iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063379

Ensembl Protein ID

ENSMUSP00000047825.5

UniProt Accession

Q8VC51; WAP53_MOUSE

Genbank Protein ID

CAI52013.1; AAH21790.1; AAH69868.1

Protein Name

Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene

Genbank Nucleotide ID

AL731687; BC021790; BC069868

Gene Name

Wrap53; Tcab1; Wdr79

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000041346.11	ENSMUST00000048139.11	ENSMUSP00000047825.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.80e-21	74.8	349	383

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs.dDgtikvWDlrt 32
           gH++++t l+f +d +l+ sG+  D  + +WDlr+
   Q: 349  GHQGGITHLCFhPDgNLFFSGArKDAELLCWDLRQ 383
           8***********999*******88899*****997 PP

Organism

Mus musculus

Functional Description
(View)

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage (By similarity).

Protein Sequence
(Fasta)

MKTSEERLLA PDSLPPDLAP APVPQGSPAE KNTDFEPVPP PCGGDDQPQL ATDPVASLVV 60
SQELQQGDSV PLEVEFNTSS ELSPGIEEQD VSEHASLPGE ETNLPELESG EATEGVSEER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGACTT GCAGAGTCAG GATTCTCCCT GAGATGTTGC CCTCAGCAGG AACGCTTTGT 60
GAAAAGTCGT CTAAGATATA GAGCTGTGAG GGCAAAATGG GTGGAAACCG ATTCGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015030--C:Cajal body
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005697--C:telomerase holoenzyme complex
GO:0051087--F:chaperone binding
GO:0032403--F:protein complex binding
GO:0003723--F:RNA binding
GO:0070034--F:telomerase RNA binding
GO:0070200--P:establishment of protein localization to telomere
GO:1904851--P:positive regulation of establishment of protein localization to telomere
GO:0051973--P:positive regulation of telomerase activity
GO:0032212--P:positive regulation of telomere maintenance via telomerase
GO:0090666--P:scaRNA localization to Cajal body
GO:0090671--P:telomerase RNA localization to Cajal body
GO:0032203--P:telomere formation via telomerase

KEGG

mmu:216853

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000305	Aegilops tauschii	43.96	4.00e-66	244.00
IUUC-Aml-001893	Ailuropoda melanoleuca	76.40	0.00e+00	764.00
IUUC-Atr-002472	Amborella trichopoda	40.05	2.00e-72	266.00
IUUC-Aca-004937	Anolis carolinensis	67.45	5.00e-137	480.00
IUUC-Aly-006492	Arabidopsis lyrata	42.60	2.00e-77	283.00
IUUC-Ath-006592	Arabidopsis thaliana	42.73	9.00e-78	284.00
IUUC-Acl-008296	Aspergillus clavatus	27.98	1.00e-15	76.60
IUUC-Ani-009149	Aspergillus nidulans	27.76	3.00e-28	119.00
IUUC-Aor-009938	Aspergillus oryzae	27.81	2.00e-23	103.00
IUUC-Ate-010481	Aspergillus terreus	29.60	3.00e-30	125.00
IUUC-Ame-011296	Astyanax mexicanus	68.31	1.00e-132	466.00
IUUC-Bgr-012232	Blumeria graminis	26.05	1.00e-16	80.90
IUUC-Bta-012362	Bos taurus	78.42	0.00e+00	799.00
IUUC-Bdi-014971	Brachypodium distachyon	43.37	4.00e-78	285.00
IUUC-Bol-016557	Brassica oleracea	41.99	8.00e-77	280.00
IUUC-Bra-016734	Brassica rapa	41.09	7.00e-76	277.00
IUUC-Cja-019681	Callithrix jacchus	76.32	0.00e+00	763.00
IUUC-Cfa-020148	Canis familiaris	81.49	0.00e+00	717.00
IUUC-Cpo-022128	Cavia porcellus	85.61	0.00e+00	699.00
IUUC-Cre-022680	Chlamydomonas reinhardtii	44.41	7.00e-71	260.00
IUUC-Csa-023779	Chlorocebus sabaeus	81.76	0.00e+00	746.00
IUUC-Cin-025318	Ciona intestinalis	41.78	1.00e-66	247.00
IUUC-Cne-026778	Cryptococcus neoformans	33.14	2.00e-39	156.00
IUUC-Dre-027809	Danio rerio	53.68	7.00e-140	490.00
IUUC-Dno-028896	Dasypus novemcinctus	86.42	1.00e-160	558.00
IUUC-Dor-030656	Dipodomys ordii	71.67	0.00e+00	632.00
IUUC-Dme-031828	Drosophila melanogaster	37.03	4.00e-63	235.00
IUUC-Eca-033305	Equus caballus	87.03	0.00e+00	700.00
IUUC-Eeu-034936	Erinaceus europaeus	79.90	4.00e-89	322.00
IUUC-Fca-036371	Felis catus	78.21	0.00e+00	738.00
IUUC-Gmo-039283	Gadus morhua	64.78	9.00e-89	319.00
IUUC-Gac-042297	Gasterosteus aculeatus	69.00	2.00e-93	335.00
IUUC-Gma-044331	Glycine max	41.54	5.00e-73	268.00
IUUC-Ggo-044938	Gorilla gorilla	76.78	0.00e+00	754.00
IUUC-Hsa-046795	Homo sapiens	76.59	0.00e+00	760.00
IUUC-Itr-048964	Ictidomys tridecemlineatus	79.70	0.00e+00	824.00
IUUC-Lch-050551	Latimeria chalumnae	53.82	4.00e-90	325.00
IUUC-Lpe-051458	Leersia perrieri	40.23	2.00e-71	263.00
IUUC-Loc-052833	Lepisosteus oculatus	69.21	5.00e-128	451.00
IUUC-Laf-054404	Loxodonta africana	76.00	0.00e+00	729.00
IUUC-Mcc-055500	Macaca mulatta	80.38	0.00e+00	754.00
IUUC-Meu-056062	Macropus eugenii	81.44	2.00e-36	146.00
IUUC-Mtr-058157	Medicago truncatula	43.37	1.00e-77	283.00
IUUC-Mla-058898	Melampsora laricipopulina	28.81	6.00e-31	127.00
IUUC-Mvi-060351	Microbotryum violaceum	28.70	9.00e-38	150.00
IUUC-Mmr-061204	Microcebus murinus	80.87	0.00e+00	804.00
IUUC-Mdo-062997	Monodelphis domestica	77.08	4.00e-151	527.00
IUUC-Mac-065509	Musa acuminata	40.91	7.00e-77	283.00
IUUC-Mpu-066898	Mustela putorius furo	80.67	0.00e+00	694.00
IUUC-Mlu-067405	Myotis lucifugus	85.56	0.00e+00	639.00
IUUC-Nle-069679	Nomascus leucogenys	67.79	0.00e+00	627.00
IUUC-Opr-070544	Ochotona princeps	72.89	9.00e-89	320.00
IUUC-Oan-073233	Ornithorhynchus anatinus	60.98	5.00e-86	310.00
IUUC-Ocu-074700	Oryctolagus cuniculus	87.08	0.00e+00	682.00
IUUC-Oba-075164	Oryza barthii	38.95	1.00e-72	270.00
IUUC-Ogl-077700	Oryza glaberrima	43.38	3.00e-78	288.00
IUUC-Ogu-078612	Oryza glumaepatula	35.53	5.00e-49	191.00
IUUC-Oin-079494	Oryza indica	43.38	1.00e-78	286.00
IUUC-Olo-081051	Oryza longistaminata	43.70	2.00e-68	252.00
IUUC-Ome-081868	Oryza meridionalis	36.00	3.00e-55	212.00
IUUC-Oni-082904	Oryza nivara	43.38	1.00e-78	290.00
IUUC-Opu-084082	Oryza punctata	43.08	4.00e-78	288.00
IUUC-Oru-084683	Oryza rufipogon	43.38	6.00e-79	287.00
IUUC-Osa-085518	Oryza sativa	43.38	2.00e-78	286.00
IUUC-Ola-086492	Oryzias latipes	62.10	3.00e-41	160.00
IUUC-Oga-088207	Otolemur garnettii	78.67	0.00e+00	799.00
IUUC-Oar-089463	Ovis aries	78.81	0.00e+00	785.00
IUUC-Ptr-090994	Pan troglodytes	76.78	0.00e+00	766.00
IUUC-Pan-091793	Papio anubis	81.00	0.00e+00	742.00
IUUC-Psi-093816	Pelodiscus sinensis	60.70	2.00e-127	449.00
IUUC-Ppa-095348	Physcomitrella patens	42.77	8.00e-80	290.00
IUUC-Pfo-096740	Poecilia formosa	65.60	4.00e-135	474.00
IUUC-Pab-098447	Pongo abelii	86.88	2.00e-162	565.00
IUUC-Pop-099065	Populus trichocarpa	40.65	1.00e-76	280.00
IUUC-Pca-101130	Procavia capensis	73.90	0.00e+00	690.00
IUUC-Ppe-101669	Prunus persica	43.73	7.00e-79	287.00
IUUC-Pva-102685	Pteropus vampyrus	69.43	2.00e-96	346.00
IUUC-Pgr-103262	Puccinia graminis	32.02	1.00e-41	164.00
IUUC-Ptt-103932	Puccinia triticina	33.45	2.00e-37	149.00
IUUC-Pte-104073	Pyrenophora teres	22.92	5.00e-11	62.40
IUUC-Rno-105017	Rattus norvegicus	91.54	0.00e+00	944.00
IUUC-Sha-107405	Sarcophilus harrisii	69.87	1.00e-177	615.00
IUUC-Sja-107997	Schizosaccharomyces japonicus	27.49	7.00e-20	91.70
IUUC-Spo-108316	Schizosaccharomyces pombe	29.17	6.00e-27	115.00
IUUC-Smo-108985	Selaginella moellendorffii	44.88	8.00e-79	287.00
IUUC-Sit-109820	Setaria italica	44.62	4.00e-80	291.00
IUUC-Sly-110899	Solanum lycopersicum	43.97	8.00e-81	294.00
IUUC-Stu-112753	Solanum tuberosum	43.48	6.00e-79	288.00
IUUC-Sar-113155	Sorex araneus	74.23	0.00e+00	701.00
IUUC-Sbi-114408	Sorghum bicolor	42.78	5.00e-84	304.00
IUUC-Sre-115186	Sporisorium reilianum	28.50	3.00e-32	132.00
IUUC-Ssc-116125	Sus scrofa	78.98	0.00e+00	803.00
IUUC-Tru-117888	Takifugu rubripes	61.70	3.00e-135	474.00
IUUC-Tsy-119064	Tarsius syrichta	73.53	0.00e+00	627.00
IUUC-Tni-120323	Tetraodon nigroviridis	65.10	1.00e-132	466.00
IUUC-Tca-121784	Theobroma cacao	42.77	1.00e-75	276.00
IUUC-Tae-123366	Triticum aestivum	43.94	2.00e-77	283.00
IUUC-Tur-126046	Triticum urartu	44.81	8.00e-68	250.00
IUUC-Tbe-127406	Tupaia belangeri	83.73	5.00e-96	345.00
IUUC-Ttr-128268	Tursiops truncatus	79.46	0.00e+00	783.00
IUUC-Vpa-130534	Vicugna pacos	82.83	1.00e-129	456.00
IUUC-Vvi-131612	Vitis vinifera	40.53	2.00e-80	293.00
IUUC-Xtr-132969	Xenopus tropicalis	57.29	1.00e-125	442.00
IUUC-Xma-134075	Xiphophorus maculatus	55.51	4.00e-135	474.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence