iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045803

UUCD1 version

UUC-HoS-01090

Ensembl Protein ID

ENSP00000460380.1

UniProt Accession

P35125; Q15634; Q86WP6; Q8IWT4; UBP6_HUMAN

Genbank Protein ID

CAA45108.1; CAA45111.1; AAN38838.1; AAO21348.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Proto-oncogene TRE-2; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6

Genbank Nucleotide ID

X63546; X63547; AY143550; AY163314

Gene Name

USP6; HRP1; TRE2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000129204.16	ENST00000574788.5	ENSP00000460380.1
ENSG00000129204.16	ENST00000575709.5	ENSP00000461817.1
ENSG00000129204.16	ENST00000572949.5	ENSP00000461581.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20418905

Classification

Family	E-value	Score	Start	End
DUB/USP	5.00e-105	353.1	532	1369

Active Site

Position(s)	Description	Evidence
541	Nucleophile
1328	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl+NlgNtC+mNS +Qc sn+++l++++ + ++  +ln++np ++kg+++k++ +l++elw++++k+v+p +l ++++k+a++f+g++q
   Q: 532  TGLSNLGNTCFMNSSIQCVSNTQPLTQYFISgRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQ 621
           7******************************9********************************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qD+qE+laflld+l+e+l++ ++kp+ e++++d   ++d+     a++++ ++n+s+i+dlF+gql+sq+kc++c+++s+r++pf+ lsl
   Q: 622  QDSQELLAFLLDGLHEDLNRVHEKPYVELKDSD--GRPDWevaaeAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 709
           *****************************9999..6666666777********************************************* PP
   S: 175  pvpgkeetkke............................................................................... 185
           p+p+++ +++e                                                                               
   Q: 710  PLPMDSYMDLEitvikldgttpvryglrlnmdekytglkkqlrdlcglnseqillaevhdsniknfpqdnqkvqlsvsgflcafeipvps 799
           ******99999******************************************************************************* PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 800  spisassptqidfssspstngmftlttngdlpkpifipngmpntvvpcgteknftngmvnghmpslpdspftgyiiavhrkmmrtelyfl 889
           ****************************************************************************************** PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 890  spqenrpslfgmplivpctvhtrkkdlydavwiqvswlarplppqeasihaqdrdncmgyqypftlrvvqkdgnscawcpqyrfcrgcki 979
           ****************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
                                                               +l++cL++ft+eeel ++++yyc+kck ++ a+kkl+l
   Q: 980  dcgedrafignayiavdwhptalhlryqtsqervvdkhesveqsrraqaepiNLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDL 1069
           ****************************************************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts............................................. 267
           ++lP++Li+hLkRf+f ++q+   k +k v f +e +d s f++                                              
   Q: 1070 WRLPPFLIIHLKRFQFVNDQWI--KSQKIVRFLREsFDPSAFLVPrdpalcqhkpltpqgdelskprilarevkkvdaqssagkedmlls 1157
           ***************9998776..89******9999*******99999999999999999999999999999999999999999999999 PP
   S: 268  .................................................................peekqke.................. 274
                                                                            +     +                  
   Q: 1158 kspsslsanissspkgspsssrksgtscpssknsspnssprtlgrskgrlrlpqigsknkpssskK-----Nldaskengagqicelada 1242
           998888888888888888888888888877777777777777777777777766666666555550.....1555555555556666666 PP
   S: 275  ..................................................................kkkYeLiavvvHsGslssGHYvay 298
                                                                             k +Y+L+a+ +HsG ls+GHY++y
   Q: 1243 lsrghmrggsqpelvtpqdhevalangflyeheacgngcgdgysngqlgnhseedstddqredthiKPIYNLYAISCHSGILSGGHYITY 1332
           666666666666666666666666666666666666666666666666666666677777778888************************ PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +kn + kW++++Ds+++e++ +e+ +   ++aY+lfY+++
   Q: 1333 AKNPNCKWYCYNDSSCEELHPDEIDT---DSAYILFYEQQ 1369
           **************************...********985 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Protein Sequence
(Fasta)

MDMVENADSL QAQERKDILM KYDKGHRAGL PEDKGPEPVG INSSIDRFGI LHETELPPVT 60
AREAKKIRRE MTRTSKWMEM LGEWETYKHS SKLIDRVYKG IPMNIRGPVW SVLLNIQEIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCCGTCT CGTGTGGTGT CTGAGGGGCG TCTACCTGGA GTCACTGAGC CGACGAAAGG 60
GAAAAGGCCA GTGCCTGTCC GGGAAGAGCT CAGCCTAGTG GGGCGGGCGA CAAGTTACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0621--Polymorphism
KW-0645--Protease
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR000195--Rab-GTPase-TBC_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50086--TBC_RABGAP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00566--RabGAP-TBC
PF00443--UCH

SMART

SM00164--TBC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005764--C:lysosome
GO:0005886--C:plasma membrane
GO:0055037--C:recycling endosome
GO:0005516--F:calmodulin binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0005096--F:GTPase activator activity
GO:0003676--F:nucleic acid binding
GO:0017137--F:Rab GTPase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0090630--P:activation of GTPase activity
GO:0006464--P:cellular protein modification process
GO:0006886--P:intracellular protein transport
GO:0016579--P:protein deubiquitination
GO:0031338--P:regulation of vesicle fusion
GO:0060627--P:regulation of vesicle-mediated transport
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:9098

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ggo-045453	Gorilla gorilla	84.02	0.00e+00	2126.00
IUUC-Ptr-090817	Pan troglodytes	97.87	0.00e+00	2725.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence