iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046810

UUCD1 version

UUC-HoS-00384

Ensembl Protein ID

ENSP00000282369.3

UniProt Accession

Q9NQ86; A1L3Z1; A6NDD0; B7Z3V4; B7ZAV7; E9PFI8; Q0P5Z9; TRI36_HUMAN

Genbank Protein ID

CAB94831.1; BAH14793.1; BAH12340.1; EAW48972.1; AAH45164.1; AAH46096.1; AAI30335.1

Protein Name

E3 ubiquitin-protein ligase TRIM36; RING finger protein 98; RING-type E3 ubiquitin transferase TRIM36; Tripartite motif-containing protein 36; Zinc-binding protein Rbcc728

Genbank Nucleotide ID

AJ272269; BX460627; AK296389; AC008494; BC045164; BC046096; BC130334

Gene Name

TRIM36; RBCC728; RNF98

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000152503.9	ENST00000282369.7	ENSP00000282369.3
ENSG00000152503.9	ENST00000513154.5	ENSP00000423934.1
ENSG00000152503.9	ENST00000508894.1	ENSP00000424743.1
ENSG00000152503.9	ENST00000379618.6	ENSP00000368938.2
ENSG00000152503.9	ENST00000379617.2	ENSP00000368937.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19232519; 19675128

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.80e-05	26.8	33	118

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw............pglknssskefr................................CPlC 45
           C+ C+e f + pl+lpC+H ++++C++ +             + +n+ss+  r                                CP C
   Q: 33   CPACKELFTH-PLILPCQHSICHKCVKELlltlddsfndvgSDNSNQSSP--RlrlpspsmdkidrinrpgwkrnsltprttvfpCPGC 118
           ********99.**************9888888899998854333334444..3448888888888888888888888888888888888 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.

Protein Sequence
(Fasta)

MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL 60
LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGGGCTT TTTTCCAGAT CTTCGCGCCG AGAGCCGGGG ACGGCCAACC TGCCGGCATG 60
CGATAAAGGC CGGGGAATGT CTAGCTGGGG CCGCGCTGAG CCGAGTGCGG ACCCGCTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027726--Trim36
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00041--fn3
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0001669--C:acrosomal vesicle
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007340--P:acrosome reaction
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle

KEGG

hsa:55521

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002038	Ailuropoda melanoleuca	94.79	0.00e+00	1428.00
IUUC-Apl-003863	Anas platyrhynchos	76.12	0.00e+00	1080.00
IUUC-Aca-005003	Anolis carolinensis	78.01	0.00e+00	1182.00
IUUC-Ame-011283	Astyanax mexicanus	64.75	0.00e+00	926.00
IUUC-Bta-013517	Bos taurus	94.79	0.00e+00	1430.00
IUUC-Cja-019181	Callithrix jacchus	97.94	0.00e+00	1470.00
IUUC-Cfa-020375	Canis familiaris	95.34	0.00e+00	1434.00
IUUC-Cpo-021827	Cavia porcellus	92.45	0.00e+00	1404.00
IUUC-Csa-023819	Chlorocebus sabaeus	98.73	0.00e+00	1440.00
IUUC-Cho-024602	Choloepus hoffmanni	94.29	0.00e+00	1246.00
IUUC-Dre-028570	Danio rerio	62.53	0.00e+00	918.00
IUUC-Dno-029385	Dasypus novemcinctus	94.80	0.00e+00	1375.00
IUUC-Ete-032498	Echinops telfairi	93.19	0.00e+00	1376.00
IUUC-Eca-034142	Equus caballus	94.65	0.00e+00	1431.00
IUUC-Eeu-034756	Erinaceus europaeus	86.11	7.00e-144	504.00
IUUC-Fca-035508	Felis catus	95.34	0.00e+00	1394.00
IUUC-Fal-037617	Ficedula albicollis	73.76	0.00e+00	1144.00
IUUC-Gmo-038943	Gadus morhua	62.46	0.00e+00	783.00
IUUC-Gac-041330	Gasterosteus aculeatus	61.83	0.00e+00	796.00
IUUC-Ggo-045308	Gorilla gorilla	99.04	0.00e+00	1484.00
IUUC-Lch-050382	Latimeria chalumnae	68.71	0.00e+00	1012.00
IUUC-Loc-051809	Lepisosteus oculatus	62.69	0.00e+00	884.00
IUUC-Laf-054251	Loxodonta africana	93.97	0.00e+00	1376.00
IUUC-Mcc-054735	Macaca mulatta	98.90	0.00e+00	1483.00
IUUC-Meu-056861	Macropus eugenii	83.45	0.00e+00	1041.00
IUUC-Mmr-061266	Microcebus murinus	94.79	0.00e+00	1430.00
IUUC-Mdo-061996	Monodelphis domestica	87.03	0.00e+00	1318.00
IUUC-Mmu-063846	Mus musculus	92.46	0.00e+00	1431.00
IUUC-Mpu-065916	Mustela putorius furo	94.51	0.00e+00	1427.00
IUUC-Mlu-067753	Myotis lucifugus	91.52	0.00e+00	1366.00
IUUC-Nle-068991	Nomascus leucogenys	98.35	0.00e+00	1471.00
IUUC-Opr-070512	Ochotona princeps	89.22	0.00e+00	1126.00
IUUC-Ont-072641	Oreochromis niloticus	62.52	0.00e+00	927.00
IUUC-Oan-072998	Ornithorhynchus anatinus	73.10	0.00e+00	1092.00
IUUC-Ocu-074891	Oryctolagus cuniculus	90.36	0.00e+00	1244.00
IUUC-Ola-086318	Oryzias latipes	63.58	0.00e+00	785.00
IUUC-Oga-088089	Otolemur garnettii	94.63	0.00e+00	1386.00
IUUC-Oar-089836	Ovis aries	94.79	0.00e+00	1430.00
IUUC-Ptr-091083	Pan troglodytes	99.18	0.00e+00	1486.00
IUUC-Pan-092310	Papio anubis	97.65	0.00e+00	1447.00
IUUC-Psi-093663	Pelodiscus sinensis	80.70	0.00e+00	1227.00
IUUC-Pfo-096697	Poecilia formosa	63.98	0.00e+00	914.00
IUUC-Pab-098766	Pongo abelii	96.44	0.00e+00	732.00
IUUC-Pca-100938	Procavia capensis	86.59	0.00e+00	743.00
IUUC-Pva-102799	Pteropus vampyrus	94.92	0.00e+00	1025.00
IUUC-Rno-105823	Rattus norvegicus	92.73	0.00e+00	1432.00
IUUC-Sha-106921	Sarcophilus harrisii	87.00	0.00e+00	1343.00
IUUC-Sar-113002	Sorex araneus	77.72	0.00e+00	883.00
IUUC-Ssc-115356	Sus scrofa	95.20	0.00e+00	1461.00
IUUC-Tgu-117350	Taeniopygia guttata	71.95	0.00e+00	1067.00
IUUC-Tru-117786	Takifugu rubripes	62.85	0.00e+00	921.00
IUUC-Tsy-119009	Tarsius syrichta	93.69	0.00e+00	1395.00
IUUC-Tni-119753	Tetraodon nigroviridis	62.15	0.00e+00	919.00
IUUC-Ttr-128842	Tursiops truncatus	95.06	0.00e+00	1431.00
IUUC-Vpa-130330	Vicugna pacos	95.62	0.00e+00	1427.00
IUUC-Xtr-132760	Xenopus tropicalis	68.46	0.00e+00	1053.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence