iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.30e-59	200.6	52	365

Active Site

Position(s)	Description	Evidence
61	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
314	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS+LQ+ ++  ++r  l++    ++++++ +e+k ++  +l  l+e++++s++kav p+el+++l+k+++    + q
   Q: 52   VGLHNIGQTCCLNSLLQVFMMNMDFRMILKR---ITVPRSA-EERKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVP--LFVQ 134
           6******************************...6666654.58899**********************************99..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + +  ++++                          +++  ++ ++ lF + ++++++c  c  +ssr+++ l+lslp+ +
   Q: 135  HDAAQLYLTIWNLTKDQI--------------------------TDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFD 197
           ******************..........................67888999************************************* PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           k+ + +++l+d+L+ f++++el ++  + ce+c +k+  ++ lkl++lP++L++hL+Rf  s ++++ eki  +v+fp++Ld s+++ +
   Q: 198  KDAKPLKTLEDALRCFVQPKELASS-DMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRF--SARNSRTEKICHSVNFPQSLDFSQVLPT 283
           **********************975.59*******************************..6677899****************97766 PP
   S: 268  .....peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
                + +k++++  YeL+av+ H G ++ GHY+ay++n  +gkW++f+Ds+V  v++++v+ + g       +taY+l+Y++
   Q: 284  eedlgD-TKEQSEIHYELFAVIAHVGMADFGHYCAYIRNpVDGKWFCFNDSHVCWVTWKDVQCTYGnhryrwrETAYLLVYTK 365
           344421.2333499*************************55777*******************888***************97 PP

Organism

Mus musculus

Functional Description
(View)

Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (By similarity).

Protein Sequence
(Fasta)

MGKGFGLLRK PCQSVVAEPQ QYSALEEERT MKRKRVLSRD LCSAWDSPHG LVGLHNIGQT 60
CCLNSLLQVF MMNMDFRMIL KRITVPRSAE ERKRSVPFQL LLLLEKMQDS RQKAVLPTEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCCAGGG CGGCTGTGCC TAGGGGACAG CAGACACTCC TGAGCTGAGA GGCTGGGAGG 60
CAGCAAGACT GCTCTGCTCC GCGGTGCCGC GTCCTCTTCT GTAGCCCTTT GCAGATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:24110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	70.79	8.00e-145	506.00
IUUC-Apl-004006	Anas platyrhynchos	55.31	3.00e-103	367.00
IUUC-Aca-005088	Anolis carolinensis	54.10	1.00e-90	326.00
IUUC-Ame-010606	Astyanax mexicanus	35.02	1.00e-41	163.00
IUUC-Bta-013036	Bos taurus	70.94	1.00e-135	476.00
IUUC-Cja-019052	Callithrix jacchus	67.91	3.00e-124	437.00
IUUC-Cfa-020554	Canis familiaris	74.34	1.00e-151	529.00
IUUC-Cpo-022421	Cavia porcellus	69.50	7.00e-149	520.00
IUUC-Csa-023737	Chlorocebus sabaeus	69.00	2.00e-80	291.00
IUUC-Cho-024807	Choloepus hoffmanni	59.90	7.00e-58	217.00
IUUC-Dre-027408	Danio rerio	34.56	6.00e-44	171.00
IUUC-Dno-029813	Dasypus novemcinctus	59.41	3.00e-109	388.00
IUUC-Dor-030532	Dipodomys ordii	68.82	2.00e-148	518.00
IUUC-Ete-032254	Echinops telfairi	64.17	4.00e-140	491.00
IUUC-Eca-033482	Equus caballus	74.38	5.00e-141	493.00
IUUC-Eeu-034451	Erinaceus europaeus	66.04	1.00e-82	298.00
IUUC-Fca-036313	Felis catus	70.43	3.00e-150	524.00
IUUC-Fal-037216	Ficedula albicollis	51.55	3.00e-99	355.00
IUUC-Gmo-038649	Gadus morhua	33.65	1.00e-41	163.00
IUUC-Gga-041082	Gallus gallus	53.85	2.00e-92	332.00
IUUC-Gac-042439	Gasterosteus aculeatus	34.92	2.00e-47	182.00
IUUC-Ggo-044957	Gorilla gorilla	72.43	2.00e-116	411.00
IUUC-Hsa-046381	Homo sapiens	70.62	4.00e-153	533.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	70.78	6.00e-155	540.00
IUUC-Loc-052688	Lepisosteus oculatus	32.39	4.00e-42	165.00
IUUC-Laf-054109	Loxodonta africana	69.52	7.00e-155	540.00
IUUC-Mcc-054814	Macaca mulatta	69.81	5.00e-152	530.00
IUUC-Meu-056253	Macropus eugenii	66.90	1.00e-106	379.00
IUUC-Mmr-061613	Microcebus murinus	73.75	7.00e-148	516.00
IUUC-Mdo-061890	Monodelphis domestica	62.72	3.00e-119	421.00
IUUC-Mpu-066342	Mustela putorius furo	71.08	1.00e-151	529.00
IUUC-Mlu-067010	Myotis lucifugus	69.71	2.00e-151	528.00
IUUC-Nle-069148	Nomascus leucogenys	69.38	5.00e-148	517.00
IUUC-Opr-070988	Ochotona princeps	68.59	4.00e-61	228.00
IUUC-Ont-072039	Oreochromis niloticus	35.33	5.00e-48	184.00
IUUC-Oan-073740	Ornithorhynchus anatinus	56.83	6.00e-72	263.00
IUUC-Ocu-074498	Oryctolagus cuniculus	71.08	2.00e-140	492.00
IUUC-Ola-086753	Oryzias latipes	36.94	5.00e-50	191.00
IUUC-Oga-088497	Otolemur garnettii	70.95	3.00e-148	517.00
IUUC-Oar-089505	Ovis aries	71.56	1.00e-136	478.00
IUUC-Ptr-091656	Pan troglodytes	70.62	1.00e-153	536.00
IUUC-Pan-092498	Papio anubis	69.81	6.00e-152	530.00
IUUC-Psi-093409	Pelodiscus sinensis	53.01	1.00e-102	366.00
IUUC-Pfo-096507	Poecilia formosa	35.09	3.00e-46	178.00
IUUC-Pab-097828	Pongo abelii	73.12	1.00e-138	485.00
IUUC-Pca-100299	Procavia capensis	67.08	3.00e-88	318.00
IUUC-Pva-102972	Pteropus vampyrus	68.55	1.00e-144	505.00
IUUC-Rno-105738	Rattus norvegicus	85.91	0.00e+00	658.00
IUUC-Sha-107309	Sarcophilus harrisii	62.73	2.00e-114	405.00
IUUC-Sar-112983	Sorex araneus	69.69	2.00e-111	395.00
IUUC-Ssc-116049	Sus scrofa	69.69	4.00e-136	477.00
IUUC-Tgu-117115	Taeniopygia guttata	54.11	2.00e-97	348.00
IUUC-Tru-118022	Takifugu rubripes	33.43	2.00e-42	166.00
IUUC-Tsy-118986	Tarsius syrichta	52.61	1.00e-52	199.00
IUUC-Tni-120306	Tetraodon nigroviridis	34.81	4.00e-43	168.00
IUUC-Tbe-127768	Tupaia belangeri	63.42	1.00e-99	356.00
IUUC-Ttr-128686	Tursiops truncatus	71.21	3.00e-138	484.00
IUUC-Xtr-132032	Xenopus tropicalis	44.30	3.00e-66	244.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence