iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000023456.6	ENSRNOT00000090689.1	ENSRNOP00000073126.1
ENSRNOG00000023456.6	ENSRNOT00000029778.4	ENSRNOP00000034376.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.40e-06	28.7	12	69
E3 activity/RING/RING	4.00e-06	27.6	18	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99998887764 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDSLM SHLSDCEHNP KRPVTCEQGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTAGCAGC AGTGGGCGTG GTCAAGGGCT AGCTCGAGAA GGCGAGGAGT GGTCGGAACC 60
TTCTTCTCCA TCCTTCTCTT CCCCTTCCCC TACGGGGAAA GGTTGAGACC CGGTACGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0031386--F:protein tag
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	99.37	0.00e+00	658.00
IUUC-Apl-003568	Anas platyrhynchos	95.91	0.00e+00	631.00
IUUC-Aca-005119	Anolis carolinensis	96.53	0.00e+00	643.00
IUUC-Ame-010708	Astyanax mexicanus	91.17	3.00e-179	620.00
IUUC-Bta-013428	Bos taurus	93.38	3.00e-178	617.00
IUUC-Cja-019844	Callithrix jacchus	99.37	0.00e+00	654.00
IUUC-Cfa-021124	Canis familiaris	99.68	0.00e+00	659.00
IUUC-Cpo-022325	Cavia porcellus	99.37	0.00e+00	657.00
IUUC-Csa-023113	Chlorocebus sabaeus	99.68	0.00e+00	659.00
IUUC-Cho-024991	Choloepus hoffmanni	98.97	8.00e-114	402.00
IUUC-Cne-026870	Cryptococcus neoformans	38.52	4.00e-20	93.20
IUUC-Dre-028730	Danio rerio	90.85	6.00e-179	619.00
IUUC-Dno-028908	Dasypus novemcinctus	99.30	2.00e-171	594.00
IUUC-Dor-030411	Dipodomys ordii	99.37	0.00e+00	659.00
IUUC-Dse-031478	Dothistroma septosporum	30.10	3.00e-09	57.00
IUUC-Dme-031868	Drosophila melanogaster	57.46	3.00e-111	394.00
IUUC-Ete-032896	Echinops telfairi	81.13	1.00e-124	438.00
IUUC-Eca-034135	Equus caballus	99.68	0.00e+00	659.00
IUUC-Eeu-034675	Erinaceus europaeus	99.37	0.00e+00	657.00
IUUC-Fca-035612	Felis catus	99.68	0.00e+00	659.00
IUUC-Fal-036922	Ficedula albicollis	98.77	1.00e-42	164.00
IUUC-Gmo-039648	Gadus morhua	87.70	2.00e-172	597.00
IUUC-Gga-040474	Gallus gallus	96.85	0.00e+00	644.00
IUUC-Gac-041951	Gasterosteus aculeatus	88.96	2.00e-175	607.00
IUUC-Ggo-045126	Gorilla gorilla	99.37	0.00e+00	654.00
IUUC-Hsa-046402	Homo sapiens	99.68	0.00e+00	659.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	99.68	0.00e+00	659.00
IUUC-Lch-050266	Latimeria chalumnae	93.69	0.00e+00	631.00
IUUC-Loc-052547	Lepisosteus oculatus	92.11	4.00e-180	623.00
IUUC-Laf-054332	Loxodonta africana	99.06	0.00e+00	654.00
IUUC-Mcc-055869	Macaca mulatta	99.68	0.00e+00	659.00
IUUC-Meu-056735	Macropus eugenii	99.65	7.00e-172	595.00
IUUC-Mla-059113	Melampsora laricipopulina	30.10	1.00e-08	54.30
IUUC-Mga-060100	Meleagris gallopavo	96.85	0.00e+00	644.00
IUUC-Mmr-061382	Microcebus murinus	99.68	0.00e+00	659.00
IUUC-Mmu-064225	Mus musculus	99.37	0.00e+00	658.00
IUUC-Mpu-066709	Mustela putorius furo	99.68	0.00e+00	659.00
IUUC-Mlu-067168	Myotis lucifugus	98.74	0.00e+00	656.00
IUUC-Nle-070176	Nomascus leucogenys	99.68	0.00e+00	659.00
IUUC-Opr-070259	Ochotona princeps	99.37	0.00e+00	658.00
IUUC-Ont-071235	Oreochromis niloticus	90.22	9.00e-178	615.00
IUUC-Oan-072850	Ornithorhynchus anatinus	96.05	8.00e-84	303.00
IUUC-Ocu-074165	Oryctolagus cuniculus	99.37	0.00e+00	658.00
IUUC-Ola-086658	Oryzias latipes	88.64	9.00e-174	602.00
IUUC-Oga-088933	Otolemur garnettii	99.68	0.00e+00	659.00
IUUC-Oar-090089	Ovis aries	99.37	0.00e+00	659.00
IUUC-Ptr-091263	Pan troglodytes	99.68	0.00e+00	659.00
IUUC-Pan-092926	Papio anubis	99.68	0.00e+00	659.00
IUUC-Psi-093934	Pelodiscus sinensis	89.31	6.00e-168	583.00
IUUC-Pma-094578	Petromyzon marinus	68.97	4.00e-127	447.00
IUUC-Pno-094854	Phaeosphaeria nodorum	35.77	6.00e-13	68.90
IUUC-Pfo-097431	Poecilia formosa	90.22	3.00e-177	613.00
IUUC-Pab-097852	Pongo abelii	99.68	0.00e+00	659.00
IUUC-Pca-100496	Procavia capensis	91.19	1.00e-168	585.00
IUUC-Pva-103157	Pteropus vampyrus	98.50	3.00e-116	410.00
IUUC-Pgr-103416	Puccinia graminis	32.04	2.00e-13	70.50
IUUC-Pyt-104429	Pyrenophora triticirepentis	36.70	4.00e-12	65.90
IUUC-Sha-107556	Sarcophilus harrisii	99.06	0.00e+00	652.00
IUUC-Sar-113208	Sorex araneus	99.68	0.00e+00	659.00
IUUC-Ssc-116011	Sus scrofa	99.37	0.00e+00	659.00
IUUC-Tgu-116882	Taeniopygia guttata	75.00	1.00e-73	268.00
IUUC-Tru-117987	Takifugu rubripes	89.91	6.00e-177	612.00
IUUC-Tsy-118785	Tarsius syrichta	99.37	0.00e+00	652.00
IUUC-Tni-120165	Tetraodon nigroviridis	89.59	2.00e-176	611.00
IUUC-Tbe-127920	Tupaia belangeri	99.00	3.00e-118	417.00
IUUC-Ttr-129160	Tursiops truncatus	99.05	0.00e+00	657.00
IUUC-Vpa-130629	Vicugna pacos	99.68	0.00e+00	659.00
IUUC-Xtr-131895	Xenopus tropicalis	94.95	0.00e+00	634.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence