iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

DNA & RNA Element
CircNet
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	17070805

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	1.10e-13	52.1	19	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 1    aeaqWaCsaCTflNePeavkCemCsrpRgc 30
           +e++W+Cs+CTf+N++ea+kC++C+ ++g+
   Q: 19   DEGFWDCSVCTFRNSAEAFKCSICDVRKGT 48
           589*************************95 PP

Organism

Homo sapiens

Functional Description
(View)

Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.

Protein Sequence
(Fasta)

MGDKKSPTRP KRQAKPAADE GFWDCSVCTF RNSAEAFKCS ICDVRKGTST RKPRINSQLV 60
AQQVAQQYAT PPPPKKEKKE KVEKQDKEKP EKDKEISPSV TKKNTNKKTK PKSDILKDPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGACTA GTCTCGTCCG GAGACTGGCA GCGGCGGCGG CGGCGGCGGC CGGAGCTCGA 60
GCCCCAGCGG CTGAGGGCGG GCGGGCGGGC GCGGGGGAGG GAGGGGGGCC GGTCCGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033774--YAF2_RYBP
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF17219--YAF2_RYBP
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0035518--P:histone H2A monoubiquitination
GO:0007275--P:multicellular organism development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:23429

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003475	Anas platyrhynchos	96.35	1.00e-61	229.00
IUUC-Aca-004725	Anolis carolinensis	94.25	2.00e-65	241.00
IUUC-Ame-011035	Astyanax mexicanus	87.72	2.00e-27	116.00
IUUC-Bta-012724	Bos taurus	99.24	2.00e-36	144.00
IUUC-Cja-019921	Callithrix jacchus	100.00	2.00e-64	238.00
IUUC-Cfa-020363	Canis familiaris	100.00	1.00e-62	233.00
IUUC-Cpo-022408	Cavia porcellus	100.00	6.00e-37	146.00
IUUC-Csa-023628	Chlorocebus sabaeus	100.00	3.00e-69	254.00
IUUC-Cho-024871	Choloepus hoffmanni	100.00	5.00e-40	156.00
IUUC-Cin-025723	Ciona intestinalis	58.93	9.00e-17	79.30
IUUC-Dre-027750	Danio rerio	96.49	1.00e-29	123.00
IUUC-Dno-029292	Dasypus novemcinctus	100.00	5.00e-37	146.00
IUUC-Dor-030691	Dipodomys ordii	100.00	5.00e-37	146.00
IUUC-Ete-032320	Echinops telfairi	98.17	9.00e-63	233.00
IUUC-Eca-034330	Equus caballus	100.00	2.00e-64	238.00
IUUC-Eeu-035193	Erinaceus europaeus	84.40	3.00e-44	171.00
IUUC-Fca-035645	Felis catus	100.00	5.00e-37	146.00
IUUC-Fal-036647	Ficedula albicollis	96.73	4.00e-59	221.00
IUUC-Gmo-039120	Gadus morhua	90.00	1.00e-24	107.00
IUUC-Gga-040262	Gallus gallus	96.90	1.00e-66	246.00
IUUC-Gac-041354	Gasterosteus aculeatus	92.65	1.00e-28	120.00
IUUC-Ggo-045026	Gorilla gorilla	100.00	6.00e-37	146.00
IUUC-Itr-048728	Ictidomys tridecemlineatus	97.71	3.00e-35	140.00
IUUC-Lch-050014	Latimeria chalumnae	98.25	2.00e-30	125.00
IUUC-Loc-051746	Lepisosteus oculatus	72.66	5.00e-68	250.00
IUUC-Laf-054352	Loxodonta africana	99.54	1.00e-62	232.00
IUUC-Mor-057038	Magnaporthe oryzae	50.00	1.80e-01	31.20
IUUC-Mpo-057432	Magnaporthe poae	43.75	1.50e-01	31.20
IUUC-Mga-059812	Meleagris gallopavo	96.18	2.00e-34	137.00
IUUC-Mmr-061669	Microcebus murinus	97.71	1.00e-41	162.00
IUUC-Mdo-061964	Monodelphis domestica	97.26	5.00e-63	234.00
IUUC-Mmu-063177	Mus musculus	99.12	3.00e-69	254.00
IUUC-Mpu-065711	Mustela putorius furo	100.00	2.00e-64	238.00
IUUC-Mlu-067973	Myotis lucifugus	97.59	2.00e-17	81.30
IUUC-Opr-070623	Ochotona princeps	100.00	6.00e-37	146.00
IUUC-Ont-071994	Oreochromis niloticus	63.57	8.00e-49	187.00
IUUC-Oan-072949	Ornithorhynchus anatinus	97.35	8.00e-68	249.00
IUUC-Oar-090312	Ovis aries	99.24	2.00e-36	145.00
IUUC-Pan-091877	Papio anubis	100.00	3.00e-69	254.00
IUUC-Psi-093195	Pelodiscus sinensis	96.31	3.00e-60	224.00
IUUC-Pfo-096909	Poecilia formosa	62.45	2.00e-49	189.00
IUUC-Pca-100706	Procavia capensis	96.39	2.00e-42	165.00
IUUC-Pva-102682	Pteropus vampyrus	99.08	1.00e-61	228.00
IUUC-Sha-107156	Sarcophilus harrisii	97.71	5.00e-35	140.00
IUUC-Sar-113234	Sorex araneus	93.95	1.00e-57	215.00
IUUC-Ssc-116262	Sus scrofa	100.00	6.00e-37	146.00
IUUC-Tgu-116730	Taeniopygia guttata	96.35	8.00e-62	229.00
IUUC-Tru-118642	Takifugu rubripes	92.65	4.00e-28	119.00
IUUC-Tsy-119328	Tarsius syrichta	100.00	5.00e-37	146.00
IUUC-Tni-120066	Tetraodon nigroviridis	58.52	1.00e-50	193.00
IUUC-Tre-121881	Trichoderma reesei	38.71	2.50e-02	33.50
IUUC-Tvi-122470	Trichoderma virens	44.83	4.00e-03	36.20
IUUC-Tbe-127332	Tupaia belangeri	99.54	8.00e-64	236.00
IUUC-Ttr-128963	Tursiops truncatus	100.00	2.00e-64	238.00
IUUC-Vpa-130270	Vicugna pacos	99.22	8.00e-36	142.00
IUUC-Xtr-132256	Xenopus tropicalis	80.14	4.00e-31	128.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence