iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063603

UUCD1 version

UUC-MuM-00632

Ensembl Protein ID

ENSMUSP00000142184.1

UniProt Accession

Q8BHJ5; Q3UWL6; Q8CBG4; Q8VEG3; Q9EQD4; TBL1R_MOUSE

Genbank Protein ID

AAG44738.1; BAC26526.1; BAC28241.1; BAC29294.1; BAE22898.1; AAH18512.1

Protein Name

F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1

Genbank Nucleotide ID

AF268195; AK029595; AK033347; AK036064; AK136255; BC018512

Gene Name

Tbl1xr1; Ira1; Tblr1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027630.13	ENSMUST00000193734.5	ENSMUSP00000142184.1
ENSMUSG00000027630.13	ENSMUST00000201509.1	ENSMUSP00000144547.1
ENSMUSG00000027630.13	ENSMUST00000201467.1	ENSMUSP00000144340.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.70e-54	178.0	347	385
UBD/Beta-Prp	2.80e-65	221.6	312	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 347  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 385
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
            +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h+++++++++
   Q: 312  LDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
           44555.66777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP
   S: 103  sp........sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           sp        +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+ 
   Q: 400  SPtgpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TGG 485
           7755555444222467777777777777777777777.7777777777777777777777777777777777777777777776..777 PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlq 210
           +  + ++  g  + + + dg+v + dl+
   Q: 486  IFEVCWNAAGDKVGASASDGSVCVLDLR 513
           7777777777777777777777776665 PP

Organism

Mus musculus

Functional Description
(View)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQHAAA AAAAAAATNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGCCGCT CGGGTTTGTT TTGCTGCGCG GCCGTCGCCG CCGCGGGCCC GGAGCTCATT 60
TGTGCCTGGC TGGTCCCCGC GCTCCCCGGT GCCGAGCCGG AGCCGTTGGC CGCTCGCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0047485--F:protein N-terminus binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060612--P:adipose tissue development
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016575--P:histone deacetylation
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0010468--P:regulation of gene expression
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation

KEGG

mmu:81004

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.71	4.00e-55	206.00
IUUC-Aml-001717	Ailuropoda melanoleuca	98.64	0.00e+00	953.00
IUUC-Atr-002514	Amborella trichopoda	65.66	1.00e-145	509.00
IUUC-Apl-003708	Anas platyrhynchos	98.79	0.00e+00	920.00
IUUC-Aca-004611	Anolis carolinensis	98.64	0.00e+00	960.00
IUUC-Aly-005622	Arabidopsis lyrata	58.68	2.00e-120	426.00
IUUC-Ath-007137	Arabidopsis thaliana	59.50	1.00e-121	430.00
IUUC-Ago-007869	Ashbya gossypii	28.27	1.00e-32	134.00
IUUC-Ame-011601	Astyanax mexicanus	92.22	0.00e+00	905.00
IUUC-Bta-012418	Bos taurus	99.03	0.00e+00	991.00
IUUC-Bdi-014315	Brachypodium distachyon	61.21	7.00e-136	477.00
IUUC-Bol-016277	Brassica oleracea	57.51	1.00e-127	450.00
IUUC-Bra-016944	Brassica rapa	60.83	5.00e-127	448.00
IUUC-Cja-018832	Callithrix jacchus	99.22	0.00e+00	959.00
IUUC-Cfa-020029	Canis familiaris	98.83	0.00e+00	955.00
IUUC-Cpo-022080	Cavia porcellus	93.79	0.00e+00	928.00
IUUC-Csa-024075	Chlorocebus sabaeus	99.03	0.00e+00	955.00
IUUC-Cho-024872	Choloepus hoffmanni	98.29	3.00e-111	395.00
IUUC-Csv-026257	Ciona savignyi	69.96	0.00e+00	761.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.14	1.00e-106	380.00
IUUC-Dre-028075	Danio rerio	95.91	0.00e+00	932.00
IUUC-Dno-029196	Dasypus novemcinctus	99.42	0.00e+00	969.00
IUUC-Dor-030732	Dipodomys ordii	98.90	0.00e+00	728.00
IUUC-Eeu-034952	Erinaceus europaeus	89.22	0.00e+00	827.00
IUUC-Fca-035734	Felis catus	99.03	0.00e+00	967.00
IUUC-Fal-037185	Ficedula albicollis	98.83	0.00e+00	960.00
IUUC-Gmo-038870	Gadus morhua	90.27	0.00e+00	932.00
IUUC-Gga-041161	Gallus gallus	99.03	0.00e+00	963.00
IUUC-Gac-041844	Gasterosteus aculeatus	91.84	0.00e+00	955.00
IUUC-Gma-042796	Glycine max	48.08	2.00e-152	532.00
IUUC-Ggo-044882	Gorilla gorilla	99.03	0.00e+00	955.00
IUUC-Hsa-046488	Homo sapiens	99.03	0.00e+00	955.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	99.45	0.00e+00	736.00
IUUC-Kpa-049338	Komagataella pastoris	28.91	6.00e-32	132.00
IUUC-Lch-050672	Latimeria chalumnae	96.50	0.00e+00	973.00
IUUC-Lpe-051084	Leersia perrieri	62.91	3.00e-137	482.00
IUUC-Loc-052030	Lepisosteus oculatus	95.95	0.00e+00	962.00
IUUC-Laf-054280	Loxodonta africana	98.64	0.00e+00	990.00
IUUC-Mcc-055203	Macaca mulatta	99.03	0.00e+00	956.00
IUUC-Meu-056563	Macropus eugenii	98.32	5.00e-135	474.00
IUUC-Mtr-058624	Medicago truncatula	47.26	9.00e-147	513.00
IUUC-Mga-059660	Meleagris gallopavo	99.03	0.00e+00	963.00
IUUC-Mmr-060925	Microcebus murinus	97.60	0.00e+00	919.00
IUUC-Mdo-062078	Monodelphis domestica	98.45	0.00e+00	958.00
IUUC-Mac-065508	Musa acuminata	61.80	2.00e-93	336.00
IUUC-Mpu-066741	Mustela putorius furo	98.83	0.00e+00	955.00
IUUC-Mlu-068152	Myotis lucifugus	99.22	0.00e+00	962.00
IUUC-Nle-069229	Nomascus leucogenys	99.03	0.00e+00	955.00
IUUC-Opr-070277	Ochotona princeps	88.36	0.00e+00	818.00
IUUC-Ont-072623	Oreochromis niloticus	92.04	0.00e+00	956.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.32	0.00e+00	957.00
IUUC-Oba-075618	Oryza barthii	48.83	1.00e-145	509.00
IUUC-Obr-076718	Oryza brachyantha	63.46	2.00e-138	486.00
IUUC-Ogl-077302	Oryza glaberrima	50.99	1.00e-157	550.00
IUUC-Ogu-078718	Oryza glumaepatula	50.99	1.00e-157	549.00
IUUC-Oin-079515	Oryza indica	44.34	3.00e-95	343.00
IUUC-Olo-080427	Oryza longistaminata	63.32	2.00e-132	466.00
IUUC-Ome-081696	Oryza meridionalis	49.91	3.00e-152	531.00
IUUC-Oni-082137	Oryza nivara	50.99	1.00e-157	549.00
IUUC-Opu-083505	Oryza punctata	48.57	2.00e-145	508.00
IUUC-Oru-085276	Oryza rufipogon	50.81	4.00e-157	548.00
IUUC-Osa-085791	Oryza sativa	50.99	1.00e-157	549.00
IUUC-Ola-087365	Oryzias latipes	95.15	0.00e+00	953.00
IUUC-Olu-087589	Ostreococcus lucimarinus	52.43	2.00e-156	545.00
IUUC-Oga-088357	Otolemur garnettii	95.14	0.00e+00	908.00
IUUC-Oar-089214	Ovis aries	99.22	0.00e+00	994.00
IUUC-Ptr-091532	Pan troglodytes	99.03	0.00e+00	955.00
IUUC-Pan-091927	Papio anubis	99.03	0.00e+00	955.00
IUUC-Psi-093941	Pelodiscus sinensis	92.03	0.00e+00	938.00
IUUC-Pma-094105	Petromyzon marinus	65.87	3.00e-101	361.00
IUUC-Ppa-095868	Physcomitrella patens	66.30	1.00e-139	489.00
IUUC-Pfo-096158	Poecilia formosa	92.04	0.00e+00	956.00
IUUC-Pab-098705	Pongo abelii	99.03	0.00e+00	955.00
IUUC-Pca-100256	Procavia capensis	98.43	0.00e+00	946.00
IUUC-Ppe-101572	Prunus persica	63.69	5.00e-128	451.00
IUUC-Pva-102616	Pteropus vampyrus	98.82	0.00e+00	948.00
IUUC-Rno-105411	Rattus norvegicus	99.81	0.00e+00	982.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.96	3.00e-43	169.00
IUUC-Sha-106636	Sarcophilus harrisii	97.86	0.00e+00	951.00
IUUC-Smo-109301	Selaginella moellendorffii	63.76	4.00e-144	504.00
IUUC-Sit-110710	Setaria italica	64.01	5.00e-143	501.00
IUUC-Sly-111042	Solanum lycopersicum	50.87	1.00e-151	530.00
IUUC-Stu-112744	Solanum tuberosum	49.81	2.00e-144	505.00
IUUC-Sar-112971	Sorex araneus	90.00	0.00e+00	863.00
IUUC-Sbi-114420	Sorghum bicolor	63.74	2.00e-143	502.00
IUUC-Sre-115175	Sporisorium reilianum	37.17	1.00e-58	221.00
IUUC-Ssc-115695	Sus scrofa	97.47	0.00e+00	947.00
IUUC-Tgu-117009	Taeniopygia guttata	99.01	0.00e+00	947.00
IUUC-Tru-118581	Takifugu rubripes	94.76	0.00e+00	959.00
IUUC-Tsy-119424	Tarsius syrichta	82.05	0.00e+00	737.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.15	0.00e+00	961.00
IUUC-Tca-121739	Theobroma cacao	56.87	4.00e-125	441.00
IUUC-Tae-125368	Triticum aestivum	62.16	2.00e-136	479.00
IUUC-Tur-126856	Triticum urartu	42.39	2.00e-75	276.00
IUUC-Tme-127126	Tuber melanosporum	38.42	2.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	83.04	0.00e+00	822.00
IUUC-Uma-129469	Ustilago maydis	42.75	3.00e-59	223.00
IUUC-Vpa-130768	Vicugna pacos	98.62	0.00e+00	942.00
IUUC-Xtr-132842	Xenopus tropicalis	92.38	0.00e+00	912.00
IUUC-Xma-134020	Xiphophorus maculatus	92.04	0.00e+00	956.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence