iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024077.15	ENSMUST00000145910.8	ENSMUSP00000120830.2
ENSMUSG00000024077.15	ENSMUST00000145480.1	ENSMUSP00000117663.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-28	98.7	567	599
UBD/Beta-Prp	1.40e-44	153.6	563	777

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHtd v++la+   +  +l+s+s Dgt+++W+++
   Q: 567  GHTDAVWGLAYsaaH-QRLLSCSADGTLRLWNTT 599
           8**********9853.89**************76 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk......ghedsvlslsfspsgdklvsGshdrtirvwdletgqc 128
             l gh+++v+ + +s   + l+++s D+t+++w+     +  ++       g  +sv ++s++p  +++v+  +  +  ++++et+q 
   Q: 563  GPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFndnqelGIPASVDLVSSDP--SHMVASFSKGYTSIFNMETQQR 649
           4589******************************8887766666661444444444555566666..8888888899************ PP
   S: 129  lee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqt 211
           + +        s  +  +n v +hp+  + ++++ Dr ++++d +tgkl++ +   h ++v+sl++d+ng +l+sgs+d +++lw+l++
   Q: 650  VLTlesnvdSTSSSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVA-HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
           **9998866445555567788899999**************************98.********************************* PP
   S: 212  gecvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           ++c++++++h+    + + +v+f+p + +++s+++D   +
   Q: 738  KTCIQEFTAHRkkfeESIHDVAFHPSKCYIASAGADALAK 777
           ***********999999******************97655 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).

Protein Sequence
(Fasta)

MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 60
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAGCCCT CATGGCAAAT GTCGAACCTT AGCAGAAAGA GAGAAGACCA GAGTTCCTCC 60
TCCTAAGGGA AAACTGGTCT GTTAACAAGC ACTGAGCCCC TCTGGGGATG AATGGTAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0112--Calmodulin-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005737--C:cytoplasm
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0000159--C:protein phosphatase type 2A complex
GO:0070016--F:armadillo repeat domain binding
GO:0030331--F:estrogen receptor binding
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding
GO:0008285--P:negative regulation of cell proliferation
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:268980

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001899	Ailuropoda melanoleuca	96.05	0.00e+00	1338.00
IUUC-Apl-003927	Anas platyrhynchos	86.38	0.00e+00	1101.00
IUUC-Aca-004933	Anolis carolinensis	79.58	0.00e+00	1135.00
IUUC-Ame-010997	Astyanax mexicanus	73.53	0.00e+00	1069.00
IUUC-Bta-013077	Bos taurus	96.15	0.00e+00	1358.00
IUUC-Cja-018973	Callithrix jacchus	96.92	0.00e+00	1369.00
IUUC-Cfa-020988	Canis familiaris	92.89	0.00e+00	1211.00
IUUC-Cpo-022496	Cavia porcellus	96.15	0.00e+00	1367.00
IUUC-Csa-023829	Chlorocebus sabaeus	96.29	0.00e+00	1359.00
IUUC-Dre-028560	Danio rerio	68.92	0.00e+00	969.00
IUUC-Dno-029742	Dasypus novemcinctus	90.38	0.00e+00	1294.00
IUUC-Dor-030721	Dipodomys ordii	89.36	0.00e+00	1248.00
IUUC-Eca-033760	Equus caballus	96.02	0.00e+00	1263.00
IUUC-Eeu-034953	Erinaceus europaeus	95.57	0.00e+00	737.00
IUUC-Fca-036530	Felis catus	95.59	0.00e+00	1265.00
IUUC-Fal-037353	Ficedula albicollis	79.67	0.00e+00	873.00
IUUC-Gga-040132	Gallus gallus	86.53	0.00e+00	1119.00
IUUC-Gac-041713	Gasterosteus aculeatus	73.08	0.00e+00	1052.00
IUUC-Ggo-045455	Gorilla gorilla	85.20	0.00e+00	1170.00
IUUC-Hsa-046415	Homo sapiens	96.79	0.00e+00	1364.00
IUUC-Lch-050475	Latimeria chalumnae	80.00	0.00e+00	1169.00
IUUC-Loc-051859	Lepisosteus oculatus	76.58	0.00e+00	1120.00
IUUC-Laf-053537	Loxodonta africana	95.26	0.00e+00	1362.00
IUUC-Mcc-055817	Macaca mulatta	96.05	0.00e+00	1358.00
IUUC-Meu-055946	Macropus eugenii	67.99	0.00e+00	889.00
IUUC-Mga-059694	Meleagris gallopavo	86.79	0.00e+00	1101.00
IUUC-Mmr-060768	Microcebus murinus	96.67	0.00e+00	1388.00
IUUC-Mdo-061901	Monodelphis domestica	84.84	0.00e+00	1290.00
IUUC-Mpu-065827	Mustela putorius furo	91.35	0.00e+00	1350.00
IUUC-Mlu-067102	Myotis lucifugus	95.51	0.00e+00	1325.00
IUUC-Ncr-068831	Neurospora crassa	39.60	6.00e-22	99.80
IUUC-Nle-070008	Nomascus leucogenys	96.16	0.00e+00	1269.00
IUUC-Opr-071067	Ochotona princeps	61.00	4.00e-177	614.00
IUUC-Ont-072025	Oreochromis niloticus	72.78	0.00e+00	1042.00
IUUC-Oan-072950	Ornithorhynchus anatinus	90.57	0.00e+00	1149.00
IUUC-Ocu-074316	Oryctolagus cuniculus	94.88	0.00e+00	1244.00
IUUC-Ola-087279	Oryzias latipes	70.69	0.00e+00	1023.00
IUUC-Oga-088284	Otolemur garnettii	96.03	0.00e+00	1362.00
IUUC-Oar-090304	Ovis aries	96.79	0.00e+00	1368.00
IUUC-Ptr-091052	Pan troglodytes	96.92	0.00e+00	1366.00
IUUC-Pan-092270	Papio anubis	90.79	0.00e+00	1316.00
IUUC-Psi-093907	Pelodiscus sinensis	86.12	0.00e+00	1022.00
IUUC-Pfo-097042	Poecilia formosa	72.06	0.00e+00	1122.00
IUUC-Pab-098110	Pongo abelii	96.92	0.00e+00	1366.00
IUUC-Pca-100266	Procavia capensis	84.19	0.00e+00	975.00
IUUC-Pva-102824	Pteropus vampyrus	93.97	0.00e+00	1334.00
IUUC-Pgr-103483	Puccinia graminis	37.28	3.00e-56	214.00
IUUC-Rno-105638	Rattus norvegicus	97.82	0.00e+00	1381.00
IUUC-Sha-107004	Sarcophilus harrisii	86.42	0.00e+00	1100.00
IUUC-Sre-115115	Sporisorium reilianum	34.37	4.00e-64	239.00
IUUC-Ssc-115280	Sus scrofa	96.92	0.00e+00	1372.00
IUUC-Tgu-116759	Taeniopygia guttata	87.07	0.00e+00	1123.00
IUUC-Tru-117944	Takifugu rubripes	72.91	0.00e+00	1045.00
IUUC-Tsy-119405	Tarsius syrichta	84.62	0.00e+00	1055.00
IUUC-Tni-120571	Tetraodon nigroviridis	72.22	0.00e+00	1052.00
IUUC-Uma-129659	Ustilago maydis	34.96	4.00e-64	239.00
IUUC-Vpa-130294	Vicugna pacos	95.58	0.00e+00	1251.00
IUUC-Xma-134233	Xiphophorus maculatus	68.10	0.00e+00	905.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence