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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045715
Ensembl Protein ID ENSP00000462664.1
UniProt Accession Q9UNA4; Q8N590; Q9H0S1; Q9NYH6; POLI_HUMAN
Genbank Protein ID AAM11872.1; AAD50381.1; CAB66605.1; AAH32662.1; AAF63383.1
Protein Name DNA polymerase iota; Eta2; RAD30 homolog B
Genbank Nucleotide ID AY094607; AC093462; AL136670; BC032662; AF245438
Gene Name POLI; RAD30B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101751.10 ENST00000579534.5 ENSP00000462664.1
ENSG00000101751.10 ENST00000406285.7 ENSP00000385196.3
ENSG00000101751.10 ENST00000577612.5 ENSP00000464025.1
ENSG00000101751.10 ENST00000217800.9 ENSP00000217800.6
ENSG00000101751.10 ENST00000579823.1 ENSP00000463065.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBM 3.80e-23 82.0 704 731
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBM
   S: 1    lPsqvDpeVfsqLPeeiQeEvmaelrqq 28
           +Ps++Dp+Vf++LPe +Q+E++ae++++
   Q: 704  FPSDIDPQVFYELPEAVQKELLAEWKRA 731
           8*************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
 Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Protein Sequence
(Fasta)
MEKLGVEPEE EGGGDDDEED AEAWAMELAD VGAAASSQGV HDQVLPTPNA SSRVIVHVDL 60
DCFYAQVEMI SNPELKDKPL GVQQKYLVVT CNYEARKLGV KKLMNVRDAK EKCPQLVLVN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045715|UBD,UBM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCGTGTCA CTCTGGGCAA CAGGCTGGTC GGCCACGACT GCGCAGGCGA GAGGCACAGA 60
GCGACTGGAG ACTGTAGTCC CCCGGTTTCC CTGGAGACCA GGCGGAAGCG GCCGGAAGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045715|UBD,UBM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase
Interpro

IPR017961--DNA_pol_Y-fam_little_finger
IPR001126--UmuC
PROSITE

PS50173--UMUC
Pfam

PF00817--IMS
PF11799--IMS_C
Gene Ontology

GO:0005622--C:intracellular
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0042276--P:error-prone translesion synthesis
GO:0019985--P:translesion synthesis
KEGG hsa:11201
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002144 Ailuropoda melanoleuca 87.27 0.00e+00 1197.00
IUUC-Apl-003303 Anas platyrhynchos 59.04 2.00e-138 486.00
IUUC-Aca-004883 Anolis carolinensis 60.16 2.00e-167 582.00
IUUC-Acl-008010 Aspergillus clavatus 31.29 2.00e-50 193.00
IUUC-Afu-008874 Aspergillus fumigatus 30.67 4.00e-51 196.00
IUUC-Ani-009354 Aspergillus nidulans 31.13 1.00e-47 184.00
IUUC-Ang-009584 Aspergillus niger 29.40 8.00e-43 168.00
IUUC-Ate-010413 Aspergillus terreus 32.76 3.00e-50 193.00
IUUC-Bgr-012031 Blumeria graminis 30.67 2.00e-45 177.00
IUUC-Bta-012393 Bos taurus 82.87 0.00e+00 1109.00
IUUC-Bci-013960 Botrytis cinerea 30.90 3.00e-51 196.00
IUUC-Cja-019032 Callithrix jacchus 91.36 0.00e+00 1283.00
IUUC-Cfa-020560 Canis familiaris 87.18 0.00e+00 1219.00
IUUC-Cpo-021756 Cavia porcellus 75.80 0.00e+00 892.00
IUUC-Cre-022555 Chlamydomonas reinhardtii 47.78 5.00e-35 140.00
IUUC-Csa-023102 Chlorocebus sabaeus 96.13 0.00e+00 1265.00
IUUC-Cho-024983 Choloepus hoffmanni 79.27 1.00e-115 410.00
IUUC-Cgl-026717 Colletotrichum gloeosporioides 32.89 3.00e-55 209.00
IUUC-Cme-027310 Cyanidioschyzon merolae 32.76 2.00e-39 157.00
IUUC-Dre-027407 Danio rerio 51.33 6.00e-132 464.00
IUUC-Dno-029723 Dasypus novemcinctus 78.61 0.00e+00 1044.00
IUUC-Dor-030274 Dipodomys ordii 77.32 0.00e+00 1048.00
IUUC-Dse-031261 Dothistroma septosporum 32.51 9.00e-45 175.00
IUUC-Dme-031707 Drosophila melanogaster 38.88 4.00e-81 296.00
IUUC-Ete-032374 Echinops telfairi 71.00 1.00e-117 417.00
IUUC-Eca-034334 Equus caballus 85.92 0.00e+00 1180.00
IUUC-Eeu-034857 Erinaceus europaeus 85.53 5.00e-179 620.00
IUUC-Fca-036361 Felis catus 78.77 0.00e+00 1057.00
IUUC-Fox-037933 Fusarium oxysporum 30.24 6.00e-46 178.00
IUUC-Fso-038328 Fusarium solani 33.41 2.00e-46 180.00
IUUC-Gmo-039026 Gadus morhua 49.39 1.00e-99 356.00
IUUC-Ggr-039773 Gaeumannomyces graminis 28.57 7.00e-40 158.00
IUUC-Gac-041577 Gasterosteus aculeatus 55.85 1.00e-126 447.00
IUUC-Ggo-045651 Gorilla gorilla 99.02 0.00e+00 1402.00
IUUC-Itr-048408 Ictidomys tridecemlineatus 85.65 0.00e+00 1209.00
IUUC-Lch-050019 Latimeria chalumnae 56.26 5.00e-168 584.00
IUUC-Loc-052755 Lepisosteus oculatus 51.49 2.00e-135 476.00
IUUC-Lma-053204 Leptosphaeria maculans 31.96 3.00e-52 200.00
IUUC-Laf-053413 Loxodonta africana 83.89 0.00e+00 1126.00
IUUC-Mcc-055581 Macaca mulatta 95.39 0.00e+00 1277.00
IUUC-Meu-056476 Macropus eugenii 86.54 1.00e-76 280.00
IUUC-Mor-057059 Magnaporthe oryzae 32.51 1.00e-34 141.00
IUUC-Mpo-057505 Magnaporthe poae 30.15 2.00e-40 160.00
IUUC-Mmr-060808 Microcebus murinus 88.60 0.00e+00 1221.00
IUUC-Mdo-062650 Monodelphis domestica 80.46 0.00e+00 1117.00
IUUC-Mmu-063692 Mus musculus 77.12 0.00e+00 1082.00
IUUC-Mpu-065972 Mustela putorius furo 81.60 7.00e-147 513.00
IUUC-Mlu-067868 Myotis lucifugus 81.97 0.00e+00 1145.00
IUUC-Nfi-068273 Neosartorya fischeri 29.57 5.00e-41 162.00
IUUC-Nle-068968 Nomascus leucogenys 96.23 0.00e+00 1355.00
IUUC-Opr-070343 Ochotona princeps 70.27 0.00e+00 870.00
IUUC-Ont-071538 Oreochromis niloticus 50.70 2.00e-136 479.00
IUUC-Oan-073027 Ornithorhynchus anatinus 68.63 0.00e+00 960.00
IUUC-Ocu-074858 Oryctolagus cuniculus 84.84 0.00e+00 1166.00
IUUC-Ola-086502 Oryzias latipes 58.73 2.00e-133 470.00
IUUC-Oga-088433 Otolemur garnettii 83.24 0.00e+00 1145.00
IUUC-Oar-090109 Ovis aries 86.66 0.00e+00 1180.00
IUUC-Ptr-091289 Pan troglodytes 98.45 0.00e+00 1374.00
IUUC-Pan-092101 Papio anubis 95.68 0.00e+00 1353.00
IUUC-Psi-093115 Pelodiscus sinensis 58.33 0.00e+00 717.00
IUUC-Pno-094836 Phaeosphaeria nodorum 27.86 7.00e-33 135.00
IUUC-Pfo-096290 Poecilia formosa 50.00 1.00e-131 463.00
IUUC-Pab-098022 Pongo abelii 92.82 0.00e+00 712.00
IUUC-Pca-100696 Procavia capensis 73.02 0.00e+00 964.00
IUUC-Pva-102750 Pteropus vampyrus 89.32 0.00e+00 665.00
IUUC-Pte-104179 Pyrenophora teres 30.07 1.00e-42 167.00
IUUC-Rno-105560 Rattus norvegicus 80.31 0.00e+00 1119.00
IUUC-Sha-107266 Sarcophilus harrisii 77.40 2.00e-167 582.00
IUUC-Smo-109490 Selaginella moellendorffii 39.00 2.00e-53 202.00
IUUC-Sar-113566 Sorex araneus 65.55 0.00e+00 776.00
IUUC-Sre-114907 Sporisorium reilianum 36.00 2.00e-37 150.00
IUUC-Ssc-116055 Sus scrofa 73.40 0.00e+00 967.00
IUUC-Tru-118294 Takifugu rubripes 48.18 4.00e-132 465.00
IUUC-Tsy-119086 Tarsius syrichta 87.32 0.00e+00 1181.00
IUUC-Tni-120067 Tetraodon nigroviridis 48.86 3.00e-128 452.00
IUUC-Tre-122247 Trichoderma reesei 29.25 3.00e-41 163.00
IUUC-Tvi-122417 Trichoderma virens 31.21 8.00e-51 195.00
IUUC-Tbe-127278 Tupaia belangeri 82.93 0.00e+00 1102.00
IUUC-Ttr-129147 Tursiops truncatus 86.46 0.00e+00 934.00
IUUC-Uma-129397 Ustilago maydis 38.40 1.00e-38 155.00
IUUC-Vda-129773 Verticillium dahliae 30.46 3.00e-42 166.00
IUUC-Vpa-130771 Vicugna pacos 82.95 0.00e+00 1116.00
IUUC-Xtr-132975 Xenopus tropicalis 53.53 2.00e-159 556.00
IUUC-Xma-133429 Xiphophorus maculatus 49.04 7.00e-133 468.00
Created Date 25-Jun-2017

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