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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045937
UUCD1 version UUC-HoS-01086
Ensembl Protein ID ENSP00000260187.2
UniProt Accession O75604; B0YJB8; E9PPM2; Q8IUM2; Q8IW04; Q96MB9; Q9BQ21; UBP2_HUMAN
Genbank Protein ID AAC28392.1; AAN65363.1; BAB71388.1; BAF84944.1; ACA06096.1; ACA06097.1; EAW67484.1; EAW67485.1; EAW67486.1; AAH02854.1; AAH02955.1; AAH41366.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Genbank Nucleotide ID AF079564; AF440755; AK057225; AK292255; EF445044; EF445044; AP003396; CH471065; CH471065; BC002854; BC002955; BC041366
Gene Name USP2; UBP41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000036672.15 ENST00000455332.6 ENSP00000407842.2
ENSG00000036672.15 ENST00000260187.6 ENSP00000260187.2
ENSG00000036672.15 ENST00000525735.1 ENSP00000436952.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 20622874
Classification
Family E-value Score Start End
DUB/USP 7.90e-98 329.4 268 597
Active Site
Position(s) Description Evidence
276 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
557 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqD 91
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l++   ++ +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+qqD
   Q: 268  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYMRDLHHG--SNAHTALVEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFVGYNQQD 357
           9*****************************7778888776..67999**************889999************************* PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           aqEfl+flld+l++e+++ +  pk++ e+ d+  l+d+      ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dlslp+ +
   Q: 358  AQEFLRFLLDGLHNEVNRVTLRPKSNPENLDH--LPDDekgrqMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAK 447
           ****************9944444444444442..2222335559************************************************ PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspe 269
           +    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k+++ v+fpl+ Ldl++f ++++
   Q: 448  RGYP-EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRF--SESRIRTSKLTTFVNFPLRdLDLREFASENT 536
           9976.779***************************************************..88899***********************955 PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+Vt+++ ++v +   s+aY+lfY+
   Q: 537  N----HAVYNLYAVSNHSGTTMGGHYTAYCRSpGTGEWHTFNDSSVTPMSSSQVRT---SDAYLLFYE 597
           3....78*************************44555*******************...********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Protein Sequence
(Fasta)
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL 60
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045937|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGACGCGA GACGCGGGGT GTGGCTCTGC CGGCCCAGGC GCGATGAGGC GGCTGCCCGC 60
TGGGTGGCGC CGATTTCCCG GGGAGGTCCC TTCTGGGCCC CCGGCGGAGG TGGGAGAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045937|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0517--Myogenesis
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0030332--F:cyclin binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0048512--P:circadian behavior
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9099
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001988 Ailuropoda melanoleuca 92.08 0.00e+00 1061.00
IUUC-Aca-005132 Anolis carolinensis 60.58 0.00e+00 671.00
IUUC-Ame-011102 Astyanax mexicanus 74.64 2.00e-144 505.00
IUUC-Bta-012529 Bos taurus 89.11 0.00e+00 991.00
IUUC-Bra-016678 Brassica rapa 35.76 6.00e-47 181.00
IUUC-Cja-019016 Callithrix jacchus 93.11 0.00e+00 1075.00
IUUC-Cfa-020714 Canis familiaris 92.41 0.00e+00 1091.00
IUUC-Cpo-021727 Cavia porcellus 87.62 0.00e+00 997.00
IUUC-Csa-023071 Chlorocebus sabaeus 99.42 0.00e+00 691.00
IUUC-Cin-025797 Ciona intestinalis 50.14 2.00e-94 338.00
IUUC-Csv-026132 Ciona savignyi 50.43 3.00e-97 348.00
IUUC-Dre-027872 Danio rerio 80.94 5.00e-162 563.00
IUUC-Dno-029329 Dasypus novemcinctus 89.93 0.00e+00 1033.00
IUUC-Dor-030574 Dipodomys ordii 90.43 0.00e+00 1022.00
IUUC-Dme-032208 Drosophila melanogaster 46.35 7.00e-82 298.00
IUUC-Ete-032725 Echinops telfairi 78.93 7.00e-168 583.00
IUUC-Eca-033361 Equus caballus 93.40 0.00e+00 1079.00
IUUC-Eeu-035272 Erinaceus europaeus 77.34 0.00e+00 684.00
IUUC-Fca-036497 Felis catus 93.23 0.00e+00 1078.00
IUUC-Fal-036766 Ficedula albicollis 63.18 0.00e+00 675.00
IUUC-Gmo-039129 Gadus morhua 62.00 2.00e-122 432.00
IUUC-Gga-040889 Gallus gallus 83.39 2.00e-146 512.00
IUUC-Gac-042475 Gasterosteus aculeatus 69.25 8.00e-136 476.00
IUUC-Ggo-044814 Gorilla gorilla 94.54 0.00e+00 627.00
IUUC-Itr-048171 Ictidomys tridecemlineatus 90.85 0.00e+00 1075.00
IUUC-Lch-050527 Latimeria chalumnae 60.11 2.00e-176 612.00
IUUC-Loc-052697 Lepisosteus oculatus 78.57 5.00e-161 561.00
IUUC-Laf-054167 Loxodonta africana 86.02 0.00e+00 996.00
IUUC-Mcc-055584 Macaca mulatta 96.69 0.00e+00 1129.00
IUUC-Meu-056542 Macropus eugenii 84.02 0.00e+00 926.00
IUUC-Mga-060020 Meleagris gallopavo 59.23 0.00e+00 628.00
IUUC-Mmr-060989 Microcebus murinus 93.56 0.00e+00 1079.00
IUUC-Mdo-062761 Monodelphis domestica 84.68 0.00e+00 935.00
IUUC-Mmu-063710 Mus musculus 88.05 0.00e+00 1019.00
IUUC-Mpu-066573 Mustela putorius furo 92.90 0.00e+00 1075.00
IUUC-Nle-070013 Nomascus leucogenys 97.57 0.00e+00 1079.00
IUUC-Opr-070907 Ochotona princeps 89.13 0.00e+00 993.00
IUUC-Ont-071944 Oreochromis niloticus 81.27 1.00e-163 569.00
IUUC-Oan-073105 Ornithorhynchus anatinus 78.47 2.00e-147 514.00
IUUC-Ocu-073941 Oryctolagus cuniculus 91.27 0.00e+00 1042.00
IUUC-Ola-087412 Oryzias latipes 69.32 4.00e-154 538.00
IUUC-Oga-088973 Otolemur garnettii 93.23 0.00e+00 1079.00
IUUC-Oar-089916 Ovis aries 89.77 0.00e+00 1035.00
IUUC-Ptr-090998 Pan troglodytes 99.34 0.00e+00 1116.00
IUUC-Pan-092686 Papio anubis 96.86 0.00e+00 1131.00
IUUC-Psi-093284 Pelodiscus sinensis 70.44 3.00e-122 431.00
IUUC-Pma-094462 Petromyzon marinus 64.71 5.00e-74 270.00
IUUC-Pno-094986 Phaeosphaeria nodorum 32.42 7.00e-40 159.00
IUUC-Pfo-097352 Poecilia formosa 78.65 7.00e-168 583.00
IUUC-Pab-098688 Pongo abelii 90.91 0.00e+00 991.00
IUUC-Pca-100205 Procavia capensis 92.80 0.00e+00 637.00
IUUC-Pva-103188 Pteropus vampyrus 91.91 0.00e+00 1029.00
IUUC-Pte-104348 Pyrenophora teres 33.04 2.00e-39 158.00
IUUC-Rno-105853 Rattus norvegicus 89.32 0.00e+00 1066.00
IUUC-Sha-107237 Sarcophilus harrisii 84.02 0.00e+00 926.00
IUUC-Sar-113103 Sorex araneus 91.35 0.00e+00 625.00
IUUC-Ssc-115955 Sus scrofa 91.58 0.00e+00 1054.00
IUUC-Tgu-116894 Taeniopygia guttata 69.25 5.00e-177 613.00
IUUC-Tru-117703 Takifugu rubripes 65.79 1.00e-132 466.00
IUUC-Tsy-118879 Tarsius syrichta 95.96 0.00e+00 835.00
IUUC-Tni-119866 Tetraodon nigroviridis 77.99 1.00e-152 532.00
IUUC-Tbe-127367 Tupaia belangeri 82.31 0.00e+00 645.00
IUUC-Ttr-128773 Tursiops truncatus 88.78 0.00e+00 1036.00
IUUC-Vpa-130402 Vicugna pacos 81.75 0.00e+00 776.00
IUUC-Xtr-132658 Xenopus tropicalis 56.15 2.00e-176 612.00
Created Date 25-Jun-2017

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