumigatus 87.64 7.00e-45 170.00
IUUC-Ani-009342 Aspergillus nidulans 86.52 1.00e-44 169.00
IUUC-Ang-009778 Aspergillus niger 88.37 2.00e-43 166.00
IUUC-Aor-009918 Aspergillus oryzae 88.37 2.00e-43 166.00
IUUC-Ame-010814 Astyanax mexicanus 89.29 3.00e-27 111.00
IUUC-Bgr-012224 Blumeria graminis 88.89 7.00e-47 177.00
IUUC-Bta-012426 Bos taurus 79.28 1.00e-47 179.00
IUUC-Bci-013839 Botrytis cinerea 89.66 7.00e-45 170.00
IUUC-Bdi-014575 Brachypodium distachyon 88.76 1.00e-45 173.00
IUUC-Bol-015671 Brassica oleracea 91.01 9.00e-47 177.00
IUUC-Bra-017034 Brassica rapa 91.01 9.00e-47 177.00
IUUC-Cja-018788 Callithrix jacchus 78.70 2.00e-45 172.00
IUUC-Cpo-021365 Cavia porcellus 79.28 1.00e-47 179.00
IUUC-Cre-022904 Chlamydomonas reinhardtii 56.32 3.00e-25 105.00
IUUC-Csa-024198 Chlorocebus sabaeus 79.28 1.00e-47 179.00
IUUC-Cho-024344 Choloepus hoffmanni 89.09 5.00e-27 110.00
IUUC-Cin-025449 Ciona intestinalis 84.31 2.00e-48 182.00
IUUC-Cgl-026522 Colletotrichum gloeosporioides 88.76 1.00e-45 173.00
IUUC-Cne-027067 Cryptococcus neoformans 70.79 7.00e-34 134.00
IUUC-Cme-027268 Cyanidioschyzon merolae 58.93 5.00e-36 141.00
IUUC-Dre-027434 Danio rerio 80.37 6.00e-48 180.00
IUUC-Dno-029252 Dasypus novemcinctus 77.78 8.00e-45 170.00
IUUC-Dor-030861 Dipodomys ordii 61.68 1.00e-30 123.00
IUUC-Dse-031355 Dothistroma septosporum 88.76 1.00e-45 173.00
IUUC-Dme-031585 Drosophila melanogaster 80.00 1.00e-48 182.00
IUUC-Ete-032747 Echinops telfairi 44.14 5.00e-15 71.20
IUUC-Eca-033758 Equus caballus 79.28 1.00e-47 179.00
IUUC-Fca-035586 Felis catus 79.28 1.00e-47 179.00
IUUC-Fal-037097 Ficedula albicollis 88.89 6.00e-41 156.00
IUUC-Fox-037881 Fusarium oxysporum 86.42 6.00e-40 154.00
IUUC-Fso-038373 Fusarium solani 73.87 1.00e-46 176.00
IUUC-Gmo-039457 Gadus morhua 78.50 8.00e-45 170.00
IUUC-Ggr-039970 Gaeumannomyces graminis 88.51 5.00e-44 167.00
IUUC-Gga-040328 Gallus gallus 79.28 1.00e-47 179.00
IUUC-Gac-041578 Gasterosteus aculeatus 80.37 6.00e-48 180.00
IUUC-Gma-042692 Glycine max 88.64 3.00e-45 171.00
IUUC-Ggo-045249 Gorilla gorilla 56.76 3.00e-28 114.00
IUUC-Hsa-046279 Homo sapiens 79.28 1.00e-47 179.00
IUUC-Hvu-047597 Hordeum vulgare 88.76 2.00e-45 172.00
IUUC-Itr-048174 Ictidomys tridecemlineatus 79.28 1.00e-47 179.00
IUUC-Kpa-049330 Komagataella pastoris 58.41 7.00e-36 140.00
IUUC-Lch-049667 Latimeria chalumnae 80.37 9.00e-48 179.00
IUUC-Lma-053052 Leptosphaeria maculans 89.89 2.00e-45 172.00
IUUC-Laf-053827 Loxodonta africana 76.58 9.00e-46 173.00
IUUC-Mcc-055208 Macaca mulatta 79.28 1.00e-47 179.00
IUUC-Meu-056143 Macropus eugenii 90.24 3.00e-42 160.00
IUUC-Mor-057158 Magnaporthe oryzae 88.51 4.00e-44 167.00
IUUC-Mpo-057409 Magnaporthe poae 88.51 5.00e-44 167.00
IUUC-Mtr-058505 Medicago truncatula 88.64 2.00e-45 172.00
IUUC-Mla-059071 Melampsora laricipopulina 68.29 7.00e-44 167.00
IUUC-Mga-059797 Meleagris gallopavo 79.28 1.00e-47 179.00
IUUC-Mvi-060401 Microbotryum violaceum 85.26 1.00e-47 180.00
IUUC-Mmr-061077 Microcebus murinus 79.28 1.00e-47 179.00
IUUC-Mdo-062218 Monodelphis domestica 79.28 1.00e-47 179.00
IUUC-Mmu-064224 Mus musculus 79.28 1.00e-47 179.00
IUUC-Mac-064505 Musa acuminata 88.64 5.00e-45 170.00
IUUC-Mpu-066572 Mustela putorius furo 79.28 1.00e-47 179.00
IUUC-Mlu-067821 Myotis lucifugus 79.28 1.00e-47 179.00
IUUC-Nfi-068412 Neosartorya fischeri 87.64 7.00e-45 170.00
IUUC-Nle-069309 Nomascus leucogenys 79.28 1.00e-47 179.00
IUUC-Opr-070307 Ochotona princeps 79.28 1.00e-47 179.00
IUUC-Ont-071677 Oreochromis niloticus 80.00 4.00e-49 184.00
IUUC-Oan-072926 Ornithorhynchus anatinus 90.00 1.00e-40 155.00
IUUC-Oba-075405 Oryza barthii 88.76 1.00e-45 173.00
IUUC-Obr-076843 Oryza brachyantha 88.76 5.00e-46 175.00
IUUC-Ogl-077608 Oryza glaberrima 88.76 1.00e-45 173.00
IUUC-Ogu-078316 Oryza glumaepatula 88.76 1.00e-45 173.00
IUUC-Oin-079918 Oryza indica 59.23 3.00e-39 152.00
IUUC-Olo-080968 Oryza longistaminata 83.33 4.00e-24 100.00
IUUC-Ome-081246 Oryza meridionalis 87.50 5.00e-45 171.00
IUUC-Oni-082052 Oryza nivara 88.76 1.00e-45 173.00
IUUC-Opu-084035 Oryza punctata 87.64 6.00e-46 174.00
IUUC-Oru-084941 Oryza rufipogon 88.76 1.00e-45 173.00
IUUC-Osa-085800 Oryza sativa 88.76 1.00e-45 173.00
IUUC-Ola-087352 Oryzias latipes 80.37 3.00e-48 181.00
IUUC-Olu-087676 Ostreococcus lucimarinus 53.26 3.00e-27 112.00
IUUC-Oga-088880 Otolemur garnettii 79.28 1.00e-47 179.00
IUUC-Oar-089286 Ovis aries 79.28 9.00e-48 180.00
IUUC-Ptr-091402 Pan troglodytes 79.28 1.00e-47 179.00
IUUC-Pan-091687 Papio anubis 80.37 6.00e-47 177.00
IUUC-Psi-093640 Pelodiscus sinensis 80.37 4.00e-48 181.00
IUUC-Pma-094723 Petromyzon marinus 89.16 2.00e-42 161.00
IUUC-Pno-094822 Phaeosphaeria nodorum 85.26 4.00e-46 174.00
IUUC-Ppa-095730 Physcomitrella patens 88.64 2.00e-45 172.00
IUUC-Pfo-096055 Poecilia formosa 79.28 7.00e-48 180.00
IUUC-Pab-098577 Pongo abelii 79.28 1.00e-47 179.00
IUUC-Pop-099697 Populus trichocarpa 76.85 3.00e-47 178.00
IUUC-Pca-100719 Procavia capensis 79.28 1.00e-47 179.00
IUUC-Ppe-101429 Prunus persica 75.00 9.00e-47 177.00
IUUC-Pva-102885 Pteropus vampyrus 57.01 4.00e-29 118.00
IUUC-Pgr-103470 Puccinia graminis 87.64 4.00e-45 171.00
IUUC-Ptt-103909 Puccinia triticina 66.67 1.00e-26 110.00
IUUC-Pte-104144 Pyrenophora teres 81.91 2.00e-42 162.00
IUUC-Pyt-104533 Pyrenophora triticirepentis 84.21 1.00e-45 173.00
IUUC-Rno-105912 Rattus norvegicus 79.28 1.00e-47 179.00
IUUC-Sce-106407 Saccharomyces cerevisiae 63.04 2.00e-34 135.00
IUUC-Sha-107549 Sarcophilus harrisii 79.28 1.00e-47 179.00
IUUC-Sja-108003 Schizosaccharomyces japonicus 75.24 6.00e-46 174.00
IUUC-Spo-108091 Schizosaccharomyces pombe 70.75 3.00e-43 165.00
IUUC-Ssl-108634 Sclerotinia sclerotiorum 89.66 6.00e-45 171.00
IUUC-Smo-109681 Selaginella moellendorffii 88.64 4.00e-45 171.00
IUUC-Sit-110419 Setaria italica 86.52 8.00e-45 170.00
IUUC-Sly-110933 Solanum lycopersicum 74.55 2.00e-46 176.00
IUUC-Stu-112567 Solanum tuberosum 76.15 2.00e-46 175.00
IUUC-Sar-113409 Sorex araneus 56.76 6.00e-29 117.00
IUUC-Sbi-113799 Sorghum bicolor 84.21 2.00e-46 175.00
IUUC-Sre-115142 Sporisorium reilianum 74.29 7.00e-45 170.00
IUUC-Tgu-116923 Taeniopygia guttata 88.61 2.00e-39 151.00
IUUC-Tru-117710 Takifugu rubripes 80.00 7.00e-48 180.00
IUUC-Tni-119934 Tetraodon nigroviridis 80.37 2.00e-48 182.00
IUUC-Tca-121820 Theobroma cacao 89.89 2.00e-46 175.00
IUUC-Tre-122212 Trichoderma reesei 86.42 2.00e-40 155.00
IUUC-Tvi-122357 Trichoderma virens 86.52 8.00e-45 170.00
IUUC-Tae-125834 Triticum aestivum 82.29 3.00e-46 175.00
IUUC-Tur-126093 Triticum urartu 88.76 1.00e-45 172.00
IUUC-Tme-126940 Tuber melanosporum 76.92 8.00e-47 176.00
IUUC-Tbe-127918 Tupaia belangeri 90.24 3.00e-42 160.00
IUUC-Ttr-128306 Tursiops truncatus 90.24 3.00e-42 160.00
IUUC-Uma-129482 Ustilago maydis 71.70 2.00e-44 169.00
IUUC-Vda-129917 Verticillium dahliae 77.57 2.00e-46 176.00
IUUC-Vpa-130142 Vicugna pacos 75.70 2.00e-41 159.00
IUUC-Vvi-130957 Vitis vinifera 88.64 2.00e-45 172.00
IUUC-Xma-133061 Xiphophorus maculatus 79.28 7.00e-48 180.00
IUUC-Yli-134542 Yarrowia lipolytica 59.48 5.00e-39 151.00
IUUC-Zma-135466 Zea mays 88.76 1.00e-45 173.00
Created Date 25-Jun-2017

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