iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	81.53	4.00e-118	421.00	IUUC-Hsa-046256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Protein Sequence
(Fasta)

MELERIVSSA LFAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFIEM 60
MEAYVPGFAH IHRGIIEDMV QTLSVQLSSA RNKETLRRPE KLKEESRPPA ATGNTQDEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACACAGGGT ACCTACACTT CATGGTGTTC CCTTACAACA CCCCCCCCCG GGGGGGGTGT 60
CGGCCGGACC CCTTTCTCTA ATTGTCTCCG TGGCCTGTAT GGAGGAACAT CTAGTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Gene Ontology

GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0010936--P:negative regulation of macrophage cytokine production

KEGG

rno:294009

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001790	Ailuropoda melanoleuca	82.52	4.00e-129	454.00
IUUC-Apl-003944	Anas platyrhynchos	54.26	3.00e-72	265.00
IUUC-Acl-008346	Aspergillus clavatus	31.67	3.00e+00	27.70
IUUC-Ang-009821	Aspergillus niger	38.60	4.30e-02	32.70
IUUC-Ame-011202	Astyanax mexicanus	45.45	2.00e-64	238.00
IUUC-Bta-012549	Bos taurus	70.13	1.00e-110	392.00
IUUC-Cja-019719	Callithrix jacchus	74.31	3.00e-113	401.00
IUUC-Cfa-021223	Canis familiaris	81.82	8.00e-129	452.00
IUUC-Cpo-021485	Cavia porcellus	76.84	5.00e-120	423.00
IUUC-Cre-022630	Chlamydomonas reinhardtii	63.64	2.50e-01	30.80
IUUC-Csa-023808	Chlorocebus sabaeus	79.09	3.00e-120	424.00
IUUC-Dre-027377	Danio rerio	42.71	1.00e-54	206.00
IUUC-Dno-029148	Dasypus novemcinctus	78.75	4.00e-123	434.00
IUUC-Dor-030884	Dipodomys ordii	78.54	4.00e-112	397.00
IUUC-Dme-031833	Drosophila melanogaster	29.77	3.00e-16	79.00
IUUC-Eca-033224	Equus caballus	81.53	2.00e-128	451.00
IUUC-Fca-036557	Felis catus	81.88	5.00e-128	450.00
IUUC-Fal-036631	Ficedula albicollis	54.39	6.00e-78	283.00
IUUC-Gmo-038930	Gadus morhua	44.18	3.00e-63	234.00
IUUC-Gga-041066	Gallus gallus	54.86	6.00e-76	276.00
IUUC-Gac-041736	Gasterosteus aculeatus	44.41	2.00e-62	232.00
IUUC-Ggo-045551	Gorilla gorilla	79.17	6.00e-120	423.00
IUUC-Hsa-046256	Homo sapiens	79.44	2.00e-121	428.00
IUUC-Itr-047925	Ictidomys tridecemlineatus	79.72	5.00e-126	443.00
IUUC-Lch-049728	Latimeria chalumnae	56.74	4.00e-43	166.00
IUUC-Loc-052375	Lepisosteus oculatus	43.84	1.00e-55	209.00
IUUC-Laf-054367	Loxodonta africana	78.67	1.00e-122	432.00
IUUC-Mcc-055535	Macaca mulatta	78.89	3.00e-121	427.00
IUUC-Meu-056716	Macropus eugenii	56.54	1.00e-82	299.00
IUUC-Mga-059259	Meleagris gallopavo	56.21	1.00e-76	279.00
IUUC-Mdo-062874	Monodelphis domestica	53.21	6.00e-53	200.00
IUUC-Mmu-063091	Mus musculus	84.21	7.00e-132	462.00
IUUC-Mpu-066538	Mustela putorius furo	82.23	5.00e-129	453.00
IUUC-Mlu-068118	Myotis lucifugus	82.17	9.00e-127	446.00
IUUC-Nle-069262	Nomascus leucogenys	79.44	2.00e-121	428.00
IUUC-Opr-070887	Ochotona princeps	78.32	9.00e-119	419.00
IUUC-Ont-072566	Oreochromis niloticus	46.32	4.00e-66	244.00
IUUC-Oan-073555	Ornithorhynchus anatinus	55.59	8.00e-82	296.00
IUUC-Ocu-073954	Oryctolagus cuniculus	80.14	4.00e-126	443.00
IUUC-Ola-087131	Oryzias latipes	42.51	1.00e-57	216.00
IUUC-Oga-088232	Otolemur garnettii	74.91	1.00e-112	398.00
IUUC-Oar-090288	Ovis aries	75.17	6.00e-113	399.00
IUUC-Ptr-091641	Pan troglodytes	79.44	2.00e-121	428.00
IUUC-Pan-092307	Papio anubis	79.25	1.00e-124	438.00
IUUC-Psi-093174	Pelodiscus sinensis	53.24	1.00e-61	229.00
IUUC-Pfo-096255	Poecilia formosa	45.96	1.00e-64	239.00
IUUC-Pab-098066	Pongo abelii	79.66	5.00e-124	436.00
IUUC-Pca-101113	Procavia capensis	76.57	5.00e-114	403.00
IUUC-Pva-102662	Pteropus vampyrus	76.84	4.00e-114	403.00
IUUC-Sha-107507	Sarcophilus harrisii	56.36	1.00e-86	312.00
IUUC-Spo-108252	Schizosaccharomyces pombe	25.17	9.00e-02	32.00
IUUC-Ssc-115243	Sus scrofa	56.94	2.00e-52	201.00
IUUC-Tgu-117106	Taeniopygia guttata	54.45	2.00e-73	268.00
IUUC-Tru-117992	Takifugu rubripes	45.99	4.00e-64	238.00
IUUC-Tni-120145	Tetraodon nigroviridis	43.29	1.00e-65	242.00
IUUC-Tbe-127268	Tupaia belangeri	78.15	1.00e-98	352.00
IUUC-Xtr-132299	Xenopus tropicalis	50.36	3.00e-74	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence