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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-047039
Ensembl Protein ID ENSP00000337825.5
UniProt Accession P06239; D3DPP8; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8; LCK_HUMAN
Genbank Protein ID CAA28691.1; CAA31884.1; AAA59502.1; CAA32211.1; CAA32211.1; CAA32211.1; AAA18225.1; AAC50287.1; CAD55807.1; CAI22320.1; CAI22321.1; EAX07543.1; EAX07546.1; AAH13200.1; AAA59501.1; AAA59503.1; AAF34794.1; CAA29667.1; CAA28165.1
Protein Name Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Genbank Nucleotide ID X05027; X13529; M36881; X14055; X14053; X14054; U07236; U23852; BN000073; AL121991; AL121991; CH471059; CH471059; BC013200; M21510; M26692; AF228313; X06369; X04476
Gene Name LCK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000182866.16 ENST00000336890.9 ENSP00000337825.5
ENSG00000182866.16 ENST00000495610.6 ENSP00000435605.1
ENSG00000182866.16 ENST00000477031.6 ENSP00000436554.1
ENSG00000182866.16 ENST00000373557.6 ENSP00000362658.2
ENSG00000182866.16 ENST00000333070.4 ENSP00000328213.4
ENSG00000182866.16 ENST00000373564.7 ENSP00000362665.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWAS CentralOMIM
Drug and target
TTDKPIDGRACPDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDPhosphoBase
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 18539162
Classification
Family E-value Score Start End
UBD/SH3 8.30e-19 69.0 62 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with ARAP (PubMed:27335501).
 Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with ARAP (PubMed:27335501).
Protein Sequence
(Fasta)
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047039|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAGTCAGGGT GGGACGTGGG CGCGGGGAGA CAGGTGGTGG CTACGACGGC GAAGGGAGCT 60
GAGACTGTCC AGGCAGCCAG GTTAGGCCAG GAGGACCATG TGAATGGGGC CAGAGGGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047039|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0051117--F:ATPase binding
GO:0042609--F:CD4 receptor binding
GO:0042610--F:CD8 receptor binding
GO:0001948--F:glycoprotein binding
GO:0042802--F:identical protein binding
GO:0016301--F:kinase activity
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0043548--F:phosphatidylinositol 3-kinase binding
GO:0046934--F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0008022--F:protein C-terminus binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0042169--F:SH2 domain binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0006882--P:cellular zinc ion homeostasis
GO:0030097--P:hemopoiesis
GO:0045087--P:innate immune response
GO:0050900--P:leukocyte migration
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0030168--P:platelet activation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:0006468--P:protein phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0050690--P:regulation of defense response to virus by virus
GO:0051249--P:regulation of lymphocyte activation
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0042493--P:response to drug
GO:0031295--P:T cell costimulation
GO:0030217--P:T cell differentiation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032--P:viral process
KEGG hsa:3932
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001315 Ailuropoda melanoleuca 92.76 0.00e+00 1029.00
IUUC-Apl-004134 Anas platyrhynchos 80.55 0.00e+00 734.00
IUUC-Bta-013264 Bos taurus 96.27 0.00e+00 1028.00
IUUC-Cja-019574 Callithrix jacchus 95.08 0.00e+00 712.00
IUUC-Cfa-021161 Canis familiaris 91.84 0.00e+00 1021.00
IUUC-Cpo-022492 Cavia porcellus 95.87 0.00e+00 1019.00
IUUC-Csa-023270 Chlorocebus sabaeus 80.12 0.00e+00 818.00
IUUC-Dre-028005 Danio rerio 75.00 0.00e+00 719.00
IUUC-Dno-029365 Dasypus novemcinctus 94.50 0.00e+00 992.00
IUUC-Dor-030892 Dipodomys ordii 91.83 0.00e+00 945.00
IUUC-Eca-033325 Equus caballus 95.49 0.00e+00 1004.00
IUUC-Eeu-035004 Erinaceus europaeus 88.44 0.00e+00 803.00
IUUC-Fca-035908 Felis catus 97.84 0.00e+00 1042.00
IUUC-Fal-036804 Ficedula albicollis 71.13 0.00e+00 734.00
IUUC-Gmo-038984 Gadus morhua 64.40 0.00e+00 696.00
IUUC-Gga-040997 Gallus gallus 82.71 0.00e+00 902.00
IUUC-Gac-041854 Gasterosteus aculeatus 69.22 0.00e+00 735.00
IUUC-Gma-043628 Glycine max 31.84 3.00e-20 94.40
IUUC-Ggo-045238 Gorilla gorilla 94.43 0.00e+00 1049.00
IUUC-Hvu-047815 Hordeum vulgare 28.86 4.00e-20 93.60
IUUC-Itr-048479 Ictidomys tridecemlineatus 98.23 0.00e+00 1045.00
IUUC-Lch-049568 Latimeria chalumnae 77.34 0.00e+00 846.00
IUUC-Loc-052222 Lepisosteus oculatus 67.38 0.00e+00 678.00
IUUC-Laf-054499 Loxodonta africana 91.47 0.00e+00 1015.00
IUUC-Mcc-054872 Macaca mulatta 78.48 0.00e+00 867.00
IUUC-Meu-056879 Macropus eugenii 92.01 0.00e+00 989.00
IUUC-Mtr-058765 Medicago truncatula 34.15 6.00e-20 93.20
IUUC-Mga-059971 Meleagris gallopavo 82.12 0.00e+00 893.00
IUUC-Mmr-060740 Microcebus murinus 97.25 0.00e+00 1036.00
IUUC-Mdo-062192 Monodelphis domestica 92.93 0.00e+00 996.00
IUUC-Mmu-064241 Mus musculus 96.86 0.00e+00 1032.00
IUUC-Mpu-066595 Mustela putorius furo 97.25 0.00e+00 1033.00
IUUC-Mlu-067069 Myotis lucifugus 95.88 0.00e+00 1021.00
IUUC-Opr-070472 Ochotona princeps 92.51 0.00e+00 1021.00
IUUC-Ont-071711 Oreochromis niloticus 68.43 0.00e+00 704.00
IUUC-Ocu-074221 Oryctolagus cuniculus 96.86 0.00e+00 1030.00
IUUC-Ola-087000 Oryzias latipes 69.09 0.00e+00 730.00
IUUC-Oga-088225 Otolemur garnettii 96.86 0.00e+00 1032.00
IUUC-Oar-090244 Ovis aries 85.15 0.00e+00 966.00
IUUC-Ptr-090751 Pan troglodytes 99.71 0.00e+00 731.00
IUUC-Pan-091804 Papio anubis 99.02 0.00e+00 1050.00
IUUC-Psi-093252 Pelodiscus sinensis 75.10 0.00e+00 798.00
IUUC-Pfo-096542 Poecilia formosa 67.70 0.00e+00 733.00
IUUC-Pab-098168 Pongo abelii 98.77 0.00e+00 999.00
IUUC-Pca-100547 Procavia capensis 96.88 0.00e+00 650.00
IUUC-Rno-105542 Rattus norvegicus 96.66 0.00e+00 1031.00
IUUC-Sha-107524 Sarcophilus harrisii 91.94 0.00e+00 991.00
IUUC-Sar-113235 Sorex araneus 89.17 0.00e+00 860.00
IUUC-Ssc-115624 Sus scrofa 96.46 0.00e+00 1030.00
IUUC-Tru-118559 Takifugu rubripes 67.44 0.00e+00 727.00
IUUC-Tca-121341 Theobroma cacao 32.70 1.00e-21 99.00
IUUC-Ttr-129002 Tursiops truncatus 87.38 0.00e+00 958.00
IUUC-Xtr-132224 Xenopus tropicalis 76.03 0.00e+00 835.00
Created Date 25-Jun-2017

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