• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063942
UUCD1 version UUC-MuM-00221
Ensembl Protein ID ENSMUSP00000005889.9
UniProt Accession P27870; Q8BTV7; VAV_MOUSE
Genbank Protein ID CAA45713.1; BAC40436.1; AAA63402.1
Protein Name Proto-oncogene vav; p95vav
Genbank Nucleotide ID X64361; AK088586; M59833
Gene Name Vav1; Vav
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034116.17 ENSMUST00000169220.8 ENSMUSP00000126694.2
ENSMUSG00000034116.17 ENSMUST00000005889.15 ENSMUSP00000005889.9
ENSMUSG00000034116.17 ENSMUST00000112870.4 ENSMUSP00000108491.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-20 74.5 788 839
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
    ++ yd+ a + eL+lk+Gd+++++ +++ +gW++g e g+ G fP+n+ve+
   Q: 788 KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 839
    788**********************.89999******..9*************86 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:10646609, PubMed:10646608). May interact with CCPG1 (PubMed:17000758). Interacts with CLNK (PubMed:11463797). Interacts with THEMIS2 (PubMed:20644716). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK (By similarity). Interacts with ANKRD54 (PubMed:19064729). Interacts with CD6 (PubMed:24584089).
Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:10646609, PubMed:10646608). May interact with CCPG1 (PubMed:17000758). Interacts with CLNK (PubMed:11463797). Interacts with THEMIS2 (PubMed:20644716). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK (By similarity). Interacts with ANKRD54 (PubMed:19064729). Interacts with CD6 (PubMed:24584089).
Protein Sequence
(Fasta)
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPQAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063942|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGTAGTTG TCCCCACTGG GGCAGGCGGC GGCGGTGGTG AAGGAACGAG GGTGCACGGG 60
GCCTCCCCGA GGGGCCAAGT GAGAGGCCGG CAGCCACCAT GGAGCTCTGG CGACAGTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063942|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0030168--P:platelet activation
GO:0045785--P:positive regulation of cell adhesion
GO:0043547--P:positive regulation of GTPase activity
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0042110--P:T cell activation
GO:0030217--P:T cell differentiation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG mmu:22324
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Bta-013049 Bos taurus 78.93 0.00e+00 1184.00
IUUC-Cja-020009 Callithrix jacchus 92.78 0.00e+00 1583.00
IUUC-Cfa-020768 Canis familiaris 94.44 0.00e+00 1587.00
IUUC-Dno-029602 Dasypus novemcinctus 93.49 0.00e+00 1585.00
IUUC-Eca-033682 Equus caballus 93.61 0.00e+00 1578.00
IUUC-Fca-035629 Felis catus 93.03 0.00e+00 1605.00
IUUC-Gmo-039693 Gadus morhua 60.40 0.00e+00 964.00
IUUC-Gac-041567 Gasterosteus aculeatus 66.31 0.00e+00 1031.00
IUUC-Hsa-045886 Homo sapiens 93.14 0.00e+00 1590.00
IUUC-Itr-048730 Ictidomys tridecemlineatus 91.61 0.00e+00 1526.00
IUUC-Loc-051761 Lepisosteus oculatus 71.58 0.00e+00 1192.00
IUUC-Laf-054537 Loxodonta africana 92.90 0.00e+00 1579.00
IUUC-Mcc-054726 Macaca mulatta 93.02 0.00e+00 1590.00
IUUC-Mmr-060980 Microcebus murinus 92.81 0.00e+00 1593.00
IUUC-Mdo-061926 Monodelphis domestica 85.70 0.00e+00 1321.00
IUUC-Mpu-066000 Mustela putorius furo 93.85 0.00e+00 1581.00
IUUC-Mlu-067818 Myotis lucifugus 91.17 0.00e+00 1518.00
IUUC-Ont-072213 Oreochromis niloticus 67.56 0.00e+00 1115.00
IUUC-Ocu-074830 Oryctolagus cuniculus 77.45 0.00e+00 1165.00
IUUC-Ola-087345 Oryzias latipes 63.72 0.00e+00 1046.00
IUUC-Oga-089104 Otolemur garnettii 93.96 0.00e+00 1602.00
IUUC-Oar-089459 Ovis aries 92.66 0.00e+00 1561.00
IUUC-Ptr-090766 Pan troglodytes 92.79 0.00e+00 1470.00
IUUC-Pan-091994 Papio anubis 91.96 0.00e+00 1565.00
IUUC-Psi-093595 Pelodiscus sinensis 77.64 0.00e+00 1260.00
IUUC-Pfo-097210 Poecilia formosa 66.27 0.00e+00 1071.00
IUUC-Pab-098630 Pongo abelii 93.12 0.00e+00 1553.00
IUUC-Pva-102406 Pteropus vampyrus 92.07 0.00e+00 1528.00
IUUC-Pte-104123 Pyrenophora teres 48.33 1.00e-10 62.80
IUUC-Pyt-104567 Pyrenophora triticirepentis 52.00 2.00e-10 61.60
IUUC-Rno-105763 Rattus norvegicus 95.15 0.00e+00 1595.00
IUUC-Sha-106683 Sarcophilus harrisii 85.11 0.00e+00 1476.00
IUUC-Sly-111123 Solanum lycopersicum 50.00 2.00e-10 59.70
IUUC-Stu-112434 Solanum tuberosum 50.00 3.00e-10 59.70
IUUC-Sar-113457 Sorex araneus 79.39 0.00e+00 904.00
IUUC-Ssc-115338 Sus scrofa 93.96 0.00e+00 1479.00
IUUC-Tru-118199 Takifugu rubripes 64.38 0.00e+00 1007.00
IUUC-Tni-120548 Tetraodon nigroviridis 64.87 0.00e+00 1032.00
IUUC-Tbe-127235 Tupaia belangeri 70.37 1.00e-137 483.00
IUUC-Vpa-130066 Vicugna pacos 68.42 2.00e-72 267.00
IUUC-Xtr-132410 Xenopus tropicalis 71.21 0.00e+00 1232.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved