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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046444
UUCD1 version UUC-HoS-01128
Ensembl Protein ID ENSP00000303434.4
UniProt Accession Q8NB14; B3KX93; Q3ZCV1; Q8NDF5; Q96DK6; Q96PZ6; Q9BY55; UBP38_HUMAN
Genbank Protein ID BAB71627.1; BAC03730.1; BAG54405.1; CAD38820.1; EAX05075.1; EAX05076.1; AAH39115.1; AAH68975.1; BAB67784.1; AAK26248.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme 38; HP43.8KD; Ubiquitin thioesterase 38; Ubiquitin-specific-processing protease 38
Genbank Nucleotide ID AK057992; AK091712; AK126943; AL833976; AC099549; CH471056; BC039115; BC068975; AB067478; AF211481
Gene Name USP38; KIAA1891
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170185.9 ENST00000510377.5 ENSP00000427647.1
ENSG00000170185.9 ENST00000307017.8 ENSP00000303434.4
ENSG00000170185.9 ENST00000511739.1 ENSP00000424158.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12401499; 14715245
Classification
Family E-value Score Start End
DUB/USP 7.70e-83 280.1 445 949
Active Site
Position(s) Description Evidence
454 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
857 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           tGl NlgNtCYmNSv+Q+L++ +++r+++l+ + + +n         +l+k+lq+lf+ l +++++a++pr +++a +   + f+  +qqD+
   Q: 445  TGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCN---------SLMKKLQHLFAFLAHTQREAYAPRIFFEASR--PPWFTPRSQQDC 525
           7******************************5555554.........7***************************998..777********* PP
   S: 93   qEflaflldqleeelkk...eknkpkeeeeeedkselsde........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           +E+l+flld+l+ee k    +++++ +e  e ++++l++         +  ++   +k+li+++F+g+l+++i+cl+c+++s++ e f+dls
   Q: 526  SEYLRFLLDRLHEEEKIlkvQASHKPSEILECSETSLQEVaskaavltETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLS 617
           **************95577788888888888888888888888999988888888999********************************** PP
   S: 174  lpvpgkeetkke................................................................................ 185
           l++  +++ ++                                                                                 
   Q: 618  LAFCPSSSLENMsvqdpasspsiqdgglmqasvpgpseepvvynpttaaficdslvnektigsppnefycsentsvpnesnkilvnkdvpqk 709
           ***9999776669******************************************************************************* PP
   S: 186  .......slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
                  s++d+L+ f ++e l+g+n+yyce+c ++q+aek++++++ Pe+Lil L Rfs++++ ++r+ki ++v++pl L+l    ++   
   Q: 710  pggettpSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITsfs 801
           ******************************************************************************99999954444366 PP
   S: 268  ............................peekqkekkkYeLiavvvHsG.slssGHYvayvkn............................. 301
                                       +e + ++ + Y L++vvvHsG s++sGHY++y++n                             
   Q: 802  slseswsvdvdftdlsenlakklkpsgtDEASCTKLVPYLLSSVVVHSGiSSESGHYYSYARNitstdssyqmyhqsealalassqshllgr 893
           667777777777777777777777666644445559***********************************************999999999 PP
   S: 302  ...............ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                           +++W+lf+Ds+Vt ++ ++v++ t+    +taYvl+Yk++
   Q: 894  dspsavfeqdlenkeMSKEWFLFNDSRVTFTSFQSVQKITSrfpkDTAYVLLYKKQ 949
           9999999988865544555*******************999************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.
 Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.
Protein Sequence
(Fasta)
MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 60
GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD VAILDYIHNG LKLIMSCPSV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046444|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTCAAAAT CCGGGTCAAA GGGTGTCGCT TCGGTCTCTT CTCCCCGGCT GATCCCAGCA 60
CTCTCCGTGA CAGCGCCTCC TGACTCAGCC CAGGACCGGC TTCTTCTCAC GACCTGCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046444|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:84640
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002174 Ailuropoda melanoleuca 93.02 0.00e+00 1858.00
IUUC-Apl-003435 Anas platyrhynchos 76.12 0.00e+00 1264.00
IUUC-Aca-004556 Anolis carolinensis 71.16 0.00e+00 1305.00
IUUC-Ame-010616 Astyanax mexicanus 62.52 0.00e+00 1238.00
IUUC-Bta-013544 Bos taurus 92.80 0.00e+00 1825.00
IUUC-Cja-018745 Callithrix jacchus 94.46 0.00e+00 1913.00
IUUC-Cfa-020434 Canis familiaris 89.35 0.00e+00 1784.00
IUUC-Cpo-021666 Cavia porcellus 91.84 0.00e+00 1785.00
IUUC-Csa-023965 Chlorocebus sabaeus 98.08 0.00e+00 2038.00
IUUC-Cho-024809 Choloepus hoffmanni 84.11 0.00e+00 1282.00
IUUC-Cin-025604 Ciona intestinalis 37.39 7.00e-41 161.00
IUUC-Csv-026333 Ciona savignyi 44.25 4.00e-32 131.00
IUUC-Dre-028338 Danio rerio 63.28 0.00e+00 1256.00
IUUC-Dno-029372 Dasypus novemcinctus 92.03 0.00e+00 1858.00
IUUC-Dor-030752 Dipodomys ordii 89.34 0.00e+00 1241.00
IUUC-Ete-032588 Echinops telfairi 79.87 0.00e+00 1133.00
IUUC-Eca-034416 Equus caballus 94.24 0.00e+00 1943.00
IUUC-Eeu-035132 Erinaceus europaeus 73.95 0.00e+00 1400.00
IUUC-Fca-036137 Felis catus 93.57 0.00e+00 1899.00
IUUC-Fal-037297 Ficedula albicollis 75.50 0.00e+00 1445.00
IUUC-Gmo-038727 Gadus morhua 66.92 0.00e+00 1028.00
IUUC-Gga-041091 Gallus gallus 74.02 0.00e+00 1399.00
IUUC-Gac-042082 Gasterosteus aculeatus 63.90 0.00e+00 1145.00
IUUC-Ggo-045376 Gorilla gorilla 94.74 0.00e+00 1888.00
IUUC-Itr-047976 Ictidomys tridecemlineatus 93.28 0.00e+00 1910.00
IUUC-Lch-050500 Latimeria chalumnae 71.89 0.00e+00 1430.00
IUUC-Loc-052625 Lepisosteus oculatus 64.78 0.00e+00 1308.00
IUUC-Laf-053689 Loxodonta africana 93.17 0.00e+00 1887.00
IUUC-Mcc-055286 Macaca mulatta 98.18 0.00e+00 1999.00
IUUC-Mga-059905 Meleagris gallopavo 74.23 0.00e+00 1233.00
IUUC-Mmr-061397 Microcebus murinus 95.30 0.00e+00 1915.00
IUUC-Mdo-062833 Monodelphis domestica 86.03 0.00e+00 1795.00
IUUC-Mmu-063157 Mus musculus 90.12 0.00e+00 1823.00
IUUC-Mpu-066434 Mustela putorius furo 94.15 0.00e+00 1922.00
IUUC-Mlu-068178 Myotis lucifugus 91.60 0.00e+00 1806.00
IUUC-Nle-070153 Nomascus leucogenys 98.27 0.00e+00 1949.00
IUUC-Ont-072330 Oreochromis niloticus 63.41 0.00e+00 1250.00
IUUC-Oan-072709 Ornithorhynchus anatinus 80.29 0.00e+00 1285.00
IUUC-Ocu-074832 Oryctolagus cuniculus 94.24 0.00e+00 1900.00
IUUC-Ola-087003 Oryzias latipes 55.17 3.00e-48 184.00
IUUC-Oga-088517 Otolemur garnettii 90.16 0.00e+00 1803.00
IUUC-Oar-089472 Ovis aries 89.16 0.00e+00 1753.00
IUUC-Ptr-090996 Pan troglodytes 99.62 0.00e+00 2027.00
IUUC-Pan-091837 Papio anubis 96.09 0.00e+00 1985.00
IUUC-Psi-093236 Pelodiscus sinensis 76.23 0.00e+00 1159.00
IUUC-Pma-094349 Petromyzon marinus 53.04 0.00e+00 983.00
IUUC-Pfo-097193 Poecilia formosa 61.94 0.00e+00 1163.00
IUUC-Pab-098710 Pongo abelii 98.75 0.00e+00 2031.00
IUUC-Pca-100794 Procavia capensis 81.98 0.00e+00 1645.00
IUUC-Pva-102722 Pteropus vampyrus 93.19 0.00e+00 1899.00
IUUC-Rno-105743 Rattus norvegicus 89.54 0.00e+00 1788.00
IUUC-Sha-106563 Sarcophilus harrisii 85.14 0.00e+00 1452.00
IUUC-Sar-113533 Sorex araneus 77.64 0.00e+00 1559.00
IUUC-Ssc-116259 Sus scrofa 83.94 0.00e+00 1585.00
IUUC-Tgu-117475 Taeniopygia guttata 75.89 0.00e+00 1318.00
IUUC-Tru-118623 Takifugu rubripes 63.09 0.00e+00 1160.00
IUUC-Tsy-119250 Tarsius syrichta 93.24 0.00e+00 1494.00
IUUC-Tni-120441 Tetraodon nigroviridis 59.59 0.00e+00 1077.00
IUUC-Tbe-127936 Tupaia belangeri 81.38 0.00e+00 1546.00
IUUC-Ttr-128483 Tursiops truncatus 80.72 0.00e+00 1412.00
IUUC-Vpa-130303 Vicugna pacos 97.94 0.00e+00 1078.00
IUUC-Xtr-132773 Xenopus tropicalis 72.46 0.00e+00 1418.00
Created Date 25-Jun-2017

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