iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045986

UUCD1 version

UUC-HoS-00271

Ensembl Protein ID

ENSP00000311202.5

UniProt Accession

Q8WZ19; A8K0R5; Q96P93; Q96SA1; BACD1_HUMAN

Genbank Protein ID

AAL14962.2; AAK27301.1; AAL55757.1; BAF82319.1; EAW79969.1; AAH36228.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; Polymerase delta-interacting protein 1; TNFAIP1-like protein

Genbank Nucleotide ID

AF401315; AY027918; AF289573; AK289630; AC120114; BC036228

Gene Name

KCTD13; BACURD1; PDIP1; POLDIP1; FKSG86; PP6832

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174943.9	ENST00000308768.9	ENSP00000311202.5
ENSG00000174943.9	ENST00000566842.5	ENSP00000459104.1
ENSG00000174943.9	ENST00000568995.1	ENSP00000454282.1
ENSG00000174943.9	ENST00000566413.1	ENSP00000460526.1
ENSG00000174943.9	ENST00000561540.1	ENSP00000458486.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	19782033

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.90e-06	29.2	43	109

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 3    vilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           v l+vgg+   ++  +L+ +  +++a+f++  e  ++ ++ v i+ ++  +f ++l++l+ g+++++e
   Q: 43   VKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEvLTDAGGWVLID-RSGRHFGTILNYLRDGSVPLPE 109
           99********************************9999******9.******************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.

Protein Sequence
(Fasta)

MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS LHYTTLRTLT 60
GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL RDGSVPLPES TRELGELLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGATTGGGT GCTAGGTCCC ACGACATTAG CTGGGATTCT AAGACCTTTG CTCAGCTGCT 60
GCGGCCACCA CTGACACGCC CTCTGCTCCT CAAATACGGA GAACAGTTCA GTGTTCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0017049--F:GTP-Rho binding
GO:0042802--F:identical protein binding
GO:0016477--P:cell migration
GO:0006260--P:DNA replication
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045740--P:positive regulation of DNA replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0043149--P:stress fiber assembly

KEGG

hsa:253980

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001238	Ailuropoda melanoleuca	98.06	5.00e-158	550.00
IUUC-Aca-004311	Anolis carolinensis	80.20	5.00e-134	470.00
IUUC-Bta-012415	Bos taurus	96.13	6.00e-160	556.00
IUUC-Cja-019451	Callithrix jacchus	98.71	4.00e-159	553.00
IUUC-Cfa-020804	Canis familiaris	97.39	4.00e-160	557.00
IUUC-Cpo-022466	Cavia porcellus	97.24	6.00e-142	496.00
IUUC-Csa-023225	Chlorocebus sabaeus	99.67	2.00e-159	554.00
IUUC-Cho-024629	Choloepus hoffmanni	77.16	9.00e-100	356.00
IUUC-Dno-028944	Dasypus novemcinctus	98.39	6.00e-156	543.00
IUUC-Ete-032820	Echinops telfairi	82.58	7.00e-118	416.00
IUUC-Eca-034400	Equus caballus	97.61	5.00e-146	509.00
IUUC-Eeu-034457	Erinaceus europaeus	93.81	1.00e-137	482.00
IUUC-Fca-035698	Felis catus	98.37	2.00e-155	541.00
IUUC-Ggo-044675	Gorilla gorilla	99.35	3.00e-160	557.00
IUUC-Itr-048073	Ictidomys tridecemlineatus	97.74	2.00e-154	538.00
IUUC-Lch-049441	Latimeria chalumnae	78.96	1.00e-134	473.00
IUUC-Laf-053592	Loxodonta africana	97.10	3.00e-155	540.00
IUUC-Mcc-054864	Macaca mulatta	99.62	9.00e-134	469.00
IUUC-Mdo-062807	Monodelphis domestica	94.31	2.00e-137	481.00
IUUC-Mmu-064250	Mus musculus	97.31	5.00e-145	506.00
IUUC-Mpu-066138	Mustela putorius furo	97.98	3.00e-126	444.00
IUUC-Mlu-067108	Myotis lucifugus	96.81	1.00e-138	485.00
IUUC-Nle-069621	Nomascus leucogenys	100.00	4.00e-160	556.00
IUUC-Opr-070867	Ochotona princeps	94.85	4.00e-127	447.00
IUUC-Ocu-074347	Oryctolagus cuniculus	97.72	1.00e-157	548.00
IUUC-Oga-087959	Otolemur garnettii	97.73	6.00e-154	536.00
IUUC-Oar-089835	Ovis aries	96.77	6.00e-154	536.00
IUUC-Ptr-090744	Pan troglodytes	100.00	4.00e-160	556.00
IUUC-Pan-092607	Papio anubis	99.67	2.00e-159	554.00
IUUC-Psi-093501	Pelodiscus sinensis	82.96	5.00e-137	480.00
IUUC-Pab-098026	Pongo abelii	99.02	1.00e-158	552.00
IUUC-Pca-100340	Procavia capensis	94.84	4.00e-154	537.00
IUUC-Pva-102916	Pteropus vampyrus	97.10	2.00e-158	551.00
IUUC-Rno-105757	Rattus norvegicus	96.12	4.00e-150	523.00
IUUC-Sha-107042	Sarcophilus harrisii	94.33	7.00e-138	483.00
IUUC-Sar-113695	Sorex araneus	96.98	3.00e-132	464.00
IUUC-Tsy-119307	Tarsius syrichta	79.35	1.00e-89	322.00
IUUC-Ttr-128588	Tursiops truncatus	98.38	5.00e-120	423.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence