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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064294
UUCD1 version UUC-MuM-00863
Ensembl Protein ID ENSMUSP00000028696.4
UniProt Accession Q99J79; DDB2_MOUSE
Genbank Protein ID AAK16810.1
Protein Name DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
Genbank Nucleotide ID AY027937
Gene Name Ddb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000002109.14 ENSMUST00000028696.4 ENSMUSP00000028696.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.30e-11 43.2 252 275
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 7    tclafsdtllvsGsdDgtikvWDlrtg 33
            c++   +ll+++s D t+k+WDlr+ 
   Q: 252  PCCD---WLLATASIDQTVKIWDLRQI 275
           3444...5***************9975 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.
 Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.
Protein Sequence
(Fasta)
MAPKKCPETQ KSPDVAVLLR SKSRRGPQEL EPEAKKLRVQ GPVSSRTCES CCLLAELSSL 60
QIPSRSSSIV RDLYQHKLGK ATWSSLQQGL QKSFLHSLAS YQVFRKAAPF DRRTTSLAWH 120
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Protein Fasta Sequence


>IUUC-Mmu-064294|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
AAGTAAAGCA GCCCGGAGGA GCGTTTGGCG CGAAGGTGTC TTAGCTGCGC TACCTGCGAC 60
GGCGCTGCCT CATACGTAGT CCCTTCCTGT TTTCTCCACG GAGGCTTTTC CACTCCTTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064294|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0030054--C:cell junction
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035518--P:histone H2A monoubiquitination
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006290--P:pyrimidine dimer repair
GO:0009411--P:response to UV
GO:0070914--P:UV-damage excision repair
KEGG mmu:107986
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 30.09 1.00e-31 131.00
IUUC-Aml-002203 Ailuropoda melanoleuca 79.72 0.00e+00 695.00
IUUC-Atr-002957 Amborella trichopoda 31.76 1.00e-35 144.00
IUUC-Apl-003832 Anas platyrhynchos 59.29 5.00e-123 434.00
IUUC-Aca-004358 Anolis carolinensis 52.39 2.00e-125 442.00
IUUC-Aly-006296 Arabidopsis lyrata 31.21 7.00e-36 145.00
IUUC-Ath-007115 Arabidopsis thaliana 30.68 2.00e-37 150.00
IUUC-Ame-010817 Astyanax mexicanus 53.89 2.00e-119 422.00
IUUC-Bta-012914 Bos taurus 78.92 0.00e+00 704.00
IUUC-Bdi-014261 Brachypodium distachyon 30.32 3.00e-31 130.00
IUUC-Bol-015317 Brassica oleracea 31.69 4.00e-36 145.00
IUUC-Bra-016848 Brassica rapa 31.69 5.00e-36 145.00
IUUC-Cja-018967 Callithrix jacchus 77.99 0.00e+00 681.00
IUUC-Cfa-021238 Canis familiaris 81.04 0.00e+00 673.00
IUUC-Cpo-022063 Cavia porcellus 75.00 0.00e+00 678.00
IUUC-Csa-023382 Chlorocebus sabaeus 77.52 0.00e+00 701.00
IUUC-Cho-024805 Choloepus hoffmanni 57.56 1.00e-85 309.00
IUUC-Dre-028732 Danio rerio 48.76 2.00e-105 375.00
IUUC-Dor-030461 Dipodomys ordii 77.13 2.00e-120 425.00
IUUC-Ete-033038 Echinops telfairi 70.02 8.00e-180 623.00
IUUC-Eca-033772 Equus caballus 81.26 0.00e+00 679.00
IUUC-Eeu-034662 Erinaceus europaeus 57.50 6.00e-61 228.00
IUUC-Fca-036095 Felis catus 79.81 0.00e+00 676.00
IUUC-Gmo-039683 Gadus morhua 48.75 5.00e-103 367.00
IUUC-Gga-040530 Gallus gallus 59.24 3.00e-123 435.00
IUUC-Gac-041517 Gasterosteus aculeatus 48.77 8.00e-98 350.00
IUUC-Gma-043378 Glycine max 31.09 1.00e-38 154.00
IUUC-Ggo-045364 Gorilla gorilla 78.69 0.00e+00 710.00
IUUC-Hsa-046354 Homo sapiens 78.45 0.00e+00 709.00
IUUC-Hvu-047151 Hordeum vulgare 31.06 8.00e-28 117.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 82.82 0.00e+00 729.00
IUUC-Lpe-051256 Leersia perrieri 29.67 2.00e-30 127.00
IUUC-Loc-052398 Lepisosteus oculatus 57.34 9.00e-126 443.00
IUUC-Laf-053562 Loxodonta africana 79.86 0.00e+00 684.00
IUUC-Mcc-055197 Macaca mulatta 64.17 9.00e-155 539.00
IUUC-Meu-056151 Macropus eugenii 70.91 2.00e-112 398.00
IUUC-Mtr-057940 Medicago truncatula 29.45 3.00e-35 143.00
IUUC-Mga-059923 Meleagris gallopavo 59.24 8.00e-130 457.00
IUUC-Mmr-061465 Microcebus murinus 65.11 6.00e-152 530.00
IUUC-Mdo-063063 Monodelphis domestica 70.28 6.00e-152 530.00
IUUC-Mac-065598 Musa acuminata 31.04 2.00e-33 137.00
IUUC-Mpu-066831 Mustela putorius furo 79.95 0.00e+00 689.00
IUUC-Mlu-067222 Myotis lucifugus 77.12 0.00e+00 684.00
IUUC-Nle-069581 Nomascus leucogenys 78.45 0.00e+00 712.00
IUUC-Opr-070644 Ochotona princeps 76.17 0.00e+00 666.00
IUUC-Ont-072605 Oreochromis niloticus 48.46 1.00e-112 400.00
IUUC-Oan-072973 Ornithorhynchus anatinus 69.45 8.00e-148 516.00
IUUC-Ocu-074615 Oryctolagus cuniculus 78.22 0.00e+00 707.00
IUUC-Oba-075283 Oryza barthii 29.55 2.00e-30 127.00
IUUC-Obr-076605 Oryza brachyantha 30.21 6.00e-32 132.00
IUUC-Ogl-077512 Oryza glaberrima 29.55 2.00e-30 127.00
IUUC-Ogu-078329 Oryza glumaepatula 29.55 2.00e-30 127.00
IUUC-Oin-079980 Oryza indica 29.55 3.00e-30 126.00
IUUC-Olo-080516 Oryza longistaminata 29.94 3.00e-30 126.00
IUUC-Ome-081415 Oryza meridionalis 29.55 2.00e-30 127.00
IUUC-Oni-082985 Oryza nivara 29.55 3.00e-30 126.00
IUUC-Opu-084159 Oryza punctata 29.94 3.00e-30 126.00
IUUC-Oru-085137 Oryza rufipogon 29.55 1.00e-30 127.00
IUUC-Osa-085614 Oryza sativa 29.55 1.00e-30 127.00
IUUC-Ola-087044 Oryzias latipes 46.83 7.00e-103 367.00
IUUC-Oga-088274 Otolemur garnettii 80.09 0.00e+00 714.00
IUUC-Oar-089826 Ovis aries 79.16 0.00e+00 712.00
IUUC-Ptr-091631 Pan troglodytes 78.45 0.00e+00 709.00
IUUC-Pan-092535 Papio anubis 77.99 0.00e+00 706.00
IUUC-Psi-093815 Pelodiscus sinensis 53.05 2.00e-120 426.00
IUUC-Pma-094474 Petromyzon marinus 48.54 2.00e-97 348.00
IUUC-Ppa-095414 Physcomitrella patens 27.94 1.00e-27 118.00
IUUC-Pfo-096559 Poecilia formosa 45.99 9.00e-101 360.00
IUUC-Pab-098528 Pongo abelii 78.22 0.00e+00 709.00
IUUC-Pop-100064 Populus trichocarpa 29.91 2.00e-36 147.00
IUUC-Pca-100803 Procavia capensis 76.58 0.00e+00 666.00
IUUC-Ppe-101966 Prunus persica 30.70 2.00e-36 147.00
IUUC-Pva-103213 Pteropus vampyrus 79.16 0.00e+00 665.00
IUUC-Rno-105087 Rattus norvegicus 96.06 0.00e+00 837.00
IUUC-Sha-107466 Sarcophilus harrisii 70.42 2.00e-150 525.00
IUUC-Smo-108958 Selaginella moellendorffii 27.54 1.00e-26 114.00
IUUC-Sit-109968 Setaria italica 29.74 3.00e-29 123.00
IUUC-Sly-111495 Solanum lycopersicum 31.08 2.00e-35 144.00
IUUC-Stu-112182 Solanum tuberosum 28.76 7.00e-14 72.80
IUUC-Sar-113272 Sorex araneus 77.29 3.00e-162 563.00
IUUC-Sbi-114706 Sorghum bicolor 28.45 3.00e-27 116.00
IUUC-Ssc-115437 Sus scrofa 78.69 0.00e+00 697.00
IUUC-Tgu-116602 Taeniopygia guttata 58.24 1.00e-122 433.00
IUUC-Tru-118698 Takifugu rubripes 47.96 1.00e-94 340.00
IUUC-Tsy-119027 Tarsius syrichta 75.00 3.00e-176 610.00
IUUC-Tni-119787 Tetraodon nigroviridis 48.04 1.00e-100 360.00
IUUC-Tca-121447 Theobroma cacao 30.00 3.00e-36 146.00
IUUC-Tae-125839 Triticum aestivum 30.40 4.00e-32 132.00
IUUC-Tur-126724 Triticum urartu 30.40 5.00e-32 132.00
IUUC-Tbe-127680 Tupaia belangeri 79.64 2.00e-130 458.00
IUUC-Ttr-128201 Tursiops truncatus 69.32 1.00e-167 582.00
IUUC-Vpa-130451 Vicugna pacos 63.37 3.00e-97 348.00
IUUC-Vvi-131001 Vitis vinifera 30.41 5.00e-37 149.00
IUUC-Xtr-132266 Xenopus tropicalis 55.58 2.00e-127 449.00
IUUC-Xma-133034 Xiphophorus maculatus 50.00 1.00e-112 399.00
Created Date 25-Jun-2017

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