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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045906
Ensembl Protein ID ENSP00000386609.1
UniProt Accession Q562E7; B3KW16; B3KXU1; B7Z579; E9PHG7; Q24JP6; Q8N277; Q8N3F3; Q8TEL1; WDR81_HUMAN
Genbank Protein ID BAB84937.1; BAC03593.1; BAG53978.1; BAG54603.1; BAH12815.1; AAH92513.1; AAI14569.1; CAD39042.1
Protein Name WD repeat-containing protein 81
Genbank Nucleotide ID AK074111; AK091136; AK123896; AK127946; AK298567; AC130343; BC114568; AL834379
Gene Name WDR81
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000167716.18 ENST00000468539.5 ENSP00000460742.1
ENSG00000167716.18 ENST00000409644.5 ENSP00000386609.1
ENSG00000167716.18 ENST00000575206.1 ENSP00000458811.1
ENSG00000167716.18 ENST00000474958.2 ENSP00000466240.1
ENSG00000167716.18 ENST00000437219.6 ENSP00000391074.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.00e-13 49.7 1646 1676
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v c+a  s+ ++++sGs D t+++W 
   Q: 1646 GHSGAVKCVAPlSSeDFFLSGSKDRTVRLWP 1676
           8*********77555***************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Seems to have a role in maintenance of normal mitochondrial structure and organization. Promotes Purkinje and photoreceptor cell survival.
 Seems to have a role in maintenance of normal mitochondrial structure and organization. Promotes Purkinje and photoreceptor cell survival.
Protein Sequence
(Fasta)
MAQGSGGREG ALRTPAGGWH SPPSPDMQEL LRSVERDLSI DPRQLAPAPG GTHVVALVPA 60
RWLASLRDRR LPLGPCPRAE GLGEAEVRTL LQRSVQRLPA GWTRVEVHGL RKRRLSYPLG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045906|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACGAGAGT CCTAAAGAGC AGGCGAAAGC CACGGCGTCT GCGTTTGCAA TGCATGCTGG 60
TCCGTGTAGT TCTCAGCCTG ACACCGTCGT TCCCAGAACC CAGCGCGCTC TGTGAGTTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045906|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0496--Mitochondrion
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0809--Transit peptide
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR000409--BEACH_dom
IPR011009--Kinase-like_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50197--BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF02138--Beach
PF00400--WD40
SMART

SM01026--Beach
SM00320--WD40
Gene Ontology

GO:0005739--C:mitochondrion
GO:0010923--P:negative regulation of phosphatase activity
KEGG hsa:124997
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001149 Aegilops tauschii 39.00 3.00e-73 270.00
IUUC-Aml-001469 Ailuropoda melanoleuca 89.07 0.00e+00 3101.00
IUUC-Atr-003087 Amborella trichopoda 39.95 1.00e-72 269.00
IUUC-Apl-003320 Anas platyrhynchos 66.62 0.00e+00 899.00
IUUC-Aca-004757 Anolis carolinensis 66.06 3.00e-121 427.00
IUUC-Ath-007144 Arabidopsis thaliana 40.52 8.00e-69 256.00
IUUC-Ame-011832 Astyanax mexicanus 54.88 0.00e+00 1932.00
IUUC-Bta-012569 Bos taurus 89.82 0.00e+00 1481.00
IUUC-Bdi-014656 Brachypodium distachyon 38.94 1.00e-74 276.00
IUUC-Bol-016288 Brassica oleracea 40.21 8.00e-71 263.00
IUUC-Bra-017480 Brassica rapa 36.98 1.00e-54 209.00
IUUC-Cel-018315 Caenorhabditis elegans 46.91 5.00e-63 236.00
IUUC-Cja-019992 Callithrix jacchus 91.76 0.00e+00 1432.00
IUUC-Cfa-020689 Canis familiaris 88.59 0.00e+00 3230.00
IUUC-Cpo-021489 Cavia porcellus 90.11 0.00e+00 1454.00
IUUC-Csa-023209 Chlorocebus sabaeus 97.22 0.00e+00 3430.00
IUUC-Csv-025966 Ciona savignyi 30.04 4.00e-103 370.00
IUUC-Dre-027665 Danio rerio 51.73 0.00e+00 1873.00
IUUC-Dno-029751 Dasypus novemcinctus 87.01 0.00e+00 3137.00
IUUC-Dor-030379 Dipodomys ordii 91.13 0.00e+00 1496.00
IUUC-Dme-032002 Drosophila melanogaster 34.11 1.00e-100 362.00
IUUC-Eca-033529 Equus caballus 92.49 0.00e+00 1517.00
IUUC-Eeu-034915 Erinaceus europaeus 88.29 0.00e+00 1548.00
IUUC-Fca-036329 Felis catus 89.83 0.00e+00 3237.00
IUUC-Fal-037479 Ficedula albicollis 64.53 0.00e+00 1308.00
IUUC-Gmo-038831 Gadus morhua 69.94 1.00e-143 503.00
IUUC-Gga-040649 Gallus gallus 65.32 0.00e+00 1427.00
IUUC-Gac-041852 Gasterosteus aculeatus 70.32 3.00e-146 511.00
IUUC-Gma-043542 Glycine max 38.72 1.00e-73 272.00
IUUC-Ggo-044633 Gorilla gorilla 99.02 0.00e+00 3451.00
IUUC-Hvu-047635 Hordeum vulgare 37.44 9.00e-71 262.00
IUUC-Itr-048923 Ictidomys tridecemlineatus 89.26 0.00e+00 3180.00
IUUC-Lch-049479 Latimeria chalumnae 58.96 0.00e+00 2197.00
IUUC-Lpe-051541 Leersia perrieri 39.20 2.00e-76 281.00
IUUC-Loc-051885 Lepisosteus oculatus 59.77 0.00e+00 854.00
IUUC-Laf-053778 Loxodonta africana 89.76 0.00e+00 3326.00
IUUC-Mcc-055759 Macaca mulatta 97.53 0.00e+00 1552.00
IUUC-Meu-056896 Macropus eugenii 77.53 0.00e+00 1269.00
IUUC-Mtr-058486 Medicago truncatula 39.61 2.00e-68 255.00
IUUC-Mga-059219 Meleagris gallopavo 66.56 0.00e+00 1098.00
IUUC-Mmr-061010 Microcebus murinus 92.17 0.00e+00 3229.00
IUUC-Mdo-062572 Monodelphis domestica 75.75 0.00e+00 2667.00
IUUC-Mmu-063810 Mus musculus 85.83 0.00e+00 3144.00
IUUC-Mpu-066257 Mustela putorius furo 92.56 0.00e+00 1289.00
IUUC-Mlu-068111 Myotis lucifugus 90.93 0.00e+00 1498.00
IUUC-Nle-069919 Nomascus leucogenys 98.12 0.00e+00 2001.00
IUUC-Opr-071204 Ochotona princeps 85.94 0.00e+00 907.00
IUUC-Ont-072131 Oreochromis niloticus 55.58 0.00e+00 878.00
IUUC-Oan-072888 Ornithorhynchus anatinus 75.00 0.00e+00 1112.00
IUUC-Ocu-074626 Oryctolagus cuniculus 89.24 0.00e+00 3164.00
IUUC-Oba-075734 Oryza barthii 38.85 1.00e-73 272.00
IUUC-Obr-076493 Oryza brachyantha 39.00 7.00e-75 276.00
IUUC-Ogl-077248 Oryza glaberrima 38.85 1.00e-73 272.00
IUUC-Ogu-077961 Oryza glumaepatula 38.50 3.00e-72 268.00
IUUC-Oin-079930 Oryza indica 38.85 9.00e-75 276.00
IUUC-Olo-080512 Oryza longistaminata 38.52 1.00e-69 259.00
IUUC-Ome-081701 Oryza meridionalis 38.85 6.00e-75 276.00
IUUC-Oni-082138 Oryza nivara 38.69 5.00e-74 273.00
IUUC-Opu-083350 Oryza punctata 38.82 3.00e-73 271.00
IUUC-Oru-085133 Oryza rufipogon 38.85 7.00e-74 273.00
IUUC-Osa-086042 Oryza sativa 38.85 9.00e-75 276.00
IUUC-Ola-086950 Oryzias latipes 51.84 0.00e+00 833.00
IUUC-Oga-088547 Otolemur garnettii 93.15 0.00e+00 1509.00
IUUC-Oar-089796 Ovis aries 86.96 0.00e+00 2451.00
IUUC-Ptr-091248 Pan troglodytes 99.18 0.00e+00 3466.00
IUUC-Pan-091811 Papio anubis 96.60 0.00e+00 3428.00
IUUC-Psi-093656 Pelodiscus sinensis 76.52 1.00e-144 506.00
IUUC-Pfo-096830 Poecilia formosa 52.74 0.00e+00 1845.00
IUUC-Pab-098361 Pongo abelii 98.25 0.00e+00 1187.00
IUUC-Pop-100019 Populus trichocarpa 39.20 7.00e-70 259.00
IUUC-Pca-100269 Procavia capensis 89.06 9.00e-172 597.00
IUUC-Ppe-101526 Prunus persica 38.86 8.00e-69 256.00
IUUC-Pva-102214 Pteropus vampyrus 89.60 0.00e+00 1391.00
IUUC-Rno-105590 Rattus norvegicus 86.31 0.00e+00 3086.00
IUUC-Sha-106620 Sarcophilus harrisii 77.18 0.00e+00 1212.00
IUUC-Sit-109791 Setaria italica 38.10 1.00e-75 278.00
IUUC-Sly-111032 Solanum lycopersicum 39.24 8.00e-67 249.00
IUUC-Sbi-114810 Sorghum bicolor 37.91 7.00e-74 273.00
IUUC-Ssc-115972 Sus scrofa 73.94 0.00e+00 864.00
IUUC-Tgu-116944 Taeniopygia guttata 71.70 0.00e+00 1055.00
IUUC-Tru-118685 Takifugu rubripes 51.20 0.00e+00 854.00
IUUC-Tsy-119279 Tarsius syrichta 89.66 0.00e+00 1399.00
IUUC-Tni-120124 Tetraodon nigroviridis 55.91 0.00e+00 915.00
IUUC-Tca-121706 Theobroma cacao 40.15 3.00e-72 268.00
IUUC-Tae-125578 Triticum aestivum 39.00 4.00e-73 270.00
IUUC-Tur-126547 Triticum urartu 39.08 2.00e-73 271.00
IUUC-Tbe-128035 Tupaia belangeri 80.17 0.00e+00 729.00
IUUC-Ttr-128162 Tursiops truncatus 91.21 0.00e+00 1415.00
IUUC-Vvi-131247 Vitis vinifera 39.10 4.00e-72 267.00
IUUC-Xtr-132225 Xenopus tropicalis 61.36 0.00e+00 1025.00
Created Date 25-Jun-2017

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