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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018362
UUCD1 version UUC-CaE-00672
Ensembl Protein ID M7.1
UniProt Accession P35129; UBC2_CAEEL
Genbank Protein ID AAB25489.2; CAA92745.1
Protein Name Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; Lethal protein 70; Ubiquitin carrier protein 2; Ubiquitin-protein ligase 2
Genbank Nucleotide ID S56051; Z68337
Gene Name let-70; ubc-2; M7.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00002344 M7.1 M7.1
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Drug and target
SuperTarget
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 8441382; 16628214; 12894212
Classification
Family E-value Score Start End
E2/UBC 2.70e-56 189.5 5 139
UBD/UBC-like/UBD_UBC 3.80e-83 276.8 5 142
Active Site
Position(s) Description Evidence
85 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvll 103
           R++kel++l +dpp+++sa+pv + dl++w+++i+Gp+++pY+ggvF l+i+fp+dYPfkPPkv f+t+i+hPn+++nG++Cl+il+  ++Wspal++++vll
   Q: 5    RIQKELQDLGRDPPAQCSAGPVGD-DLFHWQATIMGPPESPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--SQWSPALTISKVLL 104
           9***********************.9************************************************************9..************** PP
   S: 104  siqsllaepnpesplneeaaellkknreeykkkvr 138
           si+sll++pnp++pl  e+a+++k++re+y++ +r
   Q: 105  SICSLLCDPNPDDPLVPEIARIYKTDRERYNQLAR 139
           *******************************9987 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskvllsl 102
           ri+kel+dl rd++aq+sa++v+ddlf+++ati+gpp+spy+ggvfflti++ptdypfkppkvaf+t+iyhpninsngsicldilrsqws+alt+skvlls+
   Q: 5    RIQKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPESPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSI 106
           8***************************************************************************************************** PP
   S: 103  cslladaepddplvaeiariyktdkekykriarewt 138
           csll+d++pddplv+eiariyktd+e+y++ arewt
   Q: 107  CSLLCDPNPDDPLVPEIARIYKTDRERYNQLAREWT 142
           ***********************************8 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
Protein Sequence
(Fasta)
MALKRIQKEL QDLGRDPPAQ CSAGPVGDDL FHWQATIMGP PESPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018362|E2,E2/UBC;UBD,UBD_UBC|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTACTCCGG GTGTAGCCGG GTCAATCAGC AAATCAGAAC ACCAACATGG CTCTCAAAAG 60
AATCCAGAAG GTAAGGTTTC AACACTTAAC AACAATAAAA TTATTATGTA CGTTTCAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018362|E2,E2/UBC;UBD,UBD_UBC|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005524--F:ATP binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG cel:CELE_M7.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000292 Aegilops tauschii 78.23 1.00e-69 254.00
IUUC-Aml-001563 Ailuropoda melanoleuca 89.12 6.00e-79 284.00
IUUC-Atr-002894 Amborella trichopoda 81.63 3.00e-71 258.00
IUUC-Apl-004043 Anas platyrhynchos 90.48 4.00e-79 285.00
IUUC-Aca-005236 Anolis carolinensis 93.88 6.00e-82 294.00
IUUC-Aly-006542 Arabidopsis lyrata 79.59 5.00e-71 258.00
IUUC-Ath-007224 Arabidopsis thaliana 79.59 5.00e-71 258.00
IUUC-Ago-007967 Ashbya gossypii 80.95 9.00e-73 263.00
IUUC-Acl-008266 Aspergillus clavatus 86.39 4.00e-75 271.00
IUUC-Afl-008709 Aspergillus flavus 79.58 3.00e-68 251.00
IUUC-Afu-008956 Aspergillus fumigatus 87.07 3.00e-75 272.00
IUUC-Ani-009401 Aspergillus nidulans 85.03 7.00e-74 267.00
IUUC-Ang-009725 Aspergillus niger 85.60 2.00e-62 229.00
IUUC-Aor-010157 Aspergillus oryzae 85.71 1.00e-74 270.00
IUUC-Ate-010438 Aspergillus terreus 85.71 4.00e-74 268.00
IUUC-Ame-011831 Astyanax mexicanus 94.56 4.00e-82 295.00
IUUC-Bgr-012238 Blumeria graminis 82.31 9.00e-72 260.00
IUUC-Bta-013158 Bos taurus 93.88 6.00e-82 294.00
IUUC-Bci-013661 Botrytis cinerea 85.03 5.00e-75 271.00
IUUC-Bdi-014561 Brachypodium distachyon 78.91 2.00e-70 256.00
IUUC-Bol-015583 Brassica oleracea 78.91 2.00e-70 256.00
IUUC-Bra-017581 Brassica rapa 78.91 2.00e-70 256.00
IUUC-Cja-019886 Callithrix jacchus 93.88 6.00e-82 294.00
IUUC-Cfa-020436 Canis familiaris 93.88 6.00e-82 294.00
IUUC-Cpo-021714 Cavia porcellus 91.84 3.00e-80 288.00
IUUC-Cre-022765 Chlamydomonas reinhardtii 80.95 1.00e-70 256.00
IUUC-Csa-023668 Chlorocebus sabaeus 89.12 6.00e-79 284.00
IUUC-Cho-024987 Choloepus hoffmanni 89.12 6.00e-79 284.00
IUUC-Cin-025379 Ciona intestinalis 86.30 2.00e-76 276.00
IUUC-Csv-025835 Ciona savignyi 83.56 6.00e-65 238.00
IUUC-Cgl-026490 Colletotrichum gloeosporioides 85.71 1.00e-74 270.00
IUUC-Cne-026957 Cryptococcus neoformans 81.51 1.00e-70 256.00
IUUC-Cme-027220 Cyanidioschyzon merolae 83.67 3.00e-73 265.00
IUUC-Dre-027758 Danio rerio 94.56 2.00e-82 296.00
IUUC-Dno-030067 Dasypus novemcinctus 89.12 6.00e-79 284.00
IUUC-Dor-030323 Dipodomys ordii 93.20 7.00e-81 290.00
IUUC-Dse-031397 Dothistroma septosporum 85.71 5.00e-75 271.00
IUUC-Dme-031594 Drosophila melanogaster 96.60 8.00e-84 300.00
IUUC-Ete-032540 Echinops telfairi 89.12 6.00e-79 284.00
IUUC-Eca-034167 Equus caballus 89.12 6.00e-79 284.00
IUUC-Eeu-034766 Erinaceus europaeus 92.86 8.00e-76 273.00
IUUC-Fca-035917 Felis catus 92.52 5.00e-81 291.00
IUUC-Fal-036904 Ficedula albicollis 92.86 2.00e-77 279.00
IUUC-Fox-038021 Fusarium oxysporum 85.71 1.00e-74 270.00
IUUC-Fso-038297 Fusarium solani 86.39 5.00e-75 271.00
IUUC-Gmo-038775 Gadus morhua 89.80 6.00e-79 284.00
IUUC-Ggr-039912 Gaeumannomyces graminis 80.26 6.00e-70 254.00
IUUC-Gga-040758 Gallus gallus 93.88 6.00e-82 294.00
IUUC-Gac-042231 Gasterosteus aculeatus 91.16 8.00e-80 287.00
IUUC-Gma-043923 Glycine max 79.59 2.00e-70 256.00
IUUC-Ggo-045361 Gorilla gorilla 92.52 2.00e-80 289.00
IUUC-Hsa-045885 Homo sapiens 93.88 6.00e-82 294.00
IUUC-Hvu-047546 Hordeum vulgare 77.55 5.00e-69 251.00
IUUC-Itr-048743 Ictidomys tridecemlineatus 89.12 6.00e-79 284.00
IUUC-Kpa-049290 Komagataella pastoris 78.91 1.00e-70 256.00
IUUC-Lch-050109 Latimeria chalumnae 87.76 2.00e-77 279.00
IUUC-Lpe-051194 Leersia perrieri 78.23 1.00e-69 254.00
IUUC-Loc-052838 Lepisosteus oculatus 92.52 2.00e-80 289.00
IUUC-Lma-053121 Leptosphaeria maculans 85.71 3.00e-75 272.00
IUUC-Laf-053580 Loxodonta africana 94.29 3.00e-78 281.00
IUUC-Mcc-055421 Macaca mulatta 92.52 2.00e-80 289.00
IUUC-Meu-056462 Macropus eugenii 91.37 9.00e-76 273.00
IUUC-Mor-057235 Magnaporthe oryzae 84.35 1.00e-73 266.00
IUUC-Mpo-057596 Magnaporthe poae 80.26 1.00e-69 253.00
IUUC-Mtr-058257 Medicago truncatula 78.23 3.00e-69 252.00
IUUC-Mla-059189 Melampsora laricipopulina 79.59 1.00e-68 250.00
IUUC-Mga-059237 Meleagris gallopavo 92.86 2.00e-77 279.00
IUUC-Mvi-060397 Microbotryum violaceum 82.31 3.00e-72 261.00
IUUC-Mmr-060889 Microcebus murinus 93.20 2.00e-81 292.00
IUUC-Mdo-062962 Monodelphis domestica 93.88 6.00e-82 294.00
IUUC-Mmu-063518 Mus musculus 93.88 6.00e-82 294.00
IUUC-Mac-065268 Musa acuminata 79.59 2.00e-70 256.00
IUUC-Mpu-065724 Mustela putorius furo 89.12 6.00e-79 284.00
IUUC-Mlu-067573 Myotis lucifugus 87.86 2.00e-74 269.00
IUUC-Nfi-068599 Neosartorya fischeri 87.07 3.00e-75 272.00
IUUC-Ncr-068677 Neurospora crassa 84.35 2.00e-73 266.00
IUUC-Nle-069715 Nomascus leucogenys 92.52 2.00e-80 289.00
IUUC-Opr-070191 Ochotona princeps 92.81 7.00e-77 277.00
IUUC-Ont-071766 Oreochromis niloticus 93.20 2.00e-81 292.00
IUUC-Oan-073026 Ornithorhynchus anatinus 91.43 9.00e-76 274.00
IUUC-Ocu-074315 Oryctolagus cuniculus 93.88 6.00e-82 294.00
IUUC-Oba-075411 Oryza barthii 78.23 1.00e-69 253.00
IUUC-Obr-076481 Oryza brachyantha 78.23 2.00e-69 253.00
IUUC-Ogl-076968 Oryza glaberrima 79.59 1.00e-70 256.00
IUUC-Ogu-078091 Oryza glumaepatula 78.62 3.00e-69 254.00
IUUC-Oin-079659 Oryza indica 79.59 1.00e-70 256.00
IUUC-Olo-080786 Oryza longistaminata 78.23 1.00e-69 253.00
IUUC-Ome-081967 Oryza meridionalis 78.23 2.00e-69 253.00
IUUC-Oni-082391 Oryza nivara 79.59 1.00e-70 258.00
IUUC-Opu-083833 Oryza punctata 78.23 2.00e-69 253.00
IUUC-Oru-085167 Oryza rufipogon 79.59 2.00e-70 258.00
IUUC-Osa-086003 Oryza sativa 79.59 1.00e-70 256.00
IUUC-Ola-086331 Oryzias latipes 93.20 2.00e-81 292.00
IUUC-Olu-087615 Ostreococcus lucimarinus 77.55 2.00e-66 242.00
IUUC-Oga-088477 Otolemur garnettii 91.10 2.00e-79 286.00
IUUC-Oar-090038 Ovis aries 92.52 5.00e-81 291.00
IUUC-Ptr-090707 Pan troglodytes 93.88 6.00e-82 294.00
IUUC-Pan-092143 Papio anubis 93.88 6.00e-82 294.00
IUUC-Psi-094076 Pelodiscus sinensis 92.52 5.00e-81 291.00
IUUC-Pma-094405 Petromyzon marinus 93.33 8.00e-74 267.00
IUUC-Pno-094765 Phaeosphaeria nodorum 85.71 3.00e-75 272.00
IUUC-Ppa-095564 Physcomitrella patens 79.59 2.00e-70 256.00
IUUC-Pfo-096753 Poecilia formosa 93.20 2.00e-81 292.00
IUUC-Pab-097764 Pongo abelii 93.88 6.00e-82 294.00
IUUC-Pop-099586 Populus trichocarpa 79.59 2.00e-70 256.00
IUUC-Pca-100678 Procavia capensis 89.12 6.00e-79 284.00
IUUC-Ppe-101704 Prunus persica 79.59 2.00e-70 256.00
IUUC-Pva-102770 Pteropus vampyrus 89.12 6.00e-79 284.00
IUUC-Pgr-103381 Puccinia graminis 80.95 2.00e-69 253.00
IUUC-Ptt-103723 Puccinia triticina 77.14 2.00e-61 226.00
IUUC-Pte-104015 Pyrenophora teres 85.71 4.00e-75 271.00
IUUC-Pyt-104701 Pyrenophora triticirepentis 85.71 4.00e-75 271.00
IUUC-Rno-105498 Rattus norvegicus 92.52 5.00e-81 291.00
IUUC-Sce-106153 Saccharomyces cerevisiae 80.56 1.00e-70 256.00
IUUC-Sha-106489 Sarcophilus harrisii 84.83 3.00e-75 271.00
IUUC-Sja-107729 Schizosaccharomyces japonicus 85.71 1.00e-74 270.00
IUUC-Spo-108032 Schizosaccharomyces pombe 85.71 1.00e-74 270.00
IUUC-Ssl-108443 Sclerotinia sclerotiorum 85.71 2.00e-75 272.00
IUUC-Smo-109317 Selaginella moellendorffii 79.59 2.00e-70 255.00
IUUC-Sit-109973 Setaria italica 79.59 3.00e-70 255.00
IUUC-Sly-111055 Solanum lycopersicum 80.27 5.00e-71 258.00
IUUC-Stu-112445 Solanum tuberosum 80.27 9.00e-71 257.00
IUUC-Sar-113302 Sorex araneus 94.24 1.00e-77 280.00
IUUC-Sbi-114840 Sorghum bicolor 79.59 1.00e-70 256.00
IUUC-Sre-115037 Sporisorium reilianum 80.56 4.00e-70 254.00
IUUC-Ssc-115391 Sus scrofa 92.52 2.00e-80 289.00
IUUC-Tgu-116727 Taeniopygia guttata 92.52 5.00e-81 291.00
IUUC-Tru-118272 Takifugu rubripes 93.20 6.00e-81 291.00
IUUC-Tsy-118832 Tarsius syrichta 89.80 3.00e-77 278.00
IUUC-Tni-120056 Tetraodon nigroviridis 93.20 6.00e-81 291.00
IUUC-Tca-121008 Theobroma cacao 79.59 2.00e-70 256.00
IUUC-Tre-122125 Trichoderma reesei 83.67 2.00e-72 263.00
IUUC-Tvi-122296 Trichoderma virens 83.67 2.00e-72 263.00
IUUC-Tae-123340 Triticum aestivum 80.27 1.00e-71 259.00
IUUC-Tur-126518 Triticum urartu 78.23 2.00e-70 256.00
IUUC-Tme-126912 Tuber melanosporum 82.99 5.00e-73 265.00
IUUC-Tbe-127329 Tupaia belangeri 77.86 2.00e-66 243.00
IUUC-Ttr-128363 Tursiops truncatus 89.12 6.00e-79 284.00
IUUC-Uma-129648 Ustilago maydis 81.63 6.00e-72 261.00
IUUC-Vda-129695 Verticillium dahliae 85.71 1.00e-74 270.00
IUUC-Vpa-130446 Vicugna pacos 92.91 9.00e-77 278.00
IUUC-Vvi-130986 Vitis vinifera 79.59 2.00e-70 256.00
IUUC-Xtr-132329 Xenopus tropicalis 93.88 6.00e-82 294.00
IUUC-Xma-133829 Xiphophorus maculatus 93.20 2.00e-81 292.00
IUUC-Yli-134353 Yarrowia lipolytica 80.27 4.00e-72 261.00
IUUC-Zma-134742 Zea mays 78.23 2.00e-69 253.00
Created Date 25-Jun-2017

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