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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063639
UUCD1 version UUC-MuM-01228
Ensembl Protein ID ENSMUSP00000072155.5
UniProt Accession Q5BKP2; D3YYG7; UBP13_MOUSE
Genbank Protein ID EDL35015.1; AAH90999.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13
Genbank Nucleotide ID AC111140; BC090999
Gene Name Usp13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000056900.13 ENSMUST00000072312.11 ENSMUSP00000072155.5
ENSMUSG00000056900.13 ENSMUST00000108228.7 ENSMUSP00000103863.1
ENSMUSG00000056900.13 ENSMUST00000172481.1 ENSMUSP00000133823.1
ENSMUSG00000056900.13 ENSMUST00000156769.1 ENSMUSP00000117605.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 21811243; 21962518; 21811243
Classification
Family E-value Score Start End
DUB/USP 1.70e-56 193.0 334 855
UBD/Alpha-Helix/UBA 7.30e-18 65.2 725 762
Active Site
Position(s) Description Evidence
343 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
818 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 334  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 421
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 422  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 481
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++++   ++++  ++k+  +
   Q: 482  CQTRKVRYTERVDYLMQLPVAMEAATNKDelityelmrreaeanrrplpelvrakiPFSACLQAFAEPDNVDD---FWSSALQAKSAGV 567
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+s+  ++                                        
   Q: 568  KTSRFASFPEYLVVQIKKFTFGLD-WVPRKFDVSIDMPDLLDISHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 655
           *********************997.*******************999889999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 656  vmqlaemgfpleacrkavyftgntgaevafnwiivhmeepdfaeplaipgyggagasvfgatgldnqppeeivaiitsmgfqrnqavqa 744
           87777777777777777777777777777777777777777777777777777777777777777766666666666666666666655 PP
   S: 268  .......peekqke............................................kkkYeLiavvvHsG.slssGHYvayvknekg 304
                        e                                            +  YeL+a ++H+G s+ sGHYv+++k+ +g
   Q: 745  lqatnhnL-----EraldwifshpefeedsdfviemennananivseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK-EG 827
           55555550.....055555555555555555666666666667788888888888888****************************.9* PP
   S: 305  kWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 828  RWVIYNDHKVCAS--ERPPK---DLGYMYFYRR 855
           **********999..78888...99******98 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL+a+n nle+A+++++++
   Q: 725  EEIVAIITSMGFQRNQAVQALQATNHNLERALDWIFSH 762
           899*********************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
 Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Protein Sequence
(Fasta)
MQRRGALFSV PGGGGKMAAG DLGELLVPHM PTIRVPRSGD RVYKNECAFS YDSPNSEGGL 60
YVCMNTFLAF GREHVERHFR KTGQSVYMHL KRHMREKVRG ASGGALPKRR NSKIFLDLDM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063639|UBD,UBA;DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTCGCCAT TGGATTAAAA ATAGCAGCTC CCGCCCGCCG GCCGGCCGGG GCAGAGGCCG 60
AGCCTCCCGA GCCTAAACTG ATCCTCAGCC CGCGCGACCG CCGCGTCCAG GTCCTGTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063639|UBD,UBA;DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:1904288--F:BAT3 complex binding
GO:0051087--F:chaperone binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0070628--F:proteasome binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0044389--F:ubiquitin-like protein ligase binding
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:1904294--P:positive regulation of ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:72607
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 95.34 0.00e+00 1569.00
IUUC-Apl-003712 Anas platyrhynchos 82.61 0.00e+00 1342.00
IUUC-Aca-004634 Anolis carolinensis 82.43 0.00e+00 1394.00
IUUC-Ame-011470 Astyanax mexicanus 73.51 0.00e+00 1269.00
IUUC-Bta-013349 Bos taurus 95.02 0.00e+00 1608.00
IUUC-Cja-019021 Callithrix jacchus 94.31 0.00e+00 1560.00
IUUC-Cfa-020614 Canis familiaris 95.59 0.00e+00 1582.00
IUUC-Cpo-022484 Cavia porcellus 95.82 0.00e+00 1489.00
IUUC-Csa-024078 Chlorocebus sabaeus 95.60 0.00e+00 1582.00
IUUC-Cho-024522 Choloepus hoffmanni 79.80 0.00e+00 1178.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.37 2.00e-52 201.00
IUUC-Dre-027651 Danio rerio 74.13 0.00e+00 1336.00
IUUC-Dno-028975 Dasypus novemcinctus 95.49 0.00e+00 1584.00
IUUC-Dor-030130 Dipodomys ordii 71.94 0.00e+00 1051.00
IUUC-Ete-032251 Echinops telfairi 81.16 0.00e+00 1267.00
IUUC-Eca-033568 Equus caballus 96.16 0.00e+00 1483.00
IUUC-Eeu-034612 Erinaceus europaeus 78.31 0.00e+00 1141.00
IUUC-Fca-036280 Felis catus 96.03 0.00e+00 1481.00
IUUC-Fal-036610 Ficedula albicollis 83.77 0.00e+00 1325.00
IUUC-Gmo-038906 Gadus morhua 71.85 0.00e+00 1239.00
IUUC-Gga-041215 Gallus gallus 82.50 0.00e+00 1421.00
IUUC-Gac-042441 Gasterosteus aculeatus 71.23 0.00e+00 1257.00
IUUC-Ggo-044446 Gorilla gorilla 95.60 0.00e+00 1587.00
IUUC-Hsa-046546 Homo sapiens 95.71 0.00e+00 1588.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 87.91 0.00e+00 1418.00
IUUC-Lch-050425 Latimeria chalumnae 77.15 0.00e+00 1356.00
IUUC-Loc-052072 Lepisosteus oculatus 77.43 0.00e+00 1308.00
IUUC-Laf-053909 Loxodonta africana 94.46 0.00e+00 1581.00
IUUC-Mcc-054686 Macaca mulatta 95.83 0.00e+00 1586.00
IUUC-Meu-056361 Macropus eugenii 79.79 0.00e+00 1294.00
IUUC-Mga-059972 Meleagris gallopavo 78.15 0.00e+00 1283.00
IUUC-Mmr-060916 Microcebus murinus 95.24 0.00e+00 1588.00
IUUC-Mdo-062302 Monodelphis domestica 88.22 0.00e+00 1506.00
IUUC-Mpu-066533 Mustela putorius furo 95.71 0.00e+00 1582.00
IUUC-Mlu-067786 Myotis lucifugus 89.44 0.00e+00 1449.00
IUUC-Nle-069997 Nomascus leucogenys 95.99 0.00e+00 1471.00
IUUC-Ont-071859 Oreochromis niloticus 71.56 0.00e+00 1261.00
IUUC-Oan-072959 Ornithorhynchus anatinus 87.03 3.00e-126 444.00
IUUC-Ocu-074265 Oryctolagus cuniculus 95.46 0.00e+00 1565.00
IUUC-Ola-087344 Oryzias latipes 70.92 0.00e+00 1268.00
IUUC-Oga-088734 Otolemur garnettii 95.91 0.00e+00 1536.00
IUUC-Oar-089636 Ovis aries 95.42 0.00e+00 1543.00
IUUC-Ptr-090982 Pan troglodytes 95.71 0.00e+00 1590.00
IUUC-Pan-091991 Papio anubis 95.71 0.00e+00 1584.00
IUUC-Psi-093509 Pelodiscus sinensis 85.61 0.00e+00 1456.00
IUUC-Pfo-096029 Poecilia formosa 73.46 0.00e+00 1308.00
IUUC-Pab-098672 Pongo abelii 91.43 0.00e+00 1488.00
IUUC-Pca-100860 Procavia capensis 72.57 0.00e+00 1024.00
IUUC-Pva-102545 Pteropus vampyrus 87.72 0.00e+00 1438.00
IUUC-Rno-105210 Rattus norvegicus 98.83 0.00e+00 1631.00
IUUC-Sar-113733 Sorex araneus 95.05 0.00e+00 767.00
IUUC-Tgu-116591 Taeniopygia guttata 84.22 0.00e+00 1429.00
IUUC-Tru-118627 Takifugu rubripes 70.15 0.00e+00 1273.00
IUUC-Tsy-119278 Tarsius syrichta 87.11 0.00e+00 1324.00
IUUC-Tni-120804 Tetraodon nigroviridis 73.33 0.00e+00 1304.00
IUUC-Tbe-127699 Tupaia belangeri 78.19 0.00e+00 871.00
IUUC-Ttr-128295 Tursiops truncatus 87.34 0.00e+00 1441.00
IUUC-Vpa-130170 Vicugna pacos 85.24 0.00e+00 1313.00
IUUC-Xtr-132809 Xenopus tropicalis 73.49 0.00e+00 1262.00
Created Date 25-Jun-2017

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