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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046198
Ensembl Protein ID ENSP00000451211.1
UniProt Accession Q8NHV4; B0AZN0; B4E145; G3V3F1; Q8NA30; NEDD1_HUMAN
Genbank Protein ID BAC04099.1; BAG64657.1; BAF98712.1; EAW97577.1; EAW97579.1; EAW97580.1; AAH27605.1
Protein Name Protein NEDD1; Neural precursor cell expressed developmentally down-regulated protein 1
Genbank Nucleotide ID AK093221; AK303656; AK315821; AC007564; CH471054; CH471054; BC027605
Gene Name NEDD1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139350.11 ENST00000555806.5 ENSP00000450828.1
ENSG00000139350.11 ENST00000557644.5 ENSP00000451211.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-20 74.2 88 118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 7    tclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++ s+  +lvsG+ ++t+ +WDl++ ++
   Q: 88   TCVNLnSTsMYLVSGGLNNTVNIWDLKSKRV 118
           79999866699**************998765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
 Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
Protein Sequence
(Fasta)
MHFTGAVMQE NLRFASSGDD IKIWDASSMT LVDKFNPHTS PHGISSICWS SNNNFLVTAS 60
SSGDKIVVSS CKCKPVPLLE LAEGQKQTCV NLNSTSMYLV SGGLNNTVNI WDLKSKRVHR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046198|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGTTTAAC AGTCCAGGCG GGAGCCGGAA GCCCAGCGCG GAGCCGGCCG CGGCCCCCTG 60
TTGTGTTGCT GCGGAGAGGT GAGGTTCCGG AGGCCCTGAG GTCAGCGGGC CCCCGCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046198|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0045177--C:apical part of cell
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005829--C:cytosol
GO:0000242--C:pericentriolar material
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0097711--P:ciliary basal body docking
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0071539--P:protein localization to centrosome
KEGG hsa:121441
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000871 Aegilops tauschii 37.50 3.00e-17 84.30
IUUC-Aml-002397 Ailuropoda melanoleuca 90.38 0.00e+00 1216.00
IUUC-Atr-002464 Amborella trichopoda 30.51 4.00e-39 156.00
IUUC-Apl-003870 Anas platyrhynchos 66.03 0.00e+00 870.00
IUUC-Aca-004925 Anolis carolinensis 60.12 0.00e+00 789.00
IUUC-Aly-005931 Arabidopsis lyrata 29.63 4.00e-40 160.00
IUUC-Ath-006681 Arabidopsis thaliana 28.70 2.00e-40 161.00
IUUC-Ame-010906 Astyanax mexicanus 45.16 6.00e-153 534.00
IUUC-Bta-013389 Bos taurus 90.61 0.00e+00 1207.00
IUUC-Bdi-014340 Brachypodium distachyon 28.96 2.00e-39 157.00
IUUC-Bol-015773 Brassica oleracea 32.49 4.00e-40 160.00
IUUC-Bra-016623 Brassica rapa 30.08 5.00e-40 160.00
IUUC-Cja-019541 Callithrix jacchus 95.76 0.00e+00 1285.00
IUUC-Cfa-021218 Canis familiaris 89.62 0.00e+00 1198.00
IUUC-Cpo-021697 Cavia porcellus 83.96 0.00e+00 1129.00
IUUC-Csa-023620 Chlorocebus sabaeus 97.73 0.00e+00 1315.00
IUUC-Cho-025105 Choloepus hoffmanni 84.74 0.00e+00 933.00
IUUC-Cin-025293 Ciona intestinalis 30.35 4.00e-70 259.00
IUUC-Csv-026234 Ciona savignyi 35.88 5.00e-51 194.00
IUUC-Dre-028251 Danio rerio 62.88 4.00e-104 372.00
IUUC-Dno-029281 Dasypus novemcinctus 88.00 0.00e+00 978.00
IUUC-Dor-031020 Dipodomys ordii 74.76 2.00e-175 609.00
IUUC-Ete-033113 Echinops telfairi 85.90 0.00e+00 686.00
IUUC-Eca-034230 Equus caballus 91.23 0.00e+00 1197.00
IUUC-Eeu-034671 Erinaceus europaeus 74.91 0.00e+00 799.00
IUUC-Fca-035775 Felis catus 91.36 0.00e+00 1228.00
IUUC-Fal-037557 Ficedula albicollis 63.37 0.00e+00 784.00
IUUC-Gmo-038586 Gadus morhua 59.08 2.00e-101 363.00
IUUC-Gga-040153 Gallus gallus 64.90 0.00e+00 866.00
IUUC-Gac-041385 Gasterosteus aculeatus 42.60 8.00e-135 474.00
IUUC-Gma-042844 Glycine max 31.32 5.00e-42 166.00
IUUC-Ggo-044576 Gorilla gorilla 99.10 0.00e+00 1362.00
IUUC-Hvu-047794 Hordeum vulgare 37.50 1.00e-17 82.40
IUUC-Lch-050561 Latimeria chalumnae 51.29 6.00e-166 577.00
IUUC-Lpe-051469 Leersia perrieri 30.82 7.00e-37 149.00
IUUC-Loc-052816 Lepisosteus oculatus 48.73 1.00e-155 543.00
IUUC-Laf-053880 Loxodonta africana 88.20 0.00e+00 1132.00
IUUC-Mcc-054977 Macaca mulatta 97.73 0.00e+00 1315.00
IUUC-Meu-056141 Macropus eugenii 62.85 4.00e-178 618.00
IUUC-Mtr-058441 Medicago truncatula 31.25 4.00e-41 163.00
IUUC-Mga-060141 Meleagris gallopavo 63.06 0.00e+00 832.00
IUUC-Mmr-061201 Microcebus murinus 92.12 0.00e+00 1254.00
IUUC-Mdo-061855 Monodelphis domestica 73.62 0.00e+00 968.00
IUUC-Mmu-064342 Mus musculus 85.45 0.00e+00 1145.00
IUUC-Mac-065368 Musa acuminata 29.43 1.00e-39 158.00
IUUC-Mpu-066191 Mustela putorius furo 90.61 0.00e+00 1207.00
IUUC-Mlu-067310 Myotis lucifugus 88.18 0.00e+00 1166.00
IUUC-Nle-069990 Nomascus leucogenys 98.94 0.00e+00 1349.00
IUUC-Opr-070336 Ochotona princeps 81.82 0.00e+00 1055.00
IUUC-Ont-071675 Oreochromis niloticus 44.43 1.00e-142 500.00
IUUC-Oan-072772 Ornithorhynchus anatinus 71.50 0.00e+00 795.00
IUUC-Ocu-074095 Oryctolagus cuniculus 91.39 0.00e+00 1231.00
IUUC-Oba-075327 Oryza barthii 28.85 6.00e-38 153.00
IUUC-Obr-076119 Oryza brachyantha 29.13 2.00e-38 154.00
IUUC-Ogl-077820 Oryza glaberrima 28.57 3.00e-37 150.00
IUUC-Ogu-078679 Oryza glumaepatula 29.05 9.00e-38 152.00
IUUC-Oin-079891 Oryza indica 28.85 4.00e-38 153.00
IUUC-Olo-080414 Oryza longistaminata 31.11 8.00e-37 149.00
IUUC-Ome-081888 Oryza meridionalis 29.13 3.00e-38 153.00
IUUC-Oni-082417 Oryza nivara 28.85 6.00e-38 152.00
IUUC-Opu-083393 Oryza punctata 28.37 5.00e-38 153.00
IUUC-Oru-084698 Oryza rufipogon 28.85 3.00e-38 154.00
IUUC-Osa-086121 Oryza sativa 28.85 6.00e-38 152.00
IUUC-Ola-086806 Oryzias latipes 40.67 9.00e-142 497.00
IUUC-Olu-087591 Ostreococcus lucimarinus 23.91 8.00e-16 78.60
IUUC-Oga-088622 Otolemur garnettii 89.88 0.00e+00 1217.00
IUUC-Oar-090391 Ovis aries 87.42 0.00e+00 1050.00
IUUC-Ptr-091036 Pan troglodytes 99.24 0.00e+00 1357.00
IUUC-Pan-092576 Papio anubis 97.73 0.00e+00 1317.00
IUUC-Psi-093450 Pelodiscus sinensis 68.66 0.00e+00 890.00
IUUC-Pma-094101 Petromyzon marinus 55.45 4.00e-104 370.00
IUUC-Ppa-095636 Physcomitrella patens 31.72 2.00e-41 164.00
IUUC-Pfo-097142 Poecilia formosa 59.00 7.00e-108 384.00
IUUC-Pab-097829 Pongo abelii 98.64 0.00e+00 1343.00
IUUC-Pop-098972 Populus trichocarpa 32.59 1.00e-39 158.00
IUUC-Pca-100217 Procavia capensis 85.30 0.00e+00 716.00
IUUC-Ppe-101502 Prunus persica 30.79 5.00e-40 159.00
IUUC-Pva-102736 Pteropus vampyrus 88.64 0.00e+00 1182.00
IUUC-Rno-104977 Rattus norvegicus 85.61 0.00e+00 1104.00
IUUC-Sha-107003 Sarcophilus harrisii 74.22 0.00e+00 975.00
IUUC-Smo-109328 Selaginella moellendorffii 30.03 8.00e-42 165.00
IUUC-Sit-109796 Setaria italica 28.30 3.00e-39 157.00
IUUC-Sly-110941 Solanum lycopersicum 30.94 1.00e-36 148.00
IUUC-Stu-112314 Solanum tuberosum 30.94 3.00e-37 150.00
IUUC-Sar-112926 Sorex araneus 82.58 0.00e+00 1104.00
IUUC-Sbi-113822 Sorghum bicolor 28.80 4.00e-27 116.00
IUUC-Ssc-116242 Sus scrofa 91.69 0.00e+00 662.00
IUUC-Tgu-116765 Taeniopygia guttata 64.71 0.00e+00 810.00
IUUC-Tru-117738 Takifugu rubripes 42.78 8.00e-151 527.00
IUUC-Tsy-118856 Tarsius syrichta 86.83 0.00e+00 1105.00
IUUC-Tni-120871 Tetraodon nigroviridis 43.79 3.00e-150 525.00
IUUC-Tca-120965 Theobroma cacao 30.59 2.00e-39 157.00
IUUC-Tae-123588 Triticum aestivum 28.42 6.00e-39 156.00
IUUC-Tur-126840 Triticum urartu 28.15 9.00e-39 155.00
IUUC-Ttr-128551 Tursiops truncatus 88.94 0.00e+00 1177.00
IUUC-Vpa-130324 Vicugna pacos 90.61 0.00e+00 1189.00
IUUC-Vvi-131699 Vitis vinifera 31.75 1.00e-39 158.00
IUUC-Xtr-131956 Xenopus tropicalis 60.97 0.00e+00 823.00
IUUC-Xma-132982 Xiphophorus maculatus 41.44 4.00e-135 475.00
Created Date 25-Jun-2017

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